Maria Mazzei

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Howard Nusbaum

University of Chicago

Michael Spivey

University of California, Merced

Krishna Prasad Miyapuram

Indian Institute of Technology Gandhinagar

Andrea Peto

Central European University

David Seamon

Kansas State University

Prof. Andrew Azzopardi

University of Malta

Syracuse University

Douglas College

Macquarie University

Universidade Federal do Rio Grande do Sul

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Papers by Maria Mazzei

Quantitative CT perfusion measurements in renal tumours: is it possible a differential diagnosis?

Electronic Commerce Research, 2011

Poster: "ECR 2011 / C-2325 / Quantitative CT perfusion measurements in renal tumours: is it ... more

Radiomics predicts survival of patients with advanced non‑small cell lung cancer undergoing PD‑1 blockade using Nivolumab

Oncology Letters, 2019

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Torsades de Pointes

Encyclopedia of Molecular Mechanisms of Disease, 2009

Thyroid Cancer

Encyclopedia of Molecular Mechanisms of Disease, 2009

Emangiomi epatici atipici di piccole dimensioni (≤2 cm) nel paziente non-cirrotico: classificazione in base al pattern di enhancement in TC spirale trifasica

Five years of stable disease with maintenance therapy using bevacizumab and tamoxifen in a patient with metastatic breast cancer

Cancer biology & therapy, Jan 26, 2015

Bevacizumab and Tamoxifen are valid therapeutic options for metastatic breast cancer (mBC) patien... more Bevacizumab and Tamoxifen are valid therapeutic options for metastatic breast cancer (mBC) patients. In this report, we describe a 47 year old woman with mBC successfully treated with a maintenance therapy with Bevacizumab+Tamoxifen. A maintenance approach using 2 different drugs with different targets and mechanism of action, such as anti-angiogenic and anti-hormonal treatment is particularly intriguing because they affect different pathways involved in mBC progression. Further studies including a large number of patients are needed, in order to select women who could benefit from this maintenance approach.

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[Role of computed tomography in the diagnosis of acute lung injury/acute respiratory distress syndrome]

Recenti progressi in medicina, 2012

Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a complex pulmonary pathology... more Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a complex pulmonary pathology with high mortality rates, manifesting over a wide range of severity. Clinical diagnosis relies on the following 4 criteria stated by the American-European Consensus Conference: acute onset of impaired gas exchange, severe hypoxemia defined as a PaO2 to FiO2 ratio <300 (PaO2 in mmHg), bilateral diffuse infiltration on chest X-ray; pulmonary artery wedge pressure of ≤18 mmHg to rule out cardiogenic causes of pulmonary edema. The aim of this study was to determine the usefulness of CT in the diagnosis and management of this condition.

[Diagnosis of acute mesenteric ischemia/infarction in the era of multislice CT]

Recenti progressi in medicina, 2012

Acute mesenteric ischemia/infarction is a complex and often misdiagnosed syndrome. The availabili... more

The role of US examination in the management of acute abdomen

Critical Ultrasound Journal, 2013

Acute abdomen is a medical emergency, in which there is sudden and severe pain in abdomen of rece... more Acute abdomen is a medical emergency, in which there is sudden and severe pain in abdomen of recent onset with accompanying signs and symptoms that focus on an abdominal involvement. It can represent a wide spectrum of conditions, ranging from a benign and self-limiting disease to a surgical emergency. Nevertheless, only one quarter of patients who have previously been classified with an acute abdomen actually receive surgical treatment, so the clinical dilemma is if the patients need surgical treatment or not and, furthermore, in which cases the surgical option needs to be urgently adopted. Due to this reason a thorough and logical approach to the diagnosis of abdominal pain is necessary. Some Authors assert that the location of pain is a useful starting point and will guide a further evaluation. However some causes are more frequent in the paediatric population (like appendicitis or adenomesenteritis) or are strictly related to the gender (i.e. gynaechologic causes). It is also important to consider special populations such as the elderly or oncologic patients, who may present with atypical symptoms of a disease. These considerations also reflect a different diagnostic approach. Today, surely the integrated imaging, and in particular the use of multidetector Computed Tomography (MDCT) has revolutionised the clinical approach to this condition, simplyfing the diagnosis but burdening the radiologists with the problems related to the clinical management. However although CT emerging as a modality of choice for evaluation of the acute abdomen, ultrasonography (US) remains the primary imaging technique in the majority of cases, especially in young and female patients, when the limitation of the radiation exposure should be mandatory, limiting the use of CT in cases of nondiagnostic US and in all cases where there is a discrepancy between the clinical symptoms and negative imaging at US.

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Tyrosinemia Type I

Encyclopedia of Molecular Mechanisms of Disease, 2009

Tuberous Sclerosis

Encyclopedia of Molecular Mechanisms of Disease, 2009

TBCD

Encyclopedia of Molecular Mechanisms of Disease, 2009

Clinical utility of serum tumor markers in the diagnosis of malignant intestinal occlusion. A prospective observational study

The International Journal of Biological Markers, 2011

Aim The aim of the present observational study was to evaluate the diagnostic accuracy of CEA, CA... more Aim The aim of the present observational study was to evaluate the diagnostic accuracy of CEA, CA 19-9 and CA 72-4 in patients with bowel obstruction. Methods One-hundred three patients admitted to an emergency unit with clinical and radiological signs of intestinal occlusion of unknown origin were prospectively studied. Patients submitted to emergency surgery were excluded. All patients underwent standard diagnostic procedures and serological assay of tumor markers. Results Colorectal cancer was diagnosed in 22 patients (21.4%), while 81 patients (78.6%) presented a benign condition. The sensitivity of CEA, CA 19-9 and CA 72-4 for colorectal cancer was 36.4%, 31.8% and 9.1%, respectively. Marker specificity was 91.4%, 90.1% and 95.1%, respectively. The combination of CEA and CA 19–9 increased the sensitivity to 45.5% but decreased the specificity to 83.9%. The overall accuracy was 79.6%, 77.7% and 76.7%, respectively. All positive cancer cases had advanced disease. All patients wit...

