Papers by Pallavi chaudhari
Journal of Pharmacy and Bioallied Sciences, 2012
P ulsatile drug delivery systems (DDS) are characterized by a rapid drug release after a predeter... more P ulsatile drug delivery systems (DDS) are characterized by a rapid drug release after a predetermined lag time and can be classified as single unit (e.g. tablet or capsule) or multiparticulate (e.g. pellets) systems. [1] Pellets offer advantages like free flowing, flexibility in design, spherical shape and low surface area to volume ratio of pellets help in uniform film coating. [2-3] The layering process is the process in which drug in powder, solution or suspension form is layered onto seed materials. [4] The drug loaded beads were coated with polymer solution of different concentrations from F1 toF5 (100:0, 70:30, 50:50, 30:70 and 0:100) at the flow rate of 1ml/min. The solution was plasticized by TEC (10%, w/w based polymer mass) and Talc
Abstract: Increasing research interest has been focused on controlled drug delivery using natural... more Abstract: Increasing research interest has been focused on controlled drug delivery using natural and biocompatible polymers as drug carriers in recent years. In the present study transdermal patch of Vildagliptin was developed using Aloe Vera gel powder as a polymer and Almond oil as penetration enhancer. Patches were prepared by solvent evaporation technique. Optimization was carried out by response surface methodology using central composite design with polymer concentration(X1), plasticizer concentration(X2), and concentration of permeation enhancer(X3) as independent variables. Hydrophilic nature of polymer as well as plasticizer and Interaction withintercellular protein to disrupt the structure of stratum corneum were responsible for increase in drug release with increase in their concentrations. Optimized formulation F9 exhibited high drug release, folding endurance Thus, It can be concluded that transdermal patch of Vildagliptin using aloe vera gel powder will be more effica...
Research Journal of Pharmacy and Technology, 2012
Three simple, precise and economical UV methods have been developed for estimation of Meclizine h... more Three simple, precise and economical UV methods have been developed for estimation of Meclizine hydrochloride in single component. Meclizine hydrochloride has the absorbance maxima in zero order spectra is 230nm (Method A). Method B applied was First order derivative for the analysis of Meclizine hydrochloride at 238.5.nm. Method C applied was area under curve in the wavelength range of 234–228 nm. Drug followed Beer-Lambert's law in the concentration range of 5–35μg/ml for zero order, 10-6 μg/ml for area under curve method and first order derivative spectrum. The percentage recovery of Meclizine hydrochloride ranged from 98.05 to 101.075 in pharmaceutical dosage form results of analysis were validated statistically and by recovery study.
Journal of emerging technologies and innovative research, 2020
The main objective of present work was to prepare and evaluate SLN based topical gel of Cromolyn ... more The main objective of present work was to prepare and evaluate SLN based topical gel of Cromolyn sodium for treatment of inflammation. SLN were formulated by hot homogenization technique, by use of design expert software. The influence of independent variables lipid and surfactant on properties of SLN such as particle size and drug release, was studied using central composite design. The in-vitro drug release rate of gel was evaluated using franz diffusion cell containing cellophane membrane with phosphate buffer pH 6.8 as a medium. From all formulations and the results batch 7 was selected as an optimized batch that showed 95.04% drug release after 8 hr. The different parameters like pH, viscosity, spreadability are also evaluated. It is concluded that Cromolyn sodium loaded SLN based gel containing cocoa butter as a lipid and tween 80 as a surfactant was suitable for topical application and shows effective anti-inflammatory activity.
Nowadays, due to emerging developments in the oral drug delivery systems several newer technologi... more Nowadays, due to emerging developments in the oral drug delivery systems several newer technologies are come out. Oral route of administration has achieved much more popularity because of its ease in administration. There are various dosage forms those can be administered orally. Out of which, chewing gum is most popular. It is a potentially useful means of administering drugs locally and systemically. In recent years the medicated chewing gum has gained increasing acceptance as a drug delivery system. Chlorhexidine gluconate is antibacterial agent used for management of tooth decay. In mouth, Chlorhexidine gets readily adsorbed to negatively charged area, including mucosa and pellicle coated teeth. Chlorhexidine remains bacteriostatically active also after adsorption. In this formulation chewing gum release the active ingredient into the saliva up to the time as the gum product is masticated. In present work chewing gum formulations were prepared by synthetic gum base and by using different Plasticizers such as Castor oil, Glycerin and dibutyl phthalate. Glycerin batch shows best result than castor oil as well as dibutyl phthalate.
Nanorobots is the emerging technology field of developing machines whose components are at or nea... more Nanorobots is the emerging technology field of developing machines whose components are at or near the scale of a nanometer.Nowadays these nano robots play a vital role in the field of Bio MedicineNanomedicine is the process of monitoring diagnosing, treating, and preventing disease and traumatic injury. to detect the target moleculesNanorobots have special sensors, it can be programmed to diagnosis and treat various vital diseasesThe names nanobots, nanoids, nanites or nanomites have also been used to describe this hypothetical devices they are used in medical field for treating arteriosclerosis, cancer treatment, diagnosis and treatment of diabetes, gene therapy are constructed of nanoscale ormolecular components and information listed in review.
