Metin Karakok

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Rustam Shukurov

Austrian Academy of Sciences

Sara Nur Yildiz

Middle East Technical University

Therese Martin

CSIC (Consejo Superior de Investigaciones Científicas-Spanish National Research Council)

Johannes Preiser-Kapeller

Austrian Academy of Sciences

Thomás A S Haddad

Universidade de São Paulo

Cybele C Almeida

Universidade Federal do Rio Grande do Sul

Mario Lafuente Gómez

University of Zaragoza

Petros Bouras-Vallianatos

National & Kapodistrian University of Athens

Aurélien Robert

Centre National de la Recherche Scientifique / French National Centre for Scientific Research

Jakob Tanner

University of Zurich, Switzerland

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Papers by Metin Karakok

Kültürel Mi̇rasi Kurtarma Çabasina Bi̇r Örnek: Hasan Acar Evi̇ Koruma - Restorasyon Çalişmalari

the Journal of Academic Social Sciences, 2017

Effect of Intra-Articular Administration of Hyaluronan and Cortisone on Secondary Osteoarthritis of the Infected Rabbit's Knee

by N. Tosun, Metin Karakok, and Serdar Ugras

The Tohoku Journal of Experimental Medicine, 2001

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The Relationship Between Expression of P53/BCL‐2 and Histopathological Criteria in Breast Invasive Ductal Carcinomas

International Journal of Clinical Practice, Nov 1, 2001

Seventy-five cases of invasive ductal carcinoma (IDC) on whom axillary lymph node dissection and ... more Seventy-five cases of invasive ductal carcinoma (IDC) on whom axillary lymph node dissection and mastectomy were performed between 1996 and 2000 were reviewed histopathologically. The slides were stained immunohistologically with p53 and Bcl-2. In 40 cases we observed 53% Bcl-2 and 69% p53 positivity. There were correlations between p53 and tumour grade, and also between p53 and Bcl-2. We did not observe any connection between the main histopathological prognostic factors--lymph node metastasis, tumour size, tubule formation, pleomorphism--and p53/Bcl-2. In our study, IDC with a high mitotic index and poor differentiation showed mutant p53 positive staining. Expression of Bcl-2 is associated with low nuclear grade and absence of mutant p53. This study was designed to reveal the correlation between histopathological findings and the expression of p53/Bcl-2 on prognosis.

Early diagnosed intramural ectopic pregnancy associated with adenomyosis: report of an unusual case

PubMed, 2002

Intramural pregnancy is the rarest type of ectopic pregnancy and almost always is diagnosed intra... more Intramural pregnancy is the rarest type of ectopic pregnancy and almost always is diagnosed intraoperatively. It constitutes less than 1% of ectopic pregnancies and the world literature contains only 33 cases. We present an additional case of an uncomplicated intramural pregnancy in a patient with extensive adenomyosis, which is the earliest preoperatively diagnosed (sixth week of gestation) case in the literature.

Oxidative stress and enzymatic antioxidant status in patients with nonalcoholic steatohepatitis

PubMed, 2004

Oxidative stress is an important pathophysiological mechanism in nonalcoholic steatohepatitis (NA... more Oxidative stress is an important pathophysiological mechanism in nonalcoholic steatohepatitis (NASH). To assess whether there are relationships between oxidative stress and antioxidant enzymes in the development of NASH, we investigated oxidative stress by measuring serum malondialdehyde (MDA) and nitric oxide (NO) and antioxidant status by measuring serum glutathione (GSH), glutathione peroxidase (GSH-Px), glutathione reductase (GR), and superoxide dismutase (SOD). The study included 18 patients (13 men, 5 women; mean age 42 yr) with biopsy proven NASH and 16 healthy volunteers (10 men, 6 women; mean age 38 yr). Serum levels of MDA, NO, GSH, GSH-Px, GR and SOD were determined by spectrophotometric methods. Serum levels (mean +/- SD) of MDA (6.7 +/- 1.6 vs 2.8 +/- 1.7 nmol/ml, p 0.0001), NO (135 +/- 28 vs 113 +/- 35 mmol/L, p 0.04), GSH (919 +/- 137 vs 770 +/- 128 mmol/L, p 0.003) were increased in patients with NASH vs controls. Serum levels of GSH-Px (1063 +/- 152 vs 1000 +/- 94 U/L) and GR (47 +/- 22 vs 40 +/- 21 U/L) were not singnificantly different in the patients vs controls. However, the serum level of SOD (1.24 +/- 0.32 vs 1.51 +/- 0.37 U/ml, p: 0.04) was significantly decreased. Impaired antioxidant defense mechanisms may be an important factor in the pathogenesis of NASH. Treatment approaches that affect the antioxidant enzymes may be beneficial in patients with NASH.

