Papers by Prakash Gondode
Deleted Journal, Apr 2, 2024
Objectives: This study aimed to compare the efficacy of yoga combined with an integrated multimod... more Objectives: This study aimed to compare the efficacy of yoga combined with an integrated multimodal approach on the incidence and severity of post-mastectomy pain syndrome (PMPS) and the role of miR-133B expressions in patients undergoing breast cancer surgery. Methods: With approval from the institutional ethics committee and informed consent obtained from each participant, forty patients of ASA grade I -II, aged 20 -65 years, undergoing breast cancer surgery were included. Patients received a thoracic paravertebral block for up to 72 hours and pregabalin until the end of the fourth postoperative week. Patients were randomly allocated into two groups: "Control" and "yoga." Patients in the Yoga group practiced the yogic exercise "Anulom-vilom" from the third day until the 90th day postoperatively. The delta-CT of miRNA-133B expression of genes on the 90th postoperative day was compared to the baseline, along with various pain intensity and quality of life parameters. Results: In the Yoga group, a significant up-regulation in miR-133B expression was observed on days 30 and 90 postoperatively. Patients with PMPS in the Yoga group showed a decreased ΔCT of miR-133B, indicating an up-regulation of gene expression, compared to the control group. A lower incidence of PMPS (10% vs. 30%) was observed in the experimental group, along with a significant enhancement of quality of life in post-mastectomy patients and decreased mean Visual Analogue Scale (VAS) pain scores, Pain Detect Questionnaire (PDQ) ، and Neuropathic Pain Symptom Inventory (NPSI) scores in the Yoga group; however, these were not statistically significant. Conclusions: The study demonstrated the feasibility of integrating yoga with a multimodal pain management approach and highlighted the role of miR-133B in the pathogenesis of PMPS.
Laparoscopic, endoscopic and robotic surgery, Feb 1, 2024
Annals of Cardiac Anaesthesia, Dec 31, 2022
Indian journal of critical care medicine/Indian Journal of Critical Care Medicine, May 31, 2024
Background: End-of-life care (EOLC) is a critical aspect of healthcare, yet accessing reliable in... more Background: End-of-life care (EOLC) is a critical aspect of healthcare, yet accessing reliable information remains challenging, particularly in culturally diverse contexts like India. Objective: This study investigates the potential of artificial intelligence (AI) in addressing the informational gap by analyzing patient information leaflets (PILs) generated by AI chatbots on EOLC. Methodology: Using a comparative research design, PILs generated by ChatGPT and Google Gemini were evaluated for readability, sentiment, accuracy, completeness, and suitability. Readability was assessed using established metrics, sentiment analysis determined emotional tone, accuracy, and completeness were rated by subject experts, and suitability was evaluated using the Patient Education Materials Assessment Tool (PEMAT). Results: Google Gemini PILs exhibited superior readability and actionability compared to ChatGPT PILs. Both conveyed positive sentiments and high levels of accuracy and completeness, with Google Gemini PILs showing slightly lower accuracy scores. The findings highlight the promising role of AI in enhancing patient education in EOLC, with implications for improving care outcomes and promoting informed decision-making in diverse cultural settings. Ongoing refinement and innovation in AI-driven patient education strategies are needed to ensure compassionate and culturally sensitive EOLC.
International Journal of Medical and Surgical Sciences, 2021
Indian Journal of Palliative Care
Objectives: The aim of this study is to study the modulation of extracellular signal-regulated pr... more Objectives: The aim of this study is to study the modulation of extracellular signal-regulated protein kinase (ERK) and tissue inhibitors of matrix metalloproteases 1 (TIMP 1) gene in patients with neuropathic pain (NP). Materials and Methods: In the present, cross-sectional, observational study, 2 ml of venous baseline sample was withdrawn from all the patients with neuropathic (NP) or non NP (NNP) soon after their diagnosis or on their first visit to the pain clinic. A real-time quantitative polymerase chain reaction experiment was conducted to measure the mRNA expression of TIMP1 and ERK genes in blood samples. The Delta Ct, Delta Ct, and fold change analysis of both the genes were conducted between patients with NP and NNP. Results: A total of 285 patients with chronic pain were assessed, out of which, 153 patients had NP and 132 had NNP. The average duration of chronic pain was 11 months for 285 patients. The mRNA expression of TIMP1 gene is significantly down regulated (2.65-f...
Journal of Medical Microbiology and Infectious Diseases
Coronavirus disease (COVID-19) pandemic has affected worldwide health care. Given the possibility... more Coronavirus disease (COVID-19) pandemic has affected worldwide health care. Given the possibility for coronavirus to prompt oxidative stress, masked glucose-6-phosphate dehydrogenase deficiency (G6PD) deficiency in the presence of the COVID-19 viral infection may instigate hemolytic crisis and dangerous consequences in affected individuals. G6PD deficiency is an Xlinked recessive disorder that affects some 400 million people worldwide, with a higher prevalence in Africa, the Mediterranean Region, and Asia. A dearth of studies and literature on available antivirals for managing COVID-19 patients with G6PD deficiency brings the healthcare workers to a conundrum. Here, we report an interesting symptomatic case of COVID-19 patient with G6PD deficiency, hypertension, and resolved hepatitis B. Antiviral therapy for COVID-19 positive patients with G6PD deficiency should be individualized by considering the risk and benefit of treatment involved, recommending a multidisciplinary team approach.
