Papers by Roberta Bertani
Oxazoline-containing phosphazene derivatives. Part I: the case of hexakis(4-oxazolinophenoxy)cyclophosphazene
Designed Monomers and Polymers, 2001
In this paper, the synthesis, characterization, and reactivity of a novel oxazoline-containing cy... more In this paper, the synthesis, characterization, and reactivity of a novel oxazoline-containing cyclophosphazene, hexakis(4-oxazolinophenoxy)cyclophosphazene, C-6-OXA, are reported. This product was synthesized by a two-step procedure that required first the preparation of 2-(4-hydroxyphenyl)-2-oxazoline and then the successive treatment of this compound with hexachlorocyclophosphazene in the presence of NaH (60% oil dispersion). The resulting C-6-OXA was eventually reacted with low-molecular-weight organic molecules,
Dalton Transactions, 2019
Correction for ‘New light on an old debate: does the RCN–PtCl2 bond include any back-donation? RC... more Correction for ‘New light on an old debate: does the RCN–PtCl2 bond include any back-donation? RCN ← PtCl2 backbonding vs. the IR νCN blue-shift dichotomy in organonitriles–platinum(ii) complexes. A thorough density functional theory – energy decomposition analysis study’ by Girolamo Casella et al., Dalton Trans., 2019, DOI: 10.1039/c9dt02440a.
Journal of Molecular Catalysis A: Chemical, 2017
The influence of multiwalled carbon nanotubes and graphene oxide additives on the catalytic activ... more The influence of multiwalled carbon nanotubes and graphene oxide additives on the catalytic activity of 3d metal catalysts towards 1-phenylethanol oxidation
Synthesis, crystal structure, DNA and protein binding studies of novel binuclear Pd(II) complex of 6-methoxy-2-oxo-1,2-dihydroquinoline-3-carbaldehyde-4(N,N)-dimethylthiosemicarbazone
Journal of inorganic biochemistry, 2016
A novel binuclear palladium(II) complex [(AsPh3)2ClPd(L)PdCl] (LPd2) has been synthesized by reac... more A novel binuclear palladium(II) complex [(AsPh3)2ClPd(L)PdCl] (LPd2) has been synthesized by reacting 2-oxo-1,2-dihydroquinoline-3-carbaldehyde-4(N,N)-dimethylthiosemicarbazone (HL) with [PdCl2(AsPh3)2], and the molecular structure was confirmed by single crystal X-ray diffraction studies. The DNA interactions of the free ligand and of the complex have been evaluated by absorption and ethidium bromide (EB) competitive studies which revealed that the complex could interact with calf thymus DNA (CT-DNA) through intercalation. In addition, the interactions with bovine serum albumin (BSA) were also studied showing that the new binuclear palladium complex had a strong binding affinity with BSA.
Chemical Reactions occurring in the molten state between Ny6 and Oxazoline groups linked to a Cyclophosphazene moiety
Organometallics, 1997
The reactions of [Pt(CH 2 dCH 2)(PPh 3) 2 ] and [Au(C 6 F 5)(SC 4 H 8)] with diazoalkanes have be... more The reactions of [Pt(CH 2 dCH 2)(PPh 3) 2 ] and [Au(C 6 F 5)(SC 4 H 8)] with diazoalkanes have been performed under FAB conditions. The formation of the carbene species [Pt(dCHCO 2 Et)-(PPh 3) 2 ] and [Au(dCPh 2)(C 6 F 5)], respectively, which are the key reaction intermediates and which were not detected in solution using other analytical tools, has been revealed by modern mass spectrometric techniques. Since the reaction products obtained by FAB MS were the same as those obtained in solution, mass spectrometry, providing an entry to the detection of highly reactive intermediates, may give also mechanistic information otherwise not achievable.
