Michel Lamure

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João Fonte

University of Exeter

Jose Ruben Guzman-Gutierrez

Universidad Humanista de las Americas

Stefano R L Campana

University of Siena / Università di Siena

Thomas Holtz

University of Maryland

Andrew Heckert

Appalachian State University

Barry Molloy

University College Dublin

Olof Brandt

Pontificio Istituto di Archeologia Cristiana

Despoina Tsiafakis

Research and Innovation Centre “Athena”

Songül Alpaslan-Roodenberg

University of Vienna

Jeffrey Schwartz

University of Pittsburgh

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Papers by Michel Lamure

Gesture Trajectories Modeling Using Quasipseudometrics and Pre-topology for Its Evaluation

by Michel Lamure and Cynthia Basileu

Communications in Computer and Information Science, 2014

PCN140 INFLUENCE OF HEALTH TECHNOLOGY ASSESSMENTS ON UTILIZATION OF BEVACIZUMAB IN EUROPE

Value in Health, 2010

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Proposal for a Vygotsky’s theory based approach for learning in MAS

by N. Kabachi and Michel Lamure

According to Lev Vygotsky, learning is influenced by social interactions and this confrontation o... more According to Lev Vygotsky, learning is influenced by social interactions and this confrontation of points of view enables anindividual,to evolve ,during the time. The Vygotsky’s theory gives a quite important place not only to social tools aslanguage, but also to interactions and relationships between individuals. Therefore, we try to see how, in a multi agents system, an “intelligent agent”

Agent-based simulation of coalition formation in cooperative games

by N. Kabachi and Michel Lamure

IEEE/WIC/ACM International Conference on Intelligent Agent Technology, 2005

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An anatomofunctional brain knowledge

Proceedings of the Fifth International Conference on Information Fusion. FUSION 2002. (IEEE Cat.No.02EX5997), 2002

This study proposes the elaboration of a fusion model into two kinds of data for patients present... more This study proposes the elaboration of a fusion model into two kinds of data for patients presenting sequelae of focal brain damage : anatomical and functional. The aim of our model is to merge these two kinds of information in view to help diagnostic and to contribute at the comprehension of neural basis of cognitive functions. On the one hand, interrelationships between anatomic elements constitute an anatomical graph. On the other hand, each elementary cognitive function and their relationships correspond to a functional graph. From these two graphs, the construction of an inter-graph is developed based on some anatomofunctional rules. These rules allow the expression of anatomofunctional knowledge. This model has been implemented in a software which will soon be used by clinician and searchers.

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Adaptive agent's integration in a new environment

by N. Kabachi and Michel Lamure

Proceedings of the fourth international joint conference on Autonomous agents and multiagent systems - AAMAS '05, 2005

In psychology, adaptation is a dynamic process in which behavior and physiological mechanisms of ... more In psychology, adaptation is a dynamic process in which behavior and physiological mechanisms of an individual continually change to adjust variations in the environment. Following this logic using a multi agents system, we can simulate the behavior of a person wishing to integrate easily and quickly a new environment using its interactions with the others. Indeed, we consider that information

A multiagent system to aggregate preferences

by N. Kabachi and Michel Lamure

In this paper we build a multi-agent system to aggregate preferences of decision-makers. In our s... more In this paper we build a multi-agent system to aggregate preferences of decision-makers. In our system, a decision-maker is a cognitive agent who debates with other agents in view to obtain a consensus about the preference between two objects. Our approach is based on the simulation of debates where preferences of these agents can changed according to influences or coalitions between agents. Our multiagent system gives us an iterative process to aggregate preferences and displays some informations about the processes of negotiation between decision-makers.

