Priyanka Soni

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Travis Linnemann

Kansas State University

Eric S . Kim (UBC)

University of British Columbia

Armando Marques-Guedes

UNL - New University of Lisbon

John Sutton

Macquarie University

Keith Laws

University of Hertfordshire

Roma Siugzdaite

Ghent University

Gustavo Ortiz Millán

Universidad Nacional Autónoma de México

Ignacio Aguaded

Huelva University

Antonella Tramacere

University of Roma Tre

Jorge Iván Castillo-Quan

Harvard Medical School

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Papers by Priyanka Soni

Do phosphatase of regenerating liver-3, matrix metalloproteinases-2, matrix metalloproteinases-9, and epidermal growth factor receptor-1 predict response to therapy and survival in glioblastoma multiforme?

Indian journal of pathology & microbiology

Poor survival of the glioblastoma multiforme (GBM) has been attributed in part to the invasive na... more Poor survival of the glioblastoma multiforme (GBM) has been attributed in part to the invasive nature of the lesion making complete surgical removal near impossible. Phosphatase of regenerating liver-3 (PRL-3), matrix metalloproteinases-2 and -9 (MMP-2 and MMP-9), and epidermal growth factor receptor (EGFR-1) play a role in invasive nature of tumor cells. This study was conducted to evaluate PRL-3, MMP-2, MMP-9, and EGFR-1 (markers) expression in cases to GBM and to correlate their expression with therapy response and survival. GBM cases (n = 62) underwent surgery followed by radiation (n = 34) and chemoradiation (n = 28). Using WHO Response Evaluation Criteria in Solid Tumors criteria response to therapy was assessed at 3 months and cases followed up for survival. Expression of markers was assessed by immunohistochemistry as a percentage of positive tumor cells in hot spots. Kaplan-Meier, ANOVA, Chi-square test, univariate, and multivariate Cox-regression analysis was done. Respons...

Revisiting epidermal growth factor receptor in glioblastoma multiforme: does it play a role in response to therapy?

Indian journal of pathology & microbiology

Glioblastoma multiforme (GBM) are the most aggressive class of cancer of central nervous system w... more Glioblastoma multiforme (GBM) are the most aggressive class of cancer of central nervous system with hallmark characteristics that include rampant proliferation, necrosis, and endothelial proliferation. Epidermal growth factor receptor (EGFR) has been implicated as the primary contributor to glioblastoma initiation and succession. The present study was designed to evaluate EGFR protein expression in GBM as predictor of response to therapy and survival. Epidermal growth factor receptor was assessed by immunohistochemistry as a percentage of positive tumor cells in hot spots (10 high-power fields). The study group comprised of 35 cases of GBM. All cases underwent surgical resection and subsequently underwent radiotherapy (n = 17) or radiotherapy with adjuvant temozolomide chemotherapy (n = 18). Immediate response to therapy was assessed at 3 months using World Health Organization response evaluation criteria in solid tumors criteria and cases followed up for survival. Twenty-four case...

Study of intron 22 inversion mutation in north India with review

Blood Coagulation & Fibrinolysis, 2013

The present study assessed the frequency of intron 22 inversion mutation (Inv 22) in north Indian... more The present study assessed the frequency of intron 22 inversion mutation (Inv 22) in north Indian population with a cost analysis of different methods used for Inv 22 detection. We assessed the frequency of intron 22 inversion mutation in a series of 181 cases with hemophilia A and also compared methods used for detection of the mutation including the long-distance PCR, Southern blot analysis, and inverse PCR in terms of cost, infrastructure, and technical input as well as turnaround time. The study group comprised 102 severe cases and 79 moderate cases of hemophilia A from a north Indian population of which 77 cases tested positive for Inv 22. The observed frequency of Inv22 mutation was 42.5%. Inv 22 resulted in a more severe phenotype and lower FVIII bioassay levels as compared to Inv 22 negative cases. Inv 22 positive cases also frequently presented with bleeding episodes at birth and the mean age for commencement of bleeding was lower (19 months) as compared to Inv-negative cases (50 months). The mean frequency of Inv 22 in cases with hemophilia A in a worldwide review is 44.25% of hemophilia A. Inv 22 can be conveniently detected by using the inverse PCR method. This technique is easy to standardize and lowest in cost.

