International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 2013
Background: The incidence of polycystic ovarian syndrome (PCOS) is increasing among young women. ... more Background: The incidence of polycystic ovarian syndrome (PCOS) is increasing among young women. PCOS women have decreased insulin sensitivity independent of body mass index with increase in lipid levels. Studies on measuring inflammatory status in PCOS showed varying results. The interrelationship between inflammatory status, insulin resistance and lipid levels among PCOS women was studied. Methods: Twenty PCOS women and 20 healthy controls of age 18-25 years were recruited. Fasting blood samples were collected for estimation of serum glucose, insulin levels, lipid levels and C-reactive protein (CRP) concentration. Insulin resistance was determined by homeostasis model assessment (HOMA-IR) index. Results: PCOS women had significant increase in fasting insulin, HOMA-IR and triglycerides compared to healthy controls. HOMA-IR was positively associated with serum triglycerides, VLDL levels and CRP levels among PCOS subjects. Total Cholesterol was positively associated with CRP. Regression analysis showed HOMA-IR as a sole parameter strongly linked with PCOS women. This indicates that, IR is an independent pathogenic variable linked with PCOS which in turn showed positive association with CRP and triglycerides. Conclusion: IR is the hallmark of PCOS among young adolescent women. IR is associated with elevated CRP and triglyceride levels. Taking measures to increase insulin sensitivity, may help in altering dyslipidemia and inflammatory status, thereby reducing CVD risk among young women with PCOS.
International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 2018
Background: Abnormal vaginal bleeding may be caused by an extensive spectrum of disorders, both g... more Background: Abnormal vaginal bleeding may be caused by an extensive spectrum of disorders, both gynecologic and non-gynecologic. Diagnostic accuracy of abnormal uterine bleeding is important for the management. Trans vaginal sonography (TVS) is one of the commonest investigation used for the diagnosis, but the diagnosis is not always accurate for all clinical conditions. Saline instillation sonography (SIS) has been shown to improve the diagnosis. Authors aimed to compare the TVS and SIS diagnosis with the final histopathological diagnosis.Methods: Seventy-five patients with the complained of abnormal uterine bleeding attending outpatient department of a tertiary care institute were enrolled for the study. Trans vaginal sonography (TVS) and saline instillation sonography (SIS) was done on outpatient basis. The diagnosis was compared with final histopathological diagnosis, in term of diagnostic accuracy, sensitivity, specificity, positive predictive value and negative predictive val...
International Journal of Reproduction, Contraception, Obstetrics and Gynecology
Background: Meconium stained liquor is a commonly observed phenomenon in the day-to-day obstetric... more Background: Meconium stained liquor is a commonly observed phenomenon in the day-to-day obstetric practice, the incidence being 12-22%. Meconium stained liquor can be considered as a normal physiological event in a term fetus in the absence of fetal heart rate abnormalities. It has greater significance as one of the parameters of fetal distress, when associated with abnormal fetal heart rate pattern. The aim of the present study was to study the association of, fetal heart rate abnormalities, mode of delivery and neonatal outcome with different grades of meconium stained liquor.Methods: A prospective study was conducted in one hundred and fifty cases of meconium stained liquor beyond 37 weeks gestation admitted to the labor room in a tertiary care Centre. Depending on the consistency of meconium, the patients were divided into two groups namely, Thick meconium stained liquor (group K) and Thin meconium stained liquor (group N). Maternal conditions, Intrapartum fetal heart rate patte...
Context: Adolescence is the transitional phase of physical and mental development between childho... more Context: Adolescence is the transitional phase of physical and mental development between childhood and adulthood and is characterized by immense hormonal changes.75% of girls experience some problems associated with menstruation. Aim: We tried to find out the prevalence of menstrual abnormalities in school going girls in Pondicherry and their association with dietary and exercise habits. Setting and Design: A cross-sectional questionnaire based study was conducted in adolescent girls who attained menarche in four secondary schools of Pondicherry, India. Material and Methods: All students who attained menarche and willing to participate in the study were invited to answer the questionnaire, which dealt with anthropometric data, socioeconomic data, menstrual history, and diet and exercise pattern. Statistical Analysis: Chi-square test and Fisher's exact test was used to compare the dietary and exercise patterns among students having menstrual abnormalities and those who do not have menstrual abnormalities.
