Papers by Prof Tanaji Nandgude
Asian Journal of Biomedical and Pharmaceutical Sciences, 2011
To dosage form design characterization of drug and polymers is an important aspect. The objective... more To dosage form design characterization of drug and polymers is an important aspect. The objective of this work was to characterize Capecitabine, natural polymers like, guar gum, xanthan gum, chitosan and other excipients. As a part of characterization studies of Capecitabine, Differential scanning calorimetry (DSC) was used to investigate thermal effects and nature of drug, supported by X-ray powder diffraction (X-RPD), showed two endothermic peaks and indicated crystalline nature of the drug. Scanning electron microphotographs (SEM) was used to study surface topography. Fourier-transform infrared (FT-IR), solubility study, flowability studies of drug and excipients were carried out as part of characterization. Solubility studies at different pH showed feasibility of drug at any pH. Drug excipient interaction studies carried out which shows there was no chemical interaction between the drug and the polymers. Stability of bulk drug at accelerated conditions was determined, good stability was observed.
Pharmaceutical education development: Need of academia-industry tie-up
Academia-Industry partnership plays pivotal role in knowledge-based economies. The institutions a... more Academia-Industry partnership plays pivotal role in knowledge-based economies. The institutions are therefore considered as engines of development. The partnership or synergy between academia and industry is almost missing.The education system in the country did not have much scope for this type of collaboration to sprout. The research done in academic institutions is not translated in industrial realities; hence the institutes keep on starving for the funds. Major changes have to occur in the institutional structures to make the technology based growth feasible. Therefore, it is necessary to study bottlenecks of academia and industry so that we may find a balanced mechanism to promote industry-academia collaboration by focusing on knowledge transfer. As we are, need to make, very serious attempts in developing a database, www.aiip.info, to proliferate academia-industry interaction in the country.
HIND AGRI-HORTICULTURAL SOCIETY Nigella sativa Linn: A Golden Seed
Nigella sativa is a miraculous herb due to its many properties and has no side effects as in allo... more Nigella sativa is a miraculous herb due to its many properties and has no side effects as in allopathic drugs; hence it is called as " golden seed". The present review highlights the different pharmacognostical aspects of the plant Nigella sativa. It has been traditionally used to treat many diseases like respiratory tract related diseases, inflammatory diseases, to improve defense system, to treat digestive problems etc. The most economical part of this plant is seed. The chemical composition consists of tannins, resins, proteins, reducing sugar, glycosidal saponin, melanthin and also 1.0 per cent melanthigenin.
A review on taste masking methods for bitter drug
Abstract Undesirable taste is one of several important formulation problems that are encountered ... more Abstract Undesirable taste is one of several important formulation problems that are encountered with certain drugs The problem of bitter and obnoxious taste of is a challenge to the pharmacist in the present scenario. Several oral pharmaceuticals and bulking ...
A Novel approach to Enhance Gastric Retention for better Therapeutic Activity: Gastro Retentive Drug Delivery System
Research Journal of Pharmacy and Technology
Oral route has been the most suitable and accepted route of drug delivery. But oral control relea... more Oral route has been the most suitable and accepted route of drug delivery. But oral control release dosage forms face several physiological restrictions like inability to retain and locate the controlled drug delivery system within the targeted region of the gastrointestinal tract (GIT) due to fluctuation in gastric emptying. This results in non-uniform absorption pattern, inadequate medication release and shorter residence time of the dosage form in the stomach. Gastro retentive drug delivery system (GRDDS) is novel drug delivery systems which are more advantages due to its ability of prolonged retaining ability in the stomach and thereby increase gastric residence time of drugs and also increase bioavailability of drugs. This present review covers the advantages, disadvantages, factors affecting on GRDDS, Recent approaches, floating and non-floating drug delivery system and also highlights the other effective approaches who increases gastric residence time of drug such as bio-adhe...
