Papers by Mirjana Varjacic
Book of Abstracts, 2021
Various examination methods applied for the detection of pathological changes in the nasal mucosa... more Various examination methods applied for the detection of pathological changes in the nasal mucosa and patency of the nasal passages in patients with the reduced sense of smell ..
Journal of Clinical Medicine
The inflammatory processes that occur at the maternal–fetal interface are considered one of the f... more The inflammatory processes that occur at the maternal–fetal interface are considered one of the factors that are responsible for preterm birth. The pro-inflammatory roles of the Gal-3-induced activation of NLRP3 inflammasome and the consecutive production of IL-1β have been described in several acute and chronic inflammatory diseases, but the role of this inflammatory axis in parturition has not been studied. The aim of this study was to analyze the protein expression of Gal-3, NLRP3, and IL-1β in the decidua, villi, and fetal membranes, and to analyze their mutual correlation and correlation with the clinical parameters of inflammation in preterm birth (PTB) and term birth (TB). The study included 40 women that underwent a preterm birth (gestational age of 25.0–36.6) and histological chorioamnionitis (PTB) and control subjects, 22 women that underwent a term birth (gestational age of 37.0–41.6) without histological chorioamnionitis (TB). An analysis of the tissue sections that were...
Background: Autoimmune thyroid diseases are the most common diseases in humans. Their pathogenesi... more Background: Autoimmune thyroid diseases are the most common diseases in humans. Their pathogenesis is complex. Patients are searching for ways of coping with them condition, including diet modi cations. The aim of this study was to assess the role of medical personnel in shaping eating habits in patients with autoimmune thyroid disease based on experiences declared by patients. Methods: There were 208 people that took part in the study, of which 205 were quali ed for nal analysis. The results showed that patients most often choose online sources, while medical personnel rank second as the source of information on dietary recommendations. Results: People with thyroid disease are statistically more likely to use dietitian advice than people without thyroid disease. The highest percentage of respondents decided to modify their nutrition due to their own initiative. In addition, patients with autoimmune thyroid disease are statistically more likely to consider changing their diet to improve their well-being. The connection between the source of advice and modi cation of eating behaviour was also noted. Conclusion: Thanks to the joint effort of medical staff, patients can receive reliable knowledge about their disease, treatment and nutrition adapted to their needs.
Acta Medica Medianae, 2008
Hypertension in pregnancy is associated with increased maternal and fetal mortality and morbidity... more Hypertension in pregnancy is associated with increased maternal and fetal mortality and morbidity. About 8 % of all pregnancies are complicated with hypertensive disorders. There is concordance that severe hypertension should be treated without delay to reduce maternal risks of acute cerebrovascular complications. Intravenous labetalol and oral nifedipine are as effective as intravenous hydralazine in control of severe hypertension, with less adverse effects. Still, there is no consensus as to whether mild-to-moderate hypertension in pregnancy should be treated, considering that there are no definitive conclusions which can be made about the relative maternal or perinatal benefits/risks of antihypertensive treatment. Considering their safe usage during pregnancy, methyldopa, labetalol and nifedipine are commonly used blood-pressure lowering drugs for pregnant women with hypertension. The cardio-selective β- blocker atenolol should be avoided in pregnancy, because it has been associa...
Journal of Medical Economics, 2021
Today, computer systems are widely and importantly used throughout society, and malicious codes t... more Today, computer systems are widely and importantly used throughout society, and malicious codes to take over the system and perform malicious actions are continuously being created and developed. These malicious codes are sometimes found in new forms, but in many cases they are modified from existing malicious codes. Since there are too many threatening malicious codes that are being continuously generated for human analysis, various studies to efficiently detect, classify, and analyze are essential. There are two main ways to analyze malicious code. First, static analysis is a technique to identify malicious behaviors by analyzing the structure of malicious codes or specific binary patterns at the code level. The second is a dynamic analysis technique that uses virtualization tools to build an environment in a virtual machine and executes malicious code to analyze malicious behavior. The method used to analyze malicious codes in this paper is a static analysis technique. Although there is a lot of information that can be obtained from dynamic analysis, there is a disadvantage that it can be analyzed normally only when the environment in which each malicious code is executed is matched. However, since the method proposed in this paper tracks and analyzes the execution stream of the code, static analysis is performed, but the effect of dynamic analysis can be expected.The core idea of this paper is to express the malicious code as a 25 25 pixel image using 25 API categories selected. The interaction and frequency of the API is made into a 25 25 pixel image based on a matrix using RGB values. When analyzing the malicious code, the Euclidean distance algorithm is applied to the generated image to measure the color similarity, and the similarity of the mutual malicious behavior is calculated based on the final Euclidean distance value. As a result, as a result of comparing the similarity calculated by the proposed method with the similarity calculated by the existing similarity calculation method, the similarity was calculated to be 5-10% higher on average. The method proposed in this study spends a lot of time deriving results because it analyzes, visualizes, and calculates the similarity of the visualized sample. Therefore, it takes a lot of time to analyze a huge number of malicious codes. A large amount of malware can be analyzed through followup studies, and improvements are needed to study the accuracy according to the size of the data set.