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An evaluation of special AT-rich sequence-binding protein 2 expression in primary epithelial tumors and metastatic tumors of the ovary

Clinical Cancer Investigation Journal, Mar 1, 2019

Background: Ovarian cancer is the second most common gynecologic cancer in women. Differential di... more Background: Ovarian cancer is the second most common gynecologic cancer in women. Differential diagnosis between primary and metastatic neoplasms can be problematic in some cases. The special AT-rich sequence-binding protein 2 (SATB2) is a nuclear matrix-associated protein that is important for growth and development. SATB2 has been shown to be a sensitive and highly specific marker for colorectal carcinomas (CRCs). SATB2 expression has also been reported in lung, breast, pancreas, renal, laryngeal, esophageal carcinomas and bone cancers. In this study, we aimed to evaluate SATB2 expression in primary epithelial and metastatic ovarian tumors and determine its significance in differentiating between subtypes. Material and Methods: The study group comprised 148 cases of primary epithelial tumor and 29 cases of metastatic ovarian tumor. Immunohistochemical analysis was performed by applying SATB2 on paraffin blocks. Results: SATB2 expression was identified in 54.5% of mucinous carcinomas, 51.7% of endometrioid carcinomas, 18.2% of high-grade serous carcinomas, 17.9% of borderline mucinous tumors, 6.7% of borderline serous tumors, and 51.7% of metastatic ovarian tumors. SATB2 expression did not show specificity for any of the subgroups. Metastatic ovarian tumors originating from the colon, breast, upper gastrointestinal tract, and appendix also showed SATB2 expression at different rates. All of the metastatic CRCs showed SATB2 positivity. Conclusion: It must be considered that primary carcinomas and metastatic carcinomas may manifest varying levels of SATB2 expression with different intensity and extensiveness. Extensive and strong SATB2 expression indicates metastatic colon carcinoma, consistent with the literature. Further comprehensive studies are needed in order to investigate SATB2 specificity for different subtypes.

Tarihi Dokuda “Çağdaş Ek” Kavramının Atölye Ortamında Deneyimlenmesi: Mass’ Workshop 2015

Tasarım + Kuram, 2017

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The effects of anastrozole on neonatal rat skin

European journal of gynaecological oncology, 2007

Anastrozole is a third-generation nonsteroidal aromatase inhibitor which is used in the treatment... more Anastrozole is a third-generation nonsteroidal aromatase inhibitor which is used in the treatment of breast cancers. Anastrozole has also been used in the treatment of dermatomyositis skin eruptions but its direct effects on skin have not been well documented. To study the effects of anastrozole administration on neonatal rat skin. Forty Sprague-Dawley female newborn rats were separated into two control groups and two experimental groups (n = 10). One day after birth the control group of newborn rats were given daily 0.02 ml saline subcutaneously for a period of 15 days. The first experimental group of rats were treated with 0.05 mg/100g/day anastrozole subcutaneously for 15 days whereas the second experimental group of rats were given 0.25 mg/100g/day anastrozole subcutaneously for 15 days. Histopathological assessments were made and compared with the control groups. Increased keratinization, strippling, hypertrophic epidermal cells and disorganization of the epidermal cells were o...

