Fetal alcohol spectrum disorder (FASD) is related to many comorbidities because of the permanent ... more Fetal alcohol spectrum disorder (FASD) is related to many comorbidities because of the permanent effects of prenatal alcohol exposure on the fetus. We aimed to identify the comorbid conditions that co-occur in individuals with FASD and estimate the pooled prevalence of comorbid conditions occurring in individuals with fetal alcohol syndrome (FAS). We did a systematic literature search of studies reporting on the comorbidity and cause of death in individuals with FASD using multiple electronic bibliographic databases, searching for studies published up to July, 2012. We included original research published in a peer-reviewed journal in the English language. We used the following criteria for determining study quality: use of an established FASD diagnostic guideline, study setting, method of data collection, and sample size. All comorbid disease conditions were coded according to the International Classification of Diseases, tenth revision (ICD-10). To estimate the pooled prevalence of comorbid conditions found to co-occur in individuals with FAS, we did meta-analyses assuming a random-effects model. Of 5068 studies found, 127 met eligibility criteria for data extraction. From those studies, we identified 428 comorbid conditions co-occurring in individuals with FASD, spanning across 18 of 22 chapters of the ICD-10. The most prevalent disease conditions were within the sections of congenital malformations, deformities, and chromosomal abnormalities, and mental and behavioural disorders. 33 studies reported data for frequency in a total of 1728 participants with FAS. The five comorbid conditions with the highest pooled prevalence (between 50% and 91%) included abnormal results of function studies of peripheral nervous system and special senses, conduct disorder, receptive language disorder, chronic serous otitis media, and expressive language disorder. The high prevalence of comorbid conditions in individuals with FASD highlights the importance of assessing prenatal alcohol exposure as a substantial clinical risk factor for comorbidity. The harmful effects of alcohol on a developing fetus represent many cases of preventable disability, and thus, alcohol use during pregnancy should be recognised as a public health problem globally. Public Health Agency of Canada.
FASD is an umbrella term for a set of disorders caused by the consumption of alcohol by a mother ... more FASD is an umbrella term for a set of disorders caused by the consumption of alcohol by a mother whilst pregnant. These conditions range in diversity from the full presentation of Fetal Alcohol Syndrome (FAS), involving a characteristic set of facial features combined with growth and neuro-cognitive deficits, to a range of conditions affecting the neuro-behavioural presentations of the condition without all these features classified under the umbrella term Fetal Alcohol Spectrum Disorders (FASD). The studies described in this thesis represent the research conducted as part of combined research and clinical journey, incorporating several projects over a ten year period.
Bipolar Affective Disorder (BPD) is a serious, recurrent psychiatric illness characterised by per... more Bipolar Affective Disorder (BPD) is a serious, recurrent psychiatric illness characterised by periods of mania or hypomania, and depression. The purpose of the audit was to assess whether patients presenting to primary care practices within our catchment area were being screened for BPD. Additionally we wanted to establish how effective our service was at correctly identifying both true BPD sufferers, and those suffering from other mental health conditions. We intend to examine this data and consider whether further awareness and screening is required
Whilst much has been written about understanding the diagnostic and underlying pathological proce... more Whilst much has been written about understanding the diagnostic and underlying pathological processes related to prenatal alcohol exposure, far less has been directed at the management of affected individuals. We undertake a review of the literature focusing on a range of interventions including psychological, social, educational, pharmacological as well recent advances and directions. This paper is designed to give an overview on the management of this complex disorder.
