Papers by Rujipat Samransamruajkit
The Lancet Child & Adolescent Health, Jun 1, 2023
Journal of clinical nephrology and renal care, Jun 30, 2023
Pathology Research and Practice, Oct 1, 2022
Multisystem inflammatory syndrome in children (MIS-C) is an emerging phenomenon associated with S... more Multisystem inflammatory syndrome in children (MIS-C) is an emerging phenomenon associated with SARS-COV-2 infection (COVID-19) occurring in < 1 % of infected children. MIS-C is characterized by a hyperinflammatory state with excessive cytokine release (‘storm’) leading to hemodynamic compromise and multiorgan failure, with a death rate of ∼2 %. Autopsy examination can play a particularly important role in helping to understand the pathogenesis of MIS-C. Yet, only five autopsy studies have been reported to date. We report a fatal case of MIS-C involving a previously healthy, 5-year-old Thai boy admitted with MIS-C, one month after exposure to SARS-COV-2. While in intensive care, he was found to have a hypertrophic cardiomyopathy, and despite immunosuppressive treatment for MIS-C, developed shock and died. Multiorgan inflammation was not found at autopsy, implying that the MIS-C had responded to treatment. However, there was disseminated aspergillosis and cytomegalovirus reactivation, attributed to the immunosuppression. SARS-COV-2 virus was also found in multiple organs. To the best of our knowledge, this is the first reported autopsy of an MIS-C patient from Asia, and the first report of aspergillosis in MIS-C. This case underscores that the risks of immunosuppression are also a concern in MIS-C. Although MIS-C is generally considered to be a post-infectious hyperimmune reaction, persistence of SARS-COV-2 is a feature in all autopsies of MIS-C patients reported to date, suggesting a possible role in the pathogenesis, at least in fatal cases.
Frontiers in Pediatrics, Jun 27, 2023
Virus Research, Aug 1, 2008
WU and KI polyomaviruses represent novel viruses discovered in respiratory secretions from human ... more WU and KI polyomaviruses represent novel viruses discovered in respiratory secretions from human patients with acute respiratory tract infection. However, the association between WU/KI polyomaviruses and human disease has remained unclear. In this study, the prevalence of these two novel viruses and occurrence of co-infection with other respiratory viruses were determined in Thai pediatric patients with respiratory disease. Previously described PCR assays were applied to detect WU/KI polyomaviruses as well as other respiratory viruses in 302 nasopharyngeal suction specimens collected from February 2006 through February 2007. The results revealed the anneal prevalence of WU and KI polyomaviruses in the Thai population was 6.29% and 1.99%, respectively. The frequency of co-detection of WU and KI polyomaviruses with other respiratory viral pathogens was 42.11% and 33.33%, respectively. Moreover, each of the two complete genome sequences of WU (CU 295 and CU 302) and KI (CU 255 and CU 258) polyomaviruses were genetically and phylogenetically characterized. Sequence analysis showed that they contained features common to those found in previous studies. However, there were several nucleotide variations within the non-coding regulatory regions and various non-synonymous mutations within the coding regions which may influence virulence and pathogenesis of these viruses. Nevertheless, it is still possible that these viruses are not the causative agents of clinical respiratory disease. Therefore, judging the association of WU/KI polyomavirus infections with a particular disease will be challenging and require more comprehensive case control investigations.
Pediatric Critical Care Medicine, Nov 1, 2022
Pediatric Critical Care Medicine, Jun 1, 2018
Pediatric Critical Care Medicine, Jun 1, 2018
31 patients were included into the study. Median age 33 mo. (IQR 21 – 60), PELODS-II score at 5 p... more 31 patients were included into the study. Median age 33 mo. (IQR 21 – 60), PELODS-II score at 5 pts. (IQR 1 – 7), PRISM-III score at 5 pts. (IQR 2 – 9 pts.). Median dose of resuscitation fluid was 30 mL/kg (IQR 20 – 40). Baseline demographic data were not significantly different between 3 groups. After resuscitation, acid-base status parameters and fluid-related complications were not significantly different among groups. Subgroup analysis of patients received bolus fluid ≥ 30 mL/kg showed significant better lactate clearance after 24 hrs. in RLS group (p-value 0.046). Mortality, ventilator days, PICU & hospital LOS were not different between groups.
Frontiers in Pediatrics
BackgroundA consensus on the definition of prolonged mechanical ventilation (PMV) for children do... more BackgroundA consensus on the definition of prolonged mechanical ventilation (PMV) for children does not exist. There is still lack of published work presenting the epidemiology, risk factors and outcomes at different cut-points for PMV patients. These are important for planning the goals of treatment and counseling of the prognosis for patient families. We aimed to determine the incidence, baseline characteristics, risk factors and outcomes of PMV in pediatric patients at various cut-points (>14, >21 or >30days).MethodsA retrospective cohort study among children <18-years-old who were PMV > 14 days in the PICU of King Chulalongkorn Memorial Hospital was conducted. The primary outcomes were incidence of PMV with various cut-points. We stratified patients into three groups (Group 1; PMV > 14–21, Group 2; >21–30, Group 3; >30 days) for evaluating the baseline characteristics, risk factors, and outcomes of PMV (extubation success, tracheostomy status and death). ...
Pediatric Critical Care Medicine, 2018
This paper described the wind tunnel testing apparatus and technique to acquire the dynamic stabi... more This paper described the wind tunnel testing apparatus and technique to acquire the dynamic stability derivatives of large slenderness ratio air vehicle such as the guided missiles or rockets. There have been few difficulties in conducting wind tunnel testing for slender long rocket due to the size limitation of the test section size and the installation of oscillation equipments. In this study, the dynamic stability balance was used as the wind tunnel technique for obtaining the dynamic stability derivatives. Through the wind tunnel testing, the experimental apparatus for slender air vehicle's oscillation is established. The measured data showed that it is possible to acquire the dynamic stability derivatives of large slenderness ratio rocket, properly.
Pediatric Critical Care Medicine, 2018
Journal of Investigative Medicine, 2004
http://isrctn.org/>, Jan 17, 2013
Turkish journal of emergency medicine, 2023
Pediatric Critical Care Medicine, Nov 1, 2022
Clinical nutrition ESPEN, Aug 1, 2022
Journal of Neurosurgery: Pediatrics
OBJECTIVE There is a paucity of information on pediatric traumatic brain injury (TBI) care in Asi... more OBJECTIVE There is a paucity of information on pediatric traumatic brain injury (TBI) care in Asia and Latin America. In this study, the authors aimed to describe the clinical practices of emergency departments (EDs) participating in the Saline in Asia and Latin-America Neurotrauma in the Young (SALTY) study, by comparing designated trauma centers (DTCs) and nontrauma centers (NTCs) in their networks. METHODS The authors performed a site survey study on pediatric TBI management in the EDs in 14 countries. Two European centers joined other participating sites in Asia and Latin America. Questions were formulated after a critical review of current TBI guidelines and published surveys. The authors performed a descriptive analysis and stratified centers based on DTC status. RESULTS Of 24 responding centers (70.6%), 50.0% were DTCs, 70.8% had academic affiliations, and all centers were in urban settings. Patients were predominantly transferred to DTCs by centralized prehospital services c...
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Papers by Rujipat Samransamruajkit