X UBLIC POLICY, like obscenity, is usually defined in practice by Justice Potter Stewart's m... more X UBLIC POLICY, like obscenity, is usually defined in practice by Justice Potter Stewart's maxim: "I don't know how to define it, but I know it when I see it." On a superficial level, most definitions are in basic agreement and differences are primarily semantic. Over-coming the diversity ...
... 23, 2000, at A22, available in LEXIS, News Library, NYT File (discussing the "fiuzzy log... more ... 23, 2000, at A22, available in LEXIS, News Library, NYT File (discussing the "fiuzzy logic" Internetfilter introduced at <www ... Endowment for the Arts v. Finley, 524 US 569, 587 (1998) (quoting Regan v. Taxation with Representation, 461 US ... "That editors-newspaper or broadcast ...
"In a book that is sometimes as brilliant as the best teacher you ever had ... Lessig brings... more "In a book that is sometimes as brilliant as the best teacher you ever had ... Lessig brings a keen focus to some of the thorniest issues posed by today's Internet: free speech, pornography, intellectual property, encryption, law beyond our borders and the courts' inabil-ity to stretch the ...
Page 1. JOINTCENTER AEI-BROOKINGS JOINT CENTER FOR REGULATORY STUDIES A Critical Assessment of th... more Page 1. JOINTCENTER AEI-BROOKINGS JOINT CENTER FOR REGULATORY STUDIES A Critical Assessment of the Traditional Residential Real Estate Broker Commission Rate Structure Mark S. Nadel * Related Publication 06-28 ...
More than 6,000 Americans die annually due to a shortage of organs for transplants. This article ... more More than 6,000 Americans die annually due to a shortage of organs for transplants. This article contends that the supply of donated organs could be increased (and thus many unnecessary deaths avoided) by the adoption of a policy of reciprocity, a kind of organ insurance. Those who committed to donate their organs at their death should be rewarded with a small preference in the event that they later need a transplant. Although this policy is opposed by those who hold that donations should be based solely on altruism, it would represent a form of reciprocal altruism and is consistent with the current United Network for Organ Sharing (UNOS) system of awarding 4 points to any patient seeking a kidney who has previously donated one and allowing paired exchanges. Increasing the supply of organs is already used as one of the justifications for the UNOS local first rule (whereby those located in the same local area as the donor are favored over better matches outside the area) and a recipr...
Page 1. BOOK REVIEW Customized News Services and Extremist Enclaves in Republic. com Mark S. Nade... more Page 1. BOOK REVIEW Customized News Services and Extremist Enclaves in Republic. com Mark S. Nadel* REPUBLIC.COM. By Cass Sunstein. Princeton: Princeton University Press. 2001. 224pp. I. INTRODUCTION ..... 832 ...
Somatic alterations in cellular DNA underlie almost all human cancers 1 . The prospect of targete... more Somatic alterations in cellular DNA underlie almost all human cancers 1 . The prospect of targeted therapies 2 and the development of high-resolution, genome-wide approaches 3-8 are now spurring systematic efforts to characterize cancer genomes. Here we report a large-scale project to characterize copy-number alterations in primary lung adenocarcinomas. By analysis of a large collection of tumors (n = 371) using dense single nucleotide polymorphism arrays, we identify a total of 57 significantly recurrent events. We find that 26 of 39 autosomal chromosome arms show consistent large-scale copy-number gain or loss, of which only a handful have been linked to a specific gene. We also identify 31 recurrent focal events, including 24 amplifications and 7 homozygous deletions. Only six of these focal events are currently associated with known mutations in lung carcinomas. The most common event, amplification of chromosome 14q13.3, is found in ~12% of samples. On the basis of genomic and functional analyses, we identify NKX2-1 (NK2 homeobox 1, also called TITF1), which lies in the minimal 14q13.3 amplification interval and encodes a lineage-specific transcription factor, as a novel candidate proto-oncogene involved in a significant fraction of lung adenocarcinomas. More generally, our results indicate that many of the genes that are involved in lung adenocarcinoma remain to be discovered.
