Papers by Parasuraman Padmanabhan
Electronics, Jan 26, 2023
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
Nanomaterials, Jan 28, 2023
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
RSC Advances
The effects of surface functionality on the optical characteristics of Cu nanoclusters were explo... more The effects of surface functionality on the optical characteristics of Cu nanoclusters were explored. Their in vitro and in vivo biodistribution indicated their usefulness as potential bioimaging probes.
Nanomaterials
Functional metal nanomaterials, especially in the nanocluster (NC) size regime, with strong fluor... more Functional metal nanomaterials, especially in the nanocluster (NC) size regime, with strong fluorescence, aqueous colloidal stability, and low toxicity, necessitate their application potential in biology and environmental science. Here, we successfully report a simple cost-effective method for red-/green-color-emitting protein/amino-acid-mediated Cu NCs in an aqueous medium. As-synthesized Cu NCs were characterized through UV-Vis absorption spectroscopy, fluorescence spectroscopy, time-resolved photoluminescence, dynamic light scattering, zeta potential, transmission electron microscopy and X-ray photoelectron spectroscopy. The optical properties of both Cu NCs responded linearly to the variation in pH in the neutral and alkaline ranges, and a robust pH reversible nature (between pH 7 and 11) was observed that could be extended to rapid, localized pH sensor development. However, a contrasting pH response nature between protein–Cu NCs and amino acid–Cu NCs was recorded. The alteratio...
Electronics
Brain–computer interfacing has been applied in a range of domains including rehabilitation, neuro... more Brain–computer interfacing has been applied in a range of domains including rehabilitation, neuro-prosthetics, and neurofeedback. Neuroimaging techniques provide insight into the structural and functional aspects of the brain. There is a need to identify, map and understand the various structural areas of the brain together with their functionally active roles for the accurate and efficient design of a brain–computer interface. In this review, the functionally active areas of the brain are reviewed by analyzing the research available in the literature on brain–computer interfacing in conjunction with neuroimaging experiments. This review first provides an overview of various approaches of brain–computer interfacing and basic components in the BCI system and then discuss active functional areas of the brain being utilized in non-invasive brain–computer interfacing performed with hemodynamic signals and electrophysiological recording-based signals. This paper also discusses various ch...
Frontiers in Cellular and Infection Microbiology
The present study aimed to isolate and identify potential drugs from marine actinomycete Nocardio... more The present study aimed to isolate and identify potential drugs from marine actinomycete Nocardiopsis exhalans and screen them for biomedical applications. The cell-free culture of N. exhalans was extracted with ethyl acetate and the solvent extract showed six fractions in thin-layer chromatography. The fractions were subjected to column chromatography for purification and evaluated for activity against human clinical pathogens. Fraction 4 showed significant activity and was identified as N-(2-hydroxyphenyl)-2-phenazinamine (NHP) using spectral analyses. Further, NHP showed excellent biofilm inhibitory activity against human clinical pathogens Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. The in vitro antioxidant activity confirmed that NHP is scavenging the oxidative stress-enhancing molecules. The anti-proliferative activity of NHP against human breast cancer cells showed significant activity at 300 µg/ml and less cytotoxic activity against normal cells. Add...
International Journal of Molecular Sciences
Nutritional interventions may highly contribute to the maintenance or restoration of human health... more Nutritional interventions may highly contribute to the maintenance or restoration of human health. Grapes (Vitis vinifera) are one of the oldest known beneficial nutritional components of the human diet. Their high polyphenol content has been proven to enhance human health beyond doubt in statistics-based public health studies, especially in the prevention of cardiovascular disease and cancer. The current review concentrates on presenting and classifying polyphenol bioactive molecules (resveratrol, quercetin, catechin/epicatechin, etc.) available in high quantities in Vitis vinifera grapes or their byproducts. The molecular pathways and cellular signaling cascades involved in the effects of these polyphenol molecules are also presented in this review, which summarizes currently available in vitro and in vivo experimental literature data on their biological activities mostly in easily accessible tabular form. New molecules for different therapeutic purposes can also be synthesized ba...