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Tangier Disease

Encyclopedia of Molecular Mechanisms of Disease, 2009

CT Perfusion in the Characterisation of Renal Lesions: An Added Value to Multiphasic CT

BioMed Research International, 2014

Objective.To prospectively evaluate if computed tomography perfusion (CTp) could be a useful tool... more Objective.To prospectively evaluate if computed tomography perfusion (CTp) could be a useful tool in addition to multiphasic CT in renal lesion characterisation.Materials and Methods.Fifty-eight patients that were scheduled for surgical resection of a renal mass with a suspicion of renal cell carcinoma (RCC) were enrolled. Forty-one out of 58 patients underwent total or partial nephrectomy after CTp examination, and a pathological analysis was obtained for a total of 49 renal lesions. Perfusion parameters and attenuation values at multiphasic CT for both lesion and normal cortex were analysed. All the results were compared with the histological data obtained following surgery.Results.PS and MTT values were significantly lower in malignant lesions than in the normal cortex (P<0.001andP=0.011, resp.); PS, MTT, and BF values were also statistically different between oncocytomas and malignant lesions. According to ROC analysis, the accuracy, sensitivity, and specificity to predict RC...

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Safety and potential benefit of hyperthermic intraperitoneal chemotherapy (HIPEC) in peritoneal carcinomatosis from primary or recurrent ovarian cancer

Journal of Surgical Oncology, 2010

Objectives: To analyze the outcomes of cytoreductive surgery and HIPEC in patients with peritonea... more Objectives: To analyze the outcomes of cytoreductive surgery and HIPEC in patients with peritoneal carcinomatosis from ovarian cancer. Methods: Fifty-three patients with peritoneal carcinomatosis from primary (45 cases) and recurrent (8 cases) ovarian cancer were previously treated by systemic chemotherapy with platinum and taxanes and then submitted to surgical cytoreduction and HIPEC (cisplatin and mitomycin-C) with a closed abdomen technique. The median follow-up period was 27 months (range: 3-107). Results: At the end of operation a complete cytoreduction (CCR-0) was obtained in 37 patients (70%). Major morbidity occurred in 12 patients (23%); reoperation was necessary in 2 patients (4%), and no postoperative mortality was observed. Overall 5-year survival probability was 55%; it was 71% in CCR-0, 44% in CCR-1, and none in patients with CCR-2 or CCR-3 residual tumor (log-rank test: P ¼ 0.017). The cumulative risk of recurrence in 37 CCR-0 cases was 54% at 5 years from operation. Conclusions: The results of our study indicate the feasibility and the potential benefit of a protocol including systemic chemotherapy, surgical cytoreduction and HIPEC in patients with peritoneal carcinomatosis from ovarian cancer. A phase III trial to compare this approach with conventional treatment is needed.

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Computed Tomographic Evaluation of Mesentery

Journal of Computer Assisted Tomography, 2012

Objective: To evaluate the computed tomographic appearances of mesentery in acute mesenteric isch... more Objective: To evaluate the computed tomographic appearances of mesentery in acute mesenteric ischemia (AMI) to recognize characteristic features and their prognostic values. Methods: Computed tomographic examinations of 34 patients with a confirmed diagnosis of AMI were retrospectively reviewed to evaluate the number of mesenteric vessels, diameter of the superior mesenteric artery and superior mesenteric vein, mesenteric fat stranding, mesenteric vessel pneumatosis and ascites. Results: Overall, at least one of these mesenteric signs was present in all but 1 patient. In all AMI of arterial occlusive type and in 68% of nonocclusive mesenteric ischemia, the number of arterial vessels was reduced (P = 0.067). Mesenteric vessel pneumatosis and reduced number of venous vessels were significantly associated with higher mortality (P = 0.027 and P = 0.042, respectively). Reperfusion signs were associated with a reduced mortality (28.7% vs 65.5%). Conclusion: Considering its characteristic features and its possible prognostic value, the evaluation of mesentery will supply additional information in the interpretation of computed tomography in AMI.

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Efficacy of Alendronate in the Treatment of the SAPHO Syndrome

JCR: Journal of Clinical Rheumatology, 2008

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Constrictive pericarditis in Erdheim–Chester disease: An integrated echocardiographic and magnetic resonance approach

International Journal of Cardiology, 2014

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The many faces of aortic dissections: beware of unusual presentations

Clinical Imaging, 2008

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Quantitative CT perfusion measurements in renal tumours: is it possible a differential diagnosis?

Electronic Commerce Research, 2011

Poster: "ECR 2011 / C-2325 / Quantitative CT perfusion measurements in renal tumours: is it ... more

Radiomics predicts survival of patients with advanced non‑small cell lung cancer undergoing PD‑1 blockade using Nivolumab

Oncology Letters, 2019

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Torsades de Pointes

Encyclopedia of Molecular Mechanisms of Disease, 2009

Thyroid Cancer

Encyclopedia of Molecular Mechanisms of Disease, 2009

Emangiomi epatici atipici di piccole dimensioni (≤2 cm) nel paziente non-cirrotico: classificazione in base al pattern di enhancement in TC spirale trifasica

Five years of stable disease with maintenance therapy using bevacizumab and tamoxifen in a patient with metastatic breast cancer

Cancer biology & therapy, Jan 26, 2015

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[Role of computed tomography in the diagnosis of acute lung injury/acute respiratory distress syndrome]

Recenti progressi in medicina, 2012