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CD24 and Nanog expression in Stem Cells in Glioblastoma: Correlation with Response to Chemoradiation and Overall Survival

Asian Pacific journal of cancer prevention : APJCP, Aug 27, 2017

Background and aim: Glioblastoma (GBM) is one of the most common and aggressive brain tumors with... more Background and aim: Glioblastoma (GBM) is one of the most common and aggressive brain tumors with a median survival of 12-14 months. The aim of present study was to evaluate the gene expression profile of stem cell markers Nanog and CD24 in GBM and to determine its relationship to outcome in terms of treatment response and overall survival. Material and methods: This was a retrospective as well as retrospective study which included 51 histologically confirmed cases of GBM. Expression of CD24, and Nanog was evaluated by RT-PCR. Control tissue included debrided brain tissue from open head injury cases. All cases of GBM underwent total surgical resection and subsequently chemotherapy. Immediate treatment response was evaluated at 3 months using Response Evaluation Criteria In Solid Tumors (RECIST) guidelines and overall survival was measured at 36 months. Result: As compared to control gene, expression of CD24 and Nanog was seen to be unregulated to 24.5% and 31.7% respectively. Howeve...

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Histopathological study of skin adnexal tumours-institutional study in South India

Journal of skin cancer, 2014

Objective. The aim of this study was correlation of skin adnexal tumors with age, sex, and locati... more Objective. The aim of this study was correlation of skin adnexal tumors with age, sex, and location and determining its incidence in the Department of Pathology at Dr. D. Y. Patil Medical College and Hospital, Kolhapur, Maharashtra. Material and Methods. 56 cases were included in this study from Jan 2004 to June 2010 with respect to incidence of adnexal tumors, age, and sex distribution. All slides were stained with haematoxylin and eosin and then findings were corroborated with special stains like PAS and reticulin wherever required. Results. 80.36% (45/56) were benign and 19.64% (11/56) were malignant adnexal tumors. The sweat gland tumors constituted the largest group (42.86% 24/56) cases followed by the hair follicle tumors (35.71%, 20/56) of cases and sebaceous gland tumors (21.43%, 12/56) cases. Overall male : female ratio was 1.07 : 1. The commonest age group was 51-60 years and the commonest affected body part was head and neck region (64.28%, 36/56) followed by trunk (14.28...

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Evaluation of p53, HoxD10, and E-Cadherin Status in Breast Cancer and Correlation with Histological Grade and Other Prognostic Factors

Journal of Oncology, 2014

Background. Study of tumor molecular characteristics is necessary to understand both the risk of ... more Background. Study of tumor molecular characteristics is necessary to understand both the risk of breast cancer recurrence and the response to therapy. Aims. To evaluate p53, HoxD10, and E-cadherin status in breast cancer and to correlate with histological grade and other prognostic factors. Material and Methods. The study was conducted in 60 cases of invasive ductal carcinoma NOS with 20 cases belonging to each grade and evaluation of p53 was done by IHC and that of HoxD10 and E Cadherin status by PCR and correlation was done with histological grade and other prognostic factors. Result. p53 expression was seen in 71.67% (43/60) of the tumors. HoxD10 gene was downregulated in 46.67% (28/60) of the tumors. p53 overexpression and lower HoxD10 mRNA levels showed statistically significant association higher histological grade of the tumor ( < 0.05). CDH1 gene mutation was seen in 60% (15/25) of the tumors. No significant association was found between p53 expression, HoxD10 gene, CDH1 gene mutation, and other prognostic factors. Conclusion. p53 over expression and lower HoxD10 mRNA levels were found to be significantly associated with higher grade tumours. This suggests that p53 and HoxD10 gene play an important tumor suppressor role and the loss of which results in breast cancer progression.

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Design of a High Performance Operational Amplifier

The paper presents a design of low power operational amplifier for better frequency response usin... more The paper presents a design of low power operational amplifier for better frequency response using the nested Miller compensation scheme (NMCS). It shows better performance in terms of D.C. gain, slew rate, phase margin, settling time with drastic improvement in gain bandwidth product. The proposed circuit have full output swing and is better suited for low voltage, low power design.