Preparation and characterization of PdIII-ylide complexes of type Pd(CNR)(η3-2-XC3H4)[Ph3PC(H)COMe] BF4 (X = H, Me; R = p-C6H4OMe, C(Me)3, Me, C6H11, p-C6H4NO2). Crystal structure of Pd[CNC(Me)3]-(η3-2-MeC3H4)[Ph3PC(H)COMe] BF4
Journal of Organometallic Chemistry, 1989
ABSTRACT
Convenient synthesis of cationic allylplatinum(II) complexes with tertiary phosphines by oxidative allyl transfer from ammonium cations to platinum(0) substrates. Crystal and molecular structures of η3-propenyl- and η3-2-methylpropenyl-bis(triphenylphosphine)platinum(II)perchlorates
Journal of Organometallic Chemistry, 2000
A large variety of cationic η3-allylplatinum(II) complexes of the type [Pt(η3-CH2C(R)C(R′)(R″)(PP... more A large variety of cationic η3-allylplatinum(II) complexes of the type [Pt(η3-CH2C(R)C(R′)(R″)(PPh3)2]+ (1a–f) are prepared in high yield by oxidative allyl transfer from the ammonium cations [NEt3CH2C(R)C(R′)(R″]+ to [Pt(η2-C2H4)(PPh3)2]. A similar reaction of [NEt3CH2C(R)C(R′)2]+ with [Pt(cod)2] yields the related complexes [Pt(η3-CH2C(R)C(R′)2(cod)]+ (2a–c), indicating a rather general feasibility of such synthetic route. The 1,5-cyclooctadiene ligand of complexes 2a,c can be easily displaced
Comparison of hard vaporization and soft ionization techniques in the mass spectrometry of some palladium(II) and platinum(II) complexes with C-bonded heterocyclic ligands
Inorganica Chimica Acta, 1990
... doi:10.1016/S0020-1693(00)80279-0 | How to Cite or Link Using DOI Copyright © 1990 Published ... more ... doi:10.1016/S0020-1693(00)80279-0 | How to Cite or Link Using DOI Copyright © 1990 Published by Elsevier Science BV All rights reserved. Permissions & Reprints. ... Chem., 303 (1986) 283. 5 B. Crociani, F. Di Bianca, A. Giovenco, A. Berton and R. Bertani, J. Organomet. ...
Inorganic Chemistry Communications, 2001
The reaction of cis-PtCl 2 NCMe 2 with a 5-fold excess of Me 2 NH in CH 2 Cl 2 at À10°C aords in ... more The reaction of cis-PtCl 2 NCMe 2 with a 5-fold excess of Me 2 NH in CH 2 Cl 2 at À10°C aords in high yield the bis-amidine complex cis-PtCl 2 fE-NH@CNMe 2 Meg 2 (E,E-2), where both the amidine ligands assume the E con®guration. E,E-2 was characterized by X-ray structure analysis, NMR spectroscopy and electrospray ionization mass spectrometry (ESI-MS). The corresponding reactions of trans-PtCl 2 NCMe 2 with Me 2 NH gave the bis-amidine complex trans-PtCl 2 fE-NH@CNMe 2 Meg 2 (E,E-3) and the mono-amidine derivative trans-PtCl 2 fE-NH@CNMe 2 MegNCMe (E-4).
Photochemical behavior of poly(organophosphazenes)—XIII. Sensitized photochemistry of poly[bis(4-benzylphenoxy)phosphazene] in solution and in film
European Polymer Journal, 1995
ABSTRACT
Angewandte Chemie, 1994
stoff-Abstand von 1.610(15) 8, und der entsprechende, relativ kleine Torsionswinkel von 34.1" las... more stoff-Abstand von 1.610(15) 8, und der entsprechende, relativ kleine Torsionswinkel von 34.1" lassen auf die Bindungsordnung 2 schlieDen; 3) das /p-c & A " L _ Galliumatom ist tetraedrisch umgeben. Daher beschreiben wir 6 als Me-Schema 4. Vorherrschende Grenzformel von 6. thylenphosphonium-Zwitterion mit der Grenzformel 6A (Schema 4)['01. Diese Struktur scheint in Losung erhalten zu bleiben; die Tieffeldlage des 31P-NMR-Signals (6 = 130) spricht fur eine Doppelbindung und eine positive Ladung am Phosphoratom. Auch fur die Addukte 5 und 7 schlagen wir diese Struktur vor, denn ihre 31P-NMR-chemische Verschiebung und die 3JpH-Kopplungskonstante sind identisch mit den Werten von 6['1. Die Verbindungen 5-7 sind also offensichtlich die ersten neutralen Methylenphosphonium-Zwitterionen. Nur das ahnlich gebaute Kation [(iPr,N),P=C(SiMe,),If['*~ hat ebenfalls eine ungleiche Ladungsverteilung. Zusammenfassend laIJt sich sagen, daD Phosphanylcarbene mit Lewis-Sauren sehr verschieden reagieren konnen und die-Produktbildung vom delikaten Zusammenspiel thermodynamischer und sterischer Effekte abhangt. Experirnentelles 3: Zu einer Losung von 1 (1.0 mmol) in 15 mL Et,O wird bei ~-7 8°C Tnmethylgallium im Uberschua (0.50 mL, 5.0 mmol) gegeben. Nach Erwirmen auf 25 "C werden das Losungsmittel und fluchtige Bestandteile i m Vakuum entfernt. Aus dem mikrokristallinen Ruckstand erhilt man nach Waschen mit 5 mL Pentan 0.38 g (65 YO) 3 als blaflgelbes, mikrokristallines Pulver; Schmp. 146-348 ' C. Zur Rontgenstrukturanalyse geeignete Kristalle erhilt man durch Abkuhlen einer geslttigten Toluollosung von 3 auf-~2O"C nach zwei Wochen. Die Verbindungen 2 und 4 wurden analog hergestellt. 6:ZueinerLosungvon 1 (1.0mmol)in15mLEt20 werdenbei25"C6.176gGaC13 (1.0 mmol), gelost in 3 mL Toluol, gegeben. Nach 20 min Riihren fillt ein Niederschlag aus. Entfernung der Losung mit einer Kanule und Waschen des Ruckstands rnit 5 mL Et,O Liefert 0.52 g (79%) des blaDgelben I'eststoffs 6; Schmp. 110 "C (Zers.). Zur Rontgenstrukturand~yse geeignete Kristalle von 6 ' CH,CI, bilden sich durch langsame Verdunstung einer Dichlormethanlosung von 6. Die Verbindungen 5 und 7 wurden analog hergestellt.
