Mehmet Uzunel

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Charalambos Tsekeris

National Centre of Social research

Maurizio Canavari

Università di Bologna

Bengt-Arne Vedin

KTH Royal Institute of Technology

Linda MacDonald Glenn

University of California, Santa Cruz

Hani Mahmassani

Northwestern University

Joseph Shalhoub

Imperial College London

Peter Delobelle

University of Cape Town

Miston Mapuranga

The DaVinci Institute

Luis Rodrigo

University of Oviedo / Universidad de Oviedo

Kenneth Marcu

SUNY: Stony Brook University

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Papers by Mehmet Uzunel

Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells

by Moustapha Hassan and Mehmet Uzunel

The Lancet, 2004

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Improved Survival after Allogeneic Hematopoietic Stem Cell Transplantation in Recent Years. A Single-Center Study

by Moustapha Hassan, Sofia Berglund, K. Garming Legert, Attila Szakos, Darius Sairafi, Göran Dahllöf, Aldona Dlugosz, and Mehmet Uzunel

Biology of Blood and Marrow Transplantation, 2011

A Single-Center Study analysis. When correcting for differences between the 4 groups, the hazard ... more

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An ex vivo RT-qPCR-based assay for human peripheral leukocyte responsiveness to glucocorticoids in surgically induced inflammation

Journal of Inflammation Research, 2015

An assay to determine glucocorticoid (GC) responsiveness in humans could be used to monitor GC no... more An assay to determine glucocorticoid (GC) responsiveness in humans could be used to monitor GC non-responsiveness in states of GC insufficiency and could provide a tool to adapt GC treatment to individual patients. We propose an ex vivo assay to test GC responsiveness in peripheral leukocytes. The assay was evaluated in a human experimental model of surgery-induced inflammation. Changes in expression of the GC-regulated genes GILZ, IL1R2, FKBP5, and HLA-DR and glucocorticoid receptor alpha (GRα) were determined by reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) in peripheral leukocytes from surgical patients and healthy blood donors (total n=60) in response to low (1 nM) and high (1 µM) dexamethasone (DEX). The final selection of a suitable endogenous control gene was based on the studies of stability during DEX treatment and inflammation. Correlations between pre- and postoperative GC-induced gene expression, the postoperative systemic inflammatory and metabolic response (CRP, IL-6, white blood cell count, cytokines, resistin, free fatty acids, glucose, insulin, and adiponectin), and the clinical outcome were analyzed. The length of stay in the intensive care unit (ICU-LOS), the length of stay in the hospital, and postoperative complications were used to measure clinical outcome. When the blood donors were compared to the patients, there were no significant differences in the regulation of the genes in response to DEX, except for GRα. Preoperative, but not postoperative, gene regulation of GILZ and GRα was negatively correlated to ICU-LOS (P&amp;amp;amp;amp;amp;amp;lt;0.05 and P&amp;amp;amp;amp;amp;amp;lt;0.01, respectively). Preoperative GILZ and FKBP5 gene regulation was negatively correlated to postoperative systemic TNFα and MIP-1α levels. We suggest that this assay could be used to determine GC responsiveness. An alteration in preoperative GC responsiveness may be related to a patient&amp;amp;amp;amp;amp;amp;#39;s ability to recover from surgically induced inflammatory stress.

Hypogammaglobulinemia in children after allogeneic hematopoietic stem cell transplantation: A cytokine mediated immunoglobulin isotype class switch arrest?

Pediatric blood & cancer, 2015

Hypogammaglobulinemia (hypo-IgG) is common early post-HSCT in children, occasionally necessitatin... more Hypogammaglobulinemia (hypo-IgG) is common early post-HSCT in children, occasionally necessitating long-term immunoglobulin (Ig) G replacement therapy. IgG replacement may not reduce mortality, although infectious complications are decreased Clinical data and samples from 86 children were analyzed retrospectively with the aim to identify risk factors for developing long-term hypo-IgG (i.e., requiring ≥3 months IgG replacement) post-HSCT and studying the underlying biology. Laboratory studies covered serum cytokines, IGHG2 genotyping and routine laboratory investigations. Results were analyzed statistically. Forty-eight percent of the children developed long-term hypo-IgG. These children were younger (<5 years) and had higher acute GvHD incidence, but had better overall survival (88% vs. 69%, P = 0.036). Significantly lower Ig levels post-HSCT but equal immune cell recovery were seen in patients with long-term hypo-IgG compared with those of transient or no hypo-IgG. Pre-HSCT IL-6...

