Papers by Misael Fernandez
International Congress Series, 2006
Plant material from Rheum palmatum (root) and Frangula alnus (bark) were tested to study their ef... more Plant material from Rheum palmatum (root) and Frangula alnus (bark) were tested to study their effects as feed additives to decrease methane production from ruminal fermentation of a forage-based diet, using a rumen simulating fermenter (RUSITEC). Sixteen fermentation units (vessels) were set up for the experiment that lasted 19 days. Each vessel was fed 16 g of a mixed substrate consisting of 800 g/kg forage and 200 g/kg concentrate. Treatments were assigned to the experimental units (vessels) according to a completely random design. Treatment vessels were supplied with either milled root from R. palmatum or milled bark from F. alnus (four vessels per plant species) added at 1 g/day (62.5 mg additive/g substrate or 1.66 g/l in the fermenter). Another four vessels received 12 AM of monensin (positive control) added to the basal diet, and the remaining four vessels were controls (no additive). Monensin induced changes that were coincident with those usually reported in the literature. R. palmatum caused a significant decrease in methane production, associated with changes in the VFA production pattern. F. alnus altered slightly fermentation parameters. D
International Congress Series, 2006
Plant material from Rheum palmatum (root) and Frangula alnus (bark) were tested to study their ef... more Plant material from Rheum palmatum (root) and Frangula alnus (bark) were tested to study their effects as feed additives to decrease methane production from ruminal fermentation of a forage-based diet, using a rumen simulating fermenter (RUSITEC). Sixteen fermentation units (vessels) were set up for the experiment that lasted 19 days. Each vessel was fed 16 g of a mixed substrate consisting of 800 g/kg forage and 200 g/kg concentrate. Treatments were assigned to the experimental units (vessels) according to a completely random design. Treatment vessels were supplied with either milled root from R. palmatum or milled bark from F. alnus (four vessels per plant species) added at 1 g/day (62.5 mg additive/g substrate or 1.66 g/l in the fermenter). Another four vessels received 12 AM of monensin (positive control) added to the basal diet, and the remaining four vessels were controls (no additive). Monensin induced changes that were coincident with those usually reported in the literature. R. palmatum caused a significant decrease in methane production, associated with changes in the VFA production pattern. F. alnus altered slightly fermentation parameters. D
International Congress Series, 2006
Plant material from Rheum palmatum (root) and Frangula alnus (bark) were tested to study their ef... more Plant material from Rheum palmatum (root) and Frangula alnus (bark) were tested to study their effects as feed additives to decrease methane production from ruminal fermentation of a forage-based diet, using a rumen simulating fermenter (RUSITEC). Sixteen fermentation units (vessels) were set up for the experiment that lasted 19 days. Each vessel was fed 16 g of a mixed substrate consisting of 800 g/kg forage and 200 g/kg concentrate. Treatments were assigned to the experimental units (vessels) according to a completely random design. Treatment vessels were supplied with either milled root from R. palmatum or milled bark from F. alnus (four vessels per plant species) added at 1 g/day (62.5 mg additive/g substrate or 1.66 g/l in the fermenter). Another four vessels received 12 AM of monensin (positive control) added to the basal diet, and the remaining four vessels were controls (no additive). Monensin induced changes that were coincident with those usually reported in the literature. R. palmatum caused a significant decrease in methane production, associated with changes in the VFA production pattern. F. alnus altered slightly fermentation parameters. D
International Congress Series, 2006
Plant material from Rheum palmatum (root) and Frangula alnus (bark) were tested to study their ef... more Plant material from Rheum palmatum (root) and Frangula alnus (bark) were tested to study their effects as feed additives to decrease methane production from ruminal fermentation of a forage-based diet, using a rumen simulating fermenter (RUSITEC). Sixteen fermentation units (vessels) were set up for the experiment that lasted 19 days. Each vessel was fed 16 g of a mixed substrate consisting of 800 g/kg forage and 200 g/kg concentrate. Treatments were assigned to the experimental units (vessels) according to a completely random design. Treatment vessels were supplied with either milled root from R. palmatum or milled bark from F. alnus (four vessels per plant species) added at 1 g/day (62.5 mg additive/g substrate or 1.66 g/l in the fermenter). Another four vessels received 12 AM of monensin (positive control) added to the basal diet, and the remaining four vessels were controls (no additive). Monensin induced changes that were coincident with those usually reported in the literature. R. palmatum caused a significant decrease in methane production, associated with changes in the VFA production pattern. F. alnus altered slightly fermentation parameters. D
![Research paper thumbnail of 81] EFFICACY AND SAFETY OF L-ORNITHINE-L-ASPARTATE (LOLA) ADMINISTRATION. OPEN LABEL RANDOMIZED CONTROLLED TRIAL VERSUS LACTULOSE IN CIRRHOTIC PATIENTS WITH HYPERAMMONEMIC HEPATIC ENCEPHALOPATHY](https://attachments.academia-assets.com/47496828/thumbnails/1.jpg)
Journal of Hepatology, 2007
Despite steady progress in therapeutics of liver disease, portal systemic encephalopathy remains ... more Despite steady progress in therapeutics of liver disease, portal systemic encephalopathy remains to be a great challenge for clinicians because of the heterogeneity of neuropsychiatric symptoms, multiple risk factors and complexity on achieving a sustained response. We aimed to evaluate the efficacy of L-Ornithin, L-Aspartate versus lactulose in Mexican patients with hyperammonemic hepatic encephalopathy. A total of 20 patients were randomly allocated to receive either lactulose (n = 10) or L-ornithine -L-aspartate (n = 10) for 2 weeks. At baseline, patients of both groups were comparable in age (64 ± 7 versus 60 ± 6) and degree of hepatic failure according to the Child-Pugh scale (9.2 ± 1.3 versus 9.2 ± 1.1). A significant decrease in ammonia levels was observed both in the lactulose group (120.4 ± 8.1 versus 91.4 ± 10, p < 0.05) and in the LOLA group (141.6 ± 9.1 versus 96.9 ± 9.3, p < 0.05). Moreover, in patients who received LOLA a significant improvement was observed in mental status (1.0 ± 0.14 versus 0.4 ± 0.16, p < 0.05), Number Connection Test (184 ± 43 versus 88 ± 7, p < 0.05), asterixis (14.6 ± 2.8 versus 6.7 ± 1.5, p < 0.05), as well as EEG findings (6.8 ± 0.6 versus 8.1 ± 0.2 cycles per second, p < 0.05). Compliance with study medications was similar between the lactulose group (94%) and the LOLA group (100%). No serious adverse events were reported in the two groups; however, in the lactulose group an increase in the number of weekly defecations was reported, as well as a higher incidence of abdominal pain or flatulence. Finally, both patient groups reported an improvement in the Visual Analogue Scale for EuroQol index (51.1 ± 24.1 versus 61.5 ± 15.8, p < 0.05, in the lactulose group; 56.5 ± 24.5 versus 70 ± 19.4, p < 0.05, in the LOLA group). In conclusion, oral administration of lactulose or L-ornithine -L-aspartate to Mexican patients with cirrhosis and hyperammonemic encephalopathy significantly reduced serum ammonia levels in study groups and additionally improved mental status parameters, number connection test, asterixis scores, and EEG activity in the group receiving L-ornithine-L-aspartate.
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Papers by Misael Fernandez