International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 2013
Background: The incidence of polycystic ovarian syndrome (PCOS) is increasing among young women. ... more Background: The incidence of polycystic ovarian syndrome (PCOS) is increasing among young women. PCOS women have decreased insulin sensitivity independent of body mass index with increase in lipid levels. Studies on measuring inflammatory status in PCOS showed varying results. The interrelationship between inflammatory status, insulin resistance and lipid levels among PCOS women was studied. Methods: Twenty PCOS women and 20 healthy controls of age 18-25 years were recruited. Fasting blood samples were collected for estimation of serum glucose, insulin levels, lipid levels and C-reactive protein (CRP) concentration. Insulin resistance was determined by homeostasis model assessment (HOMA-IR) index. Results: PCOS women had significant increase in fasting insulin, HOMA-IR and triglycerides compared to healthy controls. HOMA-IR was positively associated with serum triglycerides, VLDL levels and CRP levels among PCOS subjects. Total Cholesterol was positively associated with CRP. Regression analysis showed HOMA-IR as a sole parameter strongly linked with PCOS women. This indicates that, IR is an independent pathogenic variable linked with PCOS which in turn showed positive association with CRP and triglycerides. Conclusion: IR is the hallmark of PCOS among young adolescent women. IR is associated with elevated CRP and triglyceride levels. Taking measures to increase insulin sensitivity, may help in altering dyslipidemia and inflammatory status, thereby reducing CVD risk among young women with PCOS.
International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 2018
Background: Abnormal vaginal bleeding may be caused by an extensive spectrum of disorders, both g... more Background: Abnormal vaginal bleeding may be caused by an extensive spectrum of disorders, both gynecologic and non-gynecologic. Diagnostic accuracy of abnormal uterine bleeding is important for the management. Trans vaginal sonography (TVS) is one of the commonest investigation used for the diagnosis, but the diagnosis is not always accurate for all clinical conditions. Saline instillation sonography (SIS) has been shown to improve the diagnosis. Authors aimed to compare the TVS and SIS diagnosis with the final histopathological diagnosis.Methods: Seventy-five patients with the complained of abnormal uterine bleeding attending outpatient department of a tertiary care institute were enrolled for the study. Trans vaginal sonography (TVS) and saline instillation sonography (SIS) was done on outpatient basis. The diagnosis was compared with final histopathological diagnosis, in term of diagnostic accuracy, sensitivity, specificity, positive predictive value and negative predictive val...
International Journal of Reproduction, Contraception, Obstetrics and Gynecology
Background: Meconium stained liquor is a commonly observed phenomenon in the day-to-day obstetric... more Background: Meconium stained liquor is a commonly observed phenomenon in the day-to-day obstetric practice, the incidence being 12-22%. Meconium stained liquor can be considered as a normal physiological event in a term fetus in the absence of fetal heart rate abnormalities. It has greater significance as one of the parameters of fetal distress, when associated with abnormal fetal heart rate pattern. The aim of the present study was to study the association of, fetal heart rate abnormalities, mode of delivery and neonatal outcome with different grades of meconium stained liquor.Methods: A prospective study was conducted in one hundred and fifty cases of meconium stained liquor beyond 37 weeks gestation admitted to the labor room in a tertiary care Centre. Depending on the consistency of meconium, the patients were divided into two groups namely, Thick meconium stained liquor (group K) and Thin meconium stained liquor (group N). Maternal conditions, Intrapartum fetal heart rate patte...
Context: Adolescence is the transitional phase of physical and mental development between childho... more Context: Adolescence is the transitional phase of physical and mental development between childhood and adulthood and is characterized by immense hormonal changes.75% of girls experience some problems associated with menstruation. Aim: We tried to find out the prevalence of menstrual abnormalities in school going girls in Pondicherry and their association with dietary and exercise habits. Setting and Design: A cross-sectional questionnaire based study was conducted in adolescent girls who attained menarche in four secondary schools of Pondicherry, India. Material and Methods: All students who attained menarche and willing to participate in the study were invited to answer the questionnaire, which dealt with anthropometric data, socioeconomic data, menstrual history, and diet and exercise pattern. Statistical Analysis: Chi-square test and Fisher's exact test was used to compare the dietary and exercise patterns among students having menstrual abnormalities and those who do not have menstrual abnormalities.
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