Healing wounds is an important attempt to keep the internal higher organs safe. Complications in ... more Healing wounds is an important attempt to keep the internal higher organs safe. Complications in topical wound healing may lead to the formation of scars, which can affect the patient’s quality of life. Although several approaches are ongoing in parallel in the exploration of natural compounds via advanced delivery, in this article, an attempt has been made to highlight tocotrienol. Tocotrienol is a natural form of vitamin E and has shown its potential in certain pharmacological activities better than tocopherol. Its antioxidant, anti-inflammatory, cell signal-mediating effects, angiogenic properties, management of scar, and promotion of wound environment with essential factors have shown potential in the management of topical wound healing. Therefore, this review has aimed to focus on recent advances in topical wound healing through the application of tocotrienols. Challenges in delivering tocotrienols to the topical wound due to its large molecular weight and higher logP have also...
International Journal For Multidisciplinary Research
The concept of Nutraceuticals was first introduced in the survey from the UK, Germany and France,... more The concept of Nutraceuticals was first introduced in the survey from the UK, Germany and France, where diet is rated more highly by consumers than exercise or hereditary factors for achieving good health. The word nutritional is a blend of the words nutrition and pharmaceuticals. Nutraceuticals, in broad terms, are foods or parts of foods that play a significant role in modifying and maintaining normal physiological function that maintains healthy human being. “Let food be your medicine’’ is a common misquotation attributed to Hippocrates, who is the father of western medicine, according to the health Canada. Nutraceuticals are foods or products prepared from food but sold in the forms of pills, powder, etc. (portion) or in other medicinal forms not usually associated with food. The benefits of Nutraceuticals are limitless as well as effective in everyday life, from physiological heath Nutraceuticals have the potential to treat a wide array of illness and ailments. Recent studies h...
A single ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) that causes inflam... more A single ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) that causes inflammation of the colonic mucosa at the distal colon and rectum. The mainstay therapy involves anti-inflammatory immunosuppression based on the disease location and severity. The disadvantages of using systemic corticosteroids for UC treatment is the amplified risk of malignancies and infections. Therefore, topical treatments are safer as they have fewer systemic side effects due to less systemic exposure. In this context, pH sensitive and enzymatically triggered hydrogel of pectin (PC) and polyacrylamide (PAM) has been developed to facilitate colon-targeted delivery of budesonide (BUD) for the treatment of UC. The hydrogels were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), swelling ratio, and drug release. FT-IR spectroscopy confirmed the grafting as well loading of BUD in hydrogel. XRD showed the amorphous nature of hydrogel and increment in cry...
Hidradenitis suppurativa (HS) has been considered an orphan disease with limited treatments avail... more Hidradenitis suppurativa (HS) has been considered an orphan disease with limited treatments available. The available topical treatment for this condition is clindamycin lotion; however, short retention and frequent application are the main setbacks. Thus, the present study aimed to attain an optimized antibacterial in situ spray formulation for the hidradenitis suppurativa skin condition, which gels once in contact with the skin surface at around 37 °C and possesses bioadhesion as well as sustained-release properties of the incorporated drug. Different concentrations of thermo-reversible gelling polymer, Pluronic F-127, were investigated along with the selected bioadhesive polymers, HPMC and SA. The optimized formulation F3 consisting of 18% Pluronic F-127 with 0.2% HPMC and 0.2% SA was characterized based on various physicochemical properties. The gelation temperature of F3 was found to be 29.0 ± 0.50 °C with a gelation time of 1.35 ± 0.40 min and a pH of 5.8. F3 had the viscosity ...
Abstract A drug is effective in their molecular form; thus solubility in the biological fluid is ... more Abstract A drug is effective in their molecular form; thus solubility in the biological fluid is important. Pharmaceutical researchers are continuously working on the improvement of solubility of poorly aqueous soluble drugs using novel drug delivery platforms. Being the majority of the new chemical entities are impacted at the development stages due to the solubility characteristics, these novel drug delivery platforms showed a potential role on the improvement of solubility, and thus, bioavailability, increased residence within the biological system, targeting to the site-specific release and decreased toxicity. In short, therapeutic outcome can be improved by this novel drug delivery platform. Among the different approaches of improving solubility, viz. chemical modification, pH adjustment, micronization, micellar solubilization, cosolvency and solid dispersion, nanotechnology-based formulation approaches have shown tremendous performance in drug delivery. Among, dendrimers of different types, different structures, terminal surface groups and hydrophobic void spaces showed potential to formulate according to the necessity. They had shown to improve the solubility of different classes of drugs. This chapter had been focused on the solubility enhancement of drug candidates with special emphasis on the dendrimer-based formulation.