A Prospective Study of Soft Tissue Tumors Histocytopathology Correlation

Pathology Research International, 2014

Background. Soft tissue tumors are defined as nonepithelial extraskeletal tissue of the body excl... more Background. Soft tissue tumors are defined as nonepithelial extraskeletal tissue of the body exclusive of the reticuloendothelial system, glia, and supporting tissue of various parenchymal organs. The absence of recognizable tissue architectural patterns in cytological preparation makes diagnosis by FNAC more difficult. Aims. To assess the utility of FNAC in diagnosing soft tissue tumors and to determine their patterns compared with with the respective histopathology results. Materials and Methods. 150 cases of soft tissue tumors were included in this study for cytologic and histologic correlation. FNAC air dried smears were stained with Giemsa stain and 95% ethanol fixed smears were stained with Papanicolaou stain. The smears were studied for cytological diagnosis and were categorized as benign, suspicious of malignancy, and malignant along with specific subtyping of the lesion. All diagnostic FNAC results were compared for diagnostic concordance using histology results as the "gold standard. " Results. The sensitivity, specificity, positive predictive value, negative predictive value, and efficiency were 70%, 100%, 97.90%, 100%, and 98%, respectively. value was <0.0001 which shows statistically extreme significant correlation. Conclusion. FNAC is a very important preliminary diagnostic tool in palpable soft tissue lumps with high degree of correlation with the final histopathology report.

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Design of OTA Based Floating Inductor

2011 International Conference on Devices and Communications (ICDeCom), 2011

Mody Institute of Technology & Science/Faculty of Engineering and Technology, Lakshmangarh (S... more

Design of Enhanced Performance Folded Cascoded Operational Transconductance Amplifier

Design of Enhanced Performance Folded Cascoded Operational Transconductance Amplifier. [AIP Confe... more

Discriminant analysis to classify glioma grading using dynamic contrast-enhanced MRI and immunohistochemical markers

by Nuzhat Husain, RKS Rathore, and Priyanka Soni

Neuroradiology, 2012

Introduction The purpose of the present study was to look for the possible predictors which might... more

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Immunopathology and Th1/Th2 immune response of Campylobacter jejuni-induced paralysis resembling Guillain–Barré syndrome in chicken

Medical Microbiology and Immunology, 2012

Immunopathogenesis of Campylobacter jejuni-associated Guillain-Barré syndrome (GBS) is not yet we... more Immunopathogenesis of Campylobacter jejuni-associated Guillain-Barré syndrome (GBS) is not yet well established probably due to lack of experimental model. Therefore, we studied the Th1/Th2 immune response and pathological changes in C. jejuni-induced chicken model for GBS. C. jejuni (5 × 10(9) CFU/ml) and placebo were fed to 30 chickens each. Stools of all birds were negative for C. jejuni by culture and PCR before experiment. The birds were regularly assessed for disease symptoms up to 30 days. Sciatic nerves from all chickens were examined at 5 days intervals by histopathology and immunohistochemistry, and also for the expression of Th1/Th2 cytokines. Twenty-two chickens (73.3%) developed diarrhea after C. jejuni infection; 18 (60.0%) experimental chickens developed GBS-like paralytic neuropathy. Pathology in the sciatic nerves of these chickens included perinodal and/or patchy demyelination, perivascular focal lymphocytic infiltration, myelin swelling and presence of macrophages within the nerve fibers on 10th-20th post-infection day (PID). Cytokines (IFN-γ, IL-1β, TNF-α, IL-6 and IL-2) were elevated in early phase (5th-15th PID) and TGF-β2, IL-10 and IL-4 in the recovery phase (25th-30th PID) of the disease. The study provides evidence that C. jejuni infection in the chicken can provide an experimental animal model of GBS.