Serbian Journal of Experimental and Clinical Research, 2014
ABSTRACTThe Pap test (Pap smear) is a morphological cytodiagnostic test that reveals premorbid an... more ABSTRACTThe Pap test (Pap smear) is a morphological cytodiagnostic test that reveals premorbid and early stages of cervical cancer through the use of cervicovaginal cytology.The present study was conducted at the Department of Gynecology and Obstetrics, Clinical Center Kragujevac, from January 01, 2013, to December 1, 2013, with patients who were part of the national screening program and who used a secondary cytological examination (Pap test) performed using a conventional method.The patients were grouped according to the results of a Pap smear and histopathological findings. The classification of cytological smears was performed in accordance with the Bethesda system. The hypotheses established in this study were statistically tested.The greatest number of cytological findings was NILM. However, the most frequent abnormal cytological findings in terms of percentage were ASC-US. After secondary cervical findings of 8.1% of the total number of women, biopsies were performed. In 68.5...
Vojnosanitetski pregled, 2013
Background/Aim. Pregnancy-associated plasma protein A (PAPP-A) is high molecular matrix metallopr... more Background/Aim. Pregnancy-associated plasma protein A (PAPP-A) is high molecular matrix metalloproteinase originally isolated in the serum of pregnant women. The aim of this study was to analyze the values of concentration of PAPP-A in assessment of progress and outcome of pregnancy in pregnant women diagnosed with threatening preterm delivery, preeclampsia and fetal growth restriction in relation to physiological pregnancy of the same gestational age. Methods. The study included 60 pregnant women that were divided into three groups according to gestational age and the diagnosis of imminent premature birth upon reception, preeclampsia and fetal growth restriction as follows: the group I from 28 to 32 weeks of gestation, a total of 25 pregnant women, the group II from 33 to 36 weeks of gestation, a total of 23 pregnant women, and the group III from 37 to 41 weeks of gestation, a total of 12 pregnant women. The control group consisted of 60 pregnant women without complications of preg...
Croatian medical journal, 2001
Oxytocin produces concentration-dependent relaxation of isolated isthmus and ampulla of human ovi... more Oxytocin produces concentration-dependent relaxation of isolated isthmus and ampulla of human oviduct precontracted by histamine. The aim of our study was to investigate whether this oxytocin effect was specific and by which receptors it was mediated. We investigated effects of oxytocin and its antagonists on isolated isthmus and ampulla of the uterine tubes from 20 women who underwent surgery for uterine fibroids. Selective vasopressin and oxytocin antagonists were used to treat isolated preparations of the tubes. In a concentration-dependent manner, oxytocin enhanced spontaneous relaxation of both isthmus (EC50=1.23+/-0.03 x 10(-7) mol/L) and ampulla (EC50=1.04+/-0.26 x 10(-7) mol/L) precontracted by histamine. Neither predominantly selective vasopressin V1 receptor antagonist, [beta-mercapto-beta,beta-cyclopentamethylene-propionyl1,0-metyr2,arg8]-vasopressin (1.0 x 10(-9)-1.0 x 10(-7) mol/L), nor predominantly selective vasopressin V2 antagonist, [1-(beta-mercapto-beta,beta-cyclo...
TIMS. Acta, 2015
Klinički centar Kragujevac, Klinika za ginekologiju i akušerstvo, Odsek za citogenetska ispitivan... more Klinički centar Kragujevac, Klinika za ginekologiju i akušerstvo, Odsek za citogenetska ispitivanja Mirjana Varjačić, Univerzitet u Kragujevcu, Fakultet medicinskih nauka, Ginekologija i akušerstvo / Klinički centar Kragujevac, Klinika za ginekologiju i akušerstvo Tokom života ljudi su konstantno izloženi hemikalijama i agensima iz egzogenih i endogenih izvora koji putem reakcije sa molekulom DNA mogu dovesti do oštećenja genoma i genomske nestabilnosti. Formiranje mikronukleusa predstavlja posledicu nastalih hromozomskih aberacija uzrokovanih dejstvom različitih genetskih i sredinskih faktora. Mikronukleusi su citoplazmatske hromatinske mase sa izgledom malih jedara i mogu poticati od celih hromozoma ili od delova hromozoma. Mikronukleus test (MN test) se koristi za detekciju genotoksičnog efekta različitih hemijskih, fizičkih i bioloških mutagena kao i test za određivanje hromozomske nestabilnosti u različitim tipovima ćelija. Frekvenca mikronukleusa je direktno proporcionalna stepenu hromozomskih aberacija. Dokazano je da oštećenje genoma može nastati kao posledica sredinske izloženosti genotoksinima i medicinskim procedurama, usled deficijencije mikronutricijenata i pod uticajem različitih životnih navika i genetskih faktora. Nebalansirana ishrana, nedostatak fizičkog vežbanja, nedovoljno sna i prekovremeni rad doprinose statistički značajno povećanoj frekvenci mikronukleusa. Takođe je pokazano da naporno vežbanje dovodi do oštećenja DNK, što rezultira formiranjem mikronukleusa. S obzirom na to da profesionalni sportisti sprovode visoko intenzive fizičke treninge, ova populacija spada u rizičnu grupu za nastanak genomske nestabilnosti i karcinogenezu. Zdrav način života, optimalni unos antioksidanasa i redovna umerena fizička aktivnost značajno redukuju frekvencu mikronukleusa, odnosno doprinose stabilnosti genoma.
