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Murat Hokelek

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Murat Hokelek, MD, PhD Uludag University Medical School, MD degree, 1989. Ankara University Medical School, PhD degree, 1996. Ondokuz Mayıs University Medical School, Professor of Microbiology, 2009. Integrative and Functional Medicine Lecturer, 2021.

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School of the Art Institute of Chicago

University Of Kolkata

Vrije Universiteit Amsterdam

Middle East Technical University

Chosun University

Lund University

Prof. Dr. Turan Paker

Pamukkale University

Steven L Thorne

Portland State University

Edwin-Francisco Herrera-Paz

Universidad Catolica de Honduras

Irina Malkina-Pykh

Saint-Petersburg State University

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Papers by Murat Hokelek

Effects of acetic acid on the viability of <i>Ascaris lumbricoides</i> eggs

Saudi Medical Journal, Mar 1, 2016

Objectives: To investigate the effects of acetic acid on durable Ascaris lumbricoides (A. lumbric... more

Farelerde Deneysel Toxoplasma gondii Enfeksiyonunun Patogenezisinde Hücresel Prion Protein ve Doppel Protein’in Rollerinin Araştırılması

[A practical volume controlled bleeding method in animal hemorhagic shock model]

PubMed, Apr 1, 2003

The bleeding method is the most widely used technique in volume controlled hemorrhagic shock mode... more The bleeding method is the most widely used technique in volume controlled hemorrhagic shock model that was described as withdrawing blood by an heparinized syringe from veins of laboratory animals. However the difficulty in establishing a constant bleeding rate and volume at a desired time is the major disadvantage of this technique. This disadvantage may also lead to the mortality during the exsanguinating phase due to inconstant bleeding rate. Reversely connected infusion pump that was described in this report is a useful and practical method to withdraw blood with predetermined bleeding volume and rate. The described method can easily be applied to various pathophysiological and metabolic studies on acute blood loss.

Kronik Böbrek Yetmezliği Nedeni ile Diyaliz Yapılan Çocuklarda Helikobakter Pilori Enfeksiyonu

Haseki Tıp Bülteni, Mar 15, 2013

Özet Amaç: Bu çalışmada, kronik böbrek yetmezlikli çocuk hastalarda gastrointestinal semptomlar i... more Özet Amaç: Bu çalışmada, kronik böbrek yetmezlikli çocuk hastalarda gastrointestinal semptomlar ile Helicobacter pilori (HP) enfeksiyonu sıklığınının araştırılması planlanmıştır. Yöntem: Çalışmaya kronik böbrek yetmezlikli 33 hasta ile yaş ve cinsiyeti aynı olan sağlıklı kontroller dahil edildi. Hastaların demografik, serolojik ve endoskopik bulguları incelendi ve gastrointestinal sistem semptomları sorgulandı. Çalışmaya dahil edilen tüm hasta ve kontrol grubundan serumda HP-IgG düzeyi çalışıldı. Bulgular: Yirmi yedi periton diyalizi, altı hemodiyaliz hastası çalışmaya dahil edildi. HP seropozitifliği hasta grubunda %51.5, kontrol grubunda %60.6 olarak tespit edildi (p=0.46). Yirmi hastaya özefagogastroduodenoskopi uygulandı ve hastaların %30'unda dokuda HP tespit edildi. Dispepsi tüm hastaların %42.2'sinde belirlendi. Dispeptik hastaların %57.1'inde HP seropozitifliği, %36.4'ünde dokuda HP tespit edildi. Pozitif serolojisi olan hastaların %60'ında dokuda HP gösterilirken, seronegatif olan sadece bir olguda dokuda HP tespit edildi. Sonuç: Toplumumuzda sık görülen ve kolonizasyonu çocukluk yaşlarında başlayan HP enfeksiyonu, çalışmamızda da serolojik olarak hem hasta hem de kontrol grubunda yüksek bulunmuştur. Her biri transplantasyon adayı olan bu hastalar için asemptomatik olsa bile enfeksiyonun saptanması ve tedavisi önem taşımaktadır. (Ha se ki T›p Bül te ni 2013; 51: 1-4) Anah tar Ke li me ler: Helicobakter pylori, çocuk, diyaliz Abs tract Aim: We aimed to investigate the frequency of gastrointestinal symptoms and Helicobacter pylori (HP) infection in children with chronic renal failure. Methods: The study involved 33 patients with end-stage renal disease and 33 age-and sex-matched healthy controls. Serological, endoscopic and demographic features of the patients were determined and gastrointestinal symptoms were questioned. HP IgG levels were evaluated in all patients and controls. Results: Twenty-seven peritoneal dialysis and 6 hemodialysis patients were included in the study. The HP seropositivity was 51.5% and 60.6% in uremic children and normal controls, respectively (p=0.46). Twenty patients underwent esophagogastroduodenoscopy and HP was detected in 30% of them. Dyspepsia was observed in 42.4% of all patients. In patients with dyspepsia, HP seropositivity rate was 57.1% and biopsy proven HP was 36.4%. Biopsy proven HP was determined in 60% of patients with positive serology and in one with negative serology. Conclusion: HP infection, which is common in our population and begins in early childhood, is found to be frequent in both patient and healthy groups. Even if asymptomatic, it is very important to determine and treat this infection, in these patients who are potential transplant candidates.