Hydatid disease in a thyroglossal cyst

Acta chirurgica Belgica, 1997

The location of hydatid disease in organs other than the liver and lung is unusual and occasional... more The location of hydatid disease in organs other than the liver and lung is unusual and occasionally producing difficulties in diagnosis. Thyroglossal cyst itself is not so common, so that more careful search of thyroglossal cyst for the presence of scolex and/or laminated membrane may result in increase in frequency of such a condition in the area where hydatid disease is prevailed. Since we were unable to find a case of hydatid disease involving thyroglossal cyst, as in our present case, we feel justified in reporting this case, considering it would be the first publication in world literature.

Notalgia Paresthetica with a Significant Increase in the Number of Intradermal Nerves

The Journal of Dermatology, 2002

Notalgia paresthetica is an isolated mononeuropathy involving the skin over or near the scapula. ... more Notalgia paresthetica is an isolated mononeuropathy involving the skin over or near the scapula. The cause remains unknown. We histologically observed a significant increase in the number of dermal nerves in a case of notalgia paresthetica. Immunohistochemical examination using a neural marker, S‐100, positively stained the nerves. Interestingly, a biopsy from perilesional skin also showed an abnormal nerve proliferation.

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Helicobacter pylori infection in gastric carcinoma in the Van region of Turkey

Turkish Journal of …, 1999

Summary The prevalence of Helicobacter pylori (H. pylori) infection was assessed in endoscopic bi... more

Serum ubiquitin levels in patients with nonalcoholic steatohepatitis

PubMed, Jun 28, 2003

Background/aims: Nonalcoholic steatohepatitis is increasingly recognized as the most common liver... more Background/aims: Nonalcoholic steatohepatitis is increasingly recognized as the most common liver disease in patients with elevated liver enzymes. In the pathophysiology of nonalcoholic steatohepatitis, the first step is the lipid accumulation in the liver causing steatosis, the second step involves the endotoxins, cytokines and environmental toxins causing oxidative stress and lipid peroxidation, in time leading to steatohepatitis. Ubiquitin is a molecular chaperone that plays a major role in the degradation of intracellular proteins. Ubiquitin proteasome system is also considered as a cellular defense mechanism that removes damaged proteins generated by oxidative stress. In order to search for the role of ubiquitin in the pathogenesis of nonalcoholic steatohepatitis, serum levels of ubiquitin were studied in patients with nonalcoholic steatohepatitis for the first time in the literature, to our knowledge. Methodology: Eighteen patients with biopsy proven nonalcoholic steatohepatitis diagnosis (13 males and 5 females with a mean age of 41) and 16 healthy volunteers as a control group (11 males and 5 females, with a mean age of 38) were included in the study. Serum ubiquitin levels were studied by ELISA method. Results: The mean serum ubiquitin level (14.13 +/- 1.46 micrograms/mL) in patients with nonalcoholic steatohepatitis was significantly elevated compared to that of the control group (7.66 +/- 0.40 micrograms/mL) (p < 0.001). No correlation was found among serum ubiquitin levels and hepatic steatosis, inflammation and fibrosis. Conclusions: Increased serum ubiquitin levels may show that the ubiquitin proteasome pathway actively participates in defending against oxidative stress in nonalcoholic steatohepatitis. Serum ubiquitin concentration may be a marker predicting the intracellular cytoprotective response against oxidative stress rather than the degree of liver damage in pathogenesis of nonalcoholic steatohepatitis. Ubiquitin proteasome system based therapies may have a place in the treatment of patients with nonalcoholic steatohepatitis in the future.

