Papers by Mehmet Büyüktiryaki
Early Human Development, Aug 1, 2019
Background: Surfactant administration traditionally involved endotracheal intubation and mechanic... more Background: Surfactant administration traditionally involved endotracheal intubation and mechanical ventilation, which is associated with a risk of barotrauma and volutrauma. Objective: To compare the morbidity and mortality rates between LISA-treated and INSURE-treated premature babies with respiratory distress syndrome (RDS). Methods: We assessed retrospectively the medical records of preterm infants who were born at 25 0/7 to 29 6/7 weeks of gestation and were administered surfactant initially either with LISA or INSURE method over a fiveyear period. Results: Analysis of the data of 205 LISA-treated and 178 INSURE-treated infants revealed the mean gestational age as 28.1 ± 1.3 and 28 ± 1.3 weeks and mean birth weight as 1041 ± 205 and 1029 ± 222 g in LISA and INSURE groups, respectively. The mechanical ventilation requirement in the first 72 h of life (%26.8-%42.1, p = 0.002) and the incidence of moderate-severe BPD (%12.2-%21.9, p = 0.01) were lower in LISA-treated infants. LISA method was found as an independent factor in reducing mechanical ventilation requirement in the first 72 h of life and incidence of moderate-severe BPD [RR: -0.49 (%95 CI -0.28 to -0.85), p = 0.01]. Conclusion: Data obtained from our five-year clinical experience are comparable with the recent literature. LISA is currently the most suitable method of surfactant administration and it should be the first choice in spontaneously breathing infants considering its favorable effects on respiratory morbidities in preterm infants with RDS.
Turkish Journal of Pediatric Disease, 2021
Bronkopulmoner displazi (BPD), çok düşük doğum ağırlıklı her üç bebekten birini etkileyen uzun dö... more Bronkopulmoner displazi (BPD), çok düşük doğum ağırlıklı her üç bebekten birini etkileyen uzun dönem ciddi olumsuz sonuçları olan bir prematüre morbiditesidir. Bu çalışmada orta-ağır BPD için antenatal ve postnatal risk faktörlerini araştırmayı amaçladık.
Two-Year Outcomes After Minimally Invasive Surfactant Therapy in Preterm Infants
JAMA
ImportanceThe long-term effects of surfactant administration via a thin catheter (minimally invas... more ImportanceThe long-term effects of surfactant administration via a thin catheter (minimally invasive surfactant therapy [MIST]) in preterm infants with respiratory distress syndrome remain to be definitively clarified.ObjectiveTo examine the effect of MIST on death or neurodevelopmental disability (NDD) at 2 years’ corrected age.Design, Setting, and ParticipantsFollow-up study of a randomized clinical trial with blinding of clinicians and outcome assessors conducted in 33 tertiary-level neonatal intensive care units in 11 countries. The trial included 486 infants with a gestational age of 25 to 28 weeks supported with continuous positive airway pressure (CPAP). Collection of follow-up data at 2 years’ corrected age was completed on December 9, 2022.InterventionsInfants assigned to MIST (n = 242) received exogenous surfactant (200 mg/kg poractant alfa) via a thin catheter; those assigned to the control group (n = 244) received sham treatment.Main Outcomes and MeasuresThe key secondar...
