Papers by Michelle Anderson
Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses, 2017
This article describes the distinctive function of the pediatric clinical research nurse (CRN) in... more This article describes the distinctive function of the pediatric clinical research nurse (CRN) in the anesthesia setting. The pediatric CRN in anesthesia acts as a liaison between families and the research team and is the major nexus between the principal investigator or anesthesiologist on a study, and the collaborating surgeons from many different departments. This is unique because the CRNs collaborate with physicians in specialties that can include plastics, urology, neurosurgery, orthopaedics, otolaryngology, cardiology, critical care, and many other departments. The profession requires a breath of knowledge ranging from clinical understanding of diseases, surgical procedures, and recovery to cognitive and developmental stages, to expertise in the research protocol process. Our objective was to describe these specialized activities of the pediatric anesthesia CRN, with focus on care coordination, communication, and continuity of care. Defining this role will enhance the quality...
Gastroenterology, 2016
Background: Our recent literature review (Pancreas 2015, in press) shows that both type 1 DM (T1D... more Background: Our recent literature review (Pancreas 2015, in press) shows that both type 1 DM (T1DM) and type 2 DM (T2DM) are associated with significant histopathologic changes in the exocrine pancreas in the absence of clinical symptoms (pain, pancreatitis or steatorrhea). We called this entity diabetic exocrine pancreatopathy (DEP). Aim: To determine if DEP is histo-pathologically distinct from CP. Methods: Under an IRB-approved protocol we identified from the Mayo Clinic Autopsy database subjects who had provided pre-mortem study consent and had well-preserved pancreata (minimal to no autolysis) at autopsy. For this study we selected subjects with i) long-standing T2DM (n=9) without history of pancreatic disease or of alcoholism who had moderate-to-severe fibrosis in the exocrine pancreas and ii) clinical diagnosis of CP (n=7) confirmed on autopsy. Five expert pancreas pathologists from around the world were made aware of the findings of the review on DEP (Pancreas 2015, in press). Unaware of clinical history or distribution of cases they independently reviewed Hematoxylin and Eosin and Trichrome stains on a digital pathology platform. They entered their observations on a predesigned score sheet and rated their confidence in their diagnosis; >75% confidence in a diagnosis was considered definitive, less as inconclusive. Overall concordance of each reviewer for the diagnosis was calculated using the diagnosis from our center as standard. Multi-rater kappa statistics were used to calculate inter-observer agreement. Results: All 16 cases were definitively classified as CP or DEP by all 5 pathologists with a diagnostic concordance of 81%, 94%, 94%, 100% and 100%, respectively. All 7 cases of CP were correctly diagnosed by all 5 reviewers. One case of DEP was incorrectly diagnosed as CP by 3 pathologists and 2 other DEP cases were misdiagnosed as CP by 1 and 2 pathologists each. The overall multi-rater kappa statistic was 0.83 (kappa>0.81 implies near perfect agreement). DEP and CP had both overlapping and distinguishing histopathologic features (Figure). Both DEP and CP showed inter-acinar fibrosis and varying degrees of acinar atrophy; however, unlike CP, DEP had minimal inter-lobular fibrosis, compete absence of stromal inflammation, minimal to no ductal changes and frequent presence of islet amyloid. Conclusion: DEP is a novel and distinct histopathologic entity that can be readily distinguished from CP with near-perfect inter-observer agreement. The pathophysiology and clinical implications of DEP need further study.