The eyes are the window to the world and the key to communication, but they are vulnerable to mul... more The eyes are the window to the world and the key to communication, but they are vulnerable to multitudes of ailments. More serious than is thought, corneal infection by herpes simplex viruses (HSVs) is a prevalent yet silent cause of blindness in both the paediatric and adult population, especially if immunodeficient. Globally, there are 1.5 million new cases and forty thousand visual impairment cases reported yearly. The Herpetic Eye Disease Study recommends topical antiviral as the front-line therapy for HSV keratitis. Ironically, topical eye solutions undergo rapid nasolacrimal clearance, which necessitates oral drugs but there is a catch of systemic toxicity. The hurdle of antiviral penetration to reach an effective concentration is further complicated by drugs’ poor permeability and complex layers of ocular barriers. In this current review, novel delivery approaches for ocular herpetic infection, including nanocarriers, prodrugs, and peptides are widely investigated, with speci...
The potential role of naringenin (NAR), a natural flavonoid, in the treatment of chronic wound ha... more The potential role of naringenin (NAR), a natural flavonoid, in the treatment of chronic wound has prompted the present research to deliver the drug in nanoemulsion (NE) form, where synergistic role of chitosan was achieved through development of chitosan-coated NAR NE (CNNE). The NE consisted of Capryol 90, Tween 20 and Transcutol P, which was fabricated by low-energy emulsification method to encapsulate NAR within the oil core. The optimization of the formulated NEs was performed using Box–Behnken statistical design to obtain crucial variable parameters that influence globule size, size distribution and surface charge. Finally, the optimized formulation was coated with different concentrations of chitosan and subsequently characterized in vitro. The size of the CNNE was found to be increased when the drug-loaded formulation was coated with chitosan. Controlled release characteristics depicted 67–81% release of NAR from the CNNE, compared to 89% from the NE formulation. Cytotoxicit...
Increasing incidence of demented patients around the globe with limited FDA approved conventional... more Increasing incidence of demented patients around the globe with limited FDA approved conventional therapies requires pronounced research attention for the management of the demented conditions in the growing elderly population in the developing world. Dementia of Alzheimer’s type is a neurodegenerative disorder, where conventional therapies are available for symptomatic treatment of the disease but possess several peripheral toxicities due to lack of brain targeting. Nanotechnology based formulations via intranasal (IN) routes of administration have shown to improve therapeutic efficacy of several therapeutics via circumventing blood-brain barrier and limited peripheral exposure. Instead of numerous research on polymeric and lipid-based nanocarriers in the improvement of therapeutic chemicals and peptides in preclinical research, a step towards clinical studies still requires wide-ranging data on safety and efficacy. This review has focused on current approaches of nanocarrierbased ...
This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Journal of Traditional and Complementary Medicine, 2018
Herbal medicine, phytomedicine or botanical medicine are synonymous, utilizes plants intended for... more Herbal medicine, phytomedicine or botanical medicine are synonymous, utilizes plants intended for medicinal purposes. Medicinal use of herbal medicine in the treatment and prevention of diseases including diabetes has a long history compared to conventional medicine. Diabetes is one of the major public health concerns over the world. Diabetes or hyperglycemia is considered to be one of the common public health hazard; optimal control of which is still not possible. Persistent hyperglycemia or uncontrolled diabetes has the potential to cause serious complications such as kidney disease, vision loss, cardiovascular disease, and lower-limb amputations which contributed towards morbidity and mortality in diabetes. There are various approaches to treat and prevent diabetes as well as its secondary complications, one of it is herbal medicines. However, the selection of herbs might depends on several factors, which include the stage of progression of diabetes, types of comorbidities that the patients are having, availability, affordability as well as the safety profile of the herbs. This review focuses on the herbal and natural remedies that play the role in the treatment or prevention of this morbid disorder e diabetes, including their underlying mechanisms for the blood glucose-lowering property and the herbal products already been marketed for the remedial action of diabetes.