Expression of Vascular Endothelial Growth Factor Receptor2 or Tie2 on Peripheral Blood Cells Defines Functionally Competent Cell Populations Capable of Reendothelialization

Background—Receptor tyrosine kinases that include vascular endothelial growth factor (VEGFR)-1, V... more Background—Receptor tyrosine kinases that include vascular endothelial growth factor (VEGFR)-1, VEGFR-2, and Tie-2 regulate cardiovascular development and physiological and pathological angiogenesis. We were interested in the phenotypic and functional characterization of peripheral blood cells expressing these receptors and their therapeutic potential in vascular injury. Methods and Results—VEGFR-1, VEGFR-2, and Tie-2 cells constituted 3.00.2%, 0.80.5%, and 2.00.3%, respectively, of the total

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Adult porcine islets produce MCP-1 and recruit human monocytes in vitro

Xenotransplantation, 2004

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An allogeneic anti-cancer effect after hematopoietic stem cell transplantation

Transplantation Proceedings, 2001

T CELL MIXED CHIMERISM IS SIGNIFICANTLY CORRELATED TO A DECREASED RISK OF ACUTE GRAFT-VERSUS-HOST DISEASE AFTER ALLOGENEIC STEM CELL TRANSPLANTATION 1

Transplantation, 2001

It has been debated whether mixed chimerism (MC) is correlated to a decreased incidence of graft-... more It has been debated whether mixed chimerism (MC) is correlated to a decreased incidence of graft-versus-host disease (GVHD) after allogeneic stem cell transplantation (SCT). Between September 1996 and April 1999 we analyzed 102 patients for MC in the T-cell fraction post allogeneic SCT, using PCR amplification of variable numbers of tandem repeat (VNTR) loci. All samples, taken regularly post SCT, were cell separated using anti-CD3 immunomagnetic beads. T-cell mixed chimerism was detected in 58 out of 102 patients (57%). Patient characteristics were comparable in the T-cell MC- and donor chimeric-group (DC). The median follow-up time for the MC group was 714 days (range 58 - 1248) as compared to 427 days (range 45 - 1042) for the DC group. Overall probability of acute GVHD grades II-IV was significantly higher in the DC group as compared to the MC group (52% vs. 5%, P&lt;0.001). In multivariate analysis T-cell DC proved to be the most significant risk factor for acute GVHD grades II-IV. The cumulative incidence of relapse, among patients with malignant disease, did not show any statistical difference between the T-cell MC patients and the DC-group. There was a tendency for better overall survival in the T-cell MC group compared to the DC group (2 yrs; 73% vs. 54%, P=0.06). Among DC patients, 14/20 (70%) deaths were due to GVHD versus none in the MC-group(P&lt;0.001). T-cell mixed chimerism was significantly correlated to a decreased risk of moderate to severe acute GVHD and death by GVHD.

Mesenchymal Stem Cells for Treatment of Therapy-Resistant Graft-versus-Host Disease

Transplantation, 2006

Mesenchymal stem cells (MSC) have immunomodulatory effects. The aim was to study the effect of MS... more Mesenchymal stem cells (MSC) have immunomodulatory effects. The aim was to study the effect of MSC infusion on graft-versus-host disease (GVHD). We gave MSC to eight patients with steroid-refractory grades III-IV GVHD and one who had extensive chronic GVHD. The MSC dose was median 1.0 (range 0.7 to 9)x10(6)/kg. No acute side-effects occurred after the MSC infusions. Six patients were treated once and three patients twice. Two patients received MSC from HLA-identical siblings, six from haplo-identical family donors and four from unrelated mismatched donors. Acute GVHD disappeared completely in six of eight patients. One of these developed cytomegalovirus gastroenteritis. Complete resolution was seen in gut (6), liver (1) and skin (1). Two died soon after MSC treatment with no obvious response. One of them had MSC donor DNA in the colon and a lymph node. Five patients are still alive between 2 months and 3 years after the transplantation. Their survival rate was significantly better than that of 16 patients with steroid-resistant biopsy-proven gastrointestinal GVHD, not treated with MSC during the same period (P = 0.03). One patient treated for extensive chronic GVHD showed a transient response in the liver, but not in the skin and he died of Epstein-Barr virus lymphoma. MSC is a very promising treatment for severe steroid-resistant acute GVHD.