Proquest Llc, Sep 7, 2011
This descriptive study investigates the ways that students in an Ancient History class make meani... more This descriptive study investigates the ways that students in an Ancient History class make meaning of past events by relating them to their present lives and experiences. The study is grounded in theories of historical thinking, particularly focusing on the concepts of presentism and its usefulness for examining classroom teaching. The following two research questions guided the study: 1) How do students make connections between the past and present? 2) When given the opportunity in writing and discussion, in what ways are students engaging with distant events in the past? The research site was a middle school in a medium-sized city located in the Midwest. Data was collected in the Fall of 2010 over the course of eight weeks during two units of study (Ancient Civilizations Review and Ancient Greece). The following data sources were collected: five audio-recorded classroom discussions and other instruction, twelve interviews with students and student assignments and journal entries. The analysis revealed two categories of the students' thinking about the relevance of past events: (1) conflating the past with the present and the challenge of presentism, and (2) translating and adapting the past to the present. The data showed that some students viewed history from a presentist perspective that did not distinguish sufficiently between time periods. However, many students also applied lessons from the past to their own lives by associating historical ideas and themes to their individual experiences, which was especially evident in the discussions. Students tended to make sense of v history by assigning meaning to the concepts they were studying in a personal manner and by finding similarities between the past and present. vi TABLE OF CONTENTS
The Journal of chiropractic education, 2014
Objective : The purpose of this study was to compare demographics and chief complaints of the new... more Objective : The purpose of this study was to compare demographics and chief complaints of the new patient population at our institution's fee-for-service clinics to the patient population of practicing chiropractors in the United States. We also compared the prevalence of obesity and hypertension to reference standards for the adult population. Methods : Patient data were obtained from the electronic health records. All records identified as new patients during October 2013 were included. Variables of interest were clinic site, patient demographics, blood pressure, body mass index (BMI), chief complaint, and ICD-9 codes. Descriptive statistics were computed and compared to reference standards from previous reports. Results : During October 2013, there were 224 new patients that entered the clinics. The average patient was a 31- to 50-year-old white male. Our clinic patients differed from those seen by US chiropractors in the distribution of all demographic variables. For adult p...
Scientific Reports, 2013
Aedes (Ae.) aegypti is the primary vector for dengue viruses (serotypes1-4) and chikungunya virus... more Aedes (Ae.) aegypti is the primary vector for dengue viruses (serotypes1-4) and chikungunya virus. Homing endonucleases (HEs) are ancient selfish elements that catalyze double-stranded DNA breaks (DSB) in a highly specific manner. In this report, we show that the HEs Y2-I-AniI, I-CreI and I-SceI are all capable of catalyzing the excision of genomic segments from the Ae. aegypti genome in a heritable manner. Y2-I-AniI demonstrated the highest efficiency at two independent genomic targets, with 20-40% of Y2-I-AniI-treated individuals producing offspring that had lost the target transgene. HE-induced DSBs were found to be repaired via the single-strand annealing (SSA) and non-homologous end-joining (NHEJ) pathways in a manner dependent on the availability of direct repeat sequences in the transgene. These results support the development of HE-based gene editing and gene drive strategies in Ae. aegypti, and confirm the utility of HEs in the manipulation and modification of transgenes in this important vector.
People and Computers XIX — The Bigger Picture
As a new medium for questionnaire delivery, the internet has the potential to revolutionise the s... more As a new medium for questionnaire delivery, the internet has the potential to revolutionise the survey process. Online-questionnaires can provide many capabilities not found in traditional paper-based questionnaires. Despite this, and the introduction of a plethora of tools to support online-questionnaire creation, current electronic survey design typically replicates the look-and-feel of paper-based questionnaires, thus failing to harness the full power of the electronic delivery medium. A recent environmental scan of online-questionnaire design tools found that little, if any, support is incorporated within these tools to guide questionnaire designers according to best-practice (Lumsden and Morgan, 2005). This paper briefly introduces a comprehensive set of guidelines for the design of online-questionnaires. Drawn from relevant disparate sources, all the guidelines incorporated within the set are proven in their own right; as an initial assessment of the value of the set of guidelines as a practical reference guide, we undertook an informal study to observe the effect of introducing the guidelines into the design process for a complex online-questionnaire. The paper discusses the qualitative findings-which are encouraging for the role of the guidelines in the 'bigger picture' of online survey delivery across many domains such as e-Government, e-Business, and e-Health-of this case study.