[Is Blastocystis hominis an opportunist agent?]

PubMed, 2007

Despite its high prevalence throughout the world, major issues about Blastocystis hominis remain ... more Despite its high prevalence throughout the world, major issues about Blastocystis hominis remain unresolved, including fundamental areas such as taxonomy and pathogenicity. Sequences of the SSUrRNA gene place Blastocystis in the stramenophiles. Analysis of the elongation factor 1-alpha gene, however, indicates similarity to Entamoeba histolytica. There is considerable morphological variability and karyotype diversity, and it appears that more than one species is present in humans and animals. In culture, three major forms predominate: vacuolar, granular, and ameboid. The vacuolated form (usually 10 to 30 mum) was most frequently detected in fecal specimens. The prevalence of Blastocystosis in humans appears to be higher in developing countries (30% to 50%) than in developed countries (1.5% to 10%), and has been associated with travel. B. hominis is the most common parasite isolated from stool specimens in symptomatic and asymptomatic persons in a variety of settings. Isolates resembling B. hominis have been described in a variety of mammals, birds, reptiles, and even insects. The significance of this human infection is uncertain.

İnsan ve köpeklerden alınan klinik örneklere Leishmaniasis tanısı için polimeraz zincir reaksiyonu (FZR) uygulanması

Türkiye parazitoloji dergisi, 2002

Blastocystis hominis fırsatçı bir patojen mi

Türkiye parazitoloji dergisi, 2007

... Funda DOĞRUMAN AL 1 , Murat HÖKELEK 2. ... ile çoğalması, yavaş hareket eden pseudopodlarının... more

In Vivo Efficacy of Drugs against <i>Toxoplasma gondii</i> Combined with Immunomodulators

Japanese Journal of Infectious Diseases, 2016

The aim of this study is to evaluate the effects of pyrimethamine (PYR) and sulfadiazine (SDZ) co... more The aim of this study is to evaluate the effects of pyrimethamine (PYR) and sulfadiazine (SDZ) combined with levamisole and echinacea on the survival of mice infected with Toxoplasma gondii. For this, we used 99 specific pathogen-free BALB/c mice. All the mice were infected intraperitoneally with 10 5 T. gondii tachyzoites and were divided into 11 groups, each including 9 mice. Except for the control group, oral treatment was initiated in all groups 24 h post infection and was continued for 10 days. The treatment regimen included dual combinations of PYR (dose, 6.25 and 12.5 mg/kg/day) and SDZ (dose, 100 and 200 mg/kg/day), triple combinations of PYR ＋ SDZ, and levamisole (dose, 2.5 mg/kg/day) or echinacea (dose, 130 and 260 mg/kg/day) and echinacea alone (dose, 130 and 260 mg/kg/day). We observed that an effective dose of the combination of PYR ＋ SDZ and levamisole resulted in a statistically significant increase in the survival rate from 33.3z to 88.9z. Similarly, half the dose of this combination resulted an increase in the survival rate from 0z to 44.4z (p ＜ 0.05). Survival rate also increased in the groups treated with the combinations including echinacea; however, the difference did not reach statistical significance. The triple combination of PYR-SDZ-levamisole could be an alternative treatment option in case of infections caused by T. gondii.