TRANSPLANTATION OF AUTOLOGOUS AND ALLOGENEIC BONE MARROW WITH LIVER FROM A CADAVERIC DONOR FOR PRIMARY LIVER CANCER1

Transplantation, 2000

Background. In histocompatibility mismatched experimental animals, a combination of T-cell-deplet... more Background. In histocompatibility mismatched experimental animals, a combination of T-cell-depleted autologous and allogeneic marrow may induce mixed chimerism and tolerance. Patients with large primary liver tumors have a poor outcome. We investigated whether it were possible to induce mixed chimerism and obtain an antitumor effect in a patient with a large primary liver cancer after combined liver and bone marrow transplantation (BMT).

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Factors With an Impact on Chimerism Development and Long-Term Survival After Umbilical Cord Blood Transplantation

Transplantation Journal, 2012

Umbilical cord blood transplantation (UCBT) is increasingly used and produces similar results to ... more Umbilical cord blood transplantation (UCBT) is increasingly used and produces similar results to matched unrelated donor transplantation. We performed a retrospective single-center analysis of 50 umbilical cord blood transplantations UCBTs performed from 2001 to 2010, including 37 single and 13 double umbilical cord blood transplantations UCBTs. The rate of engraftment of neutrophils was 88% at a median time of 29 days (range, 3-79). Complete donor chimerism (DC) within the CD19, CD3, and CD33 cell lineages was seen in 74%, 72%, and 76% of the patients, respectively. DC was associated with acute graft-versus-host disease (GVHD) grades II to IV for the CD3 cell lineage (P=0.01) and, in multivariate analysis, with total body irradiation for all lineages (P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.01). Overall survival (OS) at 1 and 5 years was 55% and 43%. Nonmalignant diseases were associated with better 5-year OS (72%) than malignancies (28%; P=0.026). In multivariate analysis, a negative correlation was seen between OS and age (hazard ratio [HR], 1.04; 95% confidence interval [95% CI], 1.02-1.06; P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001), acute GVHD grades III and IV (HR, 3.43; 95% CI, 1.95-6.02; P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001), and mesenchymal stem cell treatment (HR, 2.66; 95% CI, 1.11-6.35; P=0.027). Transplant-related mortality at 100 days and 1 year was 16% and 30%. The incidence of acute GVHD grades II to IV was 34%. Acute GVHD grades III and IV was associated with ABO incompatibility (HR, 2.61; P=0.05) and myeloablative conditioning (HR, 4.17; P=0.047). The outcome in patients with nonmalignant diseases was acceptable, but transplant-related mortality in the whole group remains high. A significantly higher rate of DC was associated with total body irradiation-based conditioning and with acute GVHD grades II and IV.

by Mehmet Uzunel, Brigitta Omazic, and Darius Sairafi

Transplantation, 2006

Background. The use of reduced intensity conditioning (RIC) regimens in allogeneic hematopoietic ... more Background. The use of reduced intensity conditioning (RIC) regimens in allogeneic hematopoietic stem cell transplantation (HSCT) has increased over the past five years. Patients. In this study, involving 137 patients, we compared the outcome after RIC in patients receiving grafts from matched unrelated donors (MUD; nϭ74) and sibling donors (nϭ63). The MUD and sibling groups were comparable regarding diagnosis, including solid tumors and hematological malignancies, and conditioning regimens. Results. Engraftment was successful in most patients (88%), with no significant difference between MUD and sibling transplants. Cytomegalovirus (CMV) infection was more common in the MUD group (65%) than in the sibling group (46%) (Pϭ0.04). No difference in severe acute graft-versus-host disease (GVHD) was found between the groups. However, the incidence of chronic GVHD was higher after sibling transplants. This was probably due to higher donor age in this group, since this was the only significant risk factor for chronic GVHD in multivariate analysis. The incidence of transplant related mortality (TRM) was significantly higher after MUD transplantation (40%) than after sibling transplantation (16%) (PϽ0.01). Because relapse/disease progression was more common after sibling transplantation, there was no significant difference in overall survival between the two groups. Conclusion. Using unrelated donors after RIC is feasible, but it resulted in more CMV infection and increased transplantrelated mortality. Survival was comparable to that of sibling transplants. (Transplantation 2006;82: 913-919)

