Papers by Nobuhiro Fusetani
Bioorganic & Medicinal Chemistry Letters, 2004
Three new cyclostellettamines, cyclostellettamine G (1), dehydrocyclostellettamines D (2), and E ... more Three new cyclostellettamines, cyclostellettamine G (1), dehydrocyclostellettamines D (2), and E (3), were isolated together with the known cyclostellettamine A (4) from a marine sponge of the genus Xestospongia as histone deacetylase inhibitors. Their structures were determined by spectral and chemical methods. They inhibit histone deacetylase derived from K562 human leukemia cells with IC 50 values ranging from 17 to 80 lM.
Bioscience, Biotechnology, and Biochemistry, 2007
Angewandte Chemie International Edition, 2006
Inhibitory activity against histone deacetylase is displayed by the newly discovered natural prod... more Inhibitory activity against histone deacetylase is displayed by the newly discovered natural products azumamides A-E, isolated from the marine sponge Mycale izuensis, shown in the background of the cover picture. The total synthesis of azumamides A and E is reported and has allowed the stereochemical structure of the azumamides to be established. For more information on these natural products, see the Communications by N. Fusetani and co-workers and by I. Izzo, F. De Riccardis et al. on pages 7553 ff. and 7557 ff., respectively.
Angewandte Chemie International Edition, 2006
Journal of the American Chemical Society, 2003
A novel MMP inhibitor, ageladine A (1) with antiangiogenic activity was isolated from a marine sp... more A novel MMP inhibitor, ageladine A (1) with antiangiogenic activity was isolated from a marine sponge Agelas nakamurai. Structure 1 was determined by a combination of spectroscopic and chemical methods to be an unprecedented structure of 4-(4,5-dibromo-1H-pyrrol-2-yl)]-1H-imidazo[4,5-c]pyridin-2-amine.
Marine Drugs, 2012
Using theonellasterol as a novel FXR antagonist hit, we prepared a series of semi-synthetic deriv... more Using theonellasterol as a novel FXR antagonist hit, we prepared a series of semi-synthetic derivatives in order to gain insight into the structural requirements for exhibiting antagonistic activity. These derivatives are characterized by modification at the exocyclic carbon-carbon double bond at C-4 and at the hydroxyl group at C-3 and were prepared from theonellasterol using simple reactions. Pharmacological investigation showed that the introduction of a hydroxyl group at C-4 as well as the oxidation at C-3 with or without concomitant modification at the exomethylene functionality preserve the ability of theonellasterol to inhibit FXR transactivation caused by CDCA. Docking analysis
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Papers by Nobuhiro Fusetani