Papers by Priscila Santos
Pharmacological Research, 2009
To study the effects of N-acetylcysteine (NAC, C 5 H 9 -NO 3 S) on high-sucrose diet-induced obes... more To study the effects of N-acetylcysteine (NAC, C 5 H 9 -NO 3 S) on high-sucrose diet-induced obesity and its effects on energy metabolism and cardiac oxidative stress, male Wistar 24 rats were divided into four groups (n = 6): (C) given standard chow and water; (N) receiving standard chow and 2 g/l N-acetylcysteine in its drinking water; (HS) given standard chow and 30% sucrose in its drinking water, and (HS-N) receiving standard chow, 30% sucrose and N-acetylcysteine in its drinking water.
International Journal of Cardiology
Background: The AIN-93 diet was proposed by the American Institute of Nutrition with the objectiv... more Background: The AIN-93 diet was proposed by the American Institute of Nutrition with the objective of standardising studies in experimental nutrition. Our objective was to analyze the effects of AIN-93 diet after myocardial infarction in rats. Methods: Post weaning, the animals were divided into two groups: control (C, n = 62), fed the standard diet of our laboratory (Labina); AIN-93 Group (n = 70), fed the AIN-93 diet. Achieving 250 g, the animals were subjected to myocardial infarction. Results: Early mortality was increased in AIN-93 animals, associated with lower serum levels of calcium, magnesium, potassium, sodium, and phosphorus. On the other hand, after 90 days, AIN-93 showed smaller normalized left ventricular dimensions. The caloric and carbohydrate intake was smaller, but the fat intake was higher in AIN-93 rats. AIN-93 group also showed increased levels of β-hydroxyacylcoenzyme A dehydrogenase and citrate synthase. In addition, serum levels of insulin and cardiac levels of malondialdehyde, metalloproteinases-2 and -9, and TNF-α and IFN-γ were decreased in the AIN-93 group. Conclusion: AIN-93 diet increased early mortality, while attenuated the chronic remodeling process after experimental coronary occlusion. Therefore, this diet has biological effects and should be use with attention in this model.
European Journal of Pharmacology, 2008
Studies on conjugated linoleic acid ingestion and its effect on cardiac tissue are necessary for ... more Studies on conjugated linoleic acid ingestion and its effect on cardiac tissue are necessary for the safe utilization of this compound as supplement for weight loss. Male Wistar 24-rats were divided into four groups (n = 6):(C)given standard chow, water and 0.5 ml saline, twice a week by gavage; (C-CLA)receiving standard chow, water and 0.5 ml of conjugated linoleic acid, twice a week, by gavage; (S)given standard chow, saline by gavage, and 30% sucrose in its drinking water; (S-CLA)receiving standard chow, 30% sucrose in its drinking water and conjugated linoleic acid. After 42 days of treatment S rats had obesity with increased abdominal-circumference, dyslipidemia, oxidative stress and myocardial lower citrate synthase(CS) and higher lactate dehydrogenase(LDH) activities than C. Conjugated linoleic acid had no effects on morphometric parameters in C-CLA, as compared to C, but normalized morphometric parameters comparing S-CLA with S. There was a negative correlation between abdominal adiposity and resting metabolic rate. Conjugated linoleic acid effect, enhancing fasting-VO 2 /surface area, postprandial-carbohydrate oxidation and serum lipid hydroperoxide resembled to that of the S group. Conjugated linoleic acid induced cardiac oxidative stress in both fed conditions, and triacylglycerol accumulation in S-CLA rats. Conjugated linoleic acid depressed myocardial LDH comparing C-CLA with C, and beta-hydroxyacyl-coenzyme-A dehydrogenase/CS ratio, comparing S-CLA with S. In conclusion, dietary conjugated linoleic acid supplementation for weight loss can have long-term effects on cardiac health. Conjugated linoleic acid, isomers c9, t11 and t10, c12 presented undesirable pro-oxidant effect and induced metabolic changes in cardiac tissue. Nevertheless, despite its effect on abdominal adiposity in sucrose-rich diet condition, conjugated linoleic acid may be disadvantageous because it can lead to oxidative stress and dyslipidemic profile.
O presente trabalho não visa analisar a contradição entre a abertura econômica e a tão almejada r... more O presente trabalho não visa analisar a contradição entre a abertura econômica e a tão almejada reforma social, mas tem por objetivo avaliar o impacto da globalização econômica na tutela dos direitos humanos. A política promovida pela globalização rompe com a ideia de cidadania, elemento constitutivo dos direitos humanos. Por isso, na 'Era da Globalização' os direitos humanos tendem a se tornar meramente retóricos, enfrentando a cada dia grande dificuldade para sua afirmação. Diante dessa ameaça à proteção do ser humano como um fim em si mesmo é que se pretende promover um resgate à cidadania, tomando os direitos humanos não apenas como algo universalizante, mas sim, como fato universal. Compatibilizar os princípios dos direitos humanos e da globalização econômica não é tarefa fácil, mas de forma alguma pode ser considerada impossível. O presente trabalho tem por objetivo enfatizar a possibilidade e a necessidade desta compatibilização que deverá ter por pressuposto a produção de harmonia social por meio do resgate à cidadania buscando anular os conflitos, incertezas e contradições decorrentes do sistema capitalista globalizado. Afinal, deve-se ter em mente que a sociedade apenas se beneficiará plenamente da economia globalizada se houver um respaldo ético, social e jurídico e, para tanto, é preciso reaproximar realidade e legislação.
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Papers by Priscila Santos