Research carried out the University of Western Sydney and the Australian Council for Educational ... more Research carried out the University of Western Sydney and the Australian Council for Educational Research into leadership at the higher education level reveals the challenges faced by educational leaders. The study, 'Learning Leaders in Times of Change', surveyed higher educational leaders to explore the challenges they face in their roles and the capabilities involved in leadership of teaching and learning. The study lists a series of core recommendations - identified by the 513 leaders involved in the study and validated by an additional 600 higher educational leaders from Australia and across the world - designed both to help address the leadership succession and capabilities crises, and to secure the Australian education system during the challenging times that lie ahead. The next phase of 'Learning Leaders in Times of Change' project, building on the study results, is to develop an Online Leadership Learning System resource. [Author abstract, ed]
The Drama Review: TDR, 1982
... Page 2. Authentic Voodoo is Synthetic by Michelle Anderson I went to Haiti to find voodoo. At... more ... Page 2. Authentic Voodoo is Synthetic by Michelle Anderson I went to Haiti to find voodoo. At the hotel, my complimentary rum punch arrived with a voodoo-doll stirstick. The naive paintings on the walls portrayed scenes of possession. ...
School Leadership & Management, 2011
PLoS Neglected Tropical Diseases, 2013
The report provides an overview of school leadership developments and issues in Australia, as a c... more The report provides an overview of school leadership developments and issues in Australia, as a contribution to the OECD's Improving School Leadership Activity. Australia does not have a single school system. Under the federal political structure, education is the responsibility of the eight states and territories. While schooling across the country has many commonalities, there are a number of differences that affect school operations. The situation is made even more complex by the existence of a substantial and growing non-government school sector, which enrols 33 percent of all students and encompasses a wide variety of school types. However, in recent years there have been significant steps towards achieving greater national consistency across the eight states and territories. Nevertheless, caution is needed in generalising across the diversity of Australian schooling.
Insect Molecular Biology, 2010
To date, only a limited number of promoter sequences have been described to drive transgene expre... more To date, only a limited number of promoter sequences have been described to drive transgene expression in the disease vector Aedes aegypti. We sought to increase this repertoire by characterizing the ability of upstream sequences derived from the Ae. aegypti Ub L40 and polyubiquitin genes to drive the expression of marker proteins. Both genomic fragments were able to drive robust expression of luciferase in cultured mosquito cells. Following Mos1transformation, the Ub L40 promoter drove strong expression of a fluorescent marker in early larvae and in ovaries, while the polyubiquitin promoter drove robust EGFP expression in all stages of development including constitutive expression throughout the midgut. These promoter fragments provide two new expression profiles for future Ae. aegypti genetic experiments.
Gastrointestinal Endoscopy, 2005
... The initial literature review, which exposed the lack of large-scale empirical work in this a... more ... The initial literature review, which exposed the lack of large-scale empirical work in this area, led to the national survey to collect information from deputy vice-chancellors, pro vice-chancellors,deans, heads, directors and other academic ... Hamish Coates and Michelle Anderson. ...
1. The purpose of this chapter is to present a strategy and model for implementing the Multicultu... more 1. The purpose of this chapter is to present a strategy and model for implementing the Multicultural Guidelines as they relate to appreciating the role of indigenous healing practices. Specifically, we are proposing an interrogation of core beliefs (ICB) strategy, which can help ensure that the pitfalls of culturally incongruent and insensitive care are avoided and that encourages openness to indigenous healing practices. We discuss ways that our ICB strategy facilitates implementation of the Multicultural Guidelines to promote ...
International …, 2003
Abstract: In this paper we give an overview of the RACOFI (Rule-Applying Collaborative Filtering)... more Abstract: In this paper we give an overview of the RACOFI (Rule-Applying Collaborative Filtering) multidimensional rating system and its related technologies. This will be exemplified with RACOFI Music, an implemented collaboration agent that assists on-line users in the rating and recommendation of audio (Learning) Objects. It lets users rate contemporary Canadian music in the five dimensions of impression, lyrics, music, originality, and production. The collaborative filtering algorithms STI Pearson, STIN2, and the Per ...
New research reveals ways of supporting students’ transitions from school, as Jennifer Bryce and ... more New research reveals ways of supporting students’ transitions from school, as Jennifer Bryce and Michelle Anderson explain. A new report, Australian stories: Young people, their families and post-school plans, building on research undertaken by the Australian Council for Educational Research for the Smith Family, examines the stories of a group of young people who have participated in the Smith Family Learning for Life scholarship program and who have made a positive start towards achieving their post-school goals.
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Papers by Michelle Anderson