Papers by Robert Van Wesep
The American Journal of Surgery, 1989
Adequate flow cytometric DNA analysis comparing primary and concurrent metastatic squamous cell c... more Adequate flow cytometric DNA analysis comparing primary and concurrent metastatic squamous cell carcinoma of the head and neck has not been done in the past. The purpose of this study was to define any differences between the primary and concurrent metastasis of each patient with respect to flow cytometric parameters and histologic grade. Paraffin-embedded archival specimens from 28 patients with primary and metastatic tumors were prepared into nuclei and analyzed by flow cytometry using human lymphocyte standards. The mean DNA index was 0.82 for primary tumors and 0.83 for the metastases. Aneuploidy was found in 68 percent of primary tumors and in 82 percent of metastases. The percentage of cells in the proliferative fraction was 4Q.4 in the primary tumors and 24.5 in the metastases. A direct correlation was found between the differentiation of the primary and metastatic tumors. No survival difference was discovered among the flow cytometric parameters and histologic grade. We conclude that there is no difference between the primary and concurrent metastasis in squamous cell carcinoma of the head and neck with regard to DNA index, aneuploidy, or histologic grade.
Journal of Surgical Research, 1997
Arginine can be metabolized in wounds to nitric oxide and citrulline by nitric oxide synthase or ... more Arginine can be metabolized in wounds to nitric oxide and citrulline by nitric oxide synthase or to urea and ornithine by arginase. We investigated the expression of these arginine metabolic pathways over a 3-week period. Groups of 8-10 male Balb/C mice underwent a dorsal skin incision and subcutaneous polyvinyl alcohol sponge implantation. The animals were sacrificed at various times, and sponges were harvested to obtain wound fluid and wound cells. Cells or whole sponges were incubated with L-[2,3-(3)H]arginine, with or without N(G)-L-monomethyl-arginine (NMMA, a competitive inhibitor of nitric oxide synthase). Nitrite and nitrate (both stable end products of nitric oxide metabolism) and amino acids were measured in wound fluid and wound cell culture supernatants. Increasing concentrations of nitrite and nitrate were noted in wound fluid and in whole sponge cultures until the second week postwounding, indicating sustained wound nitric oxide synthesis. In wound fluid arginine levels were undetectable at all times, suggesting sustained utilization. Wound fluid citrulline levels showed an early peak and then a gradual decrease, suggesting that recycling for continued nitric oxide production may occur. Wound fluid ornithine levels increased until Day 10 and remained elevated, indicative of continued arginase activity. In vitro production of nitrite/nitrate and citrulline by cells and whole sponges was inhibitable by NMMA. Inducible nitric oxide synthase expression was confirmed by immunoblotting, while immunohistochemistry demonstrated that macrophages are a major source of wound nitric oxide. The data show that nitric oxide synthesis occurs for prolonged periods after injury and macrophages appear to be a major cellular source.
arXiv (Cornell University), Jan 26, 2012
We develop the theory of partial satisfaction relations for structures that may be proper classes... more We develop the theory of partial satisfaction relations for structures that may be proper classes and define a satisfaction predicate (|= *) appropriate to such structures. We indicate the utility of this theory as a framework for the development of the metatheory of first-order predicate logic and set theory, and we use it to prove that for any recursively enumerable extension Θ of ZF there is a finitely axiomatizable extension Θ ′ of GB that is a conservative extension of Θ. We also prove a conservative extension result that justifies the use of |= * to characterize ground models for forcing constructions.
arXiv (Cornell University), Jan 26, 2012
We develop the theory of partial satisfaction relations for structures that may be proper classes... more We develop the theory of partial satisfaction relations for structures that may be proper classes and define a satisfaction predicate (|= *) appropriate to such structures. We indicate the utility of this theory as a framework for the development of the metatheory of first-order predicate logic and set theory, and we use it to prove that for any recursively enumerable extension Θ of ZF there is a finitely axiomatizable extension Θ ′ of GB that is a conservative extension of Θ. We also prove a conservative extension result that justifies the use of |= * to characterize ground models for forcing constructions.
Social Science Research Network, 2017
Management Science
Researchers have often attributed discrete messages such as ratings to a difference in preference... more Researchers have often attributed discrete messages such as ratings to a difference in preferences between sender and receiver. By extending a standard model of information transmission, we show that discreteness can also arise when preferences are identical but misinterpretation is possible. Whereas discrete messages are less precise, they are easier to interpret. We provide predictions for the distribution of ratings. If we believe that an observed distribution results from cooperative behavior, the model provides a method for inferring the objectives of the sender and receiver. Ratings inflation and deflation arise as emergent properties of an optimal distribution. This paper was accepted by Gustavo Manso, finance. Supplemental Material: The data files are available at https://doi.org/10.1287/mnsc.2022.4297 .
SSRN Electronic Journal, 2017
Journal of Neuropathology and Experimental Neurology, 1989
American Journal of Medical Genetics, 1997
We report on an 18-month-old boy with an interstitial deletion at 10q23.2-q24.1. This region incl... more We report on an 18-month-old boy with an interstitial deletion at 10q23.2-q24.1. This region includes the PTEN gene, mutations of which have been reported to cause Cowden disease. Our patient presented with manifestations of Bannayan-Riley-Ruvalcaba (BRR) syndrome. The BRR syndrome is a rare disorder which presents most commonly in childhood. Cowden disease is a disease of adulthood and is inadequately described in children. Because of the considerable phenotypic overlap between the two disorders, and the cytogenetic and molecular findings in our patient, we suggest that BRR syndrome and Cowden disease are allelic.