Materials science & engineering. C, Materials for biological applications, 2018
Oral cavity is a gateway to the entire body and protection of this gateway is a major goal in den... more Oral cavity is a gateway to the entire body and protection of this gateway is a major goal in dentistry. Plaque biofilm is a major cause of majority of dental diseases and although various biomaterials have been applied for their cure, limitations pertaining to the material properties prevent achievement of desired outcomes. Nanoparticle applications have become useful tools for various dental applications in endodontics, periodontics, restorative dentistry, orthodontics and oral cancers. Off these, silver nanoparticles (AgNPs) have been used in medicine and dentistry due to its antimicrobial properties. AgNPs have been incorporated into biomaterials in order to prevent or reduce biofilm formation. Due to greater surface to volume ratio and small particle size, they possess excellent antimicrobial action without affecting the mechanical properties of the material. This unique property of AgNPs makes these materials as fillers of choice in different biomaterials whereby they play a v...
Drug delivery and translational research, Oct 18, 2018
Treatment of glioblastoma multiforme (GBM) is a predominant challenge in chemotherapy due to the ... more Treatment of glioblastoma multiforme (GBM) is a predominant challenge in chemotherapy due to the existence of blood-brain barrier (BBB) which restricts delivery of chemotherapeutic agents to the brain together with the problem of drug penetration through hard parenchyma of the GBM. With the structural and mechanistic elucidation of the BBB under both physiological and pathological conditions, it is now viable to target central nervous system (CNS) disorders utilizing the presence of transferrin (Tf) receptors (TfRs). However, overexpression of these TfRs on the GBM cell surface can also help to avoid restrictions of GBM cells to deliver chemotherapeutic agents within the tumor. Therefore, targeting of TfR-mediated delivery could counteract drug delivery issues in GBM and create a delivery system that could cross the BBB effectively to utilize ligand-conjugated drug complexes through receptor-mediated transcytosis. Hence, approach towards successful delivery of antitumor agents to th...
Being an emerging transdermal delivery tool, nanoemulgel, has proved to show surprising upshots f... more Being an emerging transdermal delivery tool, nanoemulgel, has proved to show surprising upshots for the lipophilic drugs over other formulations. This lipophilic nature of majority of the newer drugs developed in this modern era resulting in poor oral bioavailability, erratic absorption and pharmacokinetic variations. Therefore, this novel transdermal delivery system has been proved to be advantageous over other oral and/or topical drug delivery to avoid such disturbances. These nanoemulgels are basically oil-in-water nanoemulsions gelled with the use of some gelling agent in it. This gel phase in the formulation is non-greasy which favors user compliance and stabilize the formulation through reduction in surface as well as interfacial tension. Simultaneously, it can be targeted more specifically to the site of action and can avoid first pass metabolism and relieve the user from gastric/systemic incompatibilities. This brief review is focused on nanoemulgel as a better topical drug ...
Fast swelling highly porous superporous hydrogels (SPH) are synthesized through a method utilizin... more Fast swelling highly porous superporous hydrogels (SPH) are synthesized through a method utilizing rapid solution polymerization of acrylic acid for development of gastric retention devices. The swelling property, mechanical strength and release profile of SPH containing Metformin was investigated by changing the amount of crosslinking agents, (Bis) and AcDiSol. The results indicate that swelling ratio increases in the concentration range of 1%-2.5% w/v of Bis while beyond 2.5% w/v the swelling ratio slightly decreases but is not significant. Mechanical strength of the SPH was significantly increased by increasing the concentration of Bis from 1%-3.5% w/v. The release kinetics of SPH containing different crosslinker concentrations was measured in 0.1NHCl which was found to be consistent with the expected swelling behavior. AcDiSol was an important factor in maintaining the capillary structure required for fast swelling. Increase in AcDiSol resulted in decrease in swelling ratio of composite from 98.36±0.5% to 85.57±0.4%. As the amount of AcDiSol increases the mechanical strength increases due to increased cross linking density of the Superporous Hydrogel. This study indicates that superporous hydrogel composite possessed two properties necessary for gastric retention i.e., fast swelling and mechanical strength.
