Papers by Oriogu Chuks Daniel
American Journal of Education and Learning, 2016
The paper presents the survey of monitoring policy on access to and use of the Internet in select... more The paper presents the survey of monitoring policy on access to and use of the Internet in selected university libraries in Southwestern , Nigeria. It shows the relevance of Internet monitoring policy, ways of Internet monitoring policy, items, sites and activities to be monitored in university libraries in Nigeria. Thus, the study suggested the need for monitoring policy on access to and use of Internet in University libraries in Nigeria in order to create an enabling environment for proper use of Internet for academic purposes by students.
The fundamental aim of every academic library is to provide an effective and efficient informatio... more The fundamental aim of every academic library is to provide an effective and efficient information services to its user community; hitherto, this could be greatly achieved if university libraries are automated. This study investigated the influence of automated cataloguing and circulation systems operation on library services in three selected academic libraries in South Western Nigeria. The study shows the capabilities and functionality of the library automation, role of automation in revolutionizing the library, level of automation in the university libraries, extent of automated circulation system operation, relationshipbetween automated cataloguing and circulation systemoperationand challenges of automation in the provision of information needs of users. The study finally makes some recommendations in combating the challenges affecting university libraries in Nigeria.
Information and Knowledge Management, 2017
A good starting point towards building a sustainable future for the physically challenged in Nige... more A good starting point towards building a sustainable future for the physically challenged in Nigeria is to provide effective legal backing, access to education and institutional structure to support their educational empowerment. This paper seeks to interrogate whether the physically challenged in Nigeria have secured their legal and institutional right of access to education. It is observed that the physically challenged are continually being deprived reasonable access to education and this has contributed negatively to their social conditions in the long run. It is suggested that the Nigerian government should streamline a substantial legal and policy framework with the aim of guaranteeing access to education for all persons with disability. In order for these policies to succeed, the changes should fundamentally transform the educational approach by ensuring that persons with disability are not excluded from the general educational system on the basis of disability. Keywords: Aca...
The study investigated the availability and use of scholarly journals by students in university l... more The study investigated the availability and use of scholarly journals by students in university libraries in Nigeria: a case study of Afe Babalola university library, Ado Ekiti, Ekiti State. Six research questions guided the study and the data collection instrument used was structured questionnaire, the study adopted survey research method. The findings of the study shows that majority of the respondent use scholarly journals twice monthly and by monthly basis and they purposely used it for self-examination, learning more about a subject, for assignment and coursework. The study also shows that scholarly journals are readily available and accessible to the respondents. However, most of the respondents indicated that scholarly journals helps to direct and guild them on how to carryout research and do quality research. The study revealed that majority of the respondent encountered challenges on the changes on journal frequency, numbering, titles and format and lack of scholarly journa...
International Journal of Humanities and Social Science, 2015
The paper investigated information behaviour and political participation of women in ijebuland of... more The paper investigated information behaviour and political participation of women in ijebuland of Ogun state, Nigeria.Six research questions guided thestudy and the data collection instrument used was the questionnaire, the study adopted survey research method.The findings of the study revealed that 70% of the respondents participated actively in politics and belong to a political party known as CAN (Action Congress of Nigeria). The study shows that information sources like Radio/Television, Books/Library, Newspaper/Magazine etc are readily available and often consulted by the respondents. Also the respondents indicated that they actively participates in the party meetings, women orientation and empowerment programmes and their information needs are basically on political issues, economic issues, marital responsibilities and empowerment programs. However, majority of the respondents indicated that education, economic factors, gender issues etcare the major hindrances to their information behaviour and political participation. Therefore, the study recommends that special emphasis should be laid on mandatory and free education of the girl child, making it the corporate responsibility of all parties involved in nation building from immediate family, the community, the society and the governments at all levels.
Research on Humanities and Social Sciences, 2014
The paper investigated availability and accessibility of ICT in the provision of information reso... more The paper investigated availability and accessibility of ICT in the provision of information resources to undergraduate students in Babcock university library in Ogun State, Nigeria. Three research questions guided the study and the data collection instrument used was the questionnaire, the study adopted survey research method. The findings of the study revealed that most of the ICT facilities in the university library are available and accessible, except scanner, CD-ROM and projector that are not available, accessible and use by the students. The provision and use of ICT is an integral part of student learning and research. Therefore, the study recommends that university libraries should endeavour to put in place ICT facilities that will promote students educational pursuit.