Development and Validation of UV Spectrophotometric Method of Pirenzepine Dihydrochloride in API and Stress Degradation Studies
Research Journal of Pharmacy and Technology
A simple, accurate, precise spectrophotometric method was developed for the detection of Pirenzep... more A simple, accurate, precise spectrophotometric method was developed for the detection of Pirenzepine dihydrochloride (PZC). The optimum condition for the analysis of the drug was studied. PZC was subjected to stress degradation under different conditions like acidic, alkali, neutral, oxidation, photolytic, and thermal degradation as per recommended by the International Conference on Harmonization (ICH). The samples thus prepared were used for degradation studies by with the developed method. The lambda max i.e. absorption maxima found at 281nm and calibration curve linear over the range of 0-20µg/ml. The standard regression equation and correlation coefficient fond to be y = 0.04x + 0.056 R² = 0.998 respectively. Percent RSD found to be less than one. The accepted limits of accuracy (recovery) were found to be 90% - 120% and all observed data are within required range which indicates good recovery value. and LOD and LOQ found to be 0.165 and 0.500 respectively by simple UV spectrosc...
International journal of health sciences
Objective: Over past few decades, Peptic ulcer disease remains a common condition despite the lot... more Objective: Over past few decades, Peptic ulcer disease remains a common condition despite the lots of novelty in treatment. The objective of this research work was to formulate gastro retentive floating tablet by raft approach using Pirenzepine dihydrochloride (PNZ) as drug candidate. Formulation also contained a raft forming agent (sodium alginate) along with alkalizing agents (Calcium carbonate and Sodium Bicarbonate). Raft strength was only affected by the amount of Raft forming agent, Calcium carbonate and Sodium Bicarbonate . Method: Tablets were prepared by direct compression method and evaluated for raft strength, acid neutralization capacity, weight variation, % drug content, thickness, hardness, friability and In vitro drug release. Experimental work: A Box Behnken design was used in present study for optimization. Amount of gel forming agent, amount of cross-linkingagentsand floating agent were selected as independent variables. Raft strength, Acid neutralization capacity,...
Lipid based approach for bioavailability enhancement of boswellia serrata
Journal of medical pharmaceutical and allied sciences, Jan 30, 2022
In past numerous studies reported the potential effect of Boswellia serrata in the treatment of v... more In past numerous studies reported the potential effect of Boswellia serrata in the treatment of various topical and systemic inflammatory diseases. Despite of potential pharmacological effects the oral delivery of BS is challenging due to poor bioavailability limiting its clinical applications. The objective of this study was to formulate and optimize lipid-based sustained release pellets of Boswellia serrata in order to improve solubility and oral bioavailability. Initially, solid dispersions were formulated by fusion method using hydrophilic grade lipids Gelucire 44/14 and 50/13 in different ratio (1: 0.25, 1: 0.5, 1:0.75, 1:1, and 1:2 w/w). Extrusion spheronization technique was used to further formulate solid dispersion of Boswellia serrata into sustained release pellets utilizing hydrophobic grade lipid carrier gelucire 43/01 and ethyl cellulose as a release retarding agent. Using a 3-level, 2-factor factorial design, the effect of the amount of gelucire 43/01 and ethyl cellulose was investigated and optimized. Compared to pure drug, solid dispersion of Boswellia serrata (batch-F9) demonstrated a 5-fold increase in aqueous solubility and dissolution behavior. The optimum system (batch-F16) achieved a maximum drug release of 95.69 % in 6 hours. In comparison to the marketed preparation, pharmacokinetic investigation in male Wistar rats revealed a 2.52-fold improvement in relative bioavailability of the optimized formulation. The obtained BS lipid-based pellets could be a promising choice for its efficient use in various clinical applications. The developed system could be effectively applied to deliver other phytochemicals having potential pharmacological effects but limited clinical use due to poor bioavailability. Keywords: Boswellia serrata, Gelucire, Solid dispersion, Pellets, Spheronization, Bioavailability.
