Papers by Priyankul Palia
Due to the growing amount of multicomponent formulations, biotherapeutic medicines, and complicat... more Due to the growing amount of multicomponent formulations, biotherapeutic medicines, and complicated matrix samples in queue, quick and simple analytical methods are required. For these purposes, a variety of ultraviolet (UV) spectrophotometric approaches are used. On the basis of the principle of additivity, absorbance difference, and processing absorption spectra, many UV spectrometric methods have been created. This review will cover simultaneous equation method, difference spectrophotometry, derivative spectrophotometry, absorbance ratio spectra, derivative ratio spectra, successive ratio derivative spectra, Q-absorbance ratio method, absorptivity factor method, dual wavelength method, absorption factor method, multivariate chemometric methods, and isosbestic point method.
Tumor necrosis factor (TNFalpha) plays important role in pathophysiology of cardiovascular system... more Tumor necrosis factor (TNFalpha) plays important role in pathophysiology of cardiovascular system and had been comprehensively studied over the last 20 years. These studies demonstrate both Detrimental and potentially conflicting roles of TNF-α in pathophysiology of heart. Beneficial effects of TNF-α includes cardioprotective action against ischemia, myocarditis, pressure overload and preventive action against potential adverse effects including development of atherosclerosis, reperfusion injury, hypertrophy, and heart failure. However, TNF-α is still controversial for its beneficial or harmful effects for cardiovascular system. This review includes evaluation of possible role of TNF-α in cardiovascular system specifically in pathophysiology and morphology of cardiomyocytes. Further this article mainly emphases on the claimed role of TNF-α pathways with concerning essential cardiac cellular processes which may have unswerving adaptive effects in the heart with respect to future rese...
Mammalian heart is a dynamic organ that can adapt morphological changes in response to alteration... more Mammalian heart is a dynamic organ that can adapt morphological changes in response to alteration in workload. Various clinical and experimental findings revealed that in response to physiological stimuli or pathological insults, the heart undergoes cardiac remodeling which can be characterized by molecular, cellular or interstitial changes and can be manifested clinically as changes in size, shape and pumping function of the heart. A Sound understanding of changes in hearts cellular and molecular components and to mediators that derive homeostatic control is necessary before a specific intervention is pursued. Summarized data of this review comprises role of various novel emerging molecular pathways involvement in the pathophysiology of cardiac remodeling.
Journal of Drug Delivery and Therapeutics, 2020
Lupeol is a pentacyclic triterpenoid commonly distributed in the plant kingdom and is found in ed... more Lupeol is a pentacyclic triterpenoid commonly distributed in the plant kingdom and is found in edible fruits and vegetables. It is a naturally occurring triterpene that is used to reduce the inflammatory responses and also have immunomodulating properties. Lupeol and its derivatives have a great potential to act as an anti- inflammatory, anti-microbial, anti-proliferative, anti-invasive, anti-angiogenic, anti-protozoal, and cholesterol-lowering agent. Various studies have shown that anti-inflammatory activity of lupeol through the modulation of p-38 pathways inhibits neuroinflammation in the cerebellum and induces neuroprotection. It has been also found effective on lung cancer (i.e A427 cancer cells and normal MRC-5 cells). Observation of inhibiting the growth of lung cancer cells is checked by MTT assay. Lupeol and its ester lupeol linoleate have been used to reduce the levels of hypercholesterolemia in the rats and decrease the activities of such enzymes namely Na+, K+-ATPase, Ca2...
Asian Journal of Pharmaceutical Research and Development
Dendrimers are new effectiveness of polymeric substances. They are relatively branched, monodispe... more Dendrimers are new effectiveness of polymeric substances. They are relatively branched, monodisperse macromolecules. Structural Advantages permit dendrimers to play a critical function inside the fields of nanotechnology, pharmaceutical, and medicinal chemistry. As a result in their precise behavior dendrimers are suitable for a wide variety of biomedical and commercial packages. The paper gives a quick evaluation of dendrimers’ physicochemical properties and their possible use in various regions of research, generation, and treatment.
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Papers by Priyankul Palia