Serum Lipids, Lipoproteins and Apolipoproteins Levels in Patients With Nonalcoholic Steatohepatitis

Journal of Clinical Gastroenterology, Aug 1, 2003

Goals/Background Nonalcoholic steatohepatitis (NASH) is a form of liver disease that is histologi... more Goals/Background Nonalcoholic steatohepatitis (NASH) is a form of liver disease that is histologically indistinguishable from alcoholic hepatitis but occurs in persons who do not consume alcohol in excess. The objectives of this study are to measure serum levels of lipids, lipoproteins and apolipoproteins (apo AI, apo B), lipoprotein (a) [Lp (a)] in patients with nonalcoholic steatohepatitis (NASH), and to investigate the relationship with liver histology. Study The scope of this study is composed of 36 patients (27 males, 9 females) with NASH, diagnosed by biochemical liver function tests, sonographic examination of liver and liver biopsy and 32 healthy adults as a control group (22 males, 10 females). Serum lipids, lipoproteins and apo AI, apo B, and Lp (a) measurements were taken in the study group and controls, and a correlation with histopathologic findings was searched for. Results Serum mean levels (± SD as mg/dl) of total cholesterol (201.05 ± 34.48), triglyceride (225.94 ± 156.50), and LDL-cholesterol (111.77 ± 19.85) in patients with NASH were significantly higher than those of the control group (170.68 ± 31.06; 138.81 ± 49.96; 100.68 ± 17.98; respectively) and serum HDL-cholesterol level (41.22 ± 2.47) was less than that of the control group (45.06 ± 8.32) (P = 0.017). The serum mean level of apo AI (151.54 ± 30.90) in the study group was lower than that of the controls (160.62 ± 22.11), but the difference was not significant (P = 0.17). However, the serum apo AI level in patients with liver fibrosis (140.62 ± 35.62) was significantly lower than that of patients without liver fibrosis (164.57 ± 25.47) (P = 0.01). The serum mean level of apo B (89.80 ± 20.62) in the patients was significantly higher than the control group (73.25 ± 25.39) (P = 0.004), but not correlate with liver histopatology. The serum Lp (a) levels in both the patients (13.09 ± 9.61) and the controls (12.01 ± 7.50) were not different (P = 0.61). Hypertriglyceridemia (above 220 mg/dL) had a positive correlation with steatosis of the liver (r = 0.333, P = 0.04) and a negative correlation with liver fibrosis (r = −0.438, P = 0.008). There was a significant negative correlation between apo AI and steatosis (r = −0.360, P = 0.03), inflamation (r = −0.364, P = 0.03) and fibrosis of liver (r = −0.418, P = 0.01). A positive correlation of serum LDL-cholesterol (r = 0.507, P = 0.002) and Lp(a) (r = 0.394, P = 0.01) concentrations with liver fibrosis was also noted. Conclusions Abnormalities of lipid metabolism such as the increase of serum triglyceride, cholesterol and LDL-cholesterol level and decrease of HDL-cholesterol may be the contributing factors in the development of NASH. The decrease in apo AI and the increase in LDL and Lp (a) in patients were correlated with liver fibrosis. Apo AI may be a serum marker for liver fibrosis in patients with NASH.

Effect of Nigella sativa on experimental liver fibrosis

Biomedical Research-tokyo, 2014

Our objective was to investigate the effects of NS, Nigella Sativa oil (NSO) and thymoquinone (TQ... more Our objective was to investigate the effects of NS, Nigella Sativa oil (NSO) and thymoquinone (TQ) on liver fibrosis induced by dimethylnitrosamine (DMN) in rats. Our study groups consisted of five subgroups: the control, DMN, TQ, NS, and NSO groups. At the end of the study, the animals were sacrificed, and blood and tissue samples were obtained. Malondialdehyde (MDA) levels, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) activity, and routine biochemical parameters were analyzed. Histopathologic evaluation of the NS, NSO and TQ groups found normal liver tissue and short fibrosis, and fibrous expansion with or without a septum and in some portal areas. The DMN group evaluation found incomplete cirrhosis in the liver tissues of rats. While erythrocyte and tissue MDA levels were higher, SOD and GSH-Px activities were lower in the NS, NSO and TQ groups when compared to the DMN group. Our results showed that NS and its components reduced oxidative stress and had antioxidant...

