Papers by Sabrina DeLeonibus
Circulation, 2018
Diet induced changes in gut microbial composition and dysregulated immune responses are key playe... more Diet induced changes in gut microbial composition and dysregulated immune responses are key players in the progression of metabolic syndrome (MetSyn) and obesity.The lymphatics that are directly exposed to the gut microbiota in the mesenteric bed are central players in inflammatory and immune responses and are impaired during MetSyn. However, the mechanisms remain unknown.Endogenous tryptophan derived gut microbiota metabolites such as indole, significantly limits inflammation and immune response. We hypothesize that microbiota influence the lymphatic mesenteric microenvironment via such discrete metabolites to impact metabolic disease. We evaluated the effects of indole, tryptamine and indole-3-acetate (I-3A) on inflammatory mechanisms in vitro and in vivo using cultured models of lymphatic endothelium (HDLECs) and rat models of high fructose diet induced MetSyn and LPS induced acute inflammation. HDLECs were treated with varying doses of indole, tryptamine and I-3A (100uM-500uM) i...
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Papers by Sabrina DeLeonibus