Prevalence of antibodies to Toxoplasma gondii infection in humans and domestic animals in Samsun province, Turkey

Tropical Animal Health and Production, Nov 27, 2007

Toxoplasmosis is one of the more common parasitic zoonoses world-wide. It is caused by T. gondii ... more Toxoplasmosis is one of the more common parasitic zoonoses world-wide. It is caused by T. gondii which is a facultatively heteroxenous protozoan that has developed several potential routes of transmission within and between different host species (Tenter et al. 2000; Sroka 2001). Humans become infected with T. gondii mainly by ingesting uncooked meat containing viable tissue cysts or by ingesting food or water contaminated with oocysts from the faeces of infected cats (Dubey 2004). Transmission may also occur via tachyzoites contained in blood products, tissue transplants or unpasteurised milk (Dubey et al. 1985; Tenter et al. 2000). Apart from causing significant economic losses in animal husbandry, T. gondii also causes toxoplasmosis in humans in Turkey through the consumption of rare or raw meat of infected sheep and cattle (Altintas et al. 1997a,b; Sevgili et al. 2005). While the parasite has been frequently isolated from sheep meat, it is not so readily isolated from cattle meat (Dubey 1992; Redondo and Innes 1997). Cattle, like deer and horses, are susceptible to infection but are resistant to disease induced by T. gondii. Sheep with toxoplasmosis do not display specific clinical signs but it causes significant economic losses due to prenatal death and abortion. A broad range of serological tests has been developed to diagnose infections with T. gondii in intermediate hosts Trop Anim Health Prod (2008) 40:311–315 DOI 10.1007/s11250-007-9101-6

Strongyloides stercoralis hyperinfection in a patient with rheumatoid arthritis and bronchial asthma: a case report

Annals of Clinical Microbiology and Antimicrobials, 2010

Objective: Strongyloides stercoralis is a soil-transmitted intestinal nematode that has been esti... more Objective: Strongyloides stercoralis is a soil-transmitted intestinal nematode that has been estimated to infect at least 60 million people, especially in tropical and subtropical regions. Strongyloides infection has been described in immunosupressed patients with lymphoma, rheumatoid arthritis, diabetes mellitus etc. Our case who has rheumatoid arthritis (RA) and bronchial asthma was treated with low dose steroids and methotrexate. Methods: A 68 year old woman has bronchial asthma for 55 years and also diagnosed RA 7 years ago. She received immunusupressive agents including methotrexate and steroids. On admission at hospital, she was on deflazacort 5 mg/day and methotrexate 15 mg/week. On her physical examination, she was afebrile, had rhonchi and mild epigastric tenderness. She had joint deformities at metacarpophalengeal joints and phalanges but no active arthritis finding. Results: Oesophagogastroduodenoscopy was performed and it showed hemorrhagic focus at bulbus. Gastric biopsy obtained and showed evidence of S.Stercoralis infection. Stool and sputum parasitological examinations were also all positive for S.stercoralis larvae. Chest radiography result had no pathologic finding. Albendazole 400 mg/day was started for 23 days. After the ivermectin was retrieved, patient was treated with oral ivermectin 200 μg once a day for 3 days. On her outpatient control at 15th day, stool and sputum samples were all negative for parasites. Conclusion: S.stercoralis may cause mortal diseases in patients. Immunosupression frequently causes disseminated infections. Many infected patients are completely asymptomatic. Although it is important to detect latent S. stercoralis infections before administering chemotherapy or before the onset of immunosuppression in patients at risk, a specific and sensitive diagnostic test is lacking. In immunosupressed patients, to detect S.stercoralis might help to have the patient survived and constitute the exact therapy.