Innovative Diagnostics and Treatment: Nanorobotics and Stem Cells, 2017
Application of nanorobotic agents is one of the most-promising perspective for future development... more Application of nanorobotic agents is one of the most-promising perspective for future development and progress in medicine. Molecular machines gain significant attention with an ultimate goal to create a theranostic platform interacting with biological system and being able to perform atomic-level tasks. Such concept requires advanced technological approach i.e. design and assembly techniques, in vivo real-time navigation system, sensing methods as well as data transfer. Currently, both artificial (carbon nanotubes) and biological (DNA, proteins, bacteria) components are investigated as a building blocks of nanobots. This chapter presents advancements in nanorobotic agents biomedical application.
Additional file 1: Figure S1. Body weight analysis of 20-months-old mice. (A) Body weight analysi... more Additional file 1: Figure S1. Body weight analysis of 20-months-old mice. (A) Body weight analysis. The body weight of mice was measured and analysed in order to determine if there were variations that could have affected the behavior results. There was no significant difference observed in the body weight (g) (mean ± SEM) among all 4 groups: NTg Male (n = 7), Tg Male (n = 5), NTg Female (n = 7), and Tg Female (n = 7); two-way ANOVA with Bonferroni post hoc test. (NTg Male—Tg Male: P = 0.983, NTg Male—NTg Female: P = 0.999, Tg Male—Tg Female: P = 0.992, NTg Female—Tg Female: P = 0.997).
Plasmonics, 2021
Amyloid-beta proteins that form cytotoxic aggregates called amyloid-β derived diffusible ligands ... more Amyloid-beta proteins that form cytotoxic aggregates called amyloid-β derived diffusible ligands are responsible for various neurodegenerative diseases like Alzheimer’s and Parkinson’s disease. Novel methods for the early detection of such aggregates and inhibition of further fibrillation are highly important and need in the current situation. In this paper, we present a novel method based on fluorescence resonance energy transfer (FRET) between carbon dots and Ag nanoparticle for sensing various fibrillation stages of beta-amyloid proteins. The addition of Ag nanoparticles to carbon dot colloid is found to significantly enhance the inhibition of beta-amyloid fibrillation due to the modified hydrophobic and electrostatic interactions introduced by Ag nanoparticles and is monitored using thioflavin T (ThT) assay. Further, fluorescence quenching of carbon dots in the presence of Ag particles is found to get reduced with the increase in the incubation time of beta-amyloid fibrils. We could observe a linear trend in the variation of Stern–Volmer constants calculated based on FRET between carbon dots and Ag nanoparticles with the incubation time of beta-amyloid, indicating the potential of using the proposed FRET-based method for sensing beta-amyloid fibrillation.
Drug Discovery Today, 2022
Positron emission tomography (PET) is an extensively used nuclear functional imaging technique, e... more Positron emission tomography (PET) is an extensively used nuclear functional imaging technique, especially for central nervous system (CNS) and oncological disorders. Currently, drug development is a lengthy and costly pursuit. Imaging with PET radiotracers could be an effective way to hasten drug discovery and advancement, because it facilitates the monitoring of key facets, such as receptor occupancy quantification, drug biodistribution, pharmacokinetic (PK) analyses, validation of target engagement, treatment monitoring, and measurement of neurotransmitter concentrations. These parameters demand careful analyses for the robust appraisal of newly formulated drugs during preclinical and clinical trials. In this review, we discuss the usage of PET imaging in radiopharmaceutical development; drug development approaches with PET imaging; and PET developments in oncological and cardiac drug discovery.
The role of segmentation is vital in image processing for the extraction of region of interest. I... more The role of segmentation is vital in image processing for the extraction of region of interest. In the perspective of medical images, the region of interest corresponds to anatomical organs or anomalies such as tumor, cyst. This work analyses various algorithms for the analysis of MR brain images. The clustering-based segmentation technique was found to be efficient and for the validation of results, performance metrics like Jaccard Index, rand index, false positive, and false negative are used. The segmentation algorithms are tested on real-time MR brain and brain web database images. The algorithms are developed in Matlab 2010a and the goal of this research work is to guide the researchers for choosing appropriate algorithm for the analysis of MR brain images.