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A Comparison of Nonmyeloablative and Reduced-Intensity Conditioning for Allogeneic Stem-Cell Transplantation

Transplantation, 2004

Nonmyeloablative (NM) conditioning and reduced-intensity conditioning (RIC) are increasingly used... more Nonmyeloablative (NM) conditioning and reduced-intensity conditioning (RIC) are increasingly used for allogeneic hematopoietic stem-cell transplantation. Such regimens have not been compared. The primary endpoint was graft-versus-host disease (GVHD). Secondary endpoints included transfusions, engraftment, and transplant-related mortality (TRM). NM conditioning (n=24) consisted of fludarabine and 2-Gy total-body irradiation followed by immunosuppression with cyclosporine A (CsA) combined with mycophenolate mofetil (MMF). The RIC (n=34) protocol consisted of fludarabine combined with busulfan or cyclophosphamide, antithymocyte globulin, and posttransplant immunosuppression CsA plus methotrexate. Diagnoses included hematologic malignancies and solid tumors. Donors were 34 human leukocyte antigen-identical siblings and 24 unrelated donors. Chimerism was analyzed by polymerase chain reaction of minisatellites. Graft failure occurred in 6 of 24 in the NM group and in 1 of 34 in the RIC group, which was a significant difference (odds ratio [OR], 22.6; P=0.02). The NM group also had less leukopenia and required fewer erythrocyte and platelet transfusions than the RIC group. The time to and proportion of CD3, CD19, and CD45 donor chimerism were similar in both groups. The cumulative incidence of grades II to IV acute GVHD was higher in the NM group (59% vs. 12%; OR, 26.9; P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001), but we found no difference in the cumulative incidence of chronic GVHD (41% vs. 61%). TRM was 42% in the NM group and 20% in the RIC patients (relative hazard, 11.6; P=0.03). NM conditioning with posttransplant immunosuppression using CsA and MMF resulted in less leukopenia and fewer transfusions, but resulted in more cases of graft failure, acute GVHD, and TRM than in RIC patients.

T-Cell Receptor Excision Circle Levels After Allogeneic Stem Cell Transplantation Are Predictive of Relapse in Patients with AML and MDS

by Mehmet Uzunel and Darius Sairafi

Stem Cells and Development, 2014

In this retrospective study, 209 patients with malignant disease were analyzed for levels of T-ce... more In this retrospective study, 209 patients with malignant disease were analyzed for levels of T-cell receptor excision circles (TRECs) for the first 24 months after allogeneic stem cell transplantation. CD3 + cells were separated by direct antibody-coupled magnetic beads, followed by DNA extraction according to a standard protocol. The dRec-cJa signal joint TREC was measured with real-time quantitative PCR. Patients were grouped based on malignant disease: chronic myeloid leukemia, chronic lymphatic leukemia, acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), and myelodysplastic syndrome (MDS). Patients were further subdivided based on TREC levels below (low-TREC) or above (high-TREC) median at each time point. TREC levels were then correlated to relapse incidence and relapse-free survival (RFS). For patients with AML, low TREC levels 2 months post-transplantation were correlated to high relapse incidence at 5 years (P < 0.05). In patients with chronic leukemia, high TREC levels were correlated with improved RFS (P < 0.05). For patients with MDS, high TREC levels at 9 months post-transplantation were associated with higher RFS at 5 years (P < 0.02) and lower relapse incidence (P < 0.02). This study shows the potential use of TREC measurement in blood to predict relapse in patients with AML and MDS after allogeneic hematopoietic stem cell transplantation.