A case of severe babesiosis treated successfully with exchange transfusion

International Journal of Infectious Diseases, Sep 1, 2015

Ülseratif Kolitli Bir Hastada Entamoeba Histolytica Ve Strongyloides Stercoralis Infeksiyonu

Flora infeksiyon hastalıkları ve klinik mikrobiyoloji dergisi, 1998

Meninjit ve ensefalit bulguları ile karakterize bir lyme meninjiti olgusu

İnfeksiyon Dergisi, 2002

Özet Lyme hastalığı bir çok hastalığı taklit edebileceğinden tanısı güçtür. Tanı; karakteristik k... more Özet Lyme hastalığı bir çok hastalığı taklit edebileceğinden tanısı güçtür. Tanı; karakteristik klinik bulgular, endemik alanda bulunma ve seroloji ile konur. Semptom ve bulgular spesifik olmadığında klinik deneyim çok öne çıkmaktadır. Akut infeksiyonun tanısında serolojik ...

The in vitro effect of ivermectin on the protoscolices of Echinococcus granulosus

Türkiye parazitoloji dergisi, 2000

An experimental study to sterilize medicinal leeches

European Journal of Plastic Surgery, Mar 15, 2002

Leeches are widely used to treat venous congestion in microvascular replantation, free and conven... more Leeches are widely used to treat venous congestion in microvascular replantation, free and conventional flap surgery, and traumatology. The leeches require to be in full contact with the wound sites and this results in the contamination of the host with the leech's bacterial flora. Empirical prophylactic antibiotic administration to the patient to eradicate the flora of leeches before the application might be reasonable. The aim of this study was to sterilize or at least to reduce the number of colonies of the bacteria on Hirudo medicinalis. The leeches were immersed in several antibiotic solutions and the final results were studied. However, we failed to completely eliminate the bacteria from all leeches, but statistically significant cleaning was obtained with the combination of ciprofloxacin and chloramphenicol. The immersion of leeches before application to the patient with the predetermined antibiotic agents regionally may be beneficial to prevent invasive infection of the patient.

Re: Nonsurgical delay of cutaneous flaps using the flash lamp pumped pulsed dye laser

PubMed, Nov 1, 2000

Ivermectin used in percutaneous drug injection method for the treatment of liver hydatid disease in sheep

Gastroenterology, Apr 1, 2002

The effect of albendazole on the prevention of secondary hydatidosis

PubMed, Feb 26, 2000

Background/aims: Secondary hydatidosis and recurrence are serious complications in hydatid surger... more Background/aims: Secondary hydatidosis and recurrence are serious complications in hydatid surgery. Although medical treatment and current surgical techniques are more effective in the prevention of cyst formation resulting from spillage of cystic liquid, secondary hydatidosis is still surgically important. Albendazole, a derivative of benzoimidazole, is the most commonly used drug in the medical treatment of echinococcosis. The effectiveness of pre-operative prolonged or single dose applications is supported by the literature. Methodology: Twenty-two cases of hepatic hydatidosis are evaluated and treated by surgery. Perioperative albendazole treatment was given in a dose of 12-15 mg/kg/day in 4 divided doses. The treatment began 5-20 days before the surgery and continued 3-7 months in a cyclic monthly form, until latex agglutination tests were negative. In the postoperative period, hematological, ultrasonography and computed tomography scan evaluation was carried out. The follow-up period for 21 patients was 6-31 months (mean: 20.52 months). Results: There was no secondary hydatidosis, recurrence or mortality in this study. Early and late morbidity rates were 4.54% and 13.63% respectively. Conclusions: Our results support that perioperative albendazole treatment is effective in the prevention of secondary hydatidosis.

