In recent years, the use of web-based education as an instructional method has increased at unive... more In recent years, the use of web-based education as an instructional method has increased at universities. Web-based technology is considered a useful tool for teaching outside the classroom and off...
With its many complex structures, the anatomy of the head and neck is one of the most challenging... more With its many complex structures, the anatomy of the head and neck is one of the most challenging areas of human anatomy to study and master. These 248 flash cards are the perfect streamlined review to help you learn head and neck anatomy as well as common diseases and disorders of this region easily, efficiently, and at your own rate of study. "Netter's Advanced Head and Neck Anatomy Flash Cards" is your perfect quick resource for a fast and fun review at any stage of your healthcare career.
with a chief complaint of painful ulcerations of the oral cavity. The lesions had been present fo... more with a chief complaint of painful ulcerations of the oral cavity. The lesions had been present for at least several weeks and apparently had been slowly increasing in severity over this period. The patient had previously presented to a walk-in medical clinic for evaluation and was initially prescribed amoxicillin. When no clinical improvement was noted, she was switched to Augmentin (amoxicillin and clavulanate), prescribed nystatin troches and chlorhexidine rinses and advised to see a dentist. On initial presentation, the patient presented with multiple large crater-like erosions involving the palatal attached mucosa (figure 1a). The erosions were largely devoid of fibrin coating, except immediately along the border with the adjacent unaffected mucosa. In focal areas along the lateral margins of the erosions, an erythematous, raised, somewhat granular presentation was noted that resembled immature granulation tissue. The maxillary anterior attached gingiva had a somewhat granular appearance with linear ulcerations between the central incisors and interproximally between the left maxillary central and lateral incisors (figure 1b). The interdental papilla had a "punched out" necrotic appearance, but lacked a fetid odor. The palatal lesions were moderately painful to palpation. The patient denied having any similar vaginal or rectal lesions. The patient also reported that she had recently started to experience small pruritic erythematous skin lesions involving her arms (figure 2), legs and chest. Application of lateral pressure to the
INTRODUCTION: With the wider therapeutic use of clear aligners the need to investigate the period... more INTRODUCTION: With the wider therapeutic use of clear aligners the need to investigate the periodontal health status and microbiome of clear aligners’ patients in comparison with users of fixed orthodontic has arisen and is the objective of this thesis. METHODS: A clinical periodontal evaluation was performed, followed by professional oral hygiene treatment on a patient under clear aligner treatment, another under fixed orthodontics and two controls that never received any orthodontic therapy. One week after, supragingival plaque, swabs from the orthodontic devices, and saliva samples were collected from each volunteer for further 16s sequencing and microbiome analysis. RESULTS: All participants have overall good oral hygiene. However, our results showed increases in supragingival plaque, higher number of probing depths greater than 3mm, higher number of bleeding sites on probing, and a higher amount of gingival recession in the subject treated with fixed orthodontics. A lower bacte...
The volume of life science publications, and therefore the underlying biomedical knowledge, are g... more The volume of life science publications, and therefore the underlying biomedical knowledge, are growing at a fast pace. However the manual literature analysis is a slow and painful task. Hence, text mining systems have been developed to automatically locate the relevant information contained in the literature. An essential step in text mining is named entity recognition, but the inherent complexity of biomedical entities, such as chemical compounds, makes it dicult to obtain good performances in this task. This thesis proposes methods capable to improve the current performance of chemical entity recognition from text. Hereby a case based method for recognizing chemical entities is proposed and the obtained evaluation results outperform the most widely used methods, based in dictionaries. A lexical similarity based chemical entity resolution method was also developed and allows an ecient mapping of the recognized entities to the ChEBI database. To improve the chemical entity identication results we developed a validation method that exploits the semantic relationships in ChEBI to measure the similarity between the entities found in the text, in order to discriminate between the correctly identied entities that can be validated and identication errors that should be discarded. A machine learning method for entity recognition error is also proposed, which can eectively nd recognition errors in rule based systems. The methods were integrated in a system capable of recognizing chemical entities in texts, map them to the ChEBI database, and provide evidence of validation or recognition error for the recognized entities.