Basics of pretopology

by Michel Lamure and J.-p. Auray

Guidelines for evaluation in health care economics

Limitations of the Methods Used for Calculating Quality-Adjusted Life-Year Values

PharmacoEconomics, 2002

To test the validity of the techniques used to calculate quality-adjusted life-year (QALY) values... more To test the validity of the techniques used to calculate quality-adjusted life-year (QALY) values based on utility functions, using a real population dataset. Using the standard gamble technique, we gathered the preferences of a population sample of 189 individuals on a combination of probabilities concerning four simple health states (no physical disability, limp, walk with crutches and need a wheelchair), and three life-year spans (5, 10 and 15 years). Each of the four assumptions of the multiplicative model was tested based on the results of the experiment. The utility of the health state &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;limp&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; was high at 0.89 and that of &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;walk with crutches&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; only slightly lower at 0.85. However, of the 189 individuals, only 57 are not in contradiction with the assumption of mutual utility independence since they strictly preferred (15 years, &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;need a wheelchair&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;) over (10 years, &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;need a wheelchair&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;) and (15 years, &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;need a wheelchair&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;) over (5 years, &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;need a wheelchair&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;). For these 57 individuals, the results of this study do not fit the assumptions underpinning the multiplicative model. This work suggests that the techniques used as a basis from which to calculate QALY values are flawed. In particular, the underlying assumptions of the multiattribute utility model do not correspond to behaviour patterns observed in a real population. It therefore appears that use of the QALY technique should be questioned in healthcare decision-making settings.

Drug reformulations and repositioning in the pharmaceutical industry and their impact on market access: regulatory implications

Journal of Market Access & Health Policy, 2014

Incidence of venous thromboembolism in first-degree relatives of patients with venous thromboembolism who have factor V Leiden

Thrombosis and Haemostasis, 2006

The factor V Leiden (FVL) mutation, a genetic abnormality with an autosomal mode of inheritance, ... more The factor V Leiden (FVL) mutation, a genetic abnormality with an autosomal mode of inheritance, is associated with an increased risk of venous thromboembolism (VTE). We aimed to determine the annual incidence of VTE in first-degree relatives of patients with VTE and FVL and to identify factors in patients and the relatives that influence this incidence. In this retrospective and prospective cohort study, the incidence of objectively diagnosed first episodes of VTE was assessed in 553 first-degree relatives of 161 patients with acute VTE and FVL. The annual incidence of VTE was 0.43% (95% CI, 0.3 to 0.56) with FVL and 0.17% (95% CI, 0.07 to 0.27) without FVL (relative risk of 2.5,95% CI, 1.3 to 4.7). A majority (70%) of episodes of VTE were provoked, and this proportion was similar with and without FVL. A larger proportion of VTE was provoked in women (83%) that in men (33%), with the difference accounted for by pregnancy and use of oral contraceptives. The proportion of pregnancies complicated by VTE was 3.9% (95% CI, 2.0-5.8) with FVL and 1.4% (95% CI, 0.04-2.7) without FVL. FVL is associated with a two- to threefold increase in VTE in first-degree relatives of patients with VTE. No subgroup of relatives was identified who require more than routine prophylaxis because of a particularly high risk of VTE.

