Mathieu Wolff

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After my PhD in 2004, I did my postdoctoral research in the university of Canterbury (New Zealand) before I secured a researcher position at the CNRS in 2008. Since then, I have been working at the Aquitaine Institute for Cognitive and Integrative Neurosciences (INCIA, Bordeaux, France). My main research interest is the functional contribution of limbic thalamic nuclei to high order cognition. More specifically, I am currently interested in the neurobiology of adaptive behaviors, with a particular emphasize on thalamocortical circuits.

Web: http://www.incia.u-bordeaux1.fr/spip.php?article225

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Andrej Dujella

University of Zagreb

Hemin Koyi

Uppsala University

Jana Javornik

University of East London

Graham Martin

University of Leicester

Gwen Robbins Schug

University of North Carolina at Greensboro

Gabriel Gutierrez-Alonso

University of Salamanca

John Sutton

Macquarie University

Eros Carvalho

Universidade Federal do Rio Grande do Sul

Kevin Arbuckle

Swansea University

Jesper Hoffmeyer

University of Copenhagen

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Papers by Mathieu Wolff

Editorial: Tropism, Mapping, Modeling, or Therapy Using Canine Adenovirus Type 2 (CAV-2) Vectors in the CNS

Frontiers in Molecular Neuroscience

Targeting Reciprocally Connected Brain Regions Through CAV-2 Mediated Interventions

Frontiers in Molecular Neuroscience

An important issue in contemporary neuroscience is to identify functional principles at play with... more An important issue in contemporary neuroscience is to identify functional principles at play within neural circuits. The reciprocity of the connections between two distinct brain areas appears as an intriguing feature of some of these circuits. This organization has been viewed as "re-entry," a process whereby two or more brain regions concurrently stimulate and are stimulated by each other, thus supporting the synchronization of neural firing required for rapid neural integration. However, until relatively recently, it was not possible to provide a comprehensive functional assessment of such reciprocal pathways. In this Brief Research Report, we highlight the use of a chemogenetic strategy to target projection-defined neurons in reciprocally connected areas through CAV-2 mediated interventions in the rat. Specifically, we targeted the bidirectional pathways between the dorsomedial prefrontal cortex (dmPFC) and the mediodorsal thalamus, as well as those connecting the insular cortex (IC) and the basolateral complex of the amygdala (BLA). These data showcase the usefulness of CAV-2-related strategies to address circuit-level issues. Moreover, we illustrate the inherent limitation of Cre-dependent adeno-associated virues (AAVs) with "leaked" expression of the gene of interest in the absence of Cre and highlight the need for appropriate control conditions.

Mathieu Wolff

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Papers by Mathieu Wolff

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