Archivos Argentinos de Pediatria, 2020
RESUMEN Objetivos. Se ha demostrado, en diversos estudios llevados a cabo en adultos, que los gru... more RESUMEN Objetivos. Se ha demostrado, en diversos estudios llevados a cabo en adultos, que los grupos sanguíneos desempeñan un papel importante en muchas enfermedades. El objetivo fue investigar si hay una relación entre las morbilidades y el sistema de grupos sanguíneos ABO en lactantes prematuros. Metodología. En este estudio de cohorte retrospectivo, se incluyó a recién nacidos prematuros que habían nacido con menos de 32 semanas de gestación y con un peso al nacer inferior a 1500 g. Se los agrupó por grupo sanguíneo (0, A, B, AB) y por morbilidades de la prematurez y se los comparó. Resultados. Se analizaron los datos de 1785 recién nacidos prematuros de muy bajo peso al nacer. La comparación entre los grupos sanguíneos A y no A reveló que los lactantes de grupo sanguíneo A tenían una incidencia más alta de conducto arterial persistente (CAP) (48,7 % frente a 39,7 %, p = 0,005) y displasia broncopulmonar (DBP) (27 % frente a 20,8 %, p = 0,04), mientras que la incidencia de la hemorragia intraventricular de grado ≥3 era más baja (5,1 % frente a 10,1 %, p = 0,006). Conclusión. Este estudio es la primera y más grande investigación sobre la relación entre los grupos sanguíneos y las morbilidades en los prematuros. Con estos resultados se demuestra que el grupo sanguíneo A podría ser un factor de riesgo de CAP y DBP. Palabras clave: antígenos del grupo sanguíneo, displasia broncopulmonar, hemorragia intraventricular cerebral, conducto arterial persistente, prematuro.
Platelet mass index in very preterm infants: can it be used as a parameter for neonatal morbidities?
The Journal of Maternal-Fetal & Neonatal Medicine, 2015
Platelet mass index (PMI) is related to the platelet functionality. The aim of this study was to ... more Platelet mass index (PMI) is related to the platelet functionality. The aim of this study was to evaluate the correlation between PMI and the occurrence of various inflammation-related morbidities of prematurity, such as bronchopulmonary dysplasia (BPD), necrotizing enterocolitis (NEC), retinopathy of prematurity (ROP), intraventricular hemorrhage (IVH) and sepsis in very low-birth weight (VLBW) infants. This retrospective analysis of VLBW infants admitted to a level 3 neonatal intensive care unit from October 2012 and 2014, n = 330. Platelet mass was calculated and recorded on the day of birth and between 3 and 7 days (second measure) for each patient. Statistical analysis included analysis of paired samples t test and independent samples t test. Among VLBW neonates, PMI values were lower in infants with ROP (p = 0.016), BPD (p = 0.002), IVH (p = 0.018) and NEC (p = 0.011) when compared with the control group in the second measurement. In this study, we found that premature infants with BPD, NEC, ROP, IVH and sepsis had lower PMI levels in early postnatal life than infants without these diseases. This might be associated with the inflammatory process.
Turkiye Klinikleri Journal of Medical Sciences, 2010