X UBLIC POLICY, like obscenity, is usually defined in practice by Justice Potter Stewart's m... more X UBLIC POLICY, like obscenity, is usually defined in practice by Justice Potter Stewart's maxim: "I don't know how to define it, but I know it when I see it." On a superficial level, most definitions are in basic agreement and differences are primarily semantic. Over-coming the diversity ...
... 23, 2000, at A22, available in LEXIS, News Library, NYT File (discussing the "fiuzzy log... more ... 23, 2000, at A22, available in LEXIS, News Library, NYT File (discussing the "fiuzzy logic" Internetfilter introduced at <www ... Endowment for the Arts v. Finley, 524 US 569, 587 (1998) (quoting Regan v. Taxation with Representation, 461 US ... "That editors-newspaper or broadcast ...
"In a book that is sometimes as brilliant as the best teacher you ever had ... Lessig brings... more "In a book that is sometimes as brilliant as the best teacher you ever had ... Lessig brings a keen focus to some of the thorniest issues posed by today's Internet: free speech, pornography, intellectual property, encryption, law beyond our borders and the courts' inabil-ity to stretch the ...
Page 1. JOINTCENTER AEI-BROOKINGS JOINT CENTER FOR REGULATORY STUDIES A Critical Assessment of th... more Page 1. JOINTCENTER AEI-BROOKINGS JOINT CENTER FOR REGULATORY STUDIES A Critical Assessment of the Traditional Residential Real Estate Broker Commission Rate Structure Mark S. Nadel * Related Publication 06-28 ...
More than 6,000 Americans die annually due to a shortage of organs for transplants. This article ... more More than 6,000 Americans die annually due to a shortage of organs for transplants. This article contends that the supply of donated organs could be increased (and thus many unnecessary deaths avoided) by the adoption of a policy of reciprocity, a kind of organ insurance. Those who committed to donate their organs at their death should be rewarded with a small preference in the event that they later need a transplant. Although this policy is opposed by those who hold that donations should be based solely on altruism, it would represent a form of reciprocal altruism and is consistent with the current United Network for Organ Sharing (UNOS) system of awarding 4 points to any patient seeking a kidney who has previously donated one and allowing paired exchanges. Increasing the supply of organs is already used as one of the justifications for the UNOS local first rule (whereby those located in the same local area as the donor are favored over better matches outside the area) and a recipr...
Page 1. BOOK REVIEW Customized News Services and Extremist Enclaves in Republic. com Mark S. Nade... more Page 1. BOOK REVIEW Customized News Services and Extremist Enclaves in Republic. com Mark S. Nadel* REPUBLIC.COM. By Cass Sunstein. Princeton: Princeton University Press. 2001. 224pp. I. INTRODUCTION ..... 832 ...
Somatic alterations in cellular DNA underlie almost all human cancers 1 . The prospect of targete... more Somatic alterations in cellular DNA underlie almost all human cancers 1 . The prospect of targeted therapies 2 and the development of high-resolution, genome-wide approaches 3-8 are now spurring systematic efforts to characterize cancer genomes. Here we report a large-scale project to characterize copy-number alterations in primary lung adenocarcinomas. By analysis of a large collection of tumors (n = 371) using dense single nucleotide polymorphism arrays, we identify a total of 57 significantly recurrent events. We find that 26 of 39 autosomal chromosome arms show consistent large-scale copy-number gain or loss, of which only a handful have been linked to a specific gene. We also identify 31 recurrent focal events, including 24 amplifications and 7 homozygous deletions. Only six of these focal events are currently associated with known mutations in lung carcinomas. The most common event, amplification of chromosome 14q13.3, is found in ~12% of samples. On the basis of genomic and functional analyses, we identify NKX2-1 (NK2 homeobox 1, also called TITF1), which lies in the minimal 14q13.3 amplification interval and encodes a lineage-specific transcription factor, as a novel candidate proto-oncogene involved in a significant fraction of lung adenocarcinomas. More generally, our results indicate that many of the genes that are involved in lung adenocarcinoma remain to be discovered.
Uploads
Papers by Mark Nadel