Preformulation studies of Glipizide: First step towards developing stable Osmotic Drug Delivery System
Research Journal of Pharmacy and Technology, 2022
Objective: The goal of this research study was to conduct a preformulation analysis of glipizide ... more Objective: The goal of this research study was to conduct a preformulation analysis of glipizide in order to establish a stable, robust as well as therapeutically effective system. Methods: Glipizide was characterized to determine its flow properties. Solubility was determined in different pH-varying solvents and its purity was determined by infrared spectrum and absorption maxima. Standard UV curve was developed to aid in further analytical research studies. Finally loss on drying (LOD) and drug-excipients compatibility tests were performed. Results: Glipizide has poor flow and compressibility properties (BD 0.222 g/ml, TD 0.425 g/ml, Carr’s index 47.78%, Hauser’s ratio 1.915). Solubility of drug was found to increase with increase in pH. The purity of drug was confirmed by infrared spectrum which showed characteristics peaks and by uv spectroscopy which exhibited maxima at 276 nm. The standard curve obtained was linear with correlation coefficient (R2 =0.998) and equation y = 0.01...
Novel formulation approaches for wound healing
International Journal of Research in Pharmaceutical Sciences, 2020
A wound is damage to the typical anatomic structure. Wound healing is an immediate therapeutic re... more A wound is damage to the typical anatomic structure. Wound healing is an immediate therapeutic response to injury. It is a creation of the combined response of some cell types towards injury. Wound healing takes place by a sequence of molecular events which cooperate to fix tissue integrity and cell work. In typical healthy individual under ordinary conditions, these physiological events take place smoothly. Though sometimes, these molecular events are arrested, this brings about in struggle to heal. There is an assortment of approaches for the way toward managing and controlling both acute injuries (acute wounds) and ceaseless non-mending wounds (chronic non-healing wounds). The principal objective of these two cases is to achieve better-wound healing. Ideal formulations of wound healing should not only enhance the healing process but also reduce pain, infection and loss of electrolytes, proteins and liquids from the injury. A broad scope of items typically introduced with target v...
Asian Journal of Pharmaceutics, 2018
Aim: The aim of the present study is to develop and evaluate modified release apremilast pellets ... more Aim: The aim of the present study is to develop and evaluate modified release apremilast pellets for the treatment of rheumatoid arthritis (RA). This disease directly depends on the circadian rhythm of the body, i.e. the maximum joint stiffness generally higher during the morning. The modified release apremilast pellets can be taken before bedtime and capable of releasing drug after a predetermined lag time. Materials and Methods: Apremilast pellets were prepared employing carboxymethyl tamarind kernel powder (CMTKP) as a novel natural excipient using the extrusion-spheronization technique. The apremilast pellets were prepared using blend of microcrystalline cellulose (MCC), lactose, TKP, and crospovidone. The process variables such as spheronizing speed, amount of spheronizing aid (MCC), and binder (TKP) were optimized and reported. Results and Discussion: The obtained pellets were subjected for determination of percentage yield, hardness, physicochemical properties, and particle s...
Invitro evaluation of ethyl cellulose microsphere of pioglitazone
The Indian pharmacist, 2007
Ethyl cellulose (EC) microsphere of Pioglitazone hydrochloride (PGH) were prepared by emulsion-so... more Ethyl cellulose (EC) microsphere of Pioglitazone hydrochloride (PGH) were prepared by emulsion-solvent evaporation technique and evaluated for shape, flow properties, encapsulation efficiency (EE) and invitro drug release. EE was in the range of 83-95%. PGH release from the microsphere was slow, diffusion controlled and extended over a period of 10 days and depended on core:coat ratio, wall thickness and size of the microsphere. Good linear relationships were observed between per cent coat, wall thickness and release rate of the microsphere.