Yo ğun ba kım üni te le rin de ya tan has ta la rın kli nik du rum la rı nı ve prog noz la rı nı ... more Yo ğun ba kım üni te le rin de ya tan has ta la rın kli nik du rum la rı nı ve prog noz la rı nı nesnel ola rak de ğer len dir mek ve yo ğun ba kım üni te le rin den en yük sek ve ri mi ala bil mek ama cıy la çok sa yı da skor la ma yön te mi kul la nıl mak ta dır. Bu ça lış ma nın ama cı, ço cuk yo ğun ba kım üni te miz de bir yıl bo yun ca iz len miş has ta lar da Pe di at ric Risk of Mor ta lity(PRISM) ve Pe di at ric In dex of Mor ta lity (PIM) skor la rı nın mor ta li te yi be lir le me de ki gü ve ni lir li ği ni ve ge çer li li ği ni araş tır mak, bu skor la ma sis tem le ri ile pe di yat rik yaş gru bu na gö re mo di fi ye et ti ği miz APAC HE II (Acu te Physi o lo gi cal and Chro nic He alth Eva lu a ti on Sco re II) skor la ma sis te mi ni kar şı laş tır mak tır. G Ge e r re eç ç v ve e Y Yö ön n t te em m l le er r: : Bu ça lış ma, ço cuk yo ğun ba kım üni te sin de bir yıl lık dö nem de iz le nen 1 ay-16 yaş ara sı 250 has ta üzerin de ya pıl mış tır. PRISM, PIM ve mo di fi ye APAC HE II skor la ma sis tem le ri nin po tan si yel mor tali te ris ki ni be lir le me de ki be ce ri si üç fark lı yaş gru bu na gö re de ğer len di ril miş tir (1-12 ay, 13-60 ay and 61 ay ve üze ri). B Bu ul l g gu u l la ar r: : Ça lış ma mız da, ger çek le şen ölüm ora nı %34.4 iken PIM mor ta li te skor la ma sis te min de bek le nen or ta la ma ölüm ris ki %16.6, PRISM 'de %21.5 ve mo di fi ye et ti ği miz APAC HE II' de ise %37.6 ola rak bu lun du. Uy gu la dı ğı mız üç mor ta li te skor la ma sis te mi nin de ğerlen di ril me sin de, bek le nen or ta la ma ölüm ris ki, stan dar di ze mor ta li te ora nı (SMR) ve ROC ana li zi so nuç la rı ile her üç yaş gru bun da da, ölüm ora nı nı en iyi tah min eden sis tem mo di fi ye APAC HE II mor ta li te skor la ma sis te mi ol muş tur. S So o n nu uç ç: : Fark lı özel lik le re sa hip ço cuk yo ğun ba kım üni te le rini de içe ren çok mer kez li ça lış ma lar ile ço cuk yo ğun ba kım lar için da ha ve rim li bir skor la ma sis temi oluş tu ru la bi le ce ği ni dü şün mek te yiz.
Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi
Objective: The aim of this study is to evaluate the effect of gender on premature morbidity and m... more Objective: The aim of this study is to evaluate the effect of gender on premature morbidity and mortality in very low birth weight (VLBW) infants. Materials and Methods: In this retrospective study, infants gestational age of less than 30 weeks admitted to the neonatal intensive care unit of Zekai Tahir Burak Maternity and Teaching Hospital between January 2013 and December 2017 were evaluated. Infants of both sexes; demographic characteristics, neonatal morbidities and mortality were compared. The infants were then divided into subgroups according to their gestational weeks (<28 weeks, >28 weeks) and neonatal outcomes were reevaluated.
Amac: Patent duktus arteriozus (PDA) sikligi, gebelik haftasi ve dogum agirligiyla ters orantilid... more Amac: Patent duktus arteriozus (PDA) sikligi, gebelik haftasi ve dogum agirligiyla ters orantilidir. Patent duktus arteriozus sikligi, <1000 gr bebeklerde; %40-55, <1500 gr bebeklerde: %30 olarak belirtilmektedir. Patent duktus arteriozus, bronkopulmoner displazi (BPD), nekrotizan enterokolit (NEK), premature retinopatisi (ROP), intraventrikuler kanama (IVK) ve uzun donem olumsuz norogelisimsel sonuclar ile iliskili olup, 3 farkli tedavi yaklasimi (konservatif tedavi, siklooksijenaz (COX) inhibitorleri, cerrahi tedavi) vardir. Calismamizda cok dusuk dogum agirlikli (CDDA; <1500g) premature bebeklerde hemodinamik anlamli PDA’nin sikliginin belirlenmesi ve bu bebeklerde demografik ve klinik ozelliklerin belirlenmesi amaclanmistir. Materyal ve Metod: Calismamizda Ocak 2013 ile Aralik 2016 tarihleri arasinda unitemizde izlenen, gebelik yasi <30 hafta olan CDDA bebeklerin tibbi kayitlari retrospektif olarak incelendi. Bebeklerin demografik ve klinik ozellikleri kayit edildi. ...
