Papers by Raheela Raheela
The Professional Medical Journal, 2018
To observe the absolute, relative weight of kidney and body weight of albino rats on celecoxib in... more To observe the absolute, relative weight of kidney and body weight of albino rats on celecoxib induced kidney with protection by lycopene. Study Design: Experimental study. Place and Duration of study: This study was conducted in BMSI (Anatomy department), JPMC, Karachi, from 4 th May 2015 to 3 rd June 2015. Materials and Methods: Forty healthy adult, male Albino rats, 90-120 days old, weighing 200-220gm was taken for the study. The rats were divided into 4 groups, Group A was control group, Group B receive Celecoxib 50 mg/kg body weight orally, Group C receive Celecoxib 50 mg/kg body weight orally along with lycopene50 mg/kg body weight orally and Group D receive lycopene 50 mg/kg body weight orally for 30 days. At the end of study rats were sacrificed and renal tissue sections were stained with hematoxylin and eosin. Results: Markedly decreased weight was observed in rats taking celecoxib. Slides which were stained with hematoxylin and eosinshowed general architecture of renal parenchyma, shape and arrangement of epithelial cells. Apoptosis, hemorrhage, necrosis and vacuolation seen in Celecoxib group, whereas renal architecture were ameliorated and reverted back in celecoxib along with lycopene receiving group. Conclusion: This study concludes that lycopene restored the body weight, absolute and relative kidney weight in celecoxib treated group.
Pakistan Journal of Medical and Health Sciences, 2022
Aim: To determine the effect of zinc on spermatogenesis Methodology: the study was done at Shahid... more Aim: To determine the effect of zinc on spermatogenesis Methodology: the study was done at Shahida Islam Medical Complex, Lodhran. 60 albino rats were selected and divided into 4 groups each consisting of 15 albino rats each. The first control group-1 was feed with normal diet, while the group-2 and group-3 were treated with indomethacin and zinc respectively. Whereas the group-4 was treated with both zinc and indomethacin. This intervention was carried out for 12 weeks. Once the study was concluded, the rats were euthanized and histopathological analysis of the testes was carried out to determine the effect on spermatogenesis. Results: group 4 showed favorable results in which normal spermatogenesis could be observed, in group 2 however, focal loss of germ cells series was seen as well as focal basement membrane detachment. Conclusion: the study can safely say that zinc metal exhibits a protective role on the testes of albino rats Keywords: Spermatogenesis, Albino rats, Zinc, Indom...
The Professional Medical Journal
Objective: To observe the absolute, relative weight of kidney and body weightof albino rats on ce... more Objective: To observe the absolute, relative weight of kidney and body weightof albino rats on celecoxib induced kidney with protection by lycopene. Study Design:Experimental study. Place and Duration of study: This study was conducted in BMSI (Anatomydepartment), JPMC, Karachi, from 4th May 2015 to 3rd June 2015. Materials and Methods: Fortyhealthy adult, male Albino rats, 90-120 days old, weighing 200-220gm was taken for the study.The rats were divided into 4 groups, Group A was control group, Group B receive Celecoxib 50mg/kg body weight orally, Group C receive Celecoxib 50 mg/kg body weight orally along withlycopene50 mg/kg body weight orally and Group D receive lycopene 50 mg/kg body weightorally for 30 days. At the end of study rats were sacrificed and renal tissue sections were stainedwith hematoxylin and eosin. Results: Markedly decreased weight was observed in rats takingcelecoxib. Slides which were stained with hematoxylin and eosinshowed general architecture ofrenal paren...
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Papers by Raheela Raheela