Hoekzema, M. 2018. Small RNAs, Big Consequences. Post-transcriptional Regulation and Adaptive Imm... more Hoekzema, M. 2018. Small RNAs, Big Consequences. Post-transcriptional Regulation and Adaptive Immunity in Bacteria. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology 1637. 83 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-513-0252-2. It is nowadays widely accepted that non-coding RNAs play important roles in posttranscriptional regulation of genes in all kingdoms of life. In bacteria, the largest group of RNA regulators are the small RNAs (sRNAs). Almost all sRNAs act through anti-sense base-pairing with target mRNAs, and by doing so regulate their translation and/or stability. As important modulators of gene expression, sRNAs are involved in all aspects of bacterial physiology. My studies aimed to deepen our understanding of the mechanisms behind sRNA-mediated gene regulation. We have shown that translation of the di-guanylate-cyclase YdaM, a major player in the biofilm regulatory cascade, is repressed by the sRNAs OmrA an...
When blood vessels are cut, the forces in the bloodstream increase and change character. The dark... more When blood vessels are cut, the forces in the bloodstream increase and change character. The dark side of these forces causes hemorrhage and death. However, von Willebrand factor (VWF), with help from our circulatory system and platelets, harnesses the same forces to form a hemostatic plug. Force and VWF function are so closely intertwined that, like members of the Jedi Order in the movie Star Wars who learn to use “the Force” to do good, VWF may be considered the Jedi knight of the bloodstream. The long length of VWF enables responsiveness to flow. The shape of VWF is predicted to alter from irregularly coiled to extended thread-like in the transition from shear to elongational flow at sites of hemostasis and thrombosis. Elongational force propagated through the length of VWF in its thread-like shape exposes its monomers for multimeric binding to platelets and subendothelium and likely also increases affinity of the A1 domain for platelets. Specialized domains concatenate and compa...
Hoekzema, M. 2018. Small RNAs, Big Consequences. Post-transcriptional Regulation and Adaptive Imm... more Hoekzema, M. 2018. Small RNAs, Big Consequences. Post-transcriptional Regulation and Adaptive Immunity in Bacteria. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology 1637. 83 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-513-0252-2. It is nowadays widely accepted that non-coding RNAs play important roles in posttranscriptional regulation of genes in all kingdoms of life. In bacteria, the largest group of RNA regulators are the small RNAs (sRNAs). Almost all sRNAs act through anti-sense base-pairing with target mRNAs, and by doing so regulate their translation and/or stability. As important modulators of gene expression, sRNAs are involved in all aspects of bacterial physiology. My studies aimed to deepen our understanding of the mechanisms behind sRNA-mediated gene regulation. We have shown that translation of the di-guanylate-cyclase YdaM, a major player in the biofilm regulatory cascade, is repressed by the sRNAs OmrA an...
When blood vessels are cut, the forces in the bloodstream increase and change character. The dark... more When blood vessels are cut, the forces in the bloodstream increase and change character. The dark side of these forces causes hemorrhage and death. However, von Willebrand factor (VWF), with help from our circulatory system and platelets, harnesses the same forces to form a hemostatic plug. Force and VWF function are so closely intertwined that, like members of the Jedi Order in the movie Star Wars who learn to use “the Force” to do good, VWF may be considered the Jedi knight of the bloodstream. The long length of VWF enables responsiveness to flow. The shape of VWF is predicted to alter from irregularly coiled to extended thread-like in the transition from shear to elongational flow at sites of hemostasis and thrombosis. Elongational force propagated through the length of VWF in its thread-like shape exposes its monomers for multimeric binding to platelets and subendothelium and likely also increases affinity of the A1 domain for platelets. Specialized domains concatenate and compa...
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