Comparison of Nasal CPAP versus Bi-level CPAP in Transient Tachypnea of the Newborn: A Randomized Trial
American Journal of Perinatology, 2020
Objective The optimal noninvasive ventilation (NIV) modality in the treatment of transient tachyp... more Objective The optimal noninvasive ventilation (NIV) modality in the treatment of transient tachypnea of the newborn (TTN) is still unknown. The aim of this study was to compare nasal continuous positive airway pressure (NCPAP) versus bi-level CPAP in the treatment of TTN. Study Design This was a prospective randomized study that was conducted in a tertiary level neonatal intensive care unit of Zekai Tahir Burak Women's Health Education and Research Hospital during the 1-year period between April 2017 and March 2018. The study included infants at ≥34 gestational weeks and birth weight ≥2,000 g who were diagnosed with TTN. The patients were randomized to either NCPAP or bi-level CPAP groups as initial respiratory support. The primary outcome was the rate of NIV failure. Results A total of 151 infants were incorporated into the study. The intubation rate was significantly higher in the NCPAP group (15/75) compared with the bi-level CPAP group (6/76) (p = 0.032). There was a signifi...
İstanbul Kanuni Sultan Süleyman Tıp Dergisi, 2018
Tiroid hormonlarının, özellikle düşük total triiyodotironin (T3) ve tiroksin (T4) düzeylerinin ço... more Tiroid hormonlarının, özellikle düşük total triiyodotironin (T3) ve tiroksin (T4) düzeylerinin çocuklarda ve yeni doğanlarda bakteriyel sepsisin öngörücüsü olduğunu ileri sürülmüştür. Yalnız, hipotiroidi olan hastalarda sepsis sıklığı ve üreyen etkenlerin arasındaki ilişki özellikle prematürelerde bilinmemektedir. Çalışmamızda, çok düşük doğum ağırlıklı (ÇDDA; <1500g) prematüre bebeklerde konjenital hipotiroidi (KH) olan ve olmayan gruplar arasında geç neonatal sepsis (GNS), GNS atak sayısı, üreyen etkenler ve menenjit arasındaki ilişkiye bakılması amaçlanmıştır.
Background: Pulmonary hemorrhage (PH) is a life-threatening condition. Low gestational age, male ... more Background: Pulmonary hemorrhage (PH) is a life-threatening condition. Low gestational age, male sex, vaginal birth, presence of respiratory distress syndrome (RDS), patent ductus arteriosus (PDA), sepsis, hypoxia, severe hypothermia and congenital heart disease are associated with many conditions. Mortality in PH is reported up to 60%.
Archivos Argentinos de Pediatria, 2020
Objectives. Blood groups have been shown to play an important role in a lot of diseases in variou... more Objectives. Blood groups have been shown to play an important role in a lot of diseases in various studies conducted in adults. The objective was to investigate whether there is a relationship between morbidities and ABO blood groups system in preterm infants. Methodology. This retrospective cohort study included preterm neonates born at < 32 weeks of gestation with a birth weight < 1500 g. Neonates were grouped by blood type (O, A, B, AB) and morbidities of prematurity were compared among these groups. Results. Data pertaining to 1785 very low birth weight preterm neonates were analyzed. Comparison of the A and non-A blood groups revealed that infants with blood group A had significantly higher incidence of patent ductus arteriosus (PDA) (48.7 % vs. 39.7 %, p = 0.005) and bronchopulmonary dysplasia (BPD) (27 % vs. 20.8 %, p = 0.04), while the incidence of grade ≥ 3 intraventricular hemorrhage was lower (5.1 % vs. 10.1 %, p = 0.006). Conclusion. This study represents the first and biggest series examination of the relationship between blood groups and preterm morbidities. Our results show that blood group A may be a risk factor for PDA and BPD.
Genel Tip Dergisi, 2019
Öz Amaç: Patent duktus arteriyozus (PDA) ile konjenital hipotiroidi arasındaki ilişkinin araştırı... more Öz Amaç: Patent duktus arteriyozus (PDA) ile konjenital hipotiroidi arasındaki ilişkinin araştırılmasıdır.