New Protocol for Detection of Intron 22 Inversion Mutation From Cases With Hemophilia A

Clinical and Applied Thrombosis/Hemostasis, 2013

Background: Hemophilia A is a X-linked recessive bleeding disorder characterized by qualitative a... more Background: Hemophilia A is a X-linked recessive bleeding disorder characterized by qualitative and quantitative deficiency of factor VIII resulting from heterogeneous mutations in the factor VIII gene located in the Xq28 region. Intron 22 inversion (Inv22) mutation is one of the major causes of the protein alteration in factor VIII; its frequency is 40% to 50% in severe patients. Long polymerase chain reaction (PCR) and inverse PCR (I-PCR) have been used for the detection of Inv22 mutation. Objective: Development of new protocol for detection of Inv22 mutation. Method: We have designed a new method for the detection of Inv22 mutation in complementary DNA (cDNA) of patients. Real-time PCR targeting exons 21 to 22, 22 to 23, and 23 to 24 of factor VIII gene were used in cases with hemophilia A. Samples that were inversion positive by this new method were cross-checked by the conventional I-PCR method. We observed that region between exons 22 and 23 could not be amplified, while in negative cases and controls a 480 bp product is obtained. Result: The method was validated in 20 cases with severe hemophilia A by the new cDNA method, and 8 cases were inversion positive, whereas 12 were negative cases. The findings were confirmed by standard I-PCR method. Complete correlation was observed. Conclusion: Conventional long PCR and I-PCR methods are work intensive, prolonged, and sometimes difficult to be standardize. The cDNA method is short, involves 3 short-segment amplifications, and is easy to reproduce.

Design of Enhanced Performance Folded Cascoded Operational Transconductance Amplifier

AIP Conference Proceedings, 2010

Design of Enhanced Performance Folded Cascoded Operational Transconductance Amplifier. [AIP Confe... more

Design of a High Performance Operational Amplifier

AIP Conference Proceedings, 2010

The paper presents a design of low power operational amplifier for better frequency response usin... more

Revisiting epidermal growth factor receptor in glioblastoma multiforme: does it play a role in response to therapy?

by Nuzhat Husain and Priyanka Soni

Indian journal of pathology & microbiology

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Indian journal of pathology & microbiology

Revisiting epidermal growth factor receptor in glioblastoma multiforme: does it play a role in response to therapy?

Indian journal of pathology & microbiology

Study of intron 22 inversion mutation in north India with review

Blood Coagulation & Fibrinolysis, 2013

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CD24 and Nanog expression in Stem Cells in Glioblastoma: Correlation with Response to Chemoradiation and Overall Survival

Asian Pacific journal of cancer prevention : APJCP, Aug 27, 2017

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Histopathological study of skin adnexal tumours-institutional study in South India

Journal of skin cancer, 2014

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Evaluation of p53, HoxD10, and E-Cadherin Status in Breast Cancer and Correlation with Histological Grade and Other Prognostic Factors

Journal of Oncology, 2014

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Design of a High Performance Operational Amplifier

A Prospective Study of Soft Tissue Tumors Histocytopathology Correlation

Pathology Research International, 2014

Download

Design of OTA Based Floating Inductor

2011 International Conference on Devices and Communications (ICDeCom), 2011

Mody Institute of Technology & Science/Faculty of Engineering and Technology, Lakshmangarh (S... more

Design of Enhanced Performance Folded Cascoded Operational Transconductance Amplifier

Design of Enhanced Performance Folded Cascoded Operational Transconductance Amplifier. [AIP Confe... more

Discriminant analysis to classify glioma grading using dynamic contrast-enhanced MRI and immunohistochemical markers

by Nuzhat Husain, RKS Rathore, and Priyanka Soni

Neuroradiology, 2012

Introduction The purpose of the present study was to look for the possible predictors which might... more

Download

Immunopathology and Th1/Th2 immune response of Campylobacter jejuni-induced paralysis resembling Guillain–Barré syndrome in chicken

Medical Microbiology and Immunology, 2012

New Protocol for Detection of Intron 22 Inversion Mutation From Cases With Hemophilia A

Clinical and Applied Thrombosis/Hemostasis, 2013

Design of Enhanced Performance Folded Cascoded Operational Transconductance Amplifier

AIP Conference Proceedings, 2010

Design of Enhanced Performance Folded Cascoded Operational Transconductance Amplifier. [AIP Confe... more

Design of a High Performance Operational Amplifier

AIP Conference Proceedings, 2010

The paper presents a design of low power operational amplifier for better frequency response usin... more

Revisiting epidermal growth factor receptor in glioblastoma multiforme: does it play a role in response to therapy?

by Nuzhat Husain and Priyanka Soni

Indian journal of pathology & microbiology

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