PMH64 HEALTH CARE ORGANIZATIONS/SERVICES CLUSTERING: EXAMPLE OF PCTS IN ENGLAND

Value in Health, 2010

At the same time, verbal cognitive function was assessed with the California Verbal Learning Test... more At the same time, verbal cognitive function was assessed with the California Verbal Learning Test (CVLT) and the Verbal Fluency test (VF). The Clinical Global Impression-Severity (CGI-S) was assessed as well at the same visits. Statistical analysis was done using SAS 9.2 with the PROC MIXED module for mixed effects repeated measures analysis. RESULTS: A mixed models analyses on the QLESQ scores showed signifi cant effects for CGI-S in all subscores but " school " (p = 0,1485) and for the verbal cognitive measures only in subscores "leisure " for CVLT-LTFR (p = 0,0002). CONCLUSIONS: The observed difference over time in QLESQ values is dependent on the CGI-S score which contributes mostly to the prediction of the QLESQ outcome. Verbal cognitive outcome was not predictive . These fi ndings are not in agreement with other publications reporting an independent contribution of both measures on quality of life. As the study was open-label, interpretation of the results should be approached with some caution. OBJECTIVES: The QUALITY study evaluated Quality-of-Life in schizophrenic patients treated with atypical antipsychotics (AAPs) in the ambulatory setting. METHODS: Patients (18-65 years-old) diagnosed with schizophrenia and had started treatment with one AAP before visit-1 (minimum: 4-weeks, maximum: 8-weeks) were enrolled into this Belgian study. At visit-1 patients' demographics and medical history were recorded with follow-up visits after 3-, 6-and 9-months. At each visit, patients completed the Subjective Well-being under Neuropletic treatment short form (SWN-K), while investigators assessed the Positive and Negative Symptom Scale (PANSS-8) and the Global Assessment of Functioning (GAF). RESULTS: A total of 121 patients (mean age 36.7 ± 10.8, 75.2% male) were enrolled with the main AAP treatments risperidone (31.4%), apripirazole (23.1%), quetiapine (20.7%). At baseline, the associations between the SWN-K subscales and age, gender, positive/negative PANSSscores, Schizophrenia-subtype or treatment-subgroups were small. Mental-functioning and physical-functioning subscales were signifi cantly correlated with negative PANSSscores, as was the emotional-regulation subscale with gender. The majority of changes from baseline in the SWN-K subscale scores were between −0.5 and +0.5 (range: −1.8 to 1.6). Most mean changes were positive, suggesting that patients felt better compared to baseline. PANSS-8-score changes were slightly negative, suggesting decreases in symptom severity. 57.5% of patients showed symptom remission (PANSS-8-score ≤ 3 after 6 months-of-treatment).GAF scores increased (study end: 8.2 ± 16.0) indicating improvement in the patient's global functioning. By the study end, the number of hospitalizations and addictive substance use had decreased. Patients with more severe negative symptoms considered their mental-and physical-functioning better and men were more satisfi ed than women with their emotional-regulation. Few patients had suffi cient disease insight; most patients had a vague notion or did not see that they were ill. CONCLUSIONS: The patients' well-being seemed to improve slightly during the study without differences between the treatments. Patients having more severe negative symptoms considered their mental and physical functioning better at the study end.

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PHP6 QUANTITATIVE ANALYSIS OF THE INFLUENCE OF DISEASE AND PRODUCT CHARACTERISTICS ON ORPHAN DRUG PRICES IN EUROPE

Value in Health, 2010

OBJECTIVES: Our objective was to assess the predictive validity of the Adherence Estimator® (AE),... more OBJECTIVES: Our objective was to assess the predictive validity of the Adherence Estimator® (AE), a three-item instrument designed to estimate patients' propensity to adhere to prescription medications for chronic disease. METHODS: The AE was part of a larger survey mailed to adults who had an index prescription fill for one of five chronic diseases. Persistence over time was assessed using the continuous measure of medication gaps (CMG) from pharmacy claims data. The Wilcoxon rank sum test was used to assess differences in median PDC between pairs of the adherence risk groups (low/medium/high risk). Sensitivity, specificity, and positive predictive value (PPV) of the AE in the prediction of non-persistence were calculated at 45 days, and three, six, nine, 12, and 14 months. Multiple linear regression was used to assess whether the AE was a significant predictor of persistence at different time intervals, controlling for demographics and comorbidity. RESULTS: There were 1,674 usable responses for an overall survey response rate of 24.3%. Overall, 42.4% of the respondents were classified as being at low risk for non-adherence; 35.1% at medium risk; and 22.5% at high risk. At 14 months, median therapy gaps (CMG) for the low risk group (38.2%) were significantly lower than those for the medium-risk (48.7%) and high-risk groups (59.1%). At 14 months, sensitivity, specificity, and PPV for the AE were 61.1%, 50.5%, and 73.9%, respectively. The sensitivity and the specificity of the AE remained constant over time; the PPV increased as more respondents fell off therapy. Starting at three months, the AE risk groups (low vs. medium/high risk) significantly predicted subsequent gaps in therapy as measured by the CMG. CONCLUSIONS: Patients' propensity to adhere to prescription medications for chronic disease as measured by the AE significantly predicted patients' adherence behavior from three to 14 months post-index fill.

