Our objective is to reveal the molecular mechanism of the anti-inflammatory action of low-molecul... more Our objective is to reveal the molecular mechanism of the anti-inflammatory action of low-molecular-weight heparin (LMWH) based on its influence on the activity of two key cytokines, IFNγ and IL-6. The mechanism of heparin binding to IFNγ and IL-6 and the resulting inhibition of their activity were studied by means of extensive molecular-dynamics simulations. The effect of LMWH on IFNγ signalling inside stimulated WISH cells was investigated by measuring its antiproliferative activity and the translocation of phosphorylated STAT1 in the nucleus. We found that LMWH binds with high affinity to IFNγ and is able to fully inhibit the interaction with its cellular receptor. It also influences the biological activity of IL-6 by binding to either IL-6 or IL-6/IL-6Rα, thus preventing the formation of the IL-6/IL-6Rα/gp130 signalling complex. These findings shed light on the molecular mechanism of the anti-inflammatory action of LMWH and underpin its ability to influence favourably conditions...
Azimuthal dihadron correlations of charged particles have been measured in PbPb collisions at √ s... more Azimuthal dihadron correlations of charged particles have been measured in PbPb collisions at √ s NN = 2.76 TeV by the CMS collaboration, using data from the 2011 LHC heavy-ion run. The data set includes a sample of ultra-central (0-0.2% centrality) PbPb events collected using a trigger based on total transverse energy in the hadron forward calorimeters and the total multiplicity of pixel clusters in the silicon pixel tracker. A total of about 1.8 million ultra-central events were recorded, corresponding to an integrated luminosity of 120 µb −1 . The observed correlations in ultra-central PbPb events are expected to be particularly sensitive to initial-state fluctuations. The single-particle anisotropy Fourier harmonics, from v 2 to v 6 , are extracted as a function of particle transverse momentum. At higher transverse momentum, the v 2 harmonic becomes significantly smaller than the higher-order v n (n ≥ 3). The p T -averaged v 2 and v 3 are found to be equal within 2%, while higher-order v n decrease as n increases. The breakdown of factorization of dihadron correlations into single-particle azimuthal anisotropies is observed. This effect is found to be most prominent in the ultra-central PbPb collisions, where the initial-state fluctuations play a dominant role. A comparison of the factorization data to hydrodynamic predictions with event-byevent fluctuating initial conditions is also presented. Submitted to the Journal of High Energy Physics c 2013 CERN for the benefit of the CMS Collaboration. CC-BY-3.0 license arXiv:1312.1845v1 [nucl-ex]
Our objective is to reveal the molecular mechanism of the anti-inflammatory action of low-molecul... more Our objective is to reveal the molecular mechanism of the anti-inflammatory action of low-molecular-weight heparin (LMWH) based on its influence on the activity of two key cytokines, IFNγ and IL-6. The mechanism of heparin binding to IFNγ and IL-6 and the resulting inhibition of their activity were studied by means of extensive molecular-dynamics simulations. The effect of LMWH on IFNγ signalling inside stimulated WISH cells was investigated by measuring its antiproliferative activity and the translocation of phosphorylated STAT1 in the nucleus. We found that LMWH binds with high affinity to IFNγ and is able to fully inhibit the interaction with its cellular receptor. It also influences the biological activity of IL-6 by binding to either IL-6 or IL-6/IL-6Rα, thus preventing the formation of the IL-6/IL-6Rα/gp130 signalling complex. These findings shed light on the molecular mechanism of the anti-inflammatory action of LMWH and underpin its ability to influence favourably conditions...
Azimuthal dihadron correlations of charged particles have been measured in PbPb collisions at √ s... more Azimuthal dihadron correlations of charged particles have been measured in PbPb collisions at √ s NN = 2.76 TeV by the CMS collaboration, using data from the 2011 LHC heavy-ion run. The data set includes a sample of ultra-central (0-0.2% centrality) PbPb events collected using a trigger based on total transverse energy in the hadron forward calorimeters and the total multiplicity of pixel clusters in the silicon pixel tracker. A total of about 1.8 million ultra-central events were recorded, corresponding to an integrated luminosity of 120 µb −1 . The observed correlations in ultra-central PbPb events are expected to be particularly sensitive to initial-state fluctuations. The single-particle anisotropy Fourier harmonics, from v 2 to v 6 , are extracted as a function of particle transverse momentum. At higher transverse momentum, the v 2 harmonic becomes significantly smaller than the higher-order v n (n ≥ 3). The p T -averaged v 2 and v 3 are found to be equal within 2%, while higher-order v n decrease as n increases. The breakdown of factorization of dihadron correlations into single-particle azimuthal anisotropies is observed. This effect is found to be most prominent in the ultra-central PbPb collisions, where the initial-state fluctuations play a dominant role. A comparison of the factorization data to hydrodynamic predictions with event-byevent fluctuating initial conditions is also presented. Submitted to the Journal of High Energy Physics c 2013 CERN for the benefit of the CMS Collaboration. CC-BY-3.0 license arXiv:1312.1845v1 [nucl-ex]
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Papers by P. Petkov