Breast cancer research and treatment, Jan 13, 2017
The recent publication of the ACOSOG Z1031 trial results demonstrated that Ki-67 proliferation ma... more The recent publication of the ACOSOG Z1031 trial results demonstrated that Ki-67 proliferation marker-based neoadjuvant endocrine therapy response monitoring could be used for tailoring the use of adjuvant chemotherapy in ER+HER2-negative breast cancer patients. In this paper, we describe the development of the Ki-67 clinical trial assay used for this study. Ki-67 assay assessment focused on reproducing a 2.7% Ki-67 cut-point (CP) required for calculating the Preoperative Endocrine Prognostic Index and a 10% CP for poor endocrine therapy response identification within the first month of neoadjuvant endocrine treatment. Image analysis was assessed to increase the efficiency of the scoring process. Clinical outcome concordance for two independent Ki-67 scores was the primary performance metric. Discordant scores led to a triage approach where cases with complex histological features that software algorithms could not resolve were flagged for visual point counting (17%). The final Ki-6...
grenous changes in the setting of acute cholecystitis [7, 8]. The purpose of this study was twofo... more grenous changes in the setting of acute cholecystitis [7, 8]. The purpose of this study was twofold: first, to determine if gallbladder wall striations in patients with sonographic findings suspicious for acute cholecystitis are associated with gangrenous changes and certain histologic features; and, second, to determine if other sonographic or clinical (WBC count) findings are associated with gangrenous cholecystitis. Materials and Methods During a 4-year period, the names of 189 consecutive patients for whom the interpreting board-certified radiologist considered the sonographic findings suspicious for acute cholecystitis were prospectively recorded. The interpreting radiologists were either attending radiologists or fellows in the abdomen section of the radiology department. Sixty-eight patients who underwent cholecystectomies within 48 hours of
Breast cancer research and treatment, Jan 13, 2017
The recent publication of the ACOSOG Z1031 trial results demonstrated that Ki-67 proliferation ma... more The recent publication of the ACOSOG Z1031 trial results demonstrated that Ki-67 proliferation marker-based neoadjuvant endocrine therapy response monitoring could be used for tailoring the use of adjuvant chemotherapy in ER+HER2-negative breast cancer patients. In this paper, we describe the development of the Ki-67 clinical trial assay used for this study. Ki-67 assay assessment focused on reproducing a 2.7% Ki-67 cut-point (CP) required for calculating the Preoperative Endocrine Prognostic Index and a 10% CP for poor endocrine therapy response identification within the first month of neoadjuvant endocrine treatment. Image analysis was assessed to increase the efficiency of the scoring process. Clinical outcome concordance for two independent Ki-67 scores was the primary performance metric. Discordant scores led to a triage approach where cases with complex histological features that software algorithms could not resolve were flagged for visual point counting (17%). The final Ki-6...
grenous changes in the setting of acute cholecystitis [7, 8]. The purpose of this study was twofo... more grenous changes in the setting of acute cholecystitis [7, 8]. The purpose of this study was twofold: first, to determine if gallbladder wall striations in patients with sonographic findings suspicious for acute cholecystitis are associated with gangrenous changes and certain histologic features; and, second, to determine if other sonographic or clinical (WBC count) findings are associated with gangrenous cholecystitis. Materials and Methods During a 4-year period, the names of 189 consecutive patients for whom the interpreting board-certified radiologist considered the sonographic findings suspicious for acute cholecystitis were prospectively recorded. The interpreting radiologists were either attending radiologists or fellows in the abdomen section of the radiology department. Sixty-eight patients who underwent cholecystectomies within 48 hours of
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Papers by Neha Dahiya