Papers by Maura Regina Laureano Rocha
Práticas educativas em saúde auditiva: Nos contextos educacional, ambiental e ocupacional, 2021
Sao Paulo Medical Journal, 2021
Although substantial increases in the numbers of elderly people are now foreseen in all countries... more Although substantial increases in the numbers of elderly people are now foreseen in all countries, greater growth is expected in developing regions such as Brazil, where the proportions are expected to become 18.8% in 2020 and 29.3% in 2050. 1,2 Primary care is considered to be the front line for healthcare for the elderly and can provide regular contacts focused on preventing disabilities resulting from chronic health conditions, such as classification of cognitive impairment in this age group. 3 Healthcare professionals are faced with the challenge of evaluating the limit of normality among elderly people's cognitive alterations. Within the concept of senescence, they need to differentiate the expected changes for this age group from the pathological conditions of aging that constitute senility. If such conditions are seen at the prodromal stage, reversal or mitigation may still be possible. 4,5 Development of dementia in elderly people is a measurable risk. Thus, the pathological transition to this, from a mild stage of cognitive impairment, forms a "gray zone" between normality and initial dementia. 4 Screening for cognitive impairment among elderly people can be achieved through instruments that have already been translated and validated for application in Brazil. 6 Bustamante et al. 7 suggested that cognitive tests and functional scales should be used in combination, in populations with educational heterogeneity. This would improve the accuracy of cognitive screening among mild to moderate cases of dementia because, when used together, they
PLoS ONE, 2014
Tinnitus is characterized by the perception of sound in the absence of an external auditory stimu... more Tinnitus is characterized by the perception of sound in the absence of an external auditory stimulus. The network connectivity of auditory and non-auditory brain structures associated with emotion, memory and attention are functionally altered in debilitating tinnitus. Current studies suggest that tinnitus results from neuroplastic changes in the frontal and limbic temporal regions. The objective of this study was to use Single-Photon Emission Computed Tomography (SPECT) to evaluate changes in the cerebral blood flow in tinnitus patients with normal hearing compared with healthy controls. Methods: Twenty tinnitus patients with normal hearing and 17 healthy controls, matched for sex, age and years of education, were subjected to Single Photon Emission Computed Tomography using the radiotracer ethylenedicysteine diethyl ester, labeled with Technetium 99 m (99 mTc-ECD SPECT). The severity of tinnitus was assessed using the ''Tinnitus Handicap Inventory'' (THI). The images were processed and analyzed using ''Statistical Parametric Mapping'' (SPM8). Results: A significant increase in cerebral perfusion in the left parahippocampal gyrus (pFWE ,0.05) was observed in patients with tinnitus compared with healthy controls. The average total THI score was 50.8+18.24, classified as moderate tinnitus. Conclusion: It was possible to identify significant changes in the limbic system of the brain perfusion in tinnitus patients with normal hearing, suggesting that central mechanisms, not specific to the auditory pathway, are involved in the pathophysiology of symptoms, even in the absence of clinically diagnosed peripheral changes.
Journal of Applied Research in Intellectual Disabilities, 2010
Jackowski, AP, Laureano, MR, Del'Aquilla, MA, De Moura, LM, Assunção, I., Silva, I. and Schw... more Jackowski, AP, Laureano, MR, Del'Aquilla, MA, De Moura, LM, Assunção, I., Silva, I. and Schwartzman, JS, Update on Clinical Features and Brain Abnormalities in Neurogenetics Syndromes. Journal of Applied Research in Intellectual Disabilities, no. doi: 10.1111/j. ...
Arquivos de Neuro-Psiquiatria, 2010
Neuropeptide Y (NPY) is an important neuromodulator found in central and peripheral neurons. NPY ... more Neuropeptide Y (NPY) is an important neuromodulator found in central and peripheral neurons. NPY was investigated in the peripheral auditory pathway of conventional housed rats and after nontraumatic sound stimulation in order to localize the molecule and also to describe its response to sound stimulus. Rats from the stimulation experiment were housed in monitored sound-proofed rooms. Stimulated animals received sound stimuli (pure tone bursts of 8 kHz, 50 ms duration presented at a rate of 2 per second) at an intensity of 80 dB sound pressure level for 1 hr per day during 7 days. After euthanizing, rat cochleae were processed for one-color immunohistochemistry. The NPY immunoreactivity was detected in inner hair cells (IHC) and also in pillar and Deiters' cells of organ of Corti, and in the spiral ganglion putative type I (> or = 1,009 microm(3)) and type II (< or = 225 microm(3)) neurons. Outer hair cells (OHC) showed light immunoreaction product. Quantitative microdensitometry showed strong and moderate immunoreactions in IHC and spiral ganglion neurons, respectively, without differences among cochlear turns. One week of acoustic stimulation was not able to induce changes in the NPY immunoreactivity intensity in the IHC of cochlea. However, stimulated rats showed an overall increase in the number of putative type I and type II NPY immunoreactive spiral ganglion neurons with strong, moderate, and weak immunolabeling. Localization and responses of NPY to acoustic stimulus suggest an involvement of the neuropeptide in the neuromodulation of afferent transmission in the rat peripheral auditory pathway.
PLoS ONE, 2014
Tinnitus is characterized by the perception of sound in the absence of an external auditory stimu... more Tinnitus is characterized by the perception of sound in the absence of an external auditory stimulus. The network connectivity of auditory and non-auditory brain structures associated with emotion, memory and attention are functionally altered in debilitating tinnitus. Current studies suggest that tinnitus results from neuroplastic changes in the frontal and limbic temporal regions. The objective of this study was to use Single-Photon Emission Computed Tomography (SPECT) to evaluate changes in the cerebral blood flow in tinnitus patients with normal hearing compared with healthy controls. Methods: Twenty tinnitus patients with normal hearing and 17 healthy controls, matched for sex, age and years of education, were subjected to Single Photon Emission Computed Tomography using the radiotracer ethylenedicysteine diethyl ester, labeled with Technetium 99 m (99 mTc-ECD SPECT). The severity of tinnitus was assessed using the ''Tinnitus Handicap Inventory'' (THI). The images were processed and analyzed using ''Statistical Parametric Mapping'' (SPM8). Results: A significant increase in cerebral perfusion in the left parahippocampal gyrus (pFWE ,0.05) was observed in patients with tinnitus compared with healthy controls. The average total THI score was 50.8+18.24, classified as moderate tinnitus. Conclusion: It was possible to identify significant changes in the limbic system of the brain perfusion in tinnitus patients with normal hearing, suggesting that central mechanisms, not specific to the auditory pathway, are involved in the pathophysiology of symptoms, even in the absence of clinically diagnosed peripheral changes. Citation: Laureano MR, Onishi ET, Bressan RA, Castiglioni MLV, Batista IR, et al. (2014) Memory Networks in Tinnitus: A Functional Brain Image Study. PLoS ONE 9(2): e87839.
Journal of Applied Research in Intellectual Disabilities, 2011
Jackowski, AP, Laureano, MR, Del'Aquilla, MA, De Moura, LM, Assunção, I., Silva, I. and Schw... more Jackowski, AP, Laureano, MR, Del'Aquilla, MA, De Moura, LM, Assunção, I., Silva, I. and Schwartzman, JS, Update on Clinical Features and Brain Abnormalities in Neurogenetics Syndromes. Journal of Applied Research in Intellectual Disabilities, no. doi: 10.1111/j. ...
Arquivos de Neuro-Psiquiatria, 2010
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Papers by Maura Regina Laureano Rocha