Cumin (Cuminum cyminum L.) is an important seed spice crop, having good medicinal properties and ... more Cumin (Cuminum cyminum L.) is an important seed spice crop, having good medicinal properties and grown predominately in arid and semi-arid region of the world. India is the leading country with share of 70% in the world production of cumin. Two states of India (Rajasthan and Gujarat) cover nearly 80% of the total area under cumin cultivation. The current scenario and status of area, production and productivity in India has been reviewed to identify the various factors affecting cumin production and productivity. Apart from these major constraints related to climate, soil, agronomical, crop input, extension, marketing and farm mechanization in cumin production and their management are discussed thoroughly. Due to low productivity of cumin there is need to focus on integrated approaches such as utilizing modern technologies, advance agronomic practises, farm mechanization interventions and advanced breeding tools to enhance the cumin production. The study reveals alternative solutions...
Rotational speed is one of the most important parameters in the performance of any system. It bec... more Rotational speed is one of the most important parameters in the performance of any system. It becomes more vital when the rotational speed measurement is required on real-time basis. Measurement of rotational speed has a crucial role in automation of agricultural machineries for various purposes. The existing real-time speed measurement systems are susceptible to the varying working environment. Therefore, it was necessary to study the performance of available sensor. In this study four different sensors (inductive proximity, Infrared (IR), Hall effect and optical proximity sensors) were tested in three different working environments (indoor, outdoor and outdoor dusty condition) for two different spacings (2 and 5 mm) between sensors and target. A laboratory setup was developed to test the performance of the sensors in terms of percentage deviation in rotational speeds measurement compared to actual values. The values were recorded in Secure Digital (SD) card and analysed using full...
International Journal of Environment and Climate Change
A portable MSTD (mini solar tunnel dryer) was developed and evaluated in terms of drying rate, MR... more A portable MSTD (mini solar tunnel dryer) was developed and evaluated in terms of drying rate, MR (moisture ratio) and drying efficiency for drying of pomegranate seeds. The drying characteristic curves were also determined for drying in MSTD and OSD (open sun drying). In order to study the drying behaviour of pomegranate seeds in OSD and MSTD, seven different models were fitted. The best prediction model was determined to estimate drying kinetics as criteria for evaluating the goodness-of-fit based on R2, SSE and RMSE. The Approximation of Diffusion model was adequate to describe the drying kinetics of pomegranate seeds in OSD and MSTD with R2 value of 0.99189 and 0.9943, respectively. The MSTD was 7% more efficient in drying of pomegranate seeds compared to OSD without affecting the quality of seeds. The dryer can be used by the farmers as an alternative to sun drying for on field drying of their product without compromising the quality.
World Journal of Advanced Research and Reviews, 2021
Comparative study is just a comparison study, according to formal properties, function, purpose a... more Comparative study is just a comparison study, according to formal properties, function, purpose and effectiveness. The main purpose of comparative study is, to compare a particular drug of different brands with the help of their stability, efficacy and evaluation parameters. Here we compare the carvedilol drugs different two marketed. It acts as anti-hypertensive agent so, it mainly preferred for arterial fibrillation, inhibits tachycardia, prevention of stroke, heart failure, it also works by blocking a natural substance like epinephrine, which results to cause lowers the heart rate, blood pressure and strain on the heart. In comparative studies we determined their efficacy and effectivity on the basis of various in-vitro tests like weight variation, friability, hardness, dissolution and disintegration. It can be concluded that standard quality control parameters always should be maintained not only for carvedilol or its combination but also for all kinds of medicine for getting be...
2020 3rd International Conference on Communication System, Computing and IT Applications (CSCITA), 2020
Terrace gardens are becoming a common feature in today's urban environment. It is difficult t... more Terrace gardens are becoming a common feature in today's urban environment. It is difficult to keep a track on the plant's growth and health. Various pathogens are present in the environment which severely affects the plants and the soil in which it is planted, thereby affecting the production. Current systems cannot help people about the disease with which the plants leaves are affected by and what steps should be taken in order to prevent it from being damaged. The proposed system provides the leaf disease detection along with complete surveillance of the field with real-time values of field factors like temperature, humidity, moisture, etc. i.e. real-time monitoring. User can automatically control the flow of water if not physically present via app, also the real-time values can be tracked.
MicroRNAs (miRNAs) are critical regulators of diverse developmental and physiological processes, ... more MicroRNAs (miRNAs) are critical regulators of diverse developmental and physiological processes, and they themselves get regulated both at the level of biogenesis and turnover. We demonstrate that the ribonuclease XRN2 can degrade the mature forms of certain let-7 family members in multiple human cancer cell lines, without affecting their precursors. XRN2 also affects the accumulation of several other tumor suppressor miRNAs known to play important roles in cancer metabolism. XRN2 depletion results in a reduction in the expression of many oncogenes and diminishes the proliferative and metastatic potential of cancer cells in vitro. These experimental cancer cells also show reduced capacity to form tumors in mice and regress over time. The clinical relevance of these observations is further verified in tumour transcriptomics data from public RNA-sequencing datasets, where XRN2 mRNA expression is inversely correlated with the levels of a large number of miRNAs, including let-7 members,...