Rattus Norvegicus Acting as Reservoir of Leptospira interrogans in the Middle Black Sea Region of Turkey, as Evidenced by PCR and Presence of Serum Antibodies to Leptospira Strain

Scandinavian Journal of Infectious Diseases, 2001

Azithromycin activity and pathological assessment in experimental toxoplasmosis

Parasitology International, Aug 1, 1998

Effects of acetic acid on the viability of <i>Ascaris lumbricoides</i> eggs

Saudi Medical Journal, Mar 1, 2016

Objectives: To investigate the effects of acetic acid on durable Ascaris lumbricoides (A. lumbric... more

Farelerde Deneysel Toxoplasma gondii Enfeksiyonunun Patogenezisinde Hücresel Prion Protein ve Doppel Protein’in Rollerinin Araştırılması

[A practical volume controlled bleeding method in animal hemorhagic shock model]

PubMed, Apr 1, 2003

The bleeding method is the most widely used technique in volume controlled hemorrhagic shock mode... more The bleeding method is the most widely used technique in volume controlled hemorrhagic shock model that was described as withdrawing blood by an heparinized syringe from veins of laboratory animals. However the difficulty in establishing a constant bleeding rate and volume at a desired time is the major disadvantage of this technique. This disadvantage may also lead to the mortality during the exsanguinating phase due to inconstant bleeding rate. Reversely connected infusion pump that was described in this report is a useful and practical method to withdraw blood with predetermined bleeding volume and rate. The described method can easily be applied to various pathophysiological and metabolic studies on acute blood loss.

Kronik Böbrek Yetmezliği Nedeni ile Diyaliz Yapılan Çocuklarda Helikobakter Pilori Enfeksiyonu

Haseki Tıp Bülteni, Mar 15, 2013

Özet Amaç: Bu çalışmada, kronik böbrek yetmezlikli çocuk hastalarda gastrointestinal semptomlar i... more Özet Amaç: Bu çalışmada, kronik böbrek yetmezlikli çocuk hastalarda gastrointestinal semptomlar ile Helicobacter pilori (HP) enfeksiyonu sıklığınının araştırılması planlanmıştır. Yöntem: Çalışmaya kronik böbrek yetmezlikli 33 hasta ile yaş ve cinsiyeti aynı olan sağlıklı kontroller dahil edildi. Hastaların demografik, serolojik ve endoskopik bulguları incelendi ve gastrointestinal sistem semptomları sorgulandı. Çalışmaya dahil edilen tüm hasta ve kontrol grubundan serumda HP-IgG düzeyi çalışıldı. Bulgular: Yirmi yedi periton diyalizi, altı hemodiyaliz hastası çalışmaya dahil edildi. HP seropozitifliği hasta grubunda %51.5, kontrol grubunda %60.6 olarak tespit edildi (p=0.46). Yirmi hastaya özefagogastroduodenoskopi uygulandı ve hastaların %30'unda dokuda HP tespit edildi. Dispepsi tüm hastaların %42.2'sinde belirlendi. Dispeptik hastaların %57.1'inde HP seropozitifliği, %36.4'ünde dokuda HP tespit edildi. Pozitif serolojisi olan hastaların %60'ında dokuda HP gösterilirken, seronegatif olan sadece bir olguda dokuda HP tespit edildi. Sonuç: Toplumumuzda sık görülen ve kolonizasyonu çocukluk yaşlarında başlayan HP enfeksiyonu, çalışmamızda da serolojik olarak hem hasta hem de kontrol grubunda yüksek bulunmuştur. Her biri transplantasyon adayı olan bu hastalar için asemptomatik olsa bile enfeksiyonun saptanması ve tedavisi önem taşımaktadır. (Ha se ki T›p Bül te ni 2013; 51: 1-4) Anah tar Ke li me ler: Helicobakter pylori, çocuk, diyaliz Abs tract Aim: We aimed to investigate the frequency of gastrointestinal symptoms and Helicobacter pylori (HP) infection in children with chronic renal failure. Methods: The study involved 33 patients with end-stage renal disease and 33 age-and sex-matched healthy controls. Serological, endoscopic and demographic features of the patients were determined and gastrointestinal symptoms were questioned. HP IgG levels were evaluated in all patients and controls. Results: Twenty-seven peritoneal dialysis and 6 hemodialysis patients were included in the study. The HP seropositivity was 51.5% and 60.6% in uremic children and normal controls, respectively (p=0.46). Twenty patients underwent esophagogastroduodenoscopy and HP was detected in 30% of them. Dyspepsia was observed in 42.4% of all patients. In patients with dyspepsia, HP seropositivity rate was 57.1% and biopsy proven HP was 36.4%. Biopsy proven HP was determined in 60% of patients with positive serology and in one with negative serology. Conclusion: HP infection, which is common in our population and begins in early childhood, is found to be frequent in both patient and healthy groups. Even if asymptomatic, it is very important to determine and treat this infection, in these patients who are potential transplant candidates.