The present study was aimed at evaluating time dependent and dose dependent antioxidant effect of... more The present study was aimed at evaluating time dependent and dose dependent antioxidant effect of extract of Sida veronicaefolia (ESV) and the reductive capabilities of extract compared to ascorbic acid (reference).
The efficacy for pain and stiffness associated with arthralgia of the knee and hip was evaluated ... more The efficacy for pain and stiffness associated with arthralgia of the knee and hip was evaluated based on locomotive syndrome risk test. Furthermore, w-3polyunsaturated fatty acids (EPA and DHA) and L-Arginine with AVJ revealed a possible dietary efficacy for Parkinson's disease (PD) patients at stage 3. Prophylactic possible efficacies of AVJ as bio-functional scaffolds are fully expected for increasing collagen synthesis in knee and/or hip joint healing and for mitigation of risk factors of PD patients with diabetes.
Chemically, acrylamide is a vinyl monomer which is crystalline, odorless, and highly water-solubl... more Chemically, acrylamide is a vinyl monomer which is crystalline, odorless, and highly water-soluble have multiple chemicals, pharmaceuticals, and industrial applications. Acrylamide (Am) is a well-documented neurotoxicant in both experimental animal and human. This neurotoxicity is mainly due to the cerebellar Purkinje cell damage and central-peripheral distal axonopathy [1,2]. Am present as a residue impurity is evident in most of the polymeric preparations containing acrylamide as reactant [3,4]. Prior to the application of these polymers as therapeutic carrier, preliminary safety assessments on chemicals used in the drug delivery formulation are necessary according to the Organization for Economic Cooperation and Development (OECD) guidelines. This study reports on the synthesis and toxicity of bacterial cellulose-poly(acrylamide-sodium acrylate) hydrogel using solubilized bacterial cellulose in NaOH/urea solution. The Am-grafted bacterial cellulose (BC) three-dimensional cross-link structure was synthesized by microwave irradiation [5]. As a new therapeutic carrier, several criteria are required to be fulfilled, and these include being noncytotoxic, biocompatible, and nonacute oral toxicity [6]. Hence, further application of polymer as oral therapeutic carrier needs in depth safety evaluation along with neurotoxicological investigation. Adult female ICR mice (25-28 g), obtained from Laboratory Animal Centre of Universiti Kebangsaan Malaysia, were used in this study. The approval for the study protocol was given by Animal Ethics Committee (FF/2013/CAIRUL/15-MAY/522-MAY-2013-DEC-2013). The mice were housed in a controlled temperature maintained between 20 and 22°C with 50-60% relative humidity and dark-light cycles of 12 h. Water and food were freely accessible to the animals. All mice were in quarantine for a week before treatment. Acute oral toxicity of Am-grafted BC was performed as per OECD guidelines for the test of chemicals 425.
Address for correspondence: Mr. Rohit K Verma, Department of Pharmaceutics, Babu Banarasi Das Nat... more Address for correspondence: Mr. Rohit K Verma, Department of Pharmaceutics, Babu Banarasi Das National Institute of Technology and Management, Lucknow, Uttar Pradesh - 227105, India. E-mail: [email protected] ... The objective of this study was to describe and ...
This investigation describes the preparation and in vitro evaluation of gastroretentive buoyant S... more This investigation describes the preparation and in vitro evaluation of gastroretentive buoyant Sodium alginate microbeads of theophylline to increase the residence time in stomach and to modulate the release behaviour of the drug. Hydrophilic polymer Methocel K100M was ...
Natural polymer-based hydrogels are of interest to health care professionals as wound dressings o... more Natural polymer-based hydrogels are of interest to health care professionals as wound dressings owing to their ability to absorb exudates and provide hydration for healing. The aims of this study were to develop and characterize bacterial cellulose/acrylic acid (BC/AA) hydrogels synthesized by electron beam irradiation and investigate its wound healing potential in an animal model. The BC/AA hydrogels were characterized by SEM, tensile strength, water absorptