The contemporary goals of breast cancer treatment are not limited to cure but include maximizing ... more The contemporary goals of breast cancer treatment are not limited to cure but include maximizing quality of life. All breast cancer treatment can adversely affect breast appearance. Developing objective, quantifiable methods to assess breast appearance is important to understand the impact of deformity on patient quality of life, guide selection of current treatments, and make rational treatment advances. A few measures of aesthetic properties such as symmetry have been developed. They are computed from the distances between manually identified fiducial points on digital photographs. However, this is time-consuming and subject to intra- and inter-observer variability. The purpose of this study is to investigate methods for automatic localization of fiducial points on anterior-posterior digital photographs taken to document the outcomes of breast reconstruction. Particular emphasis is placed on automatic localization of the nipple complex since the most widely used aesthetic measure,...
RESULTS: In the patients, MOV correlated significantly with UCCV (r 0.67), BPF (r 0.45), disease ... more RESULTS: In the patients, MOV correlated significantly with UCCV (r 0.67), BPF (r 0.45), disease duration (r 0.64), age (r 0.47), EDSS score (r 0.49) and AI (r 0.52). Volume loss of the medulla oblongata was 0.008 cm3/year of age in patients with MS, but no significant linear relationship with age was found for healthy control subjects. The patients had
RESULTS: In the patients, MOV correlated significantly with UCCV (r 0.67), BPF (r 0.45), disease ... more RESULTS: In the patients, MOV correlated significantly with UCCV (r 0.67), BPF (r 0.45), disease duration (r 0.64), age (r 0.47), EDSS score (r 0.49) and AI (r 0.52). Volume loss of the medulla oblongata was 0.008 cm3/year of age in patients with MS, but no significant linear relationship with age was found for healthy control subjects. The patients had
Amyloid positron emission tomography (PET) imaging is being investigated as a screening tool to i... more Amyloid positron emission tomography (PET) imaging is being investigated as a screening tool to identify amyloid-positive patients as an enrichment strategy for Alzheimer disease (AD) clinical trial enrollment. In a multicenter, phase 1b trial, patients meeting clinical criteria for prodromal or mild AD underwent florbetapir PET scanning at screening. PET, magnetic resonance imaging, and coregistered PET/magnetic resonance imaging scans were reviewed by 2 independent readers and binary visual readings tabulated. Semiquantitative values of cortical to whole cerebellar standard uptake value ratios were computed (threshold 1.10). Of 278 patients with an evaluable PET scan, 170 (61%) and 185 (67%) were amyloid-positive by visual reading and quantitative analysis, respectively; 39% were excluded from the study due to an amyloid-negative scan based on visual readings. More ApoE ε4 carriers than noncarriers were amyloid-positive (80% vs. 43%). Comparison of visual readings with quantitative results identified 21 discordant cases (92% agreement). Interreader and intrareader agreements from visual readings were 98% and 100%, respectively. Amyloid PET imaging is an effective and feasible screening tool for enrollment of amyloid-positive patients with early stages of AD into clinical trials.
The contemporary goals of breast cancer treatment are not limited to cure but include maximizing ... more The contemporary goals of breast cancer treatment are not limited to cure but include maximizing quality of life. All breast cancer treatment can adversely affect breast appearance. Developing objective, quantifiable methods to assess breast appearance is important to understand the impact of deformity on patient quality of life, guide selection of current treatments, and make rational treatment advances. A few measures of aesthetic properties such as symmetry have been developed. They are computed from the distances between manually identified fiducial points on digital photographs. However, this is time-consuming and subject to intra- and inter-observer variability. The purpose of this study is to investigate methods for automatic localization of fiducial points on anterior-posterior digital photographs taken to document the outcomes of breast reconstruction. Particular emphasis is placed on automatic localization of the nipple complex since the most widely used aesthetic measure,...
RESULTS: In the patients, MOV correlated significantly with UCCV (r 0.67), BPF (r 0.45), disease ... more RESULTS: In the patients, MOV correlated significantly with UCCV (r 0.67), BPF (r 0.45), disease duration (r 0.64), age (r 0.47), EDSS score (r 0.49) and AI (r 0.52). Volume loss of the medulla oblongata was 0.008 cm3/year of age in patients with MS, but no significant linear relationship with age was found for healthy control subjects. The patients had
RESULTS: In the patients, MOV correlated significantly with UCCV (r 0.67), BPF (r 0.45), disease ... more RESULTS: In the patients, MOV correlated significantly with UCCV (r 0.67), BPF (r 0.45), disease duration (r 0.64), age (r 0.47), EDSS score (r 0.49) and AI (r 0.52). Volume loss of the medulla oblongata was 0.008 cm3/year of age in patients with MS, but no significant linear relationship with age was found for healthy control subjects. The patients had
Amyloid positron emission tomography (PET) imaging is being investigated as a screening tool to i... more Amyloid positron emission tomography (PET) imaging is being investigated as a screening tool to identify amyloid-positive patients as an enrichment strategy for Alzheimer disease (AD) clinical trial enrollment. In a multicenter, phase 1b trial, patients meeting clinical criteria for prodromal or mild AD underwent florbetapir PET scanning at screening. PET, magnetic resonance imaging, and coregistered PET/magnetic resonance imaging scans were reviewed by 2 independent readers and binary visual readings tabulated. Semiquantitative values of cortical to whole cerebellar standard uptake value ratios were computed (threshold 1.10). Of 278 patients with an evaluable PET scan, 170 (61%) and 185 (67%) were amyloid-positive by visual reading and quantitative analysis, respectively; 39% were excluded from the study due to an amyloid-negative scan based on visual readings. More ApoE ε4 carriers than noncarriers were amyloid-positive (80% vs. 43%). Comparison of visual readings with quantitative results identified 21 discordant cases (92% agreement). Interreader and intrareader agreements from visual readings were 98% and 100%, respectively. Amyloid PET imaging is an effective and feasible screening tool for enrollment of amyloid-positive patients with early stages of AD into clinical trials.
Uploads
Papers by Mehul Sampat