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Pollution Modeling and Simulation with Multi-Agent and Pretopology

by Michel Lamure and Murat Ahat

Lecture Notes of the Institute for Computer Sciences, Social Informatics and Telecommunications Engineering, 2009

Pollution in metropolitan cities has become a serious problem, resulting in poor living condition... more Pollution in metropolitan cities has become a serious problem, resulting in poor living conditions and serious health problems. Pollution being qualified as a complex system, we propose a multi-agent approach to model and simulate it, so that we could study, analyze and predict it better. As in the early stage of the project, we have some successful experiments and attempts

Statistical modeling for brightness-gradient elimination

Some images present a quite strong brightness gradient which may hide significant details of the ... more Some images present a quite strong brightness gradient which may hide significant details of the represented scene. A statistical method for enhancement by elimination of this gradient is proposed. In the first section we present the statistical background which is used. The second section is devoted to the description of our model. The third section consists in the description of the steps involved in the process of enhancement. In the fourth section we present results obtained on a test image. The last section gives a brief discussion on advantages and perspectives of this approach. 1.

Quasipseudometric Spaces and Topological Properties

by Cynthia Basileu and Michel Lamure

2010 IEEE RIVF International Conference on Computing & Communication Technologies, Research, Innovation, and Vision for the Future (RIVF), 2010

In this paper, we introduce a new concept of metric: quasipseudometric, by relaxing the usual axi... more In this paper, we introduce a new concept of metric: quasipseudometric, by relaxing the usual axiomatic of metrics. We study the consequences from a theoretical point of view. In particular, we focus ourselves on the ways to associate general topological structures to such a quasipseudometric. We show we get a weakened version of a topology: a pretopology, which can however be endowed with interesting properties.

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Burden of Huntington's disease in Poland

Facilities ( …

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HT2 VARIABILITY IN UTILIZATION OF INNOVATIVE DRUGS IN EUROPE AS A RESULT OF HEALTH TECHNOLOGY ASSESSMENT AND FUNDING PROCEDURES: EXAMPLES OF TRASTUZUMAB AND CETUXIMAB

by Michel Lamure and O. Cristeau

Value in Health, 2010

Abstracts 30, 2008 within a large nationwide network of outpatient oncology clinics were studied ... more Abstracts 30, 2008 within a large nationwide network of outpatient oncology clinics were studied using US Oncology's iKnowMed EMR. Costs included only those incurred within the network of outpatient oncology clinics and were derived using Medicare reimbursement rates. Patients were matched across regimens on key confounding factors at initiation of treatment: age, stage at diagnosis, ECOG performance status, and comorbidity index. A variable N:M matching ratio was used. Patients were followed through June 30, 2009. A 95% confidence intervals were estimated by bootstrapping (2500 samples) the within-cell differences in cost and time to progression (TTP) of matched patients. RESULTS: A total of 1194 patients were identified: 48 received P/P, 279 received C/P + B, and 867 received C/P. We found that P/P exhibited dominance vs. C/P + B, with higher effectiveness (mean difference in TTP = 1.7 months; CI = 1.1-2.3 months) and lower cost (mean cost difference = −$22,890; CI = $−25,445-$−20,335). Compared to C/P, P/P had higher effectiveness (mean difference in TTP = 2.0 months; CI = 1.7-2.4 months) but also higher costs (mean cost difference = $12,603; CI = $11,579-$13,667) with an incremental cost effectiveness of $6,335/progression-free month (CI = 5,404). CONCLUSIONS: This study suggests that P/P may be a cost-effective 1 st line NSCLC treatment in the outpatient community setting. Costs differences were substantial by regimen while differences in TTP were relatively small from a clinical perspective. While this preliminary study utilized conservative analytic methods and controlled for several key confounding factors, future large studies should attempt to further address selection bias and residual confounding.

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PHP104 DESIGNING EUROPEAN GUIDELINES FOR HEALTH OUTCOMES AND COST-EFFECTIVENESS ASSESSMENTS:THE ECHOUTCOME EUROPEAN COMMISSION PROJECT

Value in Health, 2010

Gesture Trajectories Modeling Using Quasipseudometrics and Pre-topology for Its Evaluation

by Michel Lamure and Cynthia Basileu

Communications in Computer and Information Science, 2014

PCN140 INFLUENCE OF HEALTH TECHNOLOGY ASSESSMENTS ON UTILIZATION OF BEVACIZUMAB IN EUROPE

Value in Health, 2010

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Proposal for a Vygotsky’s theory based approach for learning in MAS

by N. Kabachi and Michel Lamure