Polymers
Two nanomicas of similar composition, containing muscovite and quartz, but with different particl... more Two nanomicas of similar composition, containing muscovite and quartz, but with different particle size distributions, have been used to prepare transparent epoxy nanocomposites. Their homogeneous dispersion, due to the nano-size, was achieved even without being organically modified, and no aggregation of the nanoparticles was observed, thus maximizing the specific interface between matrix and nanofiller. No exfoliation or intercalation has been observed by XRD, despite the significant dispersion of the filler in the matrix which produced nanocomposites with a loss in transparency in the visible domain of less than 10% in the presence of 1% wt and 3% wt of mica fillers. The presence of micas does not affect the thermal behavior of the nanocomposites, which remains similar to that of the neat epoxy resin. The mechanical characterization of the epoxy resin composites revealed an increased Young’s modulus, whereas tensile strength was reduced. A peridynamics-based representative volume...
Iron oxide magnetic nanoparticles used for magnetic fluid hyperthermia therapy: synthesis and characterization
During recent years, an increased interest in magnetic nanoparticles (NPs) for their use in biome... more During recent years, an increased interest in magnetic nanoparticles (NPs) for their use in biomedical applications, in particular for hyperthermia therapy, has been observed [1]. This promoted the research on synthesis routes that allow better control in NPs shape and size, as the nanoparticles properties are strongly influenced by those parameters. In addition, due to the need of obtaining bio-compatible NPs, several strategies have been applied to stabilize them in aqueous media. In this study, we synthesized iron oxide magnetic nanoparticles in presence of 2-pyrrolidone, as that acts both as surfactant and solvent [2] and permits to disperse the synthesized nanoparticles in water without any further functionalization. The magnetic NPs were synthesized by thermal decomposition of iron chloride (III) hexahydrate (FeCl3∙6H2O) in presence of 2-pyrrolidone; the reagents relative concentration was changed so to access the effect of that on the morphology and on the magnetic properties of the NPs. After the synthesis, the NPs were precipitated and dried, and then dispersed in deionized water with a 10 mg per 1 ml concentration. The magnetic properties of the NPs were investigated using a superconductive quantum interference device (SQUID) magnetometer and Mössbauer spectroscopy. Size and morphology of the particles were investigated with a transmission electron microscope (TEM), while the heating rate of the magnetic liquids was measured using an inductor suitably designed using numerical methods and optimization algorithms in order to maximize the magnetic field uniformity [3]. The sample with the smallest chloride concentration shows nanoparticles with a fine dispersion (NP size ~ 5 nm); an increase in chloride concentration produces flower-shaped NPs, as those presented in fig. 1, where fine nanoparticles are aggregated so to form “flowers” with an average size of 20 nm. A further increase in chloride concentration produces again a fine dispersion of magnetic NPs. The magnetic fluid with flower-shaped NPs turns out to be the most interesting for hyperthermia, as it produces the highest heating rate; the combination of SQUID and Mössbauer characterization reveals the strong influence of magnetic dipolar interactions on sample magnetic behavior. The results of the magnetic characterization of the different NPs will be presented and discussed, and also compared with the results obtained from heating rate measurements. Finally, cell culture experiments will be also presented, as NPs have been added to a cell culture in order to evaluate cellular uptake. In particular, TEM analyses revealed a time-dependent uptake of flower-shaped NPs by breast cancer cells. [1] A. Akbarzadeh et al., Nanoscale Research Letters 7 (2012) 144. [2] K. M. Krishnan, IEEE Trans. On Magnetics, 46 (2010) 2523. [3] P. Di Barba et al., IEEE Trans. On Magnetics 46 (2010) 2931
Multi-objective design of a magnetic fluid hyperthermia device
The paper presents the design of a new device to heat a magnetic nanofluid in-vivo. The optimal d... more The paper presents the design of a new device to heat a magnetic nanofluid in-vivo. The optimal design of the device has been carried by coupling Finite Elements (FE) solutions and various multi-objective optimization algorithms based on Non-dominated Sorting Genetic Algorithms (NSGA). The theoretical heating rate of the nanofluid, as resulting from the analytical solution that describes the heating rate in adiabatic conditions, is compared to the one calculated in a FE model that takes into account more real-life thermal conditions.