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Maternal Microchimerism in Juvenile Tonsils and Adenoids

Pediatric Research, 2010

During pregnancy small amounts of cells pass between the mother and the fetus, and this transfer ... more During pregnancy small amounts of cells pass between the mother and the fetus, and this transfer may give rise to a chimeric state that persist for years in both individuals. Both fetal and maternal microchimerism (MMc) have been associated with different autoimmune disorders. Information about MMc in tissues of healthy individuals is sparse but is important when looking for maternal cells within affected tissues of certain diseases. The aim of this study was to investigate the occurrence of maternal cells in tonsils and adenoids of 20 healthy children between the ages of 2 and 15 years. All the children underwent surgery because of recurrent tonsillitis or respiratory obstruction. MMc was detected using an RT-PCR assay based on differences in gene polymorphisms between mother and child. We found maternal cells in the tonsils and/or adenoids in four of 20 children. This frequency is less than the frequency of maternal cells found in the peripheral blood of healthy adults but in agreement with the previously reported frequency of maternal chimerism in control tissues. (Pediatr Res 68:

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Leukemia lineage-specific chimerism analysis is a sensitive predictor of relapse in patients with acute myeloid leukemia and myelodysplastic syndrome after allogeneic stem cell transplantation

Leukemia, 2001

One of the major complications after allogeneic stem cell transplantation (SCT) in patients with ... more One of the major complications after allogeneic stem cell transplantation (SCT) in patients with malignant disease is a high frequency of relapse. We have prospectively analyzed the clinical impact of recipient-derived chimeric cells in 30 patients with acute myeloid leukemia and myelodysplastic syndrome after SCT. In order to improve sensitivity and specificity, all samples were cell-separated by using immunomagnetic beads according to the patient&amp;amp;#39;s leukemia phenotype, expressed at diagnosis or relapse before SCT. Twelve out of 30 patients experienced a clinical relapse after SCT. Median follow-up time for patients alive and without relapse (n = 15) was 30 (16-47) months. Mixed chimerism in peripheral blood (PB) and bone marrow (BM) &amp;amp;gt; or =1 month post SCT, in the leukemia-affected cell lineage, was detected in 14/30 patients. Ten of these 14 patients relapsed as compared to 2/16 with donor chimerism (DC) (P &amp;amp;lt;0.01). All eight patients with MC in peripheral blood &amp;amp;gt; or =1 month after SCT relapsed vs 4/22 DC patients (P &amp;amp;lt; 0.001). MC was detected a median of 66 (23-332) days before hematological relapse. No correlation was found between T cell MC and relapse. In this study, chimerism analysis showed a higher sensitivity and specificity vs morphological examination. In conclusion, this study may provide a rational basis for treatment with adoptive immunotherapy at an earlier time after SCT than at present, in patients with AML and MDS, in order to treat recurrences of malignant disease.

Minimal residual disease is common after allogeneic stem cell transplantation in patients with B cell chronic lymphocytic leukemia and may be controlled by graft-versus-host disease

Leukemia, 2000

Following allogeneic stem cell transplantation (SCT), we studied the presence of donor and recipi... more Following allogeneic stem cell transplantation (SCT), we studied the presence of donor and recipient derived cells within the CD19 ؉ B cell fraction, in patients with B cell chronic lymphocytic leukemia (CLL). The chimeric status of the six patients studied was further investigated with minimal residual disease (MRD) detection, by sequencing and using patient-specific primers derived from junctional regions of clonally rearranged immunoglobulin heavy-chain (IgH) receptor genes. To date, five of six patients are alive with a median follow-up time of 24 months (range 15-60) post-SCT. All patients experienced acute and chronic graft-versus-host disease and responded clinically to SCT. All patients were MRD positive after SCT, which correlated to mixed chimerism within the CD19 ؉ cell fraction in all samples except one (25/26). High levels of tumor necrosis factor-␣ (TNF-␣) and soluble interleukin-2 receptor (sIL-2R) indicated advanced disease, and patients with increased levels pre-and post-SCT were also those with the most long-lasting PCR-detectable MRD post-SCT. Hence, a high tumor burden pre-SCT may reflect the long duration of detectable MRD in patients with B-CLL after SCT. A durable anti-leukemic effect was probably important in these patients. Leukemia (2000) 14, 247-254.