Positron emission tomography (PET)-magnetic resonance (MR) or single photon emission computed tom... more Positron emission tomography (PET)-magnetic resonance (MR) or single photon emission computed tomography (SPECT)-MR hybrid imaging is being used in daily clinical practice. Due to its advantages over stand-alone PET, SPECT or MR imaging, in many areas such as oncology, the demand for hybrid imaging techniques is increasing dramatically. The use of multimodal imaging probes or biomarkers in a single molecule or particle to characterize the imaging subjects such as disease tissues certainly provides us with more accurate diagnosis and promotes therapeutic accuracy. A limited number of multimodal imaging probes are being used in preclinical and potential clinical investigations. The further development of multimodal PET-MR and SPECT-MR imaging probes includes several key elements: novel synthetic strategies, high sensitivity for accurate quantification and high anatomic resolution, favourable pharmacokinetic profile and target-specific binding of a new probe. This review thoroughly sum...
![Research paper thumbnail of Simplified estimation of binding parameters based on image-derived reference tissue models for dopamine transporter bindings in non-human primates using [18F]FE-PE2I and PET](https://attachments.academia-assets.com/115312555/thumbnails/1.jpg)
American journal of nuclear medicine and molecular imaging, 2017
The aim of this study on dopamine transporter binding by [18F]FE-PE2I and PET was to describe an ... more The aim of this study on dopamine transporter binding by [18F]FE-PE2I and PET was to describe an image-derived approach using reference tissue models: the Logan DVR approach and simplified reference tissue model (SRTM), the features of which were simple to operate and precise in the measurements. Using the approach, the authors sought to obtain binding images and parameters. [18F]FE-PE2I and dynamic PET as well as an MRI was performed on three rhesus monkeys, and metabolite corrected arterial plasma inputs were obtained. After co-registering of PET to MR images, both image sets were resliced. The time-activity curve of the cerebellum was used as indirect input, and binding parametric images were computed voxel-by-voxel. Voxel-wise linear calculations were used for the Logan DVR approach, and nonlinear least squares fittings for the SRTM. To determine the best linear regression in the Logan DVR approach, the distribution volume ratio was obtained using the optimal starting frame anal...
Pheromone Technology Lab, Department of Animal Science, Bharathidasan University, Tiruchirappalli... more Pheromone Technology Lab, Department of Animal Science, Bharathidasan University, Tiruchirappalli-620 024, Tamil Nadu, India Department of Zoology and Microbiology, Thiagarajar College (Autonomous), Madurai-625 009, Tamil Nadu, India Department of Zoology, Ayya Nadar Janaki Ammal College (Autonomous), Sivakasi 626 124, Tamil Nadu, India Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia-11451 Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore-637553
Frontiers in Cell and Developmental Biology, 2021
Parkinson’s disease (PD) is one of the most common neurodegenerative disorders that is implicated... more Parkinson’s disease (PD) is one of the most common neurodegenerative disorders that is implicated in aging populations. As numerous developed nations are experiencing progressively aging populations today, there is a heightened propensity for the occurrence of PD cases. Alpha-synuclein (α-syn) aggregation has been considered to be the pivotal mechanism leading to PD pathogenesis. Thus, early diagnostic and therapeutic strategies targeting the misfolded α-syn protein can potentially improve the prognosis of PD. With rapid advancements in nanotechnology in the last decade, effective solutions to various neurodegenerative and oncological diseases have been suggested. This review will explore the current innovations in nanotechnology that target the α-syn aggregation pathway, and reinstate the promise they hold as effective early diagnostic and therapeutic solutions to PD.
ACS Applied Nano Materials, 2020
Doped nanocrystals such as manganese-doped zinc sulfide (ZnS:Mn) are useful nanomedicine probes f... more Doped nanocrystals such as manganese-doped zinc sulfide (ZnS:Mn) are useful nanomedicine probes for cancer cell labelling and anticancer drug delivery. However, the synthesis and retention of fluorescence of these nanocrystals is highly indispensable for efficient cell theranostics. Herein, we report a modified synthesis of highly fluorescent hydrophobic ZnS:Mn nanocrystals with the advent of dual-ligands. Our results demonstrate that the alkylamine ligand with the carbon chain length of C 18 promotes the diffusion of Mn from surface into interior of ZnS nanocrystals. Optical measurements show that the quantum yield of Mn (QY Mn) can reach as high as 80% in the presence of a dual ligand combination of oleylamine-octadecylamine, due to the increased probability of 4 T 1 6 A 1 emission,
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Papers by Parasuraman Padmanabhan