Background: This study investigated hormonal parameters of gonadal function in severely obese men... more Background: This study investigated hormonal parameters of gonadal function in severely obese men before and 1 year after undergoing biliopancreatic diversion (BPD). Methods: This observational 1-year postoperative study conducted at medical and surgical clinics at an academic medical center in Italy followed 20 severely obese men age 21 to 63 years, with a mean (Ϯ standard deviation) body mass index (BMI) of 47.3 Ϯ 13.1. The following parameters were evaluated: body composition, using body impedance analysis (BIA), and serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), total testosterone, estradiol 17, and leptin. Results: At a mean 12 Ϯ 1 months after surgery, the patients showed a significant decrease in weight, from 132.1 Ϯ 36.9 before surgery to 93.5 Ϯ 20 kg (P Ͻ .0001), and BMI, from 47.3 Ϯ 13.1 before surgery to 33.5 Ϯ 7 (P Ͻ .0001). LH increased from 2.42 Ϯ 1.59 to 4.97 Ϯ 2.6 mIU/ml (P Ͻ .0001), FSH increased from 2.85 Ϯ 1.85 to 4.9 Ϯ 4.2 mIU/mL (P ϭ .021), and total testosterone increased from subnormal presurgical values to within normal range (2.81 Ϯ 1.08 to 9.12 Ϯ 1.37 ng/mL; P Ͻ .0001), whereas estradiol 17 decreased from elevated basal levels of 44.0 Ϯ 29 to 16.7 Ϯ 6.9 pg/mL (P Ͻ .0001). The basal leptin level dropped from 33.0 Ϯ 9.23 to 16.6 Ϯ 5.12 ng/mL (P Ͻ .0001), reflecting the decrease in body fat. Subjective improvement in sexual performance was reported by 80% of patients. Conclusions: Severe obesity is coupled with some significant alterations of the gonadotropintesticular axis and estradiol 17 and leptin blood levels. These derangements were substantially corrected by 1 year after BPD.
Las críticas q ue aparecen en periódicos y revistas, los tr atados de estét i-. ca, los ensayos, ... more Las críticas q ue aparecen en periódicos y revistas, los tr atados de estét i-. ca, los ensayos, las historias del arre a las que tenemos acceso nos resultan tan fam iliares como los museos. las salas de exposiciones. las bienales, erc., pero no siem pre fue así. Este~~o~..~. fiIa en un momento..conc rerode n uestra historia, eL~iglo XVIiI, y configura la ép~que, se co l1.oce con el --nom bre de modernidad. lampaco, en"señrídocontrario, es adecuado afirma r q üe ofrece en (000 un nacer o rigina l y defi nitivo.
Background: This study investigated hormonal parameters of gonadal function in severely obese men... more Background: This study investigated hormonal parameters of gonadal function in severely obese men before and 1 year after undergoing biliopancreatic diversion (BPD). Methods: This observational 1-year postoperative study conducted at medical and surgical clinics at an academic medical center in Italy followed 20 severely obese men age 21 to 63 years, with a mean (Ϯ standard deviation) body mass index (BMI) of 47.3 Ϯ 13.1. The following parameters were evaluated: body composition, using body impedance analysis (BIA), and serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), total testosterone, estradiol 17, and leptin. Results: At a mean 12 Ϯ 1 months after surgery, the patients showed a significant decrease in weight, from 132.1 Ϯ 36.9 before surgery to 93.5 Ϯ 20 kg (P Ͻ .0001), and BMI, from 47.3 Ϯ 13.1 before surgery to 33.5 Ϯ 7 (P Ͻ .0001). LH increased from 2.42 Ϯ 1.59 to 4.97 Ϯ 2.6 mIU/ml (P Ͻ .0001), FSH increased from 2.85 Ϯ 1.85 to 4.9 Ϯ 4.2 mIU/mL (P ϭ .021), and total testosterone increased from subnormal presurgical values to within normal range (2.81 Ϯ 1.08 to 9.12 Ϯ 1.37 ng/mL; P Ͻ .0001), whereas estradiol 17 decreased from elevated basal levels of 44.0 Ϯ 29 to 16.7 Ϯ 6.9 pg/mL (P Ͻ .0001). The basal leptin level dropped from 33.0 Ϯ 9.23 to 16.6 Ϯ 5.12 ng/mL (P Ͻ .0001), reflecting the decrease in body fat. Subjective improvement in sexual performance was reported by 80% of patients. Conclusions: Severe obesity is coupled with some significant alterations of the gonadotropintesticular axis and estradiol 17 and leptin blood levels. These derangements were substantially corrected by 1 year after BPD.
Las críticas q ue aparecen en periódicos y revistas, los tr atados de estét i-. ca, los ensayos, ... more Las críticas q ue aparecen en periódicos y revistas, los tr atados de estét i-. ca, los ensayos, las historias del arre a las que tenemos acceso nos resultan tan fam iliares como los museos. las salas de exposiciones. las bienales, erc., pero no siem pre fue así. Este~~o~..~. fiIa en un momento..conc rerode n uestra historia, eL~iglo XVIiI, y configura la ép~que, se co l1.oce con el --nom bre de modernidad. lampaco, en"señrídocontrario, es adecuado afirma r q üe ofrece en (000 un nacer o rigina l y defi nitivo.
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