Papers by Roberto Candela
Digitaler Materialanhang zum folgenden Buchkapitel: Beiswenger, Michael; Burovikhina, Veronika (2... more Digitaler Materialanhang zum folgenden Buchkapitel: Beiswenger, Michael; Burovikhina, Veronika (2019): Von der Black Box in den Inverted Classroom: Texterschliesung kooperativ gestalten mit digitalen Lese- und Annotationswerkzeugen. In: Carolin Fuhrer/Felician-Michael Fuhrer (Hrsg.): Dissonanzen in der Lehrerbildung. Theoretische, empirische und hochschuldidaktische Rekonstruktionen und Perspektiven fur das Fach Deutsch. Munster: Waxmann (Didaktik der deutschen Sprache und Literatur 2), ISBN 978-3-8309-4047-0.
Bulletin of Experimental Biology and Medicine, 2018
We analyzed cultures of 5 independent myoblast lines from human skeletal muscles. It was shown th... more We analyzed cultures of 5 independent myoblast lines from human skeletal muscles. It was shown that the content of desmin-positive cells in cultures at early passages exceeds 90%. Typical morphofunctional signs of myogenic differentiation disturbances were identified and their dynamics was studied. Signs of alternative adipogenic and chondrogenic differentiation of cells were revealed. Based on these data, limitations for the use of myoblast cultures of certain passages for biomedical research and cell therapy were evaluated.
Bollettino della Societa italiana di biologia sperimentale, Mar 15, 1979
Potassium and sodium content in lung, heart and liver of sea water-drowned mice was measured flam... more Potassium and sodium content in lung, heart and liver of sea water-drowned mice was measured flame-photometrically after destruction of tissue through nitric-percloric acid. It was found that the ratio of K+/Na+ content in the lung and even in the heart was significantly lower in the drowned group than in the control one; the liver did not show any significant eletrolyte change after drowning. The results are the basis of a test applicable to humans.
Bollettino della Societa italiana di biologia sperimentale, Jan 15, 1979
Postmortal changes of propane, butane and iso-butane concentration in the lung and fat of mice ex... more Postmortal changes of propane, butane and iso-butane concentration in the lung and fat of mice exposed to lethal intoxication with commercial liquid gas are studied. The hydrocarbon tissue concentrations after exposure were determined by gas liquid chromatography. The hydrocarbons progressively decreased in the lung and disappeared, depending on the degree of putrefaction; even in case of remarkable putrefaction, it was still possible to detect them in the fat tissue.
La Clinica terapeutica, 1988
An unusual case of poisoning by the ingestion of oleander leaves is reported. A 71 year old male ... more An unusual case of poisoning by the ingestion of oleander leaves is reported. A 71 year old male laboratory technician committed suicide at home in this unusual manner. At the death scene a steel pan and other paraphernalia, used for the extraction of oleandrin and other cardiac glycosides from the leaves of the Nerium oleander plant were found. Toxicological investigations for oleandrin, oleandrigenin, neritaloside, and odoroside were performed by LC-MS/MS on all biological samples (peripheral blood, vitreous humor, urine, liver, gastric contents) and on the yellow infusion found at the death scene. In all samples, toxic levels of oleandrin were detected (blood 37.5 ng/mL, vitreous humor 12.6 ng/mL, urine 83.8 ng/mL, liver 205 ng/mg, gastric content 31.2 µg/mL, infusion 38.5 µg/mL). Qualitative results for oleandrigenin, neritaloside, and odoroside were obtained. Oleandrigenin was present in all tissue samples whereas neritaloside and odoroside were absent in the blood and vitreous humor but present in urine, liver, gastric content, and in the leaf brew. The purpose of this study was the identification of oleandrin and its congener oleandrigenin, detected in the vitreous humor. The blood/vitreous humor ratio was also calculated in order to assess of the likely time interval from ingestion to death. According to the toxicological results death was attributed to fatal arrhythmia due to oleander intoxication. The manner of death was classified as suicide through the ingestion of the infusion.
Forensic Science, Medicine and Pathology
An unusual case of poisoning by the ingestion of oleander leaves is reported. A 71 year old male ... more An unusual case of poisoning by the ingestion of oleander leaves is reported. A 71 year old male laboratory technician committed suicide at home in this unusual manner. At the death scene a steel pan and other paraphernalia, used for the extraction of oleandrin and other cardiac glycosides from the leaves of the Nerium oleander plant were found.Toxicological investigations for oleandrin, oleandrigenin, neritaloside, and odoroside were performed by LC–MS/MS on all biological samples (peripheral blood, vitreous humor, urine, liver, gastric contents) and on the yellow infusion found at the death scene.In all samples, toxic levels of oleandrin were detected (blood 37.5 ng/mL, vitreous humor 12.6 ng/mL, urine 83.8 ng/mL, liver 205 ng/mg, gastric content 31.2 µg/mL, infusion 38.5 µg/mL). Qualitative results for oleandrigenin, neritaloside, and odoroside were obtained. Oleandrigenin was present in all tissue samples whereas neritaloside and odoroside were absent in the blood and vitreous h...