Fluids, Feb 27, 2023
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
Novel Multifunctional Magnetic Inorganic Composites: Synthesis and Characterization
Iron oxide magnetic nanoparticles for magnetic fluid hyperthermia therapy: synthesis and characterization
During recent years, an increased interest in magnetic nanoparticles (NPs) for their use in biome... more During recent years, an increased interest in magnetic nanoparticles (NPs) for their use in biomedical applications, in particular for hyperthermia therapy, has been observed [1]. This promoted the research on synthesis routes that allow better control in NPs shape and size, and, due to the need of obtaining bio-compatible NPs, NPs stabilization in aqueous media. In this study, we synthesized iron oxide magnetic nanoparticles in presence of 2-pyrrolidone, as that acts both as surfactant and solvent [2] and permits to disperse the synthesized nanoparticles in water without any further functionalization. The magnetic NPs were synthesized by thermal decomposition of iron chloride (III) hexahydrate (FeCl3 196H2O) in presence of 2-pyrrolidone; the reagents relative concentration was changed so to access the effect of that on the morphology and on the magnetic properties of the NPs. After the synthesis, the NPs were precipitated and dried, and then dispersed in deionized water with a 10 mg per 1 ml concentration. The magnetic properties of the NPs were investigated using a superconductive quantum interference device (SQUID) magnetometer; M\uf6ssbauer spectroscopy measurements were performed in the 4 K \u2013 300 K range. Size and morphology of the particles were investigated with a transmission electron microscope (TEM), while the heating rate of the magnetic liquids was measured using an inductor suitably designed to maximize the magnetic field uniformity [3]. The sample with the smallest chloride concentration shows nanoparticles with a fine dispersion (NP size ~ 5 nm); an increase in chloride concentration produces flower-shaped NPs, as those presented in fig. 1, where fine nanoparticles are aggregated so to form \u201cflowers\u201d with an average size of 20 nm. A further increase in chloride concentration produces again a fine dispersion of magnetic NPs. The magnetic fluid with flower-shaped NPs turns out to be the most interesting for hyperthermia, as it produces the highest heating rate; the combination of SQUID and M\uf6ssbauer characterization reveals the strong influence of magnetic dipolar interactions on sample magnetic behaviour. From 300 K down to 50 K the M\uf6ssbauer spectra display just a doublet contribution, whose width increases as temperature decreases, possibly due to superparamagnetic relaxation effects; just below 50 K a broad sextet appears. This may suggest that the fine nanoparticles in flower-shaped aggregates behave as single entities, interacting via dipolar and not exchange interactions. Finally, cell culture experiments will be also presented, as NPs have been added to a cell culture in order to evaluate cellular uptake. In particular, TEM analyses revealed a time-dependent uptake of flower-shaped NPs by breast cancer cells. References [1] A. Akbarzadeh et al., Nanoscale Research Letters 7 (2012) 144. [2] A. K. M. Krishnan, IEEE Trans. On Magnetics, 46 (2010) 2523. [3] P. Di Barba et al., IEEE Trans. On Magnetics 46 (2010) 2931
Ferrofluids made of magnetic nanoflowers: effect of the carrier fluid on magnetic and heating properties
We investigated the magnetic and heating properties of ferrofluids made of magnetic nanoparticles... more We investigated the magnetic and heating properties of ferrofluids made of magnetic nanoparticles having a nanoflower structure dispersed in water or polyethylene glycol. In both cases, the magnetic behavior of the fluids is ruled by the effect of magnetic interactions, and these show a higher intensity when the dispersing medium is water with respect to the polyethylene glycol case. Also the ferrofluids heating power is different, as the one made of water turns out to be more effective for what concerns the temperature increase. Both result are in favor of a modification of the nanoflower structure induced by the carrier fluid
Uploads
Papers by Roberta Bertani