Foetal alcohol spectrum disorders (FASD) are a set of preventable conditions where the foetus is ... more Foetal alcohol spectrum disorders (FASD) are a set of preventable conditions where the foetus is exposed to alcohol in utero and as a result suffers adverse consequences. To develop a public health strategy related to FASD, it is important to first establish what is known by the public about this condition. This study aimed to assess the current level of knowledge about FASD in the UK general population. A mixed methodology study was conducted using a 17-item questionnaire and focus group sessions. Four focus groups were held with an average of 10 people in each group. Semi-structured questions and thematic analysis of interviews alongside quantitative analysis of the questionnaire data was completed. The research was approved by an National Health service (NHS) research ethical committee. A total of 674 people responded to the questionnaire and a majority (86.7%) had heard about FASD, with most receiving their information from the media (26.2%) or from their work (27.7%). Four broa...
The journal of the Royal College of Physicians of Edinburgh, 2012
This review is based in part on Dr Mukherjee's lecture at the RCPE Mental Health Needs of Chi... more This review is based in part on Dr Mukherjee's lecture at the RCPE Mental Health Needs of Children and Young People Symposium held in Edinburgh on 29 September 2011.
Advances in Mental Health and Intellectual Disabilities, 2011
Associations between fetal alcohol syndrome (FAS) and other conditions have been reported, but th... more Associations between fetal alcohol syndrome (FAS) and other conditions have been reported, but the links between FAS and autistic spectrum disorders (ASD) remain unclear. This study explored the relationship between FAS and ASD in individuals attending a ...
The International Journal of Alcohol and Drug Research, 2013
Research has shown varying results regarding safe consumption levels of alcohol during pregnancy.... more Research has shown varying results regarding safe consumption levels of alcohol during pregnancy. We argued in 2005 that an individual's inability to accurately predict her alcohol consumption may be one factor influencing risk. In order to reevaluate within the England, this study sought to assess the current knowledge of the public and of healthcare practitioners.
Advances in Mental Health and Learning Disabilities, 2007
Introduction Prenatal exposure to alcohol may be the most important preventable cause of birth de... more Introduction Prenatal exposure to alcohol may be the most important preventable cause of birth defects and developmental disability (Bertrand et al, 2004) Therefore this issue is of particular relevance to professionals who sub-specialise in perinatal, substance misuse, learning ...
Fetal alcohol spectrum disorder (FASD) is related to many comorbidities because of the permanent ... more Fetal alcohol spectrum disorder (FASD) is related to many comorbidities because of the permanent effects of prenatal alcohol exposure on the fetus. We aimed to identify the comorbid conditions that co-occur in individuals with FASD and estimate the pooled prevalence of comorbid conditions occurring in individuals with fetal alcohol syndrome (FAS). We did a systematic literature search of studies reporting on the comorbidity and cause of death in individuals with FASD using multiple electronic bibliographic databases, searching for studies published up to July, 2012. We included original research published in a peer-reviewed journal in the English language. We used the following criteria for determining study quality: use of an established FASD diagnostic guideline, study setting, method of data collection, and sample size. All comorbid disease conditions were coded according to the International Classification of Diseases, tenth revision (ICD-10). To estimate the pooled prevalence of comorbid conditions found to co-occur in individuals with FAS, we did meta-analyses assuming a random-effects model. Of 5068 studies found, 127 met eligibility criteria for data extraction. From those studies, we identified 428 comorbid conditions co-occurring in individuals with FASD, spanning across 18 of 22 chapters of the ICD-10. The most prevalent disease conditions were within the sections of congenital malformations, deformities, and chromosomal abnormalities, and mental and behavioural disorders. 33 studies reported data for frequency in a total of 1728 participants with FAS. The five comorbid conditions with the highest pooled prevalence (between 50% and 91%) included abnormal results of function studies of peripheral nervous system and special senses, conduct disorder, receptive language disorder, chronic serous otitis media, and expressive language disorder. The high prevalence of comorbid conditions in individuals with FASD highlights the importance of assessing prenatal alcohol exposure as a substantial clinical risk factor for comorbidity. The harmful effects of alcohol on a developing fetus represent many cases of preventable disability, and thus, alcohol use during pregnancy should be recognised as a public health problem globally. Public Health Agency of Canada.