World Journal of Advanced Research and Reviews, 2021
Olaparib is an anti-cancer drug which comes under N-acyl piperazines class. The action of olapari... more Olaparib is an anti-cancer drug which comes under N-acyl piperazines class. The action of olaparib is PRPA inhibition. Drug taken by oral route which shows action in 1 to 3 hrs. after administration. It is FDA approved drug for various cancer treatment such as ovarian cancer, breast cancer, prostatic cancer and pancreatic cancer. Olaparib also useful different mutation conditions such as BRCA1/2 mutation. Olaparib prescribes after the chemotherapy treatment either singly or in combination. In serious and advanced mutation conditions combination therapy used. In this review paper, we put a narrative information about olaparib action, treatment approaches, pharmacokinetics, dosing regimen and resistance. Here we briefly give information about resistance mechanism of olaparib, treatment approaches in ovarian cancer, breast cancer and prostate cancer.
This study focuses on the development and performance evaluation of a biomass-fired dryer. The sy... more This study focuses on the development and performance evaluation of a biomass-fired dryer. The system was designed after considering the needs of small-scale rural entrepreneurs. The designed system consisted of the combustion chamber, drying chamber, the passage of flue gases, flue gas chimney, etc. The thermal performance of the developed system was tested in terms of moisture removal rate, drying rate, thermal efficiency, and heat transfer efficiency. In order to check performance, the dryer was loaded with 4 kg of Coriander leaves having an initial moisture content of 89.40% (w.b.)were dried to the final moisture content of 9.54% (w.b.) in 7 hrs of operation, 6 kg of babul wood (Acacia nilotica) was consumed during the drying process. The average drying chamber temperature was 51.84°C. The thermal and heat transfer efficiency of the dryer was 28.22 and 56% respectively. The economic parameters reveal that the developed system is technically viable and economically feasible as the payback period is very low. The net present worth, benefit-cost ratio and payback period were 3398 US$, 2.68 and 0.38 years, respectively.
Cumin (Cuminum cyminum L.) is an important seed spice crop, having good medicinal properties and ... more Cumin (Cuminum cyminum L.) is an important seed spice crop, having good medicinal properties and grown predominately in arid and semi-arid region of the world. India is the leading country with share of 70% in the world production of cumin. Two states of India (Rajasthan and Gujarat) cover nearly 80% of the total area under cumin cultivation. The current scenario and status of area, production and productivity in India has been reviewed to identify the various factors affecting cumin production and productivity. Apart from these major constraints related to climate, soil, agronomical, crop input, extension, marketing and farm mechanization in cumin production and their management are discussed thoroughly. Due to low productivity of cumin there is need to focus on integrated approaches such as utilizing modern technologies, advance agronomic practises, farm mechanization interventions and advanced breeding tools to enhance the cumin production. The study reveals alternative solutions...
Rotational speed is one of the most important parameters in the performance of any system. It bec... more Rotational speed is one of the most important parameters in the performance of any system. It becomes more vital when the rotational speed measurement is required on real-time basis. Measurement of rotational speed has a crucial role in automation of agricultural machineries for various purposes. The existing real-time speed measurement systems are susceptible to the varying working environment. Therefore, it was necessary to study the performance of available sensor. In this study four different sensors (inductive proximity, Infrared (IR), Hall effect and optical proximity sensors) were tested in three different working environments (indoor, outdoor and outdoor dusty condition) for two different spacings (2 and 5 mm) between sensors and target. A laboratory setup was developed to test the performance of the sensors in terms of percentage deviation in rotational speeds measurement compared to actual values. The values were recorded in Secure Digital (SD) card and analysed using full...
International Journal of Environment and Climate Change
A portable MSTD (mini solar tunnel dryer) was developed and evaluated in terms of drying rate, MR... more A portable MSTD (mini solar tunnel dryer) was developed and evaluated in terms of drying rate, MR (moisture ratio) and drying efficiency for drying of pomegranate seeds. The drying characteristic curves were also determined for drying in MSTD and OSD (open sun drying). In order to study the drying behaviour of pomegranate seeds in OSD and MSTD, seven different models were fitted. The best prediction model was determined to estimate drying kinetics as criteria for evaluating the goodness-of-fit based on R2, SSE and RMSE. The Approximation of Diffusion model was adequate to describe the drying kinetics of pomegranate seeds in OSD and MSTD with R2 value of 0.99189 and 0.9943, respectively. The MSTD was 7% more efficient in drying of pomegranate seeds compared to OSD without affecting the quality of seeds. The dryer can be used by the farmers as an alternative to sun drying for on field drying of their product without compromising the quality.