Useful Platelet Indices for the Diagnosis and Follow-Up of Patent Ductus Arteriosus
American Journal of Perinatology, 2019
Objective The aim of this study was to assess the utility of early postnatal platelet indices in ... more Objective The aim of this study was to assess the utility of early postnatal platelet indices in the prediction of hemodynamically significant patent ductus arteriosus (hsPDA) and its response to pharmacological treatment in preterm infants. Study Design The medical records of 971 infants with gestational age < 30 weeks and birth weight < 1,500 g were analyzed retrospectively. Infants with hsPDA comprised the study group and those without hsPDA comprised the control group. Complete blood count results were recorded, and red cell distribution width-to-platelet ratio (RPR) and platelet mass were calculated. Results A total of 481 infants, 169 in the hsPDA group and 312 in the control group, were included. In terms of platelet indices, the hsPDA group showed significantly lower mean platelet volume (MPV) and platelet mass, whereas RPR was significantly higher (p < 0.05, respectively). Multiple logistic regression analysis showed that RDS (relative ratio [RR]: 2.39; 95% confide...
Pediatric Pulmonology, 2018
Background and Objectives: It is believed, that sustained lung inflation (SLI) at birth in preter... more Background and Objectives: It is believed, that sustained lung inflation (SLI) at birth in preterm infants reduces the need for mechanical ventilation (MV) and improves respiratory outcomes. The aim of this study was to compare need for MV in preterm infants at high risk for respiratory distress syndrome (RDS) after prophylactic SLI via short binasal prongs at birth combined with early nasal continuous positive airway pressure (nCPAP) versus nCPAP alone. Methods: Medical records of infants born at 26 0/7 to 29 6/7 weeks gestation through 2015 and 2017 were retrospectively assessed. Infants who get sustained inflations at 25 cmH 2 O pressure for 15 s following delivery via binasal short prongs comprised the study group. Gestational age matched infants who was supported solely with nCPAP (6 cmH 2 O PEEP) comprised the control group. Early rescue surfactant (200 mg/kg poractant alfa) was delivered using the less invasive surfactant administration technique in infants with established RDS. Results: A total of 215 infants were analyzed. Fewer infants in the SLI group required MV within the first 72 h of life compared to the control group (25.7% vs 56.9%, P < 0.001). In multiple logistic regression analysis, SLI emerged as an independent factor for reduced MV need. Bronchopulmonary dysplasia (BPD) incidence including mild BPD was significantly lower in the SLI group (31.9% vs 48%, P = 0.01); however, moderate and severe BPD rates did not reach to a statistical significance (11.5% vs 20.6%, P = 0.06). Conclusion: Prophylactic SLI maneuver at birth for preterm infants with impending RDS reduces the need for MV with no adverse effects.
Journal of Clinical Laboratory Analysis, 2018
Background: The role of red cell distribution width-to-platelet ratio (RPR) has not previously be... more Background: The role of red cell distribution width-to-platelet ratio (RPR) has not previously been mentioned in reports on patent ductus arteriosus (PDA). Our objective was to evaluate whether RPR would have a role in the diagnosis and/or prediction of pharmacological closure of PDA. Methods: Preterm infants' gestational age ≤30 weeks and ≤1500 g who were given first ibuprofen treatment in the first week of life for hemodynamically significant PDA (hsPDA) were included in the study. The patients were matched for gestational age, birthweight, and sex. Patients were subdivided into two groups based on the response to medical treatment (open and closed PDA). Hemogram parameters were recorded before and after medical therapy. Groups were compared with regard to demographic and clinical characteristics and for three sequential hematological parameters. RPR was calculated. Patients with sepsis, anemia, perinatal asphyxia, and congenital/chromosomal anomaly were not included in the study. Results: A total of 112 infants had medically treated hsPDA. Of those, ductus closed in 70 neonates (closed PDA). A total of 96 infants constituted the control group. Mean gestational age and birthweight of the patients were 28.9 ± 2.4 weeks and 1207 ± 372 g. While RPR was significantly increased, PCT was lower in both hsPDA and open PDA groups (P < 0.05 and P < 0.05, respectively). In multivariate analysis, high RPR (OR 3.3, 95% CI 1.438-5.872, P < 0.05) and RDS (OR 2.9, 95% CI 1.903-4.811, P < 0.01) were detected as independent risk factors for hsPDA. Conclusion: Red cell distribution width-to-platelet ratio and PCT may be promising supportive tools for the diagnosis and prediction of pharmacotherapy success.