Advances in Social Sciences Research Journal, 2015
The advent of Internet have given rise to the exponential growth of health information resources ... more The advent of Internet have given rise to the exponential growth of health information resources which has invariably provided a wider means of access to health professional in meeting their immediate information needs. The study investigated the use of internet health information resources and information seeking behaviour among health professionals in federal medical center, Abuja. Five research questions guided the study and the data collection instrument used was structured questionnaire, the study adopted survey research method. The finding shows that (83.7%) of the respondents have average levels of Internet use proficiency. The study revealed that majority of the respondents rarely use e-book, e-journals, Websites, e-newspaper/ Bulletin. The finding shows that the respondents only use African Journal Online (AJOL) and Nursing Journals. Based on the information seeking behaviour of the respondents, it was revealed that (85.7%) of the respondents do not have understanding of li...
Cancer Research, 2007
AACR Annual Meeting-- Apr 14-18, 2007; Los Angeles, CA 4108 We have identified a novel human cell... more AACR Annual Meeting-- Apr 14-18, 2007; Los Angeles, CA 4108 We have identified a novel human cell surface protein, AGS-16, that is expressed in >95% of kidney cancers, predominantly in clear cell and papillary carcinomas. AGS-16 is expressed homogeneously at high levels in primary kidney cancers and in kidney metastases to lymph nodes and lung tissues. Amongst normal tissues, AGS-16 is expressed predominantly in kidney proximal tubules. In vitro studies with a purified extracellular domain (ECD) protein and AGS-16 expressing cells have indicated an involvement of AGS-16 in angiogenesis and tumor cell proliferation and migration. AGS-16 ECD induced human umbilical vein endothelial cell (HUVEC) tube formation on Matrigel in vitro , as well as their migration in a transwell chamber assay. RNAi silencing of AGS-16 expression in the kidney clear cell line RXF-393 and the liver cancer cell line HepG2 significantly reduced their proliferation, survival, migration and invasion. XenoMouse...
Clinical cancer research : an official journal of the American Association for Cancer Research, Jan 30, 2018
To determine the safety, pharmacokinetics, and recommendedphase2 dose of an antibody drug conjuga... more To determine the safety, pharmacokinetics, and recommendedphase2 dose of an antibody drug conjugate (ADC) targeting ectonucleotide phosphodiesterases-pyrophosphatase 3 (ENPP3) conjugated to monomethyl auristatin F (MMAF) in subjects with advanced metastatic renal cell carcinoma (mRCC). Two phase 1 studies were conducted sequentially with 2 ADCs considered equivalent, hybridoma derived AGS-16M8F and Chinese Hamster Ovary derived AGS-16C3F. AGS-16M8F was administered intravenously every 3 weeks at 5 dose levels ranging from 0.6 to 4.8 mg/kguntil unacceptable toxicity or progression. The study was terminated before reaching the maximum tolerated dose (MTD). A second study with AGS-16C3F started with the AGS-16M8F bridging dose of 4.8 mg/kg given every 3 weeks. The AGS-16M8F study (n=26) closed before reaching the MTD. The median duration of treatment was 12 weeks (1.7 - 83 weeks). One subject had durable partial remission (PR) (83 weeks) and 1 subject had prolonged stable disease (48 w...
Journal of Clinical Oncology, 2005
4722 Background: PSCA is a 123 amino acid GPI-linked surface antigen that is expressed in approxi... more 4722 Background: PSCA is a 123 amino acid GPI-linked surface antigen that is expressed in approximately 80% of prostate cancers and 50% of pancreatic and bladder cancers (Reiter et al., PNAS, 95:17...