FASD is an umbrella term for a set of disorders caused by the consumption of alcohol by a mother ... more FASD is an umbrella term for a set of disorders caused by the consumption of alcohol by a mother whilst pregnant. These conditions range in diversity from the full presentation of Fetal Alcohol Syndrome (FAS), involving a characteristic set of facial features combined with growth and neuro-cognitive deficits, to a range of conditions affecting the neuro-behavioural presentations of the condition without all these features classified under the umbrella term Fetal Alcohol Spectrum Disorders (FASD). The studies described in this thesis represent the research conducted as part of combined research and clinical journey, incorporating several projects over a ten year period.
Bipolar Affective Disorder (BPD) is a serious, recurrent psychiatric illness characterised by per... more Bipolar Affective Disorder (BPD) is a serious, recurrent psychiatric illness characterised by periods of mania or hypomania, and depression. The purpose of the audit was to assess whether patients presenting to primary care practices within our catchment area were being screened for BPD. Additionally we wanted to establish how effective our service was at correctly identifying both true BPD sufferers, and those suffering from other mental health conditions. We intend to examine this data and consider whether further awareness and screening is required
Whilst much has been written about understanding the diagnostic and underlying pathological proce... more Whilst much has been written about understanding the diagnostic and underlying pathological processes related to prenatal alcohol exposure, far less has been directed at the management of affected individuals. We undertake a review of the literature focusing on a range of interventions including psychological, social, educational, pharmacological as well recent advances and directions. This paper is designed to give an overview on the management of this complex disorder.
Foetal alcohol spectrum disorders (FASD) are a set of preventable conditions where the foetus is ... more Foetal alcohol spectrum disorders (FASD) are a set of preventable conditions where the foetus is exposed to alcohol in utero and as a result suffers adverse consequences. To develop a public health strategy related to FASD, it is important to first establish what is known by the public about this condition. This study aimed to assess the current level of knowledge about FASD in the UK general population. A mixed methodology study was conducted using a 17-item questionnaire and focus group sessions. Four focus groups were held with an average of 10 people in each group. Semi-structured questions and thematic analysis of interviews alongside quantitative analysis of the questionnaire data was completed. The research was approved by an National Health service (NHS) research ethical committee. A total of 674 people responded to the questionnaire and a majority (86.7%) had heard about FASD, with most receiving their information from the media (26.2%) or from their work (27.7%). Four broa...
The journal of the Royal College of Physicians of Edinburgh, 2012
This review is based in part on Dr Mukherjee's lecture at the RCPE Mental Health Needs of Chi... more This review is based in part on Dr Mukherjee's lecture at the RCPE Mental Health Needs of Children and Young People Symposium held in Edinburgh on 29 September 2011.
Advances in Mental Health and Intellectual Disabilities, 2011
Associations between fetal alcohol syndrome (FAS) and other conditions have been reported, but th... more Associations between fetal alcohol syndrome (FAS) and other conditions have been reported, but the links between FAS and autistic spectrum disorders (ASD) remain unclear. This study explored the relationship between FAS and ASD in individuals attending a ...
The International Journal of Alcohol and Drug Research, 2013
Research has shown varying results regarding safe consumption levels of alcohol during pregnancy.... more Research has shown varying results regarding safe consumption levels of alcohol during pregnancy. We argued in 2005 that an individual's inability to accurately predict her alcohol consumption may be one factor influencing risk. In order to reevaluate within the England, this study sought to assess the current knowledge of the public and of healthcare practitioners.
Advances in Mental Health and Learning Disabilities, 2007
Introduction Prenatal exposure to alcohol may be the most important preventable cause of birth de... more Introduction Prenatal exposure to alcohol may be the most important preventable cause of birth defects and developmental disability (Bertrand et al, 2004) Therefore this issue is of particular relevance to professionals who sub-specialise in perinatal, substance misuse, learning ...
Uploads
Papers by Raja Mukherjee