World Journal of Advanced Research and Reviews, 2021
Comparative study is just a comparison study, according to formal properties, function, purpose a... more Comparative study is just a comparison study, according to formal properties, function, purpose and effectiveness. The main purpose of comparative study is, to compare a particular drug of different brands with the help of their stability, efficacy and evaluation parameters. Here we compare the carvedilol drugs different two marketed. It acts as anti-hypertensive agent so, it mainly preferred for arterial fibrillation, inhibits tachycardia, prevention of stroke, heart failure, it also works by blocking a natural substance like epinephrine, which results to cause lowers the heart rate, blood pressure and strain on the heart. In comparative studies we determined their efficacy and effectivity on the basis of various in-vitro tests like weight variation, friability, hardness, dissolution and disintegration. It can be concluded that standard quality control parameters always should be maintained not only for carvedilol or its combination but also for all kinds of medicine for getting be...
2020 3rd International Conference on Communication System, Computing and IT Applications (CSCITA), 2020
Terrace gardens are becoming a common feature in today's urban environment. It is difficult t... more Terrace gardens are becoming a common feature in today's urban environment. It is difficult to keep a track on the plant's growth and health. Various pathogens are present in the environment which severely affects the plants and the soil in which it is planted, thereby affecting the production. Current systems cannot help people about the disease with which the plants leaves are affected by and what steps should be taken in order to prevent it from being damaged. The proposed system provides the leaf disease detection along with complete surveillance of the field with real-time values of field factors like temperature, humidity, moisture, etc. i.e. real-time monitoring. User can automatically control the flow of water if not physically present via app, also the real-time values can be tracked.
MicroRNAs (miRNAs) are critical regulators of diverse developmental and physiological processes, ... more MicroRNAs (miRNAs) are critical regulators of diverse developmental and physiological processes, and they themselves get regulated both at the level of biogenesis and turnover. We demonstrate that the ribonuclease XRN2 can degrade the mature forms of certain let-7 family members in multiple human cancer cell lines, without affecting their precursors. XRN2 also affects the accumulation of several other tumor suppressor miRNAs known to play important roles in cancer metabolism. XRN2 depletion results in a reduction in the expression of many oncogenes and diminishes the proliferative and metastatic potential of cancer cells in vitro. These experimental cancer cells also show reduced capacity to form tumors in mice and regress over time. The clinical relevance of these observations is further verified in tumour transcriptomics data from public RNA-sequencing datasets, where XRN2 mRNA expression is inversely correlated with the levels of a large number of miRNAs, including let-7 members,...
World Journal of Advanced Research and Reviews, 2021
Olaparib is an anti-cancer drug which comes under N-acyl piperazines class. The action of olapari... more Olaparib is an anti-cancer drug which comes under N-acyl piperazines class. The action of olaparib is PRPA inhibition. Drug taken by oral route which shows action in 1 to 3 hrs. after administration. It is FDA approved drug for various cancer treatment such as ovarian cancer, breast cancer, prostatic cancer and pancreatic cancer. Olaparib also useful different mutation conditions such as BRCA1/2 mutation. Olaparib prescribes after the chemotherapy treatment either singly or in combination. In serious and advanced mutation conditions combination therapy used. In this review paper, we put a narrative information about olaparib action, treatment approaches, pharmacokinetics, dosing regimen and resistance. Here we briefly give information about resistance mechanism of olaparib, treatment approaches in ovarian cancer, breast cancer and prostate cancer.
This study focuses on the development and performance evaluation of a biomass-fired dryer. The sy... more This study focuses on the development and performance evaluation of a biomass-fired dryer. The system was designed after considering the needs of small-scale rural entrepreneurs. The designed system consisted of the combustion chamber, drying chamber, the passage of flue gases, flue gas chimney, etc. The thermal performance of the developed system was tested in terms of moisture removal rate, drying rate, thermal efficiency, and heat transfer efficiency. In order to check performance, the dryer was loaded with 4 kg of Coriander leaves having an initial moisture content of 89.40% (w.b.)were dried to the final moisture content of 9.54% (w.b.) in 7 hrs of operation, 6 kg of babul wood (Acacia nilotica) was consumed during the drying process. The average drying chamber temperature was 51.84°C. The thermal and heat transfer efficiency of the dryer was 28.22 and 56% respectively. The economic parameters reveal that the developed system is technically viable and economically feasible as the payback period is very low. The net present worth, benefit-cost ratio and payback period were 3398 US$, 2.68 and 0.38 years, respectively.
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Papers by Rohit Nalawade