The aim of present work was to design and evaluate sustained release matrix tablets of antihyperl... more The aim of present work was to design and evaluate sustained release matrix tablets of antihyperlipidemic drug. In the present investigation, polymers used in different combinations such as Eudragit RL100 and HPMC E5 in the ratio of 1:1, 1:2, 1:3 and vice versa with PVP K25 using direct compression technique were prepared. The tablets were evaluated for physical parameters like thickness, hardness, friability, weight variation, and in vitro release studies. The FTIR study indicated that the drug is stable in formulation. The maximum drug release was found to be 94.41% over a period for 12 hours for F4 batch, thus concluded that as the concentration of Eudragit RL100 is increased the drug release decreased. The drug release mechanism followed non-fickian transport from both polymer matrices. All the formulations were stored at 25C/60% RH and 45C/75% RH for 3 months. It showed that all the formulations were physically and chemically stable.
Nanocarriers: Drug Delivery System
Asian Journal of Pharmacy and Pharmacology
Asian Journal of Pharmaceutical and Clinical Research
Objective: The aim of this study was to develop a nanoemulsion for topical delivery. Methods: Top... more Objective: The aim of this study was to develop a nanoemulsion for topical delivery. Methods: Topical nanoemulsion was prepared by homogenization method. Box-behnken design was utilized to study the effect of oil, surfactant and Co-surfactant, on droplet size, entrapment efficiency and drug release. Nabumetone a non-steroidal anti-inflammatory drug was incorporated in castor oil with Tween 80 and Polyethylene glycol 600 to form the nanoemulsion by homogenization method. The nanoemulsion was further subjected to different evaluation parameters and ex-vivo study. The crystalline nature of drug was confirmed by powder X-ray diffraction studies. Drug-excipient compatibility was confirmed by Fourier transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), respectively. Results: The average globule size of nabumetone-containing nanoemulsion decreased with decrease in concentration of oil and surfactant. Nanoemulsion was evaluated by pH, rheology, globule size, zeta...
Asian Journal of Pharmaceutical and Clinical Research
Objective: The main objective of the study was to formulate and evaluate and perform an optimizat... more Objective: The main objective of the study was to formulate and evaluate and perform an optimization study of lavender essential oil loaded solid lipid nanoparticles (SLNs) based gel. Materials and Methods: SLNs were prepared by the hot homogenization technique. A total of eight formulations were formulated as per 23 factorial design by design expert 11 software. The formulated SLNs were further evaluated for particle size, entrapment efficiency, drug release profile. After evaluation, the optimized batch was further used for formulating gel. The formulated gel was further subjected to ex vivo studies. Results: After the evaluation of all the parameters, batch 7 was found to be optimized. Batch 7 was found to have the lowest particle size of 30.91±0.30, higher entrapment efficiency of 89.99±0.87, and higher drug release of 90.41±0.55. It was further used for formulating gel which was found to be consistent, homogenous, smooth, and spreadable. The % inhibition of the formulated SLN b...
Journal of Drug Delivery and Therapeutics, 2016
The present research was designed to increase bioavailability and solubility of Montulokast Sodiu... more The present research was designed to increase bioavailability and solubility of Montulokast Sodium by formulating Chrono pharmaceutical delivery system. In the present study firstly immediate release core tablets were prepared by direct compression using Response Surface Methodology with different superdisintegrants, diluents and surfactants to release drug faster. In that formulation containing cross carmellose sodium and Poloxomer-188 with highly soluble lactose gave 95% release in 30 minutes with optimum pre & post compression characteristics. Chronopharmaceutical Drug delivery formulations were then prepared by press coating using polymers as Xanthan gum, Polyox, HPMC & Ethyl Cellulose alone and in combination. The results revealed that combinations of these polymers give better lag time rather than using a single polymer. Thus it can be concluded that combining hydrophilic and hydrophobic polymer can be done to achieve the respected lag time required for pulsatile release.
Research Journal of Pharmacy and Technology, 2012
Hepato protective activity of Tinospora cordifolia was evaluated against paracetamol (acetaminoph... more Hepato protective activity of Tinospora cordifolia was evaluated against paracetamol (acetaminophen) and alcohol induced hepatic damage in male albino rats. Hepatic damage was well manifested by significant increase in the activities of Alanine amino transferase, Aspartate amino transferase. Alkaline phosphatase, Lactate dehydrogenase in serum and enhanced lipid peroxidation. On the other hand, the activities of Superoxide dismutase, Catalase in Liver tissue were lowered. Consequent to paracetamol induced hepatic injury, the serum Bilirubin level was increased. Paracetamol toxicity, also resulted in significant reduction in total serum protein, Vitamin-E and Vitamin-C. The oral administration of varying doses of ethanolic extract of Tinospora cordifolia (10, 20, 30 mg/kg body weight) for the period of 7 days reversed these altered parameters to normal levels indicating the hepato protective efficacy of Tinospora cordifolia against paracetamol induced liver injury.
Journal of Chinese Pharmaceutical Sciences, 2014
Nanoscience &Nanotechnology-Asia
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Papers by Pallavi chaudhari