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Tissue repair using allogeneic mesenchymal stem cells for hemorrhagic cystitis, pneumomediastinum and perforated colon

Leukemia, 2007

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Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells

The Lancet, 2004

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Inhibition of Heavy Chain and 2-Microglobulin Synthesis as a Mechanism of Major Histocompatibility Complex Class I Downregulation during Epstein-Barr Virus Replication

by Mehmet Uzunel and J. Tllez-sosa

Journal of Virology, 2007

The mechanisms of major histocompatibility complex (MHC) class I downregulation during Epstein-Ba... more The mechanisms of major histocompatibility complex (MHC) class I downregulation during Epstein-Barr virus (EBV) replication are not well characterized. Here we show that in several cell lines infected with a recombinant EBV strain encoding green fluorescent protein (GFP), the virus lytic cycle coincides with GFP expression, which thus can be used as a marker of virus replication. EBV replication resulted in downregulation of MHC class II and all classical MHC class I alleles independently of viral DNA synthesis or late gene expression. Although assembled MHC class I complexes, the total pool of heavy chains, and beta2-microglobulin (beta2m) were significantly downregulated, free class I heavy chains were stabilized at the surface of cells replicating EBV. Calnexin expression was increased in GFP+ cells, and calnexin and calreticulin accumulated at the cell surface that could contribute to the stabilization of class I heavy chains. Decreased expression levels of another chaperone, ERp57, and TAP2, a transporter associated with antigen processing and presentation, correlated with delayed kinetics of MHC class I maturation. Levels of both class I heavy chain and beta2m mRNA were reduced, and metabolic labeling experiments demonstrated a very low rate of class I heavy chain synthesis in lytically infected cells. MHC class I and MHC class II downregulation was mimicked by pharmacological inhibition of protein synthesis in latently infected cells. Our data suggest that although several mechanisms may contribute to MHC class I downregulation in the course of EBV replication, inhibition of MHC class I synthesis plays the primary role in the process.

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Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells

by Moustapha Hassan and Mehmet Uzunel

The Lancet, 2004

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Improved Survival after Allogeneic Hematopoietic Stem Cell Transplantation in Recent Years. A Single-Center Study

by Moustapha Hassan, Sofia Berglund, K. Garming Legert, Attila Szakos, Darius Sairafi, Göran Dahllöf, Aldona Dlugosz, and Mehmet Uzunel

Biology of Blood and Marrow Transplantation, 2011

A Single-Center Study analysis. When correcting for differences between the 4 groups, the hazard ... more

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An ex vivo RT-qPCR-based assay for human peripheral leukocyte responsiveness to glucocorticoids in surgically induced inflammation

Journal of Inflammation Research, 2015

Hypogammaglobulinemia in children after allogeneic hematopoietic stem cell transplantation: A cytokine mediated immunoglobulin isotype class switch arrest?

Pediatric blood & cancer, 2015

Expression of Vascular Endothelial Growth Factor Receptor2 or Tie2 on Peripheral Blood Cells Defines Functionally Competent Cell Populations Capable of Reendothelialization

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Adult porcine islets produce MCP-1 and recruit human monocytes in vitro

Xenotransplantation, 2004

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An allogeneic anti-cancer effect after hematopoietic stem cell transplantation

Transplantation Proceedings, 2001

T CELL MIXED CHIMERISM IS SIGNIFICANTLY CORRELATED TO A DECREASED RISK OF ACUTE GRAFT-VERSUS-HOST DISEASE AFTER ALLOGENEIC STEM CELL TRANSPLANTATION 1

Transplantation, 2001

Mesenchymal Stem Cells for Treatment of Therapy-Resistant Graft-versus-Host Disease

Transplantation, 2006

TRANSPLANTATION OF AUTOLOGOUS AND ALLOGENEIC BONE MARROW WITH LIVER FROM A CADAVERIC DONOR FOR PRIMARY LIVER CANCER1

Transplantation, 2000

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Factors With an Impact on Chimerism Development and Long-Term Survival After Umbilical Cord Blood Transplantation

Transplantation Journal, 2012

by Mehmet Uzunel, Brigitta Omazic, and Darius Sairafi

Transplantation, 2006

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A Comparison of Nonmyeloablative and Reduced-Intensity Conditioning for Allogeneic Stem-Cell Transplantation

Transplantation, 2004

T-Cell Receptor Excision Circle Levels After Allogeneic Stem Cell Transplantation Are Predictive of Relapse in Patients with AML and MDS

by Mehmet Uzunel and Darius Sairafi

Stem Cells and Development, 2014

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Maternal Microchimerism in Juvenile Tonsils and Adenoids

Pediatric Research, 2010

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Leukemia lineage-specific chimerism analysis is a sensitive predictor of relapse in patients with acute myeloid leukemia and myelodysplastic syndrome after allogeneic stem cell transplantation

Leukemia, 2001