The aim of the research was to develop advanced lipid nanocarriers based on renewable vegetable r... more The aim of the research was to develop advanced lipid nanocarriers based on renewable vegetable resources (rice bran oil and raspberry seed oil) that manifest self-antioxidative property, have advantages in terms of minimal side effects and exhibit the ability to simultaneously co-encapsulate and co-release of two active compounds. The further focus have been oriented to develop safe cosmetic formulations with broad-spectrum photoprotection based on newly lipid nanocarriers containing high amounts of vegetable oils and low concentrations of synthetic UVA and UVB filters (butyl-methoxydibenzoylmethane -BMDBM and octocrylene -OCT). The lipid nanocarriers have spherical shape and good physical stability, with zeta potential in the range of -25.5 to -32.4 mV. Both vegetable oils presented a key role in the preparation of efficient nanocarriers, determining a less ordered arrangement of the lipid core that offers many spaces for a high entrapment of BMDBM (79%) and OCT (90%), and improved antioxidant activity and UV absorptive properties, particularly for lipid nanocarriers prepared with rice bran oil. By formulating lipid naonocarriers into creams containing only 3.5%UV filters and 10.5% vegetable oils, the resulting sunscreens presented improved photoprotection, reflecting up to 91% and 93% of the UVA and UVB rays, respectively. A new direction of research achieved by this study is the multiple release strategy of both UV filters from the same lipid nanocarriers. After 24 hours, a slow release of BMDBM (less than 4%) and of OCT (17.5%) was obtained through a Fick diffusion process. This study provides a significant advance for both areasnanotechnology and cosmetics, developing safer cosmetic formulations that possess broad antioxidant, photoprotective and co-release effectiveness due to the existence in the same carrier system of high content of nanostructured vegetable oils in conjunction with low amounts of synthetic UV filters.
Colloids and Surfaces A-physicochemical and Engineering Aspects, 2004
Mixtures of new hybrid fluorocarbon/hydrocarbon catanionic sugar-based surfactants are prepared b... more Mixtures of new hybrid fluorocarbon/hydrocarbon catanionic sugar-based surfactants are prepared by an acid-base reaction between N-alkylamino-1-lactitols and fluorinated carboxylic or phosphinic acids, respectively. The presence of the sugar moiety allows the synthesis of water soluble catanionic mixtures in an equimolar ratio over a wide range of concentrations (0.1-50 mM). These catanionic salts are able to form spontaneously supramolecular assemblies in water. Dynamic light scattering is used to identify the aggregate size in water, whereas transmission electron microscopy is used to identify the morphology of the catanionic mixtures. Slight variation of the molecular structure (perfluorooctyl moiety or perfluorodecyl-moiety) can lead to marked differences in the shape of the molecular aggregates: vesicles or coiled membranes. Moreover, perfluorodecyl-derived catanionic mixtures show an original behaviour forming lamellar dispersions in water even at concentrations as low as 1 mM.
European Journal of Lipid Science and Technology, 2014
The vegetable oils and extracts known for their beneficial effects should be identified and used ... more The vegetable oils and extracts known for their beneficial effects should be identified and used in various forms for the development of new healthy products. This study was designed to provide further investigation on new nanocarriers made with hempseed oil or a blend of amaranth and hempseed oils, for a concomitant encapsulation and release of the carotenoids enriched plant extract. The size of plant extract loaded lipid nanocarriers ranging between 109 and 130 nm was found to be less influenced by the different ratios of hempseed and amaranth oils. For all of the synthesized nanocarriers, zeta potential values were negative (À33.4 Ä À38.1 mV). The scanning calorimetry study has shown that lipid nanocarriers have favorable lattice defects for plant extract encapsulation. Entrapment efficiency results revealed an increase of carotenoids entrapment from 57.6 to 83.5% as the amaranth oil percent has been increased. High ability to scavenge the free oxygenated radicals was distinguished for all free and loaded nanocarriers. The level of antioxidant activity increase was proportional to the extent of vegetable oil and was ranging between 93.4 and 98.1%. The nanocarriers made with amaranth and hempseed oils have shown a more sustained release over time than those prepared with hempseed oil only in association with solid lipids.
Reçu le 2 novembre 2004 ; accepté après révision le 10 décembre 2004 Disponible sur internet le 2... more Reçu le 2 novembre 2004 ; accepté après révision le 10 décembre 2004 Disponible sur internet le 21 avril 2005
Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2004
Mixtures of new hybrid fluorocarbon/hydrocarbon catanionic sugar-based surfactants are prepared b... more Mixtures of new hybrid fluorocarbon/hydrocarbon catanionic sugar-based surfactants are prepared by an acid-base reaction between N-alkylamino-1-lactitols and fluorinated carboxylic or phosphinic acids, respectively. The presence of the sugar moiety allows the synthesis of water soluble catanionic mixtures in an equimolar ratio over a wide range of concentrations (0.1-50 mM). These catanionic salts are able to form spontaneously supramolecular assemblies in water. Dynamic light scattering is used to identify the aggregate size in water, whereas transmission electron microscopy is used to identify the morphology of the catanionic mixtures. Slight variation of the molecular structure (perfluorooctyl moiety or perfluorodecyl-moiety) can lead to marked differences in the shape of the molecular aggregates: vesicles or coiled membranes. Moreover, perfluorodecyl-derived catanionic mixtures show an original behaviour forming lamellar dispersions in water even at concentrations as low as 1 mM.