[Is Blastocystis hominis an opportunist agent?]

PubMed, 2007

Despite its high prevalence throughout the world, major issues about Blastocystis hominis remain ... more Despite its high prevalence throughout the world, major issues about Blastocystis hominis remain unresolved, including fundamental areas such as taxonomy and pathogenicity. Sequences of the SSUrRNA gene place Blastocystis in the stramenophiles. Analysis of the elongation factor 1-alpha gene, however, indicates similarity to Entamoeba histolytica. There is considerable morphological variability and karyotype diversity, and it appears that more than one species is present in humans and animals. In culture, three major forms predominate: vacuolar, granular, and ameboid. The vacuolated form (usually 10 to 30 mum) was most frequently detected in fecal specimens. The prevalence of Blastocystosis in humans appears to be higher in developing countries (30% to 50%) than in developed countries (1.5% to 10%), and has been associated with travel. B. hominis is the most common parasite isolated from stool specimens in symptomatic and asymptomatic persons in a variety of settings. Isolates resembling B. hominis have been described in a variety of mammals, birds, reptiles, and even insects. The significance of this human infection is uncertain.

İnsan ve köpeklerden alınan klinik örneklere Leishmaniasis tanısı için polimeraz zincir reaksiyonu (FZR) uygulanması

Türkiye parazitoloji dergisi, 2002

Blastocystis hominis fırsatçı bir patojen mi

Türkiye parazitoloji dergisi, 2007

... Funda DOĞRUMAN AL 1 , Murat HÖKELEK 2. ... ile çoğalması, yavaş hareket eden pseudopodlarının... more

In Vivo Efficacy of Drugs against <i>Toxoplasma gondii</i> Combined with Immunomodulators

Japanese Journal of Infectious Diseases, 2016

The aim of this study is to evaluate the effects of pyrimethamine (PYR) and sulfadiazine (SDZ) co... more The aim of this study is to evaluate the effects of pyrimethamine (PYR) and sulfadiazine (SDZ) combined with levamisole and echinacea on the survival of mice infected with Toxoplasma gondii. For this, we used 99 specific pathogen-free BALB/c mice. All the mice were infected intraperitoneally with 10 5 T. gondii tachyzoites and were divided into 11 groups, each including 9 mice. Except for the control group, oral treatment was initiated in all groups 24 h post infection and was continued for 10 days. The treatment regimen included dual combinations of PYR (dose, 6.25 and 12.5 mg/kg/day) and SDZ (dose, 100 and 200 mg/kg/day), triple combinations of PYR ＋ SDZ, and levamisole (dose, 2.5 mg/kg/day) or echinacea (dose, 130 and 260 mg/kg/day) and echinacea alone (dose, 130 and 260 mg/kg/day). We observed that an effective dose of the combination of PYR ＋ SDZ and levamisole resulted in a statistically significant increase in the survival rate from 33.3z to 88.9z. Similarly, half the dose of this combination resulted an increase in the survival rate from 0z to 44.4z (p ＜ 0.05). Survival rate also increased in the groups treated with the combinations including echinacea; however, the difference did not reach statistical significance. The triple combination of PYR-SDZ-levamisole could be an alternative treatment option in case of infections caused by T. gondii.

