CAR T cell therapy has transformed clinical care and management of patients with certain hematolo... more CAR T cell therapy has transformed clinical care and management of patients with certain hematological cancers. However, it remains unclear whether the success of CAR T cell therapy relies solely on CAR T cell engagement with tumor antigen, or if it also requires the stimulation of an individual patient’s endogenous T cell response. Here, we performed combined analysis of longitudinal, single cell RNA and T cell receptor sequencing on glioblastoma tumors, peripheral blood (PB), and cerebrospinal fluid (CSF) from a patient with recurrent multifocal glioblastoma that underwent a remarkable response followed by recurrence on IL13RA2-targeted CAR T cell therapy (Brown et al. 2016). Single cell analysis of a tumor resected prior to CAR T cell therapy revealed the existence of an inflamed tumor microenvironment including a CD8+ cytotoxic, clonally expanded and antigen specific T cell population that disappeared in the recurrent setting. Longitudinal tracking of T cell receptors uncovered ...
BACKGROUND Nurses are a common resource for victims of intimate partner violence (IPV) presenting... more BACKGROUND Nurses are a common resource for victims of intimate partner violence (IPV) presenting to healthcare settings. However, they often have inadequate knowledge about IPV, a lack of self-efficacy or confidence to be able to screen for IPV and communicate effectively with patients. OBJECTIVE The aim of this study was to develop and test the usability of a blended learning system aimed at educating nursing students on topics related to IPV (i.e., the mPOWERED system). METHODS Development of the mPOWERED system involved usability testing with seven nurse educators and 18 nurse practitioner students. Users were asked to complete usability testing using speak-aloud procedure, and then complete a satisfaction and usability questionnaire RESULTS Overall, the mPOWERED system was deemed to have high usability and was positively evaluated by both nurse educators and nursing students. Respondents provided critical feedback that will be used to improve the system. CONCLUSIONS By includin...
CAR T cell therapy has transformed clinical care and management of patients with certain hematolo... more CAR T cell therapy has transformed clinical care and management of patients with certain hematological cancers. However, it remains unclear whether the success of CAR T cell therapy relies solely on CAR T cell engagement with tumor antigen, or if it also requires the stimulation of an individual patient’s endogenous T cell response. Here, we performed combined analysis of longitudinal, single cell RNA and T cell receptor sequencing on glioblastoma tumors, peripheral blood (PB), and cerebrospinal fluid (CSF) from a patient with recurrent multifocal glioblastoma that underwent a remarkable response followed by recurrence on IL13RA2-targeted CAR T cell therapy (Brown et al. 2016). Single cell analysis of a tumor resected prior to CAR T cell therapy revealed the existence of an inflamed tumor microenvironment including a CD8+ cytotoxic, clonally expanded and antigen specific T cell population that disappeared in the recurrent setting. Longitudinal tracking of T cell receptors uncovered ...
BACKGROUND Nurses are a common resource for victims of intimate partner violence (IPV) presenting... more BACKGROUND Nurses are a common resource for victims of intimate partner violence (IPV) presenting to healthcare settings. However, they often have inadequate knowledge about IPV, a lack of self-efficacy or confidence to be able to screen for IPV and communicate effectively with patients. OBJECTIVE The aim of this study was to develop and test the usability of a blended learning system aimed at educating nursing students on topics related to IPV (i.e., the mPOWERED system). METHODS Development of the mPOWERED system involved usability testing with seven nurse educators and 18 nurse practitioner students. Users were asked to complete usability testing using speak-aloud procedure, and then complete a satisfaction and usability questionnaire RESULTS Overall, the mPOWERED system was deemed to have high usability and was positively evaluated by both nurse educators and nursing students. Respondents provided critical feedback that will be used to improve the system. CONCLUSIONS By includin...
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Papers by Rachel Ng