Soft and functional nanocarriers based on Pumpkin and Amaranth oils are achieved. In vitro antiox... more Soft and functional nanocarriers based on Pumpkin and Amaranth oils are achieved. In vitro antioxidant activity was superior for nanocarriers based on Amaranth oil. Co-loaded vegetable nanocarriers have greatly improved the photoprotective effect. Avobenzone and Octocrylen were coreleased from nanocarriers in a prolonged manner. The co-loaded nanocarriers have been formulated into advanced cosmetic prototype. g r a p h i c a l a b s t r a c t a. The cubic shape of vegetable -lipid nanocarriers; b. The photoprotective properties of vegetable nanocarriers co-loaded with 3% AVO and 7.5% OCT; c. Effect of UV irradiation of cosmetic prototypes based on vegetable co-loaded nanocarriers (3.75% OCT and 1.5% AVO)
Due to their unique features, most nanostructured lipid carriers (NLCs) in association with veget... more Due to their unique features, most nanostructured lipid carriers (NLCs) in association with vegetable oils that exhibit UV filtering properties and bioactivity could be used in many cosmetic formulations. Therefore, in this work, a new application of pomegranate seed oil (PSO) in the cosmetic sector was developed, based on the synthesis of bioactive lipid nanocarriers loaded with various UV filters by the hot high pressure homogenization technique. To get broad spectrum photoprotection, different UVA and UVB filters have been used (Avobenzone -AVO, Octocrylen -OCT, Bemotrizinol -BEMT). The influence of the solid lipids combined with PSO on the particle size, physical stability and entrapment efficiency was investigated using 8 nanocarrier systems. An improved physical stability and an appropriate size were obtained for NLCs prepared with Emulgade, carnauba wax and PSO (e.g. -30.9÷-36.9 mV and 160÷185 nm). NLCs showed an entrapment efficiency above 90% and assured slow release rates of UV filters, especially for BEMT (5%). The developed nanocarriers have been formulated into safe and effective sunscreens containing low amounts of synthetic UV filters coupled with a high percent of natural ingredients. The highest SPF of 34.3 was obtained for a cream comprising of 11% PSO and 3.7% BEMT
The aim of the research was to develop advanced lipid nanocarriers based on renewable vegetable r... more The aim of the research was to develop advanced lipid nanocarriers based on renewable vegetable resources (rice bran oil and raspberry seed oil) that manifest self-antioxidative property, have advantages in terms of minimal side effects and exhibit the ability to simultaneously co-encapsulate and co-release of two active compounds. The further focus have been oriented to develop safe cosmetic formulations with broad-spectrum photoprotection based on newly lipid nanocarriers containing high amounts of vegetable oils and low concentrations of synthetic UVA and UVB filters (butyl-methoxydibenzoylmethane -BMDBM and octocrylene -OCT). The lipid nanocarriers have spherical shape and good physical stability, with zeta potential in the range of -25.5 to -32.4 mV. Both vegetable oils presented a key role in the preparation of efficient nanocarriers, determining a less ordered arrangement of the lipid core that offers many spaces for a high entrapment of BMDBM (79%) and OCT (90%), and improved antioxidant activity and UV absorptive properties, particularly for lipid nanocarriers prepared with rice bran oil. By formulating lipid naonocarriers into creams containing only 3.5%UV filters and 10.5% vegetable oils, the resulting sunscreens presented improved photoprotection, reflecting up to 91% and 93% of the UVA and UVB rays, respectively. A new direction of research achieved by this study is the multiple release strategy of both UV filters from the same lipid nanocarriers. After 24 hours, a slow release of BMDBM (less than 4%) and of OCT (17.5%) was obtained through a Fick diffusion process. This study provides a significant advance for both areasnanotechnology and cosmetics, developing safer cosmetic formulations that possess broad antioxidant, photoprotective and co-release effectiveness due to the existence in the same carrier system of high content of nanostructured vegetable oils in conjunction with low amounts of synthetic UV filters.
Colloids and Surfaces A-physicochemical and Engineering Aspects, 2004
Mixtures of new hybrid fluorocarbon/hydrocarbon catanionic sugar-based surfactants are prepared b... more Mixtures of new hybrid fluorocarbon/hydrocarbon catanionic sugar-based surfactants are prepared by an acid-base reaction between N-alkylamino-1-lactitols and fluorinated carboxylic or phosphinic acids, respectively. The presence of the sugar moiety allows the synthesis of water soluble catanionic mixtures in an equimolar ratio over a wide range of concentrations (0.1-50 mM). These catanionic salts are able to form spontaneously supramolecular assemblies in water. Dynamic light scattering is used to identify the aggregate size in water, whereas transmission electron microscopy is used to identify the morphology of the catanionic mixtures. Slight variation of the molecular structure (perfluorooctyl moiety or perfluorodecyl-moiety) can lead to marked differences in the shape of the molecular aggregates: vesicles or coiled membranes. Moreover, perfluorodecyl-derived catanionic mixtures show an original behaviour forming lamellar dispersions in water even at concentrations as low as 1 mM.