Prevalence of antibodies to Toxoplasma gondii infection in humans and domestic animals in Samsun province, Turkey

Tropical Animal Health and Production, Nov 27, 2007

Toxoplasmosis is one of the more common parasitic zoonoses world-wide. It is caused by T. gondii ... more Toxoplasmosis is one of the more common parasitic zoonoses world-wide. It is caused by T. gondii which is a facultatively heteroxenous protozoan that has developed several potential routes of transmission within and between different host species (Tenter et al. 2000; Sroka 2001). Humans become infected with T. gondii mainly by ingesting uncooked meat containing viable tissue cysts or by ingesting food or water contaminated with oocysts from the faeces of infected cats (Dubey 2004). Transmission may also occur via tachyzoites contained in blood products, tissue transplants or unpasteurised milk (Dubey et al. 1985; Tenter et al. 2000). Apart from causing significant economic losses in animal husbandry, T. gondii also causes toxoplasmosis in humans in Turkey through the consumption of rare or raw meat of infected sheep and cattle (Altintas et al. 1997a,b; Sevgili et al. 2005). While the parasite has been frequently isolated from sheep meat, it is not so readily isolated from cattle meat (Dubey 1992; Redondo and Innes 1997). Cattle, like deer and horses, are susceptible to infection but are resistant to disease induced by T. gondii. Sheep with toxoplasmosis do not display specific clinical signs but it causes significant economic losses due to prenatal death and abortion. A broad range of serological tests has been developed to diagnose infections with T. gondii in intermediate hosts Trop Anim Health Prod (2008) 40:311–315 DOI 10.1007/s11250-007-9101-6

Strongyloides stercoralis hyperinfection in a patient with rheumatoid arthritis and bronchial asthma: a case report

Annals of Clinical Microbiology and Antimicrobials, 2010

Objective: Strongyloides stercoralis is a soil-transmitted intestinal nematode that has been esti... more Objective: Strongyloides stercoralis is a soil-transmitted intestinal nematode that has been estimated to infect at least 60 million people, especially in tropical and subtropical regions. Strongyloides infection has been described in immunosupressed patients with lymphoma, rheumatoid arthritis, diabetes mellitus etc. Our case who has rheumatoid arthritis (RA) and bronchial asthma was treated with low dose steroids and methotrexate. Methods: A 68 year old woman has bronchial asthma for 55 years and also diagnosed RA 7 years ago. She received immunusupressive agents including methotrexate and steroids. On admission at hospital, she was on deflazacort 5 mg/day and methotrexate 15 mg/week. On her physical examination, she was afebrile, had rhonchi and mild epigastric tenderness. She had joint deformities at metacarpophalengeal joints and phalanges but no active arthritis finding. Results: Oesophagogastroduodenoscopy was performed and it showed hemorrhagic focus at bulbus. Gastric biopsy obtained and showed evidence of S.Stercoralis infection. Stool and sputum parasitological examinations were also all positive for S.stercoralis larvae. Chest radiography result had no pathologic finding. Albendazole 400 mg/day was started for 23 days. After the ivermectin was retrieved, patient was treated with oral ivermectin 200 μg once a day for 3 days. On her outpatient control at 15th day, stool and sputum samples were all negative for parasites. Conclusion: S.stercoralis may cause mortal diseases in patients. Immunosupression frequently causes disseminated infections. Many infected patients are completely asymptomatic. Although it is important to detect latent S. stercoralis infections before administering chemotherapy or before the onset of immunosuppression in patients at risk, a specific and sensitive diagnostic test is lacking. In immunosupressed patients, to detect S.stercoralis might help to have the patient survived and constitute the exact therapy.

