Papers by PAULA PERAZZO DE SOUZA BARBOSA
Brazilian Archives of Biology and Technology
Lectins were discovered first in plants and later in other living things, and nowadays it is know... more Lectins were discovered first in plants and later in other living things, and nowadays it is known that they are present in almost all many life forms. These proteins can bind to specific carbohydrates, which make them perform a number of biological activities and can be used as tools in the study of glycoconjugate structures present on the cell surface, being effective in medical research. Plant lectins, leguminosae lectins particularly, are among the most studied plant proteins. They are very versatile molecules, which show several interesting biological properties. Thus, the present paper reviewed the advances about the leguminosae lectins biological properties studies in the last ten years, taking into account their possible applications in the fields of Clinical Microbiology, Pharmacy and Cancerology through a search in the electronic databases, providing opportunity to exchange information about the theme. Leguminosae lectins can neutralize pathogenic organisms, be they viruses, prokaryotes and eukaryotes, in addition carcinogenic cells, besides decreasing oxidative stress, conditions which increases the possibility of alternative substances for the design of new drugs to be used in current therapeutic, expanding the possibilities of diseases cure. HIGHLIGHTS Leguminous lectins are proteins found in various parts of leguminous plants. Leguminous lectins are versatile in the carbohydrate binding specificity. Leguminous lectins have antimicrobial, antioxidant and antiproliferative features. Leguminous lectins are promising molecules for the design of new drugs.
Journal of Biotechnology and Biodiversity, 2021
Henriettea succosa is a tree species consumed in abundance by birds, however, there is no report ... more Henriettea succosa is a tree species consumed in abundance by birds, however, there is no report on its phytochemical profile and biological activity. This study performed the phytochemical screening and the antimicrobial and antioxidant potential of H. succosa leaves. The hexane (Hex), ethyl acetate (AcOEt) and methanol (MeOH) extracts of the leaves were evaluated for chemical composition by Thin Layer Chromatography and spectrophotometric analysis; the antimicrobial activity was determined by the Minimum Inhibitory Concentration (MIC) and Minimum Microbicide Concentration (MMC); antioxidant activity was determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging, determination of the reducing power and the phosphomolybdenum complex reduction assay. The photoprotor action of the extracts was also evaluated. The results showed a higher content of phenolic compounds (444.08 ± 0.020 mg EAG/g) and tannins (414.37 ± 0.16 mg EAG/g) in the MeOH extract, which was effecti...
Arbovirosis are diseases caused by arthropod-borne viruses and affect the region of the Americas,... more Arbovirosis are diseases caused by arthropod-borne viruses and affect the region of the Americas, including the South American continent, where provoke impact on the economy and public health. Among the more than 500 viruses registered in the International Catalog of Arbovirus, those that cause dengue, zika fever and chikungunya stand out. Thus, this article comprises a descriptive study based on secondary data where we compare biological and diagnostic aspects these diseases, as well as assessing its presence, between 2015 and 2020, in the countries that integrate the su-american continental portion. Despite the considerable progress made in recent years to better understand the molecular aspects of etiologic agents and clinical conditions, the scenario is complex and the three arboviruses caused outbreaks in South America, in the period described, even in different proportions, with dengue remaining the most common arbovirus infection, whose the incidence rates fluctuate each anal...
Research, Society and Development, 2021
Os linfomas são neoplasias caracterizadas por um ambiente tumoral imunocomprometido que induz pro... more Os linfomas são neoplasias caracterizadas por um ambiente tumoral imunocomprometido que induz processos inflamatórios cuja produção de células de defesa pode ser posteriormente afetada pela quimioterapia. Esses detalhes levam a supor que indivíduos com esses cânceres apresentam complicações clínicas mais graves quando contaminados pelo SARS-CoV-2, o que torna necessário a atenção para o correto manejo terapêutico. Assim, este estudo resume os medicamentos usados no tratamento dos linfomas e na terapia experimental da COVID-19, e discute as possíveis interações esperadas entre os medicamentos. A maioria das interações medicamentosas ocorre por meio de alterações no metabolismo do sistema enzimático do citocromo P450 ou no transportador de efluxo da glicoproteína P (gp-P). Dependendo das combinações, pode haver aumento ou diminuição da concentração do medicamento e, consequentemente, aumento da toxicidade ou diminuição da eficácia, o que significa que a farmacocinética deve ser fort...
Scientia Plena
This study performed the phytochemical screening and bioactivity of Celosia argentea leaves. The ... more This study performed the phytochemical screening and bioactivity of Celosia argentea leaves. The phytochemical profile of hexane (Hex), ethyl acetate (AcOEt) and methanolic (MeOH) extracts of C. argentea leaves was observed by Thin Layer Chromatography and spectrophotometric analysis. In the susceptibility test, the disk-diffusion technique was performed. Minimum Inhibitory Concentration (MIC) was assessed by microdilution. Minimum Microbic Concentration (MMC) was determined in the extracts which presented MIC. Antioxidant activities were measured using 2,2-diphenyl-1-picril-hidrazil (DPPH), determination of reducing power and total antioxidant capacity (TAC). The results showed a higher content of phenolic compounds (252.02 ± 0.02 mg GAE/g) in the extract AcOEt, and of tannins (103.72 ± 0.004 mg/EAT/g) in MeOH; this was effective against Micrococcus luteus (inhibition of 24.7 ± 0.6 mm). MIC and CMM of the AcOEt for M. luteus were 0.06 and 0.25 mg/mL, respectively. The MeOH extract ...
A Bioquímica é uma ciência complexa e importante que estuda os aspectos químicos dos organismos v... more A Bioquímica é uma ciência complexa e importante que estuda os aspectos químicos dos organismos vivos, partindo da estrutura das biomoléculas até o seu metabolismo. Existem dificuldades no processo de aprendizagem de bioquímica devido à necessidade de relacionar conceitos químicos e sua relevância no contexto das moléculas biológicas. Considerando estes aspectos, o presente trabalho tem como objetivo apresentar um jogo didático, Perfil-biomoléculas, que possa ser utilizado nas aulas de todos os cursos onde bioquímica faça parte da grade curricular. É necessário diversificar as estratégias didáticas na educação superior objetivando obter melhores resultados no processo de aprendizagem.
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Papers by PAULA PERAZZO DE SOUZA BARBOSA