Molecular cancer therapeutics, Nov 22, 2016
Here we report the development of an antibody-drug conjugate, ASG-5ME, which targets the solute c... more Here we report the development of an antibody-drug conjugate, ASG-5ME, which targets the solute carrier receptor SLC44A4. SLC44A4 is a member of a family of putative choline transporters which we show to be markedly upregulated in a variety of epithelial tumors, most notably prostate and pancreatic cancer. SLC44A4 is normally expressed on the apical surface of secretory epithelial cells but in cancer we show expression is not restricted to the luminal surface in advanced and undifferentiated tumors. ASG-5ME consists of a human IgG2 anti-SLC44A4 antibody conjugated through a cleavable linker to the microtubule-disrupting agent, monomethylauristatin E. It has potent anti-tumor activity in both cell line and patient-derived xenograft models of pancreatic and prostate cancers. Combination studies with ASG-5ME and nab-paclitaxel demonstrated combination effect in both pancreatic and prostate tumor models. Altogether, the data presented here suggests that ASG-5ME may have the potential to...
Molecular Cancer Therapeutics, Nov 1, 2007
B59 We identified a novel human cell surface protein, AGS-8, which is expressed in >70% of ova... more B59 We identified a novel human cell surface protein, AGS-8, which is expressed in >70% of ovarian cancers, predominantly in advanced stages of serous adenocarcinoma. Amongst normal tissues, AGS-8 expression is restricted to testis and the red pulp of spleen. In vitro studies with AGS-8 expressing cells indicated an involvement of AGS-8 in tumor cell survival, migration, invasion and cell-cell interaction. Furthermore, a purified AGS-8 extracellular domain (ECD) protein mediated Ca2+-dependent binding to human umbilical vein endothelial cells (HUVEC), supported their survival and induced tube formation in vitro. Recombinant expression of AGS-8 in murine fibroblasts was oncogenic, leading to aggressive tumor growth and metastasis in mice. Additionally, these cells induced significant angiogenesis when implanted in vivo. Recombinant AGS-8 expression in ovarian carcinoma cells (OVCAR-5) led to enhancement of their intrinsic tumor growth in vivo.
XenoMouse® technology was employed to generate a panel of high affinity fully human monoclonal antibodies (MAbs) to AGS-8, targeting diverse epitope groups. One MAb that exhibited potent inhibitory activity in all functional assays was AGS-8M4, an IgG1κ MAb with a Kd = 5 x 10-9 M for cell surface AGS-8. AGS-8M4 dose-dependently inhibited tube formation in vitro. In addition, AGS-8M4 inhibited the migration, invasion and cell-cell interaction of AGS-8 expressing cells. Significant anti-tumor efficacy of AGS-8M4 in vivo was observed in both recombinant models and in endogenous models, either during tumor formation or in well-established tumors. Efficacy of AGS-8M4 was maintained after MAb de-glycosylation, indicating an intrinsic anti-tumor activity of the MAb without significant contribution by immune effector functions. AGS-8M4 inhibited lung metastases in the 3T3/AGS-8 tumor model, further suggesting a role of AGS-8 in tumor cell migration and invasion. Studies evaluating the anti-tumor efficacy of AGS-8M4 with drug combinations are underway. Together, these data establish AGS-8 as a novel and attractive ovarian cancer target and AGS-8M4 as a potential therapeutic MAb for this cancer indication.
Neoplasia, 2013
Preclinical evaluation of novel cancer agents requires models that accurately reflect the biology... more Preclinical evaluation of novel cancer agents requires models that accurately reflect the biology and molecular characteristics of human tumors. Molecular profiles of eight pancreatic ductal adenocarcinoma patient tumors were compared to corresponding passages of xenografts obtained by grafting tumor fragments into immunocompromised mice. Molecular characterization was performed by copy number analysis, gene expression and microRNA microarrays, mutation analysis, short tandem repeat (STR) profiling, and immunohistochemistry. Xenografts were found to be highly representative of their respective tumors, with a high degree of genetic stability observed by STR profiling and mutation analysis. Copy number variation (CNV) profiles of early and late xenograft passages were similar, with recurrent losses on chromosomes 1p,
Cancer Research, 2011
Nectin-4 is a type I transmembrane antigen identified by Agensys to be highly expressed at the RN... more Nectin-4 is a type I transmembrane antigen identified by Agensys to be highly expressed at the RNA level in a significant number of bladder and breast cancer specimens. Analysis of protein expression carried out in an extensive panel of tumor specimens by immunohistochemistry confirmed strong to moderate expression levels of Nectin-4 in bladder, breast and pancreatic cancers (40-60%). A subset of lung and ovarian cancers (up to 30%) also showed significant expression levels of this protein. We have generated an antibody-drug conjugate (ADC) targeting Nectin-4, AGS-22M6E. The highly potent microtubule disrupting drug monomethyl auristatin E (MMAE) was conjugated via valine-citrulline cleavable linker to a fully human IgG1k antibody specific for Nectin-4. AGS-22M6E was characterized for binding affinity, species crossreactivity and cytotoxicity in vitro. AGS-22M6E binds to cell surface Nectin-4 with high affinity and crossreacts with Nectin-4 orthologs of cynomolgus monkey, rat and mu...