Open Access Macedonian Journal of Medical Sciences
The Apulian Poison Centre (PC) of Foggia, Italy, annually manages numerous consultations concerni... more The Apulian Poison Centre (PC) of Foggia, Italy, annually manages numerous consultations concerning certain or suspected poisonings from pesticides, starting at the same time a careful activity related to the risk assessment phase. The management of the exposure to pesticides and to other chemicals, and the alerting of the “National center for chemicals, cosmetics and consumer protection” at the Istituto Superiore di Sanità (ISS), actively contributes to the improvement of products quality and safety. Thus, leading to a reduction in the number of intoxications - and therefore of the accesses to the emergency services - allows greater protection for workers, bystanders, residents and consumers. The reported case of methomyl poisoning has been of fundamental importance both from the medical point of view and for the management of the intoxicated patient, both for the risk assessment actions, and for cooperation with the competent authorities, generating discussion points on the regula...
Endocrine, Metabolic & Immune Disorders - Drug Targets
: Suffice it to say that the first traces of its use by man date back to ten thousand years ago t... more : Suffice it to say that the first traces of its use by man date back to ten thousand years ago the venom or poison since the last period of the Paleolithic man used poison to hunt and for defence. Indeed, in the second half of the 19th century, was found in some caves arrows made from the bones of animals characterized by particular grooves. In ancient Greece, the term pharmakon (φάρμακον) had a double meaning: remedy for therapy and venom. This is the period in which we become aware of the fact that a poison cannot be defined only as a substance capable of changing the properties of things. The poisonings are very frequent in the history of the Roman Empire and later in the Renaissance and the modern era. Poison was the protagonist political intrigues of power and is one of the most used lethal weapons over the years. Optimal solution for a perfect murder, the poison has a long history. Its success is due to the invisible and often unpunished death.
Endocrine, Metabolic & Immune Disorders - Drug Targets
Historical relevanc: Cannabis sativa L. (C. sativa) is a plant whose use as a therapeutic agent s... more Historical relevanc: Cannabis sativa L. (C. sativa) is a plant whose use as a therapeutic agent shares its origins with the first Far East’s human societies. Cannabis has been used not only for recreational purposes, but as a food to obtain textile fibers, to produce hemp paper, to treat many physical and mental disorders. Aim of the study: This review aims to provide a complete assessment of the deep knowledge of the cannabis psychoactive effects and medicinal properties in the course of history covering i.) the empirical use of the seeds and the inflorescences to treat many physical ailments by the ancient Oriental physicians ii.) the current use of cannabis as a therapeutic agent after the discovery of its key psychoactive constituent and the human endogenous endocannabinoid system. Methods: This study was performed through a detailed analysis of the studies on historical significance and medical applications of Cannabis sativa by using international scientific databases, histori...
Forensic Science International
Developments in Analytical Methods in Pharmaceutical, Biomedical, and Forensic Sciences, 1987
Bollettino della Società italiana di biologia sperimentale, Jan 15, 1979
La Clinica terapeutica
The aim of this work was to examine the role of substance use as factor which increase risk of as... more The aim of this work was to examine the role of substance use as factor which increase risk of assault. A review of the some of the most important international literature about drug-facilitated crimes is presented here. The whole part of the papers shows a relationship between substance use and risk increase of assault, particularly in family violence and rape. The effects of psychotropic substances use depend on the user's emotional state and on drugs use expectations. This prospective shows that we need to be cautious in interpreting processes of linear causality between abusive behaviour, processes of victimisation, abuses and abnormal sexual behaviours, which are related to the patient's desires, enhanced and validated by drugs.
Annali di igiene : medicina preventiva e di comunità
In order to plan a correct planning and a realization of interventions to support Regional Enviro... more In order to plan a correct planning and a realization of interventions to support Regional Environmental Authority, results of "Technological Risk" methodology applied in a Italian region (Puglia) are reported. In this paper two main risk factors has been evaluated (high risk activities, areas with environmental crisis high risk) and determined indicators able to describe, in case of accident or anomalous event, potential interactions in the normal industrial process. Than has been described operative phases to consent risk factors evaluation and their evolution, considering also pressures on the environment identified by other issues. Some themes were in detail studied through territorial analysis and set of rules. This work enables to carry out a specific database for factories subject to "substantial risk" and finally was completed data processing with thematic maps and statistic analysis.
Annali di igiene : medicina preventiva e di comunità
The excessive content of toxic elements in the human environment is associated with the etiology ... more The excessive content of toxic elements in the human environment is associated with the etiology of a number of diseases. Soils' pollutants decontamination regards the main industrialised countries. Heavy metals represent the main problem for soil pollution characterisation. The first approach for pollution evaluation is the determination of total metal concentration; the evaluation of their bioavailability is required for a correct knowledge of the environmental risk. In the present work is shown the procedure to evaluate the sites, which require decontamination and which need the following data: knowledge of the threshold for each metal in the soil and its range, chemical analysis of the components, determination of bioavailability and soil destination. The bioavailability is easily calculated by the procedure of aimed extractions.
Bollettino della Società italiana di biologia sperimentale, Jan 30, 1985
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Papers by Roberto Candela