Formulation of Modified Release Pellets of Montelukast Sodium
Research Journal of Pharmacy and Technology, 2018
The present study was carried out with an aim of preparing modified release pellets of the antias... more The present study was carried out with an aim of preparing modified release pellets of the antiasthma drug montelukast sodium. The patients suffering from chronic asthma many a times suffer from exacerbations during the early morning hours i.e. around 4am to 6 am. Thus the need to take an immediate release medication arises during early morning hours which is not quiet feasible for the patients. The delivery of the drug at this time can be made possible by the use of modified release formulation of montelukast sodium which when taken at the bed time would release the drug as a pulsed delivery without the need of the patient to wake up. The montelukast sodium pellets prepared by extrusion-spheronization were coated with release retarding polymer ethyl cellulose using the Wurster method. The ethyl cellulose coating helped in lag time increase due to prolonged water uptake time. The increase in the coating level increased the lag time sufficiently that might release the drug during the early morning hours. Thus a modified release pellets dosage form to prevent the early morning asthma attacks and exacerbations was developed successfully.
International Journal of Research in Pharmaceutical Sciences, 2020
Flurbiprofen via oral route has many side effects. Many inflammatory infections occur locally and... more Flurbiprofen via oral route has many side effects. Many inflammatory infections occur locally and close to the body's surface, so topical application of flurbiprofen is advantageous. Still, intact skin acts as a barrier and hampers skin penetration of the drug. Present objective of this work was to reduce the adverse effect of flurbiprofen and increase its bioavailability by formulating Flurbiprofen microemulsion based gel, evaluating it for its Physico-chemical properties and then finally conducting its in-vitro and animal studies to determine its efficiency. Arachis oil was selected as an oil phase as flurbiprofen showed maximum solubility in it. Microemulsion formulations (A1 to A9) were prepared by varying the qty of tween 80 (as a surfactant) and propylene glycol (as co-surfactant). Microemulsions which were found to give satisfactory results w.r.t microemulsion formation (F1 to F5) were converted to microemulsion gel using Carbopol 934 as gel base. The ability of different...
Overview on Trends in Development of Gastroretentive Drug Delivery System
Research Journal of Pharmacy and Technology, 2019
The present review on gastroretentive Drug Delivery Systems was aim with overview on various tren... more The present review on gastroretentive Drug Delivery Systems was aim with overview on various trends in development of gastroretentive approaches in the area of site-specific orally administered controlled release drug delivery. Gastroretentive dosage form can improve the delivery and performance of drug into the stomach because the drug remains in stomach for sufficient time of interval. The review summarized various physiological requirements and factors affecting gastric retention with merit and demerits of gastroretentive system. Various gastroretentive approaches designed and developed by researchers such as high density (sinking), floating system, bioadhesive, expandable, unfoldable, super porous hydrogel and magnetic systems were highlighted in the article.
Nanoarchitectonics: a New Horizon for Drug Targeting
Journal of Pharmaceutical Innovation, 2021
Nanoarchitectonics is an emerging multidisciplinary field that has the potential to offer trailbl... more Nanoarchitectonics is an emerging multidisciplinary field that has the potential to offer trailblazing solutions to various challenging therapies by facilitating precise and tailored control of physicochemical properties, morphology, and also the biological effects of nano-sized drugs. In this review, various examples of drug delivery based on the nanoarchitectonic approach are discussed. The article consists of various nanoarchitectured materials like cell-penetrating peptide (CPP), mesoporous substances, layered structural motifs, tumour-triggered targeting mesoporous silica nanoparticle (TTTMSN), DNA hybrid, clay based, fullerene based, and inorganic materials like gold and silver. This new concept is a horizon for drug delivery and can significantly expand the possibilities in this area.