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Olfactory Neuroblastoma with Facial Metastasis

Eastern Journal of Medicine, 2002

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Mide Karsinomlarında Patoloji ve Moleküler Patogenezis

Vhl, Pbrm1 And Setd2 Genes In Kidney Cancer: A Molecular Investigation

Kidney cancer is the most lethal urological cancer accounting for 3% of adult malignancies. VHL, ... more Kidney cancer is the most lethal urological cancer accounting for 3% of adult malignancies. VHL, a tumor-suppressor gene, is best known to be associated with renal cell carcinoma (RCC). The VHL functions as negative regulator of hypoxia inducible factors. Recent sequencing efforts have identified several novel frequent mutations of histone modifying and chromatin remodeling genes in ccRCC (clear cell RCC) including PBRM1 and SETD2. The PBRM1 gene encodes the BAF180 protein, which involved in transcriptional activation and repression of selected genes. SETD2 encodes a histone methyltransferase, which may play a role in suppressing tumor development. In this study, RNAs of 30 paired tumor and normal samples that were grouped according to the types of kidney cancer and clinical characteristics of patients, including gender and average age were examined by RT-PCR, SSCP and sequencing techniques. VHL, PBRM1 and SETD2 expressions were relatively down-regulated. However, statistically no s...

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Contents Vol. 73, 2007

Oncology, 2007

Access to full text and tables of contents, including tentative ones for forthcoming issues: www.... more

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Aktuelles Programm der DGHO Frühjahrstagung 2009, Berlin

Oncology Research and Treatment, 2009

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Deri Lezyonlarının Klinik Ön Tanı ve Histopatolojik Tanılarının Karşılaştırılması

Deri lezyonlarina, plastik ve rekonstruktif cerrahi kliniklerinde sikca karsilasilmakta ve tedavi... more Deri lezyonlarina, plastik ve rekonstruktif cerrahi kliniklerinde sikca karsilasilmakta ve tedavileri yapilmaktadir. Deri lezyonunun on tanisinin dogrulugu histopatolojik incelenmesi ile ortaya konulur. Plastik ve Rekonstruktif Cerrahi Egitiminin bir parcasi olan cesitli deri lezyonlarinin tedavisi, on tani ile sekillenir. Eylul 1995-Aralik 2000 tarihleri arasinda, cesitli deri lezyonlari nedeniyle klinigimize basvuran ve cerrahi olarak cikartilan, 132 der kanserli ve 319 bengn deri lezyonlu toplam 451 hastanin klinik on tanilari ve histopatolojik inceleme ile konan tanilari karsilastirildi. Deri kanserlerinde tani uyusmazligi %9.84 iken benign deri lezyonlarinda bu oran %11.91 ve toplamda %11.31 olarak saptandi. Bu calisma, klinigimizde tani ve tedavileri yapilan deri lezyonlarinin tanisindaki yanilma ve/veya dogruluk oranlarini belirlemek amaciyla yapildi. Deri lezyonlarinin klinik on tanisinin dogruluk oraninin artmasi, klinik ici egitimin bu konuya agirlik vermesi ile artabilir.

Kültürel Mi̇rasi Kurtarma Çabasina Bi̇r Örnek: Hasan Acar Evi̇ Koruma - Restorasyon Çalişmalari

the Journal of Academic Social Sciences, 2017

Effect of Intra-Articular Administration of Hyaluronan and Cortisone on Secondary Osteoarthritis of the Infected Rabbit's Knee

by N. Tosun, Metin Karakok, and Serdar Ugras

The Tohoku Journal of Experimental Medicine, 2001

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The Relationship Between Expression of P53/BCL‐2 and Histopathological Criteria in Breast Invasive Ductal Carcinomas

International Journal of Clinical Practice, Nov 1, 2001