The proceedings of the Los Angeles Caltech-UCLA 'Cabal Seminar' were originally published... more The proceedings of the Los Angeles Caltech-UCLA 'Cabal Seminar' were originally published in the 1970s and 1980s. Wadge Degrees and Projective Ordinals is the second of a series of four books collecting the seminal papers from the original volumes together with extensive unpublished material, new papers on related topics and discussion of research developments since the publication of the original volumes. Focusing on the subjects of 'Wadge Degrees and Pointclasses' (Part III) and 'Projective Ordinals' (Part IV), each of the two sections is preceded by an introductory survey putting the papers into present context. These four volumes will be a necessary part of the book collection of every set theorist.
Transactions of the American Mathematical Society, 1982
We begin with a ground model satisfying ZF + AD + ACR, and from it construct a generic extension ... more We begin with a ground model satisfying ZF + AD + ACR, and from it construct a generic extension satisfying ZFC + ô2 = w2 + "me nonstationary ideal on w | is w2-saturated".
Journal of Symbolic Logic, 1978
Let Γ be a class of subsets of Baire space (ωω) closed under inverse images by continuous functio... more Let Γ be a class of subsets of Baire space (ωω) closed under inverse images by continuous functions. We say such a Γ is continuously closed. Let , the class dual to Γ, consist of the complements relative to ωω of members of Γ. If Γ is not selfdual, i.e., , then let . A continuously closed nonselfdual class Γ of subsets of ωΓ is said to have the first separation property [2] ifThe set C is said to separate A and B. The class Γ is said to have the second separation property [3] ifWe shall assume the axiom of determinateness and show that if Γ is a continuously closed class of subsets of ωω and then(1) Γ has the first separation property iff does not have the second separation property, and(2) either Γ or has the second separation property.Of course, (1) and (2) taken together imply that Γ and cannot both have the first separation property.
The Journal of Symbolic Logic, 2013
We develop the theory of partial satisfaction relations for structures that may be proper classes... more We develop the theory of partial satisfaction relations for structures that may be proper classes and define a satisfaction predicate (⊨*) appropriate to such structures. We indicate the utility of this theory as a framework for the development of the metatheory of first-order predicate logic and set theory, and we use it to prove that for any recursively enumerable extension Θ of ZF there is a finitely axiomatizable extension *Θ′ of GB that is a conservative extension of Θ. We also prove a conservative extension result that justifies the use of ⊨* to characterize ground models for forcing constructions.
Arxiv preprint quant-ph/0612096, 2006
Annals of Physics, 2006
Submitted for the MAR08 Meeting of The American Physical Society Hidden variables in quantum mech... more Submitted for the MAR08 Meeting of The American Physical Society Hidden variables in quantum mechanics: Generic models, settheoretic forcing, and the appearance of probability ROBERT A. VAN WE-SEP-The hidden-variables (HV) program in quantum mechanics proposes that physical states have properties that are not observable in the ordinary sense and which uniquely determine the outcome of any observation. It is well known that one cannot consistently assign values to all propositions in a Hilbert space of dimension ≥ 3, but for systems of commuting propositions one always can, so there is some interest in HV in this limited setting. But the same objection has been raised against HV as against the many-worlds view (MW), viz., that it cannot accommodate the notion of probability, specifically the Born rule. We have shown that the Born rule is actually derivable in MW[1]. In the present work we do the same in the HV setting[2]. Specifically, we show that the HV premise implies that the sequence of values assigned by a given HV state to a set of commuting propositions is indistinguishable from a sequence randomly generated according to the Born rule. In fact, the same is true for systems of noncommuting propositions satisfying a natural condition[3]. The sequences demanded by HV are generic in the set-theoretic sense. The fascinating ontology of generic objects in set theory therefore applies to HV states in physics.
Annals of Physics, 2006
Submitted for the MAR08 Meeting of The American Physical Society Many worlds and the appearance o... more Submitted for the MAR08 Meeting of The American Physical Society Many worlds and the appearance of probability in quantum mechanics ROBERT A. VAN WESEP-The theory of measurement has posed a conceptual problem since the beginning of quantum mechanics (QM). One the one hand, the quantum theory of interacting systems says that when a system O measures the value of a quantity A associated with a system S, the state of the compound system SO following the measurement is a superposition of pure product states, one for each eigenvalue of A. On the other hand, one's subjective experience (as the observer O) is that this statevector "collapses" nondeterministically to a pure state with probability given by the Born rule. The Copenhagen interpretation (CI) says that this collapse actually occurs. The many-worlds view (MW) is that it doesn't. The defects of CI are obvious: there is no way to say which interactions are measurements to which the interpretation applies, and there is no way to describe the process of collapse that it calls for. MW, on the other hand, does not seem able to incorporate the Born rule. If this were true, it would rule out MW as a description of reality. We show that it is not true, in the strongest possible way: the Born rule is actually a derivable consequence of the quantum theory of measurement as long as we accept the theory as is, i..e, as long as we accept MW[1]. The proof uses the strong law of large numbers, which is the link between the abstract notion of probability and the concrete properties of sequences of observations.
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Papers by Robert Van Wesep