WHEN ANIMALS are given 3,4-dihydroxyphenylalanine (L-dopa) in doses (100 mg/kg, i.p.) similar to ... more WHEN ANIMALS are given 3,4-dihydroxyphenylalanine (L-dopa) in doses (100 mg/kg, i.p.) similar to those used to treat patients with Parkinson's disease, a major portion of the administered catechol amino acid is O-methylated to form 3-O-methyldopa (OMD) and other methylated products.' In the process, the concentrations of the methyl donor, S-adenosylmethionine (SAM), in brain and adrenal fall markedly.Z Single doses of SAM do not affect its concentration in liver. However, after chronic r_-dopa treatment, hepatic SAM levels are acutely lowered by further doses.3
WHEN ANIMALS are given 3,4-dihydroxyphenylalanine (L-dopa) in doses (100 mg/kg, i.p.) similar to ... more WHEN ANIMALS are given 3,4-dihydroxyphenylalanine (L-dopa) in doses (100 mg/kg, i.p.) similar to those used to treat patients with Parkinson's disease, a major portion of the administered catechol amino acid is O-methylated to form 3-O-methyldopa (OMD) and other methylated products.' In the process, the concentrations of the methyl donor, S-adenosylmethionine (SAM), in brain and adrenal fall markedly.Z Single doses of SAM do not affect its concentration in liver. However, after chronic r_-dopa treatment, hepatic SAM levels are acutely lowered by further doses.3
WHEN ANIMALS are given 3,4-dihydroxyphenylalanine (L-dopa) in doses (100 mg/kg, i.p.) similar to ... more WHEN ANIMALS are given 3,4-dihydroxyphenylalanine (L-dopa) in doses (100 mg/kg, i.p.) similar to those used to treat patients with Parkinson's disease, a major portion of the administered catechol amino acid is O-methylated to form 3-O-methyldopa (OMD) and other methylated products.' In the process, the concentrations of the methyl donor, S-adenosylmethionine (SAM), in brain and adrenal fall markedly.Z Single doses of SAM do not affect its concentration in liver. However, after chronic r_-dopa treatment, hepatic SAM levels are acutely lowered by further doses.3
WHEN ANIMALS are given 3,4-dihydroxyphenylalanine (L-dopa) in doses (100 mg/kg, i.p.) similar to ... more WHEN ANIMALS are given 3,4-dihydroxyphenylalanine (L-dopa) in doses (100 mg/kg, i.p.) similar to those used to treat patients with Parkinson's disease, a major portion of the administered catechol amino acid is O-methylated to form 3-O-methyldopa (OMD) and other methylated products.' In the process, the concentrations of the methyl donor, S-adenosylmethionine (SAM), in brain and adrenal fall markedly.Z Single doses of SAM do not affect its concentration in liver. However, after chronic r_-dopa treatment, hepatic SAM levels are acutely lowered by further doses.3
WHEN ANIMALS are given 3,4-dihydroxyphenylalanine (L-dopa) in doses (100 mg/kg, i.p.) similar to ... more WHEN ANIMALS are given 3,4-dihydroxyphenylalanine (L-dopa) in doses (100 mg/kg, i.p.) similar to those used to treat patients with Parkinson's disease, a major portion of the administered catechol amino acid is O-methylated to form 3-O-methyldopa (OMD) and other methylated products.' In the process, the concentrations of the methyl donor, S-adenosylmethionine (SAM), in brain and adrenal fall markedly.Z Single doses of SAM do not affect its concentration in liver. However, after chronic r_-dopa treatment, hepatic SAM levels are acutely lowered by further doses.3
WHEN ANIMALS are given 3,4-dihydroxyphenylalanine (L-dopa) in doses (100 mg/kg, i.p.) similar to ... more WHEN ANIMALS are given 3,4-dihydroxyphenylalanine (L-dopa) in doses (100 mg/kg, i.p.) similar to those used to treat patients with Parkinson's disease, a major portion of the administered catechol amino acid is O-methylated to form 3-O-methyldopa (OMD) and other methylated products.' In the process, the concentrations of the methyl donor, S-adenosylmethionine (SAM), in brain and adrenal fall markedly.Z Single doses of SAM do not affect its concentration in liver. However, after chronic r_-dopa treatment, hepatic SAM levels are acutely lowered by further doses.3
WHEN ANIMALS are given 3,4-dihydroxyphenylalanine (L-dopa) in doses (100 mg/kg, i.p.) similar to ... more WHEN ANIMALS are given 3,4-dihydroxyphenylalanine (L-dopa) in doses (100 mg/kg, i.p.) similar to those used to treat patients with Parkinson's disease, a major portion of the administered catechol amino acid is O-methylated to form 3-O-methyldopa (OMD) and other methylated products.' In the process, the concentrations of the methyl donor, S-adenosylmethionine (SAM), in brain and adrenal fall markedly.Z Single doses of SAM do not affect its concentration in liver. However, after chronic r_-dopa treatment, hepatic SAM levels are acutely lowered by further doses.3
WHEN ANIMALS are given 3,4-dihydroxyphenylalanine (L-dopa) in doses (100 mg/kg, i.p.) similar to ... more WHEN ANIMALS are given 3,4-dihydroxyphenylalanine (L-dopa) in doses (100 mg/kg, i.p.) similar to those used to treat patients with Parkinson's disease, a major portion of the administered catechol amino acid is O-methylated to form 3-O-methyldopa (OMD) and other methylated products.' In the process, the concentrations of the methyl donor, S-adenosylmethionine (SAM), in brain and adrenal fall markedly.Z Single doses of SAM do not affect its concentration in liver. However, after chronic r_-dopa treatment, hepatic SAM levels are acutely lowered by further doses.3
WHEN ANIMALS are given 3,4-dihydroxyphenylalanine (L-dopa) in doses (100 mg/kg, i.p.) similar to ... more WHEN ANIMALS are given 3,4-dihydroxyphenylalanine (L-dopa) in doses (100 mg/kg, i.p.) similar to those used to treat patients with Parkinson's disease, a major portion of the administered catechol amino acid is O-methylated to form 3-O-methyldopa (OMD) and other methylated products.' In the process, the concentrations of the methyl donor, S-adenosylmethionine (SAM), in brain and adrenal fall markedly.Z Single doses of SAM do not affect its concentration in liver. However, after chronic r_-dopa treatment, hepatic SAM levels are acutely lowered by further doses.3
WHEN ANIMALS are given 3,4-dihydroxyphenylalanine (L-dopa) in doses (100 mg/kg, i.p.) similar to ... more WHEN ANIMALS are given 3,4-dihydroxyphenylalanine (L-dopa) in doses (100 mg/kg, i.p.) similar to those used to treat patients with Parkinson's disease, a major portion of the administered catechol amino acid is O-methylated to form 3-O-methyldopa (OMD) and other methylated products.' In the process, the concentrations of the methyl donor, S-adenosylmethionine (SAM), in brain and adrenal fall markedly.Z Single doses of SAM do not affect its concentration in liver. However, after chronic r_-dopa treatment, hepatic SAM levels are acutely lowered by further doses.3
Uploads
Papers by Luis Ordonez