Güncel Pediatri
Introduction: There is insufficient data on neurodevelopmental outcomes of infants small for gest... more Introduction: There is insufficient data on neurodevelopmental outcomes of infants small for gestational age (SGA) with ≤30 weeks of gestation. The aim of our study was to compare the neurodevelopmental outcomes of preterm infants who are ≤30 weeks, in terms of being SGA or appropriate for gestational age (AGA). Materials and Methods: The data of infants who were born at ≤30 GW, were evaluated retrospectively. Neurological examinations and developmental assessment using Bayley Scales of Infant Development 2 nd edition was performed at the corrected age of 18-24 months. Results: The data of 228 infants of whom 65 were SGA and 163 were AGA was evaluated in terms of neurodevelopment at the corrected age of 18-24 months. The mean gestational age (GA) was 28.4±1.1 in both groups (p=0.82) and the mean BW was 810±135 g in the SGA group and 1175±183 g in the AGA group (p<0.001). The SGA group had significantly lower Mental Development Index (p=0.01) and Psychomotor Development Index (p<0.001). In multivariate regression analysis, SGA was identified as an independent risk factor for neurodevelopmental delay (RR: 2.27; p=0.02). Conclusion: Being SGA is a risk factor for neurodevelopmental impairment of preterm infants (≤30 GW). Öz Giriş: Gestasyon haftasına göre küçük (SGA) olan ≤30 hafta bebeklerin nörogelişimsel sonuçları hakkında yeterli veri bulunmamaktadır. Çalışmadaki amacımız SGA ve gestasyon haftasına göre normal (AGA) doğum ağırlığına sahip ≤30 hafta prematüre bebeklerde nörogelişimsel sonuçları karşılaştırmaktır. Gereç ve Yöntem: Düzeltilmiş 18-24. aylarda nörolojik muayeneleri ve "Bayley Bebekler için Gelişimsel Değerlendirme Ölçeği II" ile gelişimsel değerlendirmeleri yapılan ≤30 hafta prematüre bebeklerin verileri retrospektif olarak değerlendirildi. Bulgular: Düzeltilmiş 18-24. ayda SGA (n=65) ve AGA (n=163) gruplarında toplam 228 bebek nörogelişimsel açıdan değerlendirildi. SGA ve AGA grubunda ortalama gestasyon yaşı (sırasıyla 28,4±1,1 ve 28,4±1,1, p=0,82) ve doğum ağırlığı (sırasıyla 810±135 ve 1175±183 g, p<0,001) olarak tespit edildi. Nörogelişimsel değerlendirmede, SGA grubunda bilişsel ölçek puanı (p<0,01) ve hareket ölçek Keywords Neurodevelopmental delay, prematurity, small for gestational age Anah tar ke li me ler Nörogelişimsel gerilik, prematürite, gebelik yaşına göre küçük
Effect of Minimally Invasive Surfactant Therapy vs Sham Treatment on Death or Bronchopulmonary Dysplasia in Preterm Infants With Respiratory Distress Syndrome
JAMA, 2021
Importance The benefits of surfactant administration via a thin catheter (minimally invasive surf... more Importance The benefits of surfactant administration via a thin catheter (minimally invasive surfactant therapy [MIST]) in preterm infants with respiratory distress syndrome are uncertain. Objective To examine the effect of selective application of MIST at a low fraction of inspired oxygen threshold on survival without bronchopulmonary dysplasia (BPD). Design, Setting, and Participants Randomized clinical trial including 485 preterm infants with a gestational age of 25 to 28 weeks who were supported with continuous positive airway pressure (CPAP) and required a fraction of inspired oxygen of 0.30 or greater within 6 hours of birth. The trial was conducted at 33 tertiary-level neonatal intensive care units around the world, with blinding of the clinicians and outcome assessors. Enrollment took place between