In dental education, the anatomical sciences, which include gross anatomy, histology, embryology,... more In dental education, the anatomical sciences, which include gross anatomy, histology, embryology, and neuroanatomy, encompass an important component of the basic science curriculum. At Creighton University School of Dentistry, strength in anatomic science education has been coupled with a solid applicant pool to develop a novel Master of Science in Oral Biology, Anatomic Sciences track degree program. The program provides a heavy emphasis on developing teaching skills in predoctoral students as well as exposure to research processes to encourage the cohort to pursuing a career in academic dentistry. The individuals considered for this program are applicants for admission to the School of Dentistry that have not been accepted into the entering dental class for that year. The students undertake a two year curriculum, studying anatomic sciences with a special emphasis on teaching. The students also must complete a research project that requires a thesis. The students in the program are guaranteed acceptance to dental school upon successful completion of the program. After six years, the first ten students have received their Master of Science degrees and continued in dental school. The program is favorably viewed by the faculty and participating students. It is also considered successful by metrics. Nine of the ten graduates have said they would like to participate in academic dentistry in some capacity during their careers. Anat Sci Educ 00: 000-000.
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 1996
The age-related decline in growth hormone (GH) secretion has been largely attributed to age-relat... more The age-related decline in growth hormone (GH) secretion has been largely attributed to age-related degeneration of hypothalamic growth hormone-releasing hormone (GHRH)-producing neurons. GH decline has recently been linked to age-related bone changes in humans. Bone loss and decreased bone strength are common in aging rats and humans, but density of remaining mineral tissue is known to be increased. The effect of induced hypothalamic GHRH deficiency on bone was assessed, and similarities between bone changes encountered and those taking place in aging were identified. Female rats received monosodium glutamate (MSG) following birth, and they were euthanized at 19 weeks of age. Femurs from MSG-treated rats had greater mineral density (p < .05), greater mineral! matrix ratio (p < Ml), lower mineral apposition rate (p < .005), and lower bone formation rate (p < .05). These results suggest that hypothalamic GHRH decline plays a substantial role in the development of bone pathology similar to that observed in aging individuals.
A rare case of multiple enamel pearl formation is presented involving the maxillary molars in two... more A rare case of multiple enamel pearl formation is presented involving the maxillary molars in two siblings incidentally recognized during volumetric CT examination. Although the pathogenesis of ectopic enamel formation is not known, possible mechanisms to account for this phenomenon are discussed in the context of current knowledge regarding root genesis. The radiographic presentation of enamel pearls and its clinical significance is also discussed. The observation of multiple enamel pearls in two siblings raises the possibility of a hereditary association in the formation of enamel pearls.
In recent years, the use of web-based education as an instructional method has increased at unive... more In recent years, the use of web-based education as an instructional method has increased at universities. Web-based technology is considered a useful tool for teaching outside the classroom and off...
With its many complex structures, the anatomy of the head and neck is one of the most challenging... more With its many complex structures, the anatomy of the head and neck is one of the most challenging areas of human anatomy to study and master. These 248 flash cards are the perfect streamlined review to help you learn head and neck anatomy as well as common diseases and disorders of this region easily, efficiently, and at your own rate of study. "Netter's Advanced Head and Neck Anatomy Flash Cards" is your perfect quick resource for a fast and fun review at any stage of your healthcare career.
with a chief complaint of painful ulcerations of the oral cavity. The lesions had been present fo... more with a chief complaint of painful ulcerations of the oral cavity. The lesions had been present for at least several weeks and apparently had been slowly increasing in severity over this period. The patient had previously presented to a walk-in medical clinic for evaluation and was initially prescribed amoxicillin. When no clinical improvement was noted, she was switched to Augmentin (amoxicillin and clavulanate), prescribed nystatin troches and chlorhexidine rinses and advised to see a dentist. On initial presentation, the patient presented with multiple large crater-like erosions involving the palatal attached mucosa (figure 1a). The erosions were largely devoid of fibrin coating, except immediately along the border with the adjacent unaffected mucosa. In focal areas along the lateral margins of the erosions, an erythematous, raised, somewhat granular presentation was noted that resembled immature granulation tissue. The maxillary anterior attached gingiva had a somewhat granular appearance with linear ulcerations between the central incisors and interproximally between the left maxillary central and lateral incisors (figure 1b). The interdental papilla had a "punched out" necrotic appearance, but lacked a fetid odor. The palatal lesions were moderately painful to palpation. The patient denied having any similar vaginal or rectal lesions. The patient also reported that she had recently started to experience small pruritic erythematous skin lesions involving her arms (figure 2), legs and chest. Application of lateral pressure to the
INTRODUCTION: With the wider therapeutic use of clear aligners the need to investigate the period... more INTRODUCTION: With the wider therapeutic use of clear aligners the need to investigate the periodontal health status and microbiome of clear aligners’ patients in comparison with users of fixed orthodontic has arisen and is the objective of this thesis. METHODS: A clinical periodontal evaluation was performed, followed by professional oral hygiene treatment on a patient under clear aligner treatment, another under fixed orthodontics and two controls that never received any orthodontic therapy. One week after, supragingival plaque, swabs from the orthodontic devices, and saliva samples were collected from each volunteer for further 16s sequencing and microbiome analysis. RESULTS: All participants have overall good oral hygiene. However, our results showed increases in supragingival plaque, higher number of probing depths greater than 3mm, higher number of bleeding sites on probing, and a higher amount of gingival recession in the subject treated with fixed orthodontics. A lower bacte...
