Papers by Oluwadurotimi Aworunse
Journal of Herbmed Pharmacology
In the last few decades, Moringa oleifera, a multipurpose medicinal plant (MMP) has received incr... more In the last few decades, Moringa oleifera, a multipurpose medicinal plant (MMP) has received increased research attention and commercial interest for its nutritional, therapeutic and pharmacological properties. Rigorous approaches including biological assays, animal and clinical trials are required towards safe usage as herbal therapy. We conducted a systematic review of the known pharmacological activities, toxicity, and safety of M. oleifera, usually used locally in the treatment and prevention of myriads of illnesses. Five major bibliographic databases (SCOPUS, Web of Science, Science Direct, PubMed, and Mendeley) were searched for studies reported on pharmacological activities, toxicity, and safety assessment of M. oleifera in the last 29 years (1990 – 2019). Studies on animals and humans involving aqueous leaf extracts and different preparations from M. oleifera seed and bark were also considered. All articles retained, and data collected were evaluated based on the period of t...
Journal of Physics: Conference Series
Indigenous Nigerian pumpkin is a cucurbitaceous plant primarily grown in Southwestern Nigeria for... more Indigenous Nigerian pumpkin is a cucurbitaceous plant primarily grown in Southwestern Nigeria for its young leaves, which are relished as pleasant-tasting vegetable. In spite of its nutritional value, the plant is scarcely available compared to other vegetables. As a result, development of a rapid in vitro regeneration procedure is imperative to ensure all year round availability. The influence of 6-Benzylaminopurine (BAP) and 2,4-dichlorophenoxyacetic acid on multiple shoots induction from cotyledonary node explant of indigenous Nigerian pumpkin has been previously reported. However, the concentrations of BAP used may have been high, hence the inhibition of shoots formation on medium amended with plant growth regulators (PGRs). Can low concentrations of BAP alone elicit multiple shoots from cotyledonary node explant of indigenous Nigerian pumpkin? To ascertain this, we cultured cotyledonary node explants derived from 3-week-old in vitro grown seedlings for 8 weeks on Murashige and Skoog (MS) basal medium fortified with 0.35, 0.45 and 0.55 mg/L BAP. Medium without BAP (0.00 mg/L) was used as control. Mean number of shoots per explant was not statistically significant (P≤0.05) among the BAP concentrations employed except for control and medium augmented with 0.45 mg/L BAP. Medium fortified with 0.45 mg/L of BAP gave 3.25±0.921 shoots per explant and was therefore most effective for multiple shoots induction. The result showed that low levels of BAP were capable of inducing shoots formation from cotyledonary node explant of indigenous Nigerian pumpkin. Nevertheless, much lower BAP concentration than used in the present study should be investigated for the likelihood to elicit higher shoot responses.
International Journal of Genomics
Plasmodium falciparum, a malaria pathogen, has shown substantial resistance to treatment coupled ... more Plasmodium falciparum, a malaria pathogen, has shown substantial resistance to treatment coupled with poor response to some vaccines thereby requiring urgent, holistic, and broad approach to prevent this endemic disease. Understanding the biology of the malaria parasite has been identified as a vital approach to overcome the threat of malaria. This study is aimed at identifying essential proteins unique to malaria parasites using a reconstructed iPfa genome-scale metabolic model (GEM) of the 3D7 strain of Plasmodium falciparum by filling gaps in the model with nineteen (19) metabolites and twenty-three (23) reactions obtained from the MetaCyc database. Twenty (20) currency metabolites were removed from the network because they have been identified to produce shortcuts that are biologically infeasible. The resulting modified iPfa GEM was a model using the k-shortest path algorithm to identify possible alternative metabolic pathways in glycolysis and pentose phosphate pathways of Plas...
Annual Research & Review in Biology
Bioinformatics and Biology Insights
Lately, the term “genomics” has become ubiquitous in many scientific articles. It is a rapidly gr... more Lately, the term “genomics” has become ubiquitous in many scientific articles. It is a rapidly growing aspect of the biomedical sciences that studies the genome. The human genome contains a torrent of information that gives clues about human origin, evolution, biological function, and diseases. In a bid to demystify the workings of the genome, the Human Genome Project (HGP) was initiated in 1990, with the chief goal of sequencing the approximately 3 billion nucleotide base pairs of the human DNA. Since its completion in 2003, the HGP has opened new avenues for the application of genomics in clinical practice. This review attempts to overview some milestone discoveries that paved way for the initiation of the HGP, remarkable revelations from the HGP, and how genomics is influencing a paradigm shift in routine clinical practice. It further highlights the challenges facing the implementation of genomic medicine, particularly in Africa. Possible solutions are also discussed.
Annual Research & Review in Biology
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Papers by Oluwadurotimi Aworunse