International Journal of Applied Pharmaceutics, 2020
Pelletization is an agglomeration process which converts fine granules or powders of bulk drugs i... more Pelletization is an agglomeration process which converts fine granules or powders of bulk drugs into small, free-flowing, spherical units, known as pellets. The pelletization can be achieved either through agitation, compaction (extrusion-spheronization), drug layering and globulation. Among the various pelletization techniques extrusion–spheronization process is preferred over other methods for the preparation of pellets as it allows the incorporation of the higher amount of drug, modified physical characteristics of the drug (density, sphericity, narrow size distribution, smoother surface) and multiple drugs can be easily combined in the same unit. This current review summarizes the findings or investigations by the researchers on various variables, including process parameters, equipment parameters and formulation parameters influencing the quality of pellets. The article also focuses on process optimization and additives used in pellets formulation. To prepare the current review...
Hepatoprotective Activity of Calotropis gigantea Root Bark Experimental Liver Damage Induced by D-Galactosamine in Rats
International Journal of Pharmaceutical Sciences and Nanotechnology, 1970
The suspensions of alcoholic extract of root bark of the plant Calotropis gigantea in 0.6% carbox... more The suspensions of alcoholic extract of root bark of the plant Calotropis gigantea in 0.6% carboxy methyl cellulose (CMC) were evaluated for hepatoprotective activity in Wistar albino rats by inducing hepatic injury with D-galactosamine (400 mg/kg). Alcoholic extract of root bark of the plant Calotropis gigantea at an oral dose of 200 mg/kg and 400 mg/kg exhibited a significant (P<0.001, P<0.01 and P<0.05) protection effect by normalizing the levels of aspartate amino transferase (ASAT/ GOT), alanine amino transferase (ALAT/GPT), alkaline phosphatase (ALP), total bilirubin (TB), lactate dehydrogenase (LDH), which were significantly (P<0.001) increased in rats by treatment with 400 mg/kg i.p. of D-galactosamine. Silymarin (25 mg/kg), a known hepatoprotective drug used for comparison exhibited significant activity (P<0.001).
Formulation and Evaluation of pH Induced In-situ Nasal Gel of Salbutamol Sulphate
International Journal of Pharmaceutical Sciences and Nanotechnology, 1970
Nasal solutions of Salbutamol Sulphate were prepared for sustaining its release and improving its... more Nasal solutions of Salbutamol Sulphate were prepared for sustaining its release and improving its bioavailability. Carbopol was used as a key ingredient to effect pH induced sol to gel conversion of the formulations. Different formulations were prepared by varying the concentrations of Carbopol 934 and Hydroxyl Propyl Methyl Cellulose. These formulations were evaluated for parameters like pH, drug content, viscosity, gel strength and drug release. Release profile of some formulations showed rapid phase while some showed slow phase. At extreme low concentrations of the polymers, the formulations drained out due to poor viscosity while at higher concentrations of the same the formulations formed stiff gel and showed slow release of drug. Finally optimized formulation with specific concentrations of carbopol 934 and Hydroxyl Propyl Methyl Cellulose showed pH induced sol-gel conversion, sustained release and higher bioavailability
International Journal of Research in Pharmaceutical Sciences, 2019
The aim of the present research is to design and optimize floating multiparticulate drug delivery... more The aim of the present research is to design and optimize floating multiparticulate drug delivery system of Ketorolac tromethamine (KT) so as to reduce its irritant effect on the gastric mucosa. Extrusion and spheronization process were used to prepare a drug-containing core pellets. A 3 level 2 experimental factor design was used to examine the effect of the amount of Eudragit RS 100, effervescent agent (NaHCO3: HPMC K4M) on floating lag time and drug release in 6 h. Fourier Transform Infra-Red (FTIR) spectrum, physical characterization, particle size distribution analysis, scanning electron microscopy, floating studies and in vitro drug release studies of prepared floating pellets were evaluated. The study reveals the significant effect of the amount of Eudragit RS 100 and NaHCO3: HPMC K4M on floating lag time and drug release. The optimized batch showed floating lag time of 3.2 min and 95.15% average drug release in 6 hours. 80–95% of pellets remained floating for up to 6 h. All ...
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Papers by Prof Tanaji Nandgude