Cancer Research, 2010
AGS-16 is a novel transmembrane antigen discovered by Agensys using transcription profiling and i... more AGS-16 is a novel transmembrane antigen discovered by Agensys using transcription profiling and is expressed in kidney, liver and other cancers. A fully human IgG2k monoclonal antibody that binds to AGS-16 with high affinity was conjugated to the anti-microtubulin drug monomethyl auristatin F (MMAF) via a noncleavable maleimidocaproyl (mc) linker to yield the antibody drug conjugate, AGS-16M8F. AGS-16M8F was evaluated for binding affinity, species cross reactivity and cell cytotoxicity in vitro. Its’ anti-tumor activity was investigated using multiple established patient-derived and cell line models of renal clear cell carcinomas. The pharmacokinetics (PK) of AGS-16M8F was evaluated in mice. In addition, the expression of AGS-16 protein in patient kidney and liver cancer specimens was confirmed using IHC. AGS-16M8F bound with high affinity (Kd = 0.3 nM) to both human and cynomolgus monkey AGS-16 orthologs. Following cell surface binding, AGS-16M8F was internalized and trafficked to ...
Electronic legal journals are vital electronic information resources that are germane to legal re... more Electronic legal journals are vital electronic information resources that are germane to legal research development and advancement. The study assesses the final year law students access to and use of electronic legal journals: A case study of Oluayola Law Library, College of Law, Afe Babalola University. Five research questions guided the study and the data collection instrument used was structured questionnaire. The study adopted survey descriptive research method. The findings of the study show that the respondents use electronic legal journals mostly occasionally. It also reveals that majority of the respondents mostly access electronic databases like Elaw, Compulaw, Lexis Nexis and Jstor. Also they indicated that electronic legal journals are very vital to their academic growth and accomplishment. Based on the level of preference, majority of the respondents prefer to access both print and electronic legal journals. Finally, the hindrances to law students access to and use of e...
The advent of information and communication technology has greatly provided an enabling means of ... more The advent of information and communication technology has greatly provided an enabling means of electronic version of book that is vital to today users educational pursuit. Therefore, this study review literature on the conceptual overview of e-book, growth, relevance, challenges to university libraries and opportunity for sustainability. Hence, to overcome the turbulence issue of discourse, university libraries should endeavour to provide technological facilities that will facilitate effective use of e-book. Therein publishers, aggregators, vendors and librarians should collaborate on a streamlined mutual congenial business models which will enable effective subscription platform stable for easy restitution.
Reading habit is a fundamental skill necessary in the life of every student. It is essential in d... more Reading habit is a fundamental skill necessary in the life of every student. It is essential in developing a more civilized and knowledgeable society. Therefore, the study investigated reading habit of secondary school students and ways of developing and improving of school libraries in Nigeria. The study reviewed the basis of reading skills, reading skill as a prerequisite of students’ development, strategies for improving reading habit in schools, guidelines for improving reading habit and the influence of new technology in child development. However, the study finally recommended that school administrators should see the library as a necessity in the development and improvement of teaching and learning. And should employ professional librarians and, or, media specialist to direct and coordinate the activities of the school library.
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Papers by Oriogu Chuks Daniel