December 16, 2011, and March 26, 2020; follow-up was completed on December 2, 2020. Interventions Infants were randomized to the MIST group (n = 241) and received exogenous surfactant (200 mg/kg of poractant alfa) via a thin catheter or to the control group (n = 244) and received a sham (control) treatment; CPAP was continued thereafter in both groups unless specified intubation criteria were met. Main Outcomes and Measures The primary outcome was the composite of death or physiological BPD assessed at 36 weeks' postmenstrual age. The components of the primary outcome (death prior to 36 weeks' postmenstrual age and BPD at 36 weeks' postmenstrual age) also were considered separately. Results Among the 485 infants randomized (median gestational age, 27.3 weeks; 241 [49.7%] female), all completed follow-up. Death or BPD occurred in 105 infants (43.6%) in the MIST group and 121 (49.6%) in the control group (risk difference [RD], -6.3% [95% CI, -14.2% to 1.6%]; relative risk [RR], 0.87 [95% CI, 0.74 to 1.03]; P = .10). Incidence of death before 36 weeks' postmenstrual age did not differ significantly between groups (24 [10.0%] in MIST vs 19 [7.8%] in control; RD, 2.1% [95% CI, -3.6% to 7.8%]; RR, 1.27 [95% CI, 0.63 to 2.57]; P = .51), but incidence of BPD in survivors to 36 weeks' postmenstrual age was lower in the MIST group (81/217 [37.3%] vs 102/225 [45.3%] in the control group; RD, -7.8% [95% CI, -14.9% to -0.7%]; RR, 0.83 [95% CI, 0.70 to 0.98]; P = .03). Serious adverse events occurred in 10.3% of infants in the MIST group and 11.1% in the control group. Conclusions and Relevance Among preterm infants with respiratory distress syndrome supported with CPAP, minimally invasive surfactant therapy compared with sham (control) treatment did not significantly reduce the incidence of the composite outcome of death or bronchopulmonary dysplasia at 36 weeks' postmenstrual age. However, given the statistical uncertainty reflected in the 95% CI, a clinically important effect cannot be excluded. Trial Registration anzctr.org.au Identifier: ACTRN12611000916943.
Comparison of Different Growth Curves in the Assessment of Extrauterine Growth Restriction in Very Low Birth Weight Preterm Infants
SSRN Electronic Journal, 2021
Gebelik Yaşına Göre Normal ve Düşük Doğum Ağırlıklı Prematüre Bebeklerde Mortalite ve Morbiditelerin Karşılaştırılması
Amac Gebelik yasina gore kucuk (SGA) ve normal (AGA) dogum agirligi olan cok dusuk dogum agirlikl... more Amac Gebelik yasina gore kucuk (SGA) ve normal (AGA) dogum agirligi olan cok dusuk dogum agirlikli premature bebeklerde (CDDA) morbiditeleri ve mortaliteyi karsilastirmaktir. Materyal ve metot Unitemizde 2013-2017 yillari arasinda izlenen CDDA’li bebeklerin kayitlari retrospektif olarak incelendi. SGA, dogum agirliginin gebelik haftasina gore 10 persentilin altinda olmasi, AGA dogum agirliginin 10-90 persentil arasinda olmasi olarak tanimlandi. Toplam 96 SGA’si olan bebek calisma grubu ve calisma grubunun gestasyon haftasina uygun olarak rastgele secilen 204 AGA olan bebek kontrol grubu olarak belirlendi. Major konjenital anomalisi olan ve verilerinde eksiklik olan bebekler calisma disi birakildi. Bulgular SGA ve AGA gurubunda ortalama gestasyon yasi (28.3±1.1–28.3±1.2, sirasiyla, p=0.94) ve dogum agirligi ise (769±144–1132±190 gr, sirasiyla, <0.001) idi. SGA grubunda preeklampsi ve sezaryen ile dogum anlamli olarak daha sik, 5. dakika APGAR skoru daha dusuk iken, CRIB skoru ise ...
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Papers by Mehmet Büyüktiryaki