A case of severe babesiosis treated successfully with exchange transfusion

International Journal of Infectious Diseases, Sep 1, 2015

Ülseratif Kolitli Bir Hastada Entamoeba Histolytica Ve Strongyloides Stercoralis Infeksiyonu

Flora infeksiyon hastalıkları ve klinik mikrobiyoloji dergisi, 1998

Meninjit ve ensefalit bulguları ile karakterize bir lyme meninjiti olgusu

İnfeksiyon Dergisi, 2002

Özet Lyme hastalığı bir çok hastalığı taklit edebileceğinden tanısı güçtür. Tanı; karakteristik k... more Özet Lyme hastalığı bir çok hastalığı taklit edebileceğinden tanısı güçtür. Tanı; karakteristik klinik bulgular, endemik alanda bulunma ve seroloji ile konur. Semptom ve bulgular spesifik olmadığında klinik deneyim çok öne çıkmaktadır. Akut infeksiyonun tanısında serolojik ...

The in vitro effect of ivermectin on the protoscolices of Echinococcus granulosus

Türkiye parazitoloji dergisi, 2000

An experimental study to sterilize medicinal leeches

European Journal of Plastic Surgery, Mar 15, 2002

Leeches are widely used to treat venous congestion in microvascular replantation, free and conven... more Leeches are widely used to treat venous congestion in microvascular replantation, free and conventional flap surgery, and traumatology. The leeches require to be in full contact with the wound sites and this results in the contamination of the host with the leech's bacterial flora. Empirical prophylactic antibiotic administration to the patient to eradicate the flora of leeches before the application might be reasonable. The aim of this study was to sterilize or at least to reduce the number of colonies of the bacteria on Hirudo medicinalis. The leeches were immersed in several antibiotic solutions and the final results were studied. However, we failed to completely eliminate the bacteria from all leeches, but statistically significant cleaning was obtained with the combination of ciprofloxacin and chloramphenicol. The immersion of leeches before application to the patient with the predetermined antibiotic agents regionally may be beneficial to prevent invasive infection of the patient.

Re: Nonsurgical delay of cutaneous flaps using the flash lamp pumped pulsed dye laser

PubMed, Nov 1, 2000

Ivermectin used in percutaneous drug injection method for the treatment of liver hydatid disease in sheep

Gastroenterology, Apr 1, 2002

The effect of albendazole on the prevention of secondary hydatidosis

PubMed, Feb 26, 2000

Background/aims: Secondary hydatidosis and recurrence are serious complications in hydatid surger... more Background/aims: Secondary hydatidosis and recurrence are serious complications in hydatid surgery. Although medical treatment and current surgical techniques are more effective in the prevention of cyst formation resulting from spillage of cystic liquid, secondary hydatidosis is still surgically important. Albendazole, a derivative of benzoimidazole, is the most commonly used drug in the medical treatment of echinococcosis. The effectiveness of pre-operative prolonged or single dose applications is supported by the literature. Methodology: Twenty-two cases of hepatic hydatidosis are evaluated and treated by surgery. Perioperative albendazole treatment was given in a dose of 12-15 mg/kg/day in 4 divided doses. The treatment began 5-20 days before the surgery and continued 3-7 months in a cyclic monthly form, until latex agglutination tests were negative. In the postoperative period, hematological, ultrasonography and computed tomography scan evaluation was carried out. The follow-up period for 21 patients was 6-31 months (mean: 20.52 months). Results: There was no secondary hydatidosis, recurrence or mortality in this study. Early and late morbidity rates were 4.54% and 13.63% respectively. Conclusions: Our results support that perioperative albendazole treatment is effective in the prevention of secondary hydatidosis.

Rattus Norvegicus Acting as Reservoir of Leptospira interrogans in the Middle Black Sea Region of Turkey, as Evidenced by PCR and Presence of Serum Antibodies to Leptospira Strain

Scandinavian Journal of Infectious Diseases, 2001

Azithromycin activity and pathological assessment in experimental toxoplasmosis

Parasitology International, Aug 1, 1998