Medicine Papers by Mathieu Glaizal
Papers by Mathieu Glaizal
Clinical toxicology (Philadelphia, Pa.), 2015
Methadone for opiate substitution was available only in syrup formulation prior to 2008. In 2007,... more Methadone for opiate substitution was available only in syrup formulation prior to 2008. In 2007, the French Health Authorities made solid forms available. A national survey was performed in order to evaluate the modification of child poisonings induced by such a new pharmaceutical formulation. A prospective study was set up (April 15, 2008 to April 15, 2014) with the analysis of cases of unintentional ingestion of methadone by patients under 18 years old and managed by the 10 French poison control centers at the national level. As soon as a new pediatric exposure was recorded in the informatics data bank of the Poison Centers, a telephone survey was performed by the Marseilles' Poison Center to obtain the evolution and all the necessary details. 87 cases of child poisonings with the 2 forms were reviewed (syrup, 56 patients; capsules, 31 patients). Comparison shows that patients were similar for both formulations (no significant difference concerning age [median 2 years], sex r...
Toxicologie Analytique et Clinique, 2014
Presse médicale (Paris, France : 1983), 2009
Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2013
Paraquat, a widely used herbicide in the world, has caused severe and fatal poisonings. Because o... more Paraquat, a widely used herbicide in the world, has caused severe and fatal poisonings. Because of its high toxicity, the European Union withdrew paraquat from its market in July 2007. The purpose of this report is to describe cases of paraquat poisoning recorded at the Poison Control Center in Marseille over the 9-year period starting and ending 4.5 years before and after the paraquat ban. Data analysis showed that the most severe exposures were linked to ingestion. The fatality rate of deliberate consumption was near 50 % (34 suicide attempts and 15 deaths). Our data showed a marginal decline in total number of poisonings observed after the paraquat ban (38 vs 33 after the ban) mostly due to a decrease in the number of unintentional exposure (21 vs 16 after the ban). However, there was no apparent change in the number suicidal attempts using paraquat. Regarding geographical distribution, data showed that most poisonings in mainland France were unintentional, while poisonings in ov...
Presse médicale (Paris, France : 1983), 2013
Presse médicale (Paris, France : 1983), 2011
La Presse Médicale, 2009
Centre d'évaluation et d'information sur la pharmacodépendance, Centre antipoison, Service de pha... more Centre d'évaluation et d'information sur la pharmacodépendance, Centre antipoison, Service de pharmacologie clinique (Pr Bruguerolle) CHU
Toxins, 2009
A retrospective case review study of viper envenomations collected by the Marseille's Poison Cent... more A retrospective case review study of viper envenomations collected by the Marseille's Poison Centre between 1996 and 2008 was performed. Results: 174 cases were studied (52 grade 1 = G1, 90 G2 and 32 G3). G1 patients received symptomatic treatments (average hospital stay 0.96 day). One hundred and six (106) of the G2/G3 patients were treated with the antivenom Viperfav* (2.1+/-0.9 days in hospital), while 15 of them received symptomatic treatments only (plus one immediate death) (8.1+/-4 days in hospital, 2 of them died). The hospital stay was significantly reduced in the antivenom treated group (p < 0.001), and none of the 106 antivenom treated patients had immediate (anaphylaxis) or delayed (serum sickness) allergic reactions. Conclusion: Viperfav* antivenom was safe and effective for treating asp viper venom-induced toxicity.
Thérapie, 2011
Texte reçu le 24 juin 2011 ; accepté le 6 juillet 2011 Mots clés : buprénorphine ; injection intr... more Texte reçu le 24 juin 2011 ; accepté le 6 juillet 2011 Mots clés : buprénorphine ; injection intra-artérielle ; ischémie ; sympathectomie ; iloprost Résumé -La buprénorphine haut dosage (BHD) est un traitement de substitution de la dépendance aux opiacés (TSO) sublingual aux bénéfices sanitaires démontrés, mais aussi connu pour être fréquemment dévié, notamment par voie intraveineuse, avec des conséquences délétères. L'usage intra-artériel est beaucoup plus rarement décrit avec cette substance, tout comme le traitement de ses complications essentiellement ischémiques, allant parfois jusqu'à la nécrose. Nous rapportons ici un cas de ce type, chez un homme de 30 ans s'étant injecté dans l'artère radiale droite une solution de comprimés écrasés de BHD, et présentant quelques heures plus tard une ischémie sévère du pouce, de l'index et du majeur. Un traitement à la fois chirurgical (sympathectomie thoracique par vidéo-thoracoscopie) et médicamenteux (héparine, iloprost et piribédil mésilate) a permis une récupération digitale quasi complète (persistance d'une nécrose de la pulpe de l'index ayant nécessité une amputation distale) et un retour à domicile après 2 semaines d'hospitalisation.
Journal of Agromedicine, 2013
To gain better insight into the problem of accidental occupational exposure to phytosanitary prod... more To gain better insight into the problem of accidental occupational exposure to phytosanitary products, a retrospective study of experience at the Poison Control Center in Marseille, France, was conducted for the period between January 1, 2008, and December 31, 2010. A 129-case series was compiled. The study population was overwhelmingly male (83%), and the most common cause was insecticides (56.6% with a half pyrethrin and 21% organophosphate) and herbicides (26%). Although various exposure routes were observed, the most common were inhalation (43%) and skin contact (34%). The symptoms were mainly neurologic, digestive, and/or cutaneous. The severity of poisoning was generally mild, with no deaths or sequels. Only 5% of cases required hospitalization.
Clinical Toxicology, 2012
Context . Methadone is used in France since March 1995, only for opioid maintenance treatment, in... more Context . Methadone is used in France since March 1995, only for opioid maintenance treatment, in a syrup form. For the launching of a capsule form in April 2008, French health authorities requested a prospective survey of all cases involving exposure to methadone in either of the two available pharmaceutical forms. Objective . The aim was to document, in different circumstances and compare the safety of the new capsule form to the syrup. This report presents the fi ndings of one arm of the study, devoted to methadone-related suicide attempts. Materials and method . From April 15, 2008 to April 15, 2010, all self-injurious methadone poisonings notifi ed to or managed by the French Toxicovigilance Centers network were included. Analysis mainly focused on patients ' age and gender, estimated quantity ingested, eventual concomitantly taken substances, distribution of symptoms, and site of treatment. Results . 135 methadone-related suicide attempts were recorded. Analysis showed identical epidemiologic and clinical patient characteristics for the two pharmaceutical forms. Ten deaths occurred. The only discrepancy was a higher incidence of suicide attempts in the capsule group. However, as the number of capsule-treated patients increased during the second year, this difference remained signifi cant but tended to decrease. Discussion. Combining these results with Pharmacovigilance and Addictovigilance arms, health authorities estimated that the benefi t/risk balance of this new pharmaceutical form remains positive. They revised their position on requirements for prescribing and dispensing of the capsule form, and made them slightly easier. Following this, this " suicide " arm of Toxicovigilance survey was suspended, whereas the second one, concerning accidental pediatric methadone-related poisonings, has been extended until April 2014. Conclusion . In France, suicide attempts were more likely to occur with the capsule formulation. The clinical severity of intoxication was similar between the capsule and liquid forms.
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Medicine Papers by Mathieu Glaizal
Papers by Mathieu Glaizal