Vojnosanitetski pregled, 2013
Introduction. Almost all individual antipsychotics are classified into the intermediate pregnancy... more Introduction. Almost all individual antipsychotics are classified into the intermediate pregnancy risk category as no or limited data exist about human pregnancy outcomes. We presented the case of zuclopenthixol decanoate using in two successive pregnancies of the same woman, which had not been published in the available peer-reviewed literature. Case report. A middle-age female subject who suffered from schizophrenia received zuclopenthixol decanoate injection during her two consecutive pregnancies. About four and a half months before diagnosis of the first pregnancy (~3.5 years after psychosis emergence), zuclopenthixol decanoate (400 mg every other week, im injection) was introduced to the treatment protocol (due to previous non-compliance with haloperidol and risperidone). A significant clinical improvement was achieved and the dose during pregnancy was reduced to 200 mg once monthly and maintained to date. In both pregnancies the women gave birth to healthy girls who have been ...
Journal of Medical Economics
Gestational diabetes mellitus refers to both transient diabetes that arises during pregnancy and ... more Gestational diabetes mellitus refers to both transient diabetes that arises during pregnancy and is restored postpartum as well as forms of the disease that arise for the fi rst time during pregnancy and persistently exhibit insulin-dependence (type 1) after childbirth. Th e basis for the development of gestational diabetes is the existence of insulin resistance. Our target population was pregnant women between 20 and 46 years of age who were diagnosed with gestational diabetes (after the 24th week of pregnancy) and who were treated at the Department of Pathology of Pregnancy, Clinical Centre Kragujevac. During the research period, data were collected from 95 pregnant women with diagnosed gestational diabetes. In 3 women, the pregnancy ended in intrauterine foetal demise, and the study was continued with 92 subjects. Th is is a crosssectional, retrospective and observational study. Th e average age of the examinees in our sample is 31.6 years. A total of 77.89% of the examinees achi...
Hypertension in pregnancy is associated with increased maternal and fetal mortality and morbidity... more Hypertension in pregnancy is associated with increased maternal and fetal mortality and morbidity. About 8 % of all pregnancies are complicated with hypertensive disorders. There is concordance that severe hypertension should be treated without delay to reduce maternal risks of acute cerebrovascular complications. Intravenous labetalol and oral nifedipine are as effective as intravenous hydralazine in control of severe hypertension, with less adverse effects. Still, there is no consensus as to whether mild-to-moderate hypertension in pregnancy should be treated, considering that there are no definitive conclusions which can be made about the relative maternal or perinatal benefits/risks of antihypertensive treatment. Considering their safe usage during pregnancy, methyldopa, labetalol and nifedipine are commonly used blood-pressure lowering drugs for pregnant women with hypertension. The cardio-selective β- blocker atenolol should be avoided in pregnancy, because it has been associa...
Acta Medica Medianae, 2008
Hypertension in pregnancy is associated with increased maternal and fetal mortality and morbidity... more Hypertension in pregnancy is associated with increased maternal and fetal mortality and morbidity. About 8 % of all pregnancies are complicated with hypertensive disorders. There is concordance that severe hypertension should be treated without delay to reduce maternal risks of acute cerebrovascular complications. Intravenous labetalol and oral nifedipine are as effective as intravenous hydralazine in control of severe hypertension, with less adverse effects. Still, there is no consensus as to whether mild-to-moderate hypertension in pregnancy should be treated, considering that there are no definitive conclusions which can be made about the relative maternal or perinatal benefits/risks of antihypertensive treatment. Considering their safe usage during pregnancy, methyldopa, labetalol and nifedipine are commonly used blood-pressure lowering drugs for pregnant women with hypertension. The cardio-selective β-blocker atenolol should be avoided in pregnancy, because it has been associat...
Acta medica medianae, 2011
Gastroschisis (gastroshisis) represents evisceration of the abdominal organs, most commonly small... more Gastroschisis (gastroshisis) represents evisceration of the abdominal organs, most commonly small bowels, stomach and gonads through the front abdominal wall defect, almost always to the right of the umbilicus (90%) from which it is separated by thin skin bridge. The incidence of this anomaly is 0.5 to 4 per 10.000 liveborn babies. We presented a patient, aged 27 years, who had gastroschisis of the fetus in the 13th week of gestation diagnosed by ultrasound. Ultrasound examination is the method of choice for prenatal detection of fetal anomalies. By differential diagnosis, the possible existence of omphalocele should be eliminated using (2D, 3D) and power Doppler technology which significantly makes the assessment of gynecologist easier during establishment of the final diagnosis.
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Papers by Mirjana Varjacic