Journal of Research & Health
Background: We assessed knowledge, attitudes, practice, and perceptions about COVID-19 among a co... more Background: We assessed knowledge, attitudes, practice, and perceptions about COVID-19 among a convenience sample of the general public in India anticipating the second wave of the pandemic. Methods: This questionnaire-based survey was conducted among the general population quarantined at various institutional quarantine facilities in the city of Nagpur, Maharashtra, India. Informed consent was obtained from each participant. The self-designed questionnaire comprised 25 questions regarding knowledge, eight for attitude, and ten for practice. Knowledge questions were responded to on a Yes/No basis with an additional ‘don’t know’ option. The true answer was given 1 point and false/I don’t know answers were given 0 point. Results: The majority of the participants were aware of COVID-19 (97.9%) and did not either wash or knew how to properly dispose of the used mask (88.02%). Only 10.96% of the participants agreed that they verify the social media posts shared over WhatsApp and Facebook...
Ain-Shams Journal of Anesthesiology, 2021
Introduction: Aerosol bronchodilator therapy via nebulization, using a nebulizer or metered-dose ... more Introduction: Aerosol bronchodilator therapy via nebulization, using a nebulizer or metered-dose inhaler (MDI) with a spacer device or dry powder inhaler is the mainstay in the treatment of COPD We, herein, discuss two such cases with corresponding concerns related to various modes of bronchodilation in moderate to severe COVID-19 patients with COPD Two COVID-19 patients (60 years/M and 55 years/M) with COPD presented with worsening fever, cough, and shortness of breath for around 10 days Chest radiographs revealed mid and lower lung zone involvement in both Both received tazobactam-piperacillin, teicoplanin, ivermectin, hydroxychloroquine, enoxaparin, dexamethasone, salmeterol MDI, multivitamin, and received oxygen via high FiO2 non-rebreathing mask and maintained 92 to 94% oxygen saturation and 24 to 32 breaths/minute We observed their inability to attain an optimal peak inspiration with MDI and thus increased the dose to @ 4 to 6 puffs Following no improvement, nebulization was s...
Journal of Ideas in Health
With the escalating number of covid-19 positive cases and amidst the glooming shadows of an antic... more With the escalating number of covid-19 positive cases and amidst the glooming shadows of an anticipated second wave of the covid-19 pandemic, the health care system of a developing country like India is already under pressure. With the encroachment of monsoon season, the ghosts of the past haunt India. Monsoon brings along endemic diseases like dengue, malaria, swine flu, Japanese encephalitis, chikungunya, etc. Every year there is significant morbidity and mortality. These diseases have clinical features of fever, sore throat, and body aches in common, which also happens to be the common manifestations of covid-19. The growing stigma related to COVID-19, the fake news, and fear related to hospitalization and isolation may lead to low reporting cases to the hospitals. Lockdown and non-availability of beds may perplex the situation further. There is an urgent need of the hour to address this grave issue to prevent a major mishappening. A comprehensive evaluation of the health-care sy...
Indian Journal of Otolaryngology and Head & Neck Surgery
The World Health Organization (WHO) has cautioned on specific respiratory symptoms for suspecting... more The World Health Organization (WHO) has cautioned on specific respiratory symptoms for suspecting an individual of Corona Virus Disease 2019 (COVID-19). Meanwhile, many suspects are reporting dysfunctions of smell and taste. This study aimed to investigate the percentage of positive COVID-19 who had associated loss of sensation as detected by psychophysical testing. Eight hundred and thirty two suspects were enrolled. At the time of sampling for testing COVID-19 status, olfactory dysfunction (OD) and gustatory dysfunction (GD) tested using odorants like coffee and camphor and solutions of sweet and salty solvants, respectively. The strength of the association between test results of these sensory losses and COVID-19 positivity was assessed by calculating sensitivity, specificity, and predictive values. The responses in positive and negative individuals presented as age-adjusted odds ratio with 95% CI. Seventy six (9.1%) [95% CI: 7.4%-11.3%] of 832 suspects were tested positive for COVID-19. Paediatric cases of age between 2 and 10 years could not reply appropriately, hence OD in 134 and GD in 118 could not be tested. Anosmia or hyposmia was present in 62 (81.6%) and ageusia in 64 (84.2%) of the total 76 confirmed cases. The OD and GD dysfunctions were significantly higher among confirmed COVID-19 cases compared to negative subjects [ Adj OR (95% CI): Smell 3.22 (1.77-5.88); taste 3.05 (1.61-5.76), p \ 0.001]. In this study, testing of smell and taste dysfunctions had higher sensitivity in identifying recent-onset loss of sensations in COVID-19 cases. Hence, it may be used as a simple and cost-effective screening test.
Journal of Research & Health
Background: We assessed knowledge, attitudes, practice, and perceptions about COVID-19 among a co... more Background: We assessed knowledge, attitudes, practice, and perceptions about COVID-19 among a convenience sample of the general public in India anticipating the second wave of the pandemic. Methods: This questionnaire-based survey was conducted among the general population quarantined at various institutional quarantine facilities in the city of Nagpur, Maharashtra, India. Informed consent was obtained from each participant. The self-designed questionnaire comprised 25 questions regarding knowledge, eight for attitude, and ten for practice. Knowledge questions were responded to on a Yes/No basis with an additional ‘don’t know’ option. The true answer was given 1 point and false/I don’t know answers were given 0 point. Results: The majority of the participants were aware of COVID-19 (97.9%) and did not either wash or knew how to properly dispose of the used mask (88.02%). Only 10.96% of the participants agreed that they verify the social media posts shared over WhatsApp and Facebook...
Uploads
Papers by Prakash Gondode