The volume of life science publications, and therefore the underlying biomedical knowledge, are g... more The volume of life science publications, and therefore the underlying biomedical knowledge, are growing at a fast pace. However the manual literature analysis is a slow and painful task. Hence, text mining systems have been developed to automatically locate the relevant information contained in the literature. An essential step in text mining is named entity recognition, but the inherent complexity of biomedical entities, such as chemical compounds, makes it dicult to obtain good performances in this task. This thesis proposes methods capable to improve the current performance of chemical entity recognition from text. Hereby a case based method for recognizing chemical entities is proposed and the obtained evaluation results outperform the most widely used methods, based in dictionaries. A lexical similarity based chemical entity resolution method was also developed and allows an ecient mapping of the recognized entities to the ChEBI database. To improve the chemical entity identication results we developed a validation method that exploits the semantic relationships in ChEBI to measure the similarity between the entities found in the text, in order to discriminate between the correctly identied entities that can be validated and identication errors that should be discarded. A machine learning method for entity recognition error is also proposed, which can eectively nd recognition errors in rule based systems. The methods were integrated in a system capable of recognizing chemical entities in texts, map them to the ChEBI database, and provide evidence of validation or recognition error for the recognized entities.
In dental education, the anatomical sciences, which include gross anatomy, histology, embryology,... more In dental education, the anatomical sciences, which include gross anatomy, histology, embryology, and neuroanatomy, encompass an important component of the basic science curriculum. At Creighton University School of Dentistry, strength in anatomic science education has been coupled with a solid applicant pool to develop a novel Master of Science in Oral Biology, Anatomic Sciences track degree program. The program provides a heavy emphasis on developing teaching skills in predoctoral students as well as exposure to research processes to encourage the cohort to pursuing a career in academic dentistry. The individuals considered for this program are applicants for admission to the School of Dentistry that have not been accepted into the entering dental class for that year. The students undertake a two year curriculum, studying anatomic sciences with a special emphasis on teaching. The students also must complete a research project that requires a thesis. The students in the program are guaranteed acceptance to dental school upon successful completion of the program. After six years, the first ten students have received their Master of Science degrees and continued in dental school. The program is favorably viewed by the faculty and participating students. It is also considered successful by metrics. Nine of the ten graduates have said they would like to participate in academic dentistry in some capacity during their careers. Anat Sci Educ 00: 000-000.
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 1996
The age-related decline in growth hormone (GH) secretion has been largely attributed to age-relat... more The age-related decline in growth hormone (GH) secretion has been largely attributed to age-related degeneration of hypothalamic growth hormone-releasing hormone (GHRH)-producing neurons. GH decline has recently been linked to age-related bone changes in humans. Bone loss and decreased bone strength are common in aging rats and humans, but density of remaining mineral tissue is known to be increased. The effect of induced hypothalamic GHRH deficiency on bone was assessed, and similarities between bone changes encountered and those taking place in aging were identified. Female rats received monosodium glutamate (MSG) following birth, and they were euthanized at 19 weeks of age. Femurs from MSG-treated rats had greater mineral density (p < .05), greater mineral! matrix ratio (p < Ml), lower mineral apposition rate (p < .005), and lower bone formation rate (p < .05). These results suggest that hypothalamic GHRH decline plays a substantial role in the development of bone pathology similar to that observed in aging individuals.
A rare case of multiple enamel pearl formation is presented involving the maxillary molars in two... more A rare case of multiple enamel pearl formation is presented involving the maxillary molars in two siblings incidentally recognized during volumetric CT examination. Although the pathogenesis of ectopic enamel formation is not known, possible mechanisms to account for this phenomenon are discussed in the context of current knowledge regarding root genesis. The radiographic presentation of enamel pearls and its clinical significance is also discussed. The observation of multiple enamel pearls in two siblings raises the possibility of a hereditary association in the formation of enamel pearls.
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Papers by Neil Norton