European Journal of Lipid Science and Technology, 2014
The vegetable oils and extracts known for their beneficial effects should be identified and used ... more The vegetable oils and extracts known for their beneficial effects should be identified and used in various forms for the development of new healthy products. This study was designed to provide further investigation on new nanocarriers made with hempseed oil or a blend of amaranth and hempseed oils, for a concomitant encapsulation and release of the carotenoids enriched plant extract. The size of plant extract loaded lipid nanocarriers ranging between 109 and 130 nm was found to be less influenced by the different ratios of hempseed and amaranth oils. For all of the synthesized nanocarriers, zeta potential values were negative (À33.4 Ä À38.1 mV). The scanning calorimetry study has shown that lipid nanocarriers have favorable lattice defects for plant extract encapsulation. Entrapment efficiency results revealed an increase of carotenoids entrapment from 57.6 to 83.5% as the amaranth oil percent has been increased. High ability to scavenge the free oxygenated radicals was distinguished for all free and loaded nanocarriers. The level of antioxidant activity increase was proportional to the extent of vegetable oil and was ranging between 93.4 and 98.1%. The nanocarriers made with amaranth and hempseed oils have shown a more sustained release over time than those prepared with hempseed oil only in association with solid lipids.
Reçu le 2 novembre 2004 ; accepté après révision le 10 décembre 2004 Disponible sur internet le 2... more Reçu le 2 novembre 2004 ; accepté après révision le 10 décembre 2004 Disponible sur internet le 21 avril 2005
Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2004
Mixtures of new hybrid fluorocarbon/hydrocarbon catanionic sugar-based surfactants are prepared b... more Mixtures of new hybrid fluorocarbon/hydrocarbon catanionic sugar-based surfactants are prepared by an acid-base reaction between N-alkylamino-1-lactitols and fluorinated carboxylic or phosphinic acids, respectively. The presence of the sugar moiety allows the synthesis of water soluble catanionic mixtures in an equimolar ratio over a wide range of concentrations (0.1-50 mM). These catanionic salts are able to form spontaneously supramolecular assemblies in water. Dynamic light scattering is used to identify the aggregate size in water, whereas transmission electron microscopy is used to identify the morphology of the catanionic mixtures. Slight variation of the molecular structure (perfluorooctyl moiety or perfluorodecyl-moiety) can lead to marked differences in the shape of the molecular aggregates: vesicles or coiled membranes. Moreover, perfluorodecyl-derived catanionic mixtures show an original behaviour forming lamellar dispersions in water even at concentrations as low as 1 mM.
Soft and functional nanocarriers based on Pumpkin and Amaranth oils are achieved. In vitro antiox... more Soft and functional nanocarriers based on Pumpkin and Amaranth oils are achieved. In vitro antioxidant activity was superior for nanocarriers based on Amaranth oil. Co-loaded vegetable nanocarriers have greatly improved the photoprotective effect. Avobenzone and Octocrylen were coreleased from nanocarriers in a prolonged manner. The co-loaded nanocarriers have been formulated into advanced cosmetic prototype. g r a p h i c a l a b s t r a c t a. The cubic shape of vegetable -lipid nanocarriers; b. The photoprotective properties of vegetable nanocarriers co-loaded with 3% AVO and 7.5% OCT; c. Effect of UV irradiation of cosmetic prototypes based on vegetable co-loaded nanocarriers (3.75% OCT and 1.5% AVO)
Due to their unique features, most nanostructured lipid carriers (NLCs) in association with veget... more Due to their unique features, most nanostructured lipid carriers (NLCs) in association with vegetable oils that exhibit UV filtering properties and bioactivity could be used in many cosmetic formulations. Therefore, in this work, a new application of pomegranate seed oil (PSO) in the cosmetic sector was developed, based on the synthesis of bioactive lipid nanocarriers loaded with various UV filters by the hot high pressure homogenization technique. To get broad spectrum photoprotection, different UVA and UVB filters have been used (Avobenzone -AVO, Octocrylen -OCT, Bemotrizinol -BEMT). The influence of the solid lipids combined with PSO on the particle size, physical stability and entrapment efficiency was investigated using 8 nanocarrier systems. An improved physical stability and an appropriate size were obtained for NLCs prepared with Emulgade, carnauba wax and PSO (e.g. -30.9÷-36.9 mV and 160÷185 nm). NLCs showed an entrapment efficiency above 90% and assured slow release rates of UV filters, especially for BEMT (5%). The developed nanocarriers have been formulated into safe and effective sunscreens containing low amounts of synthetic UV filters coupled with a high percent of natural ingredients. The highest SPF of 34.3 was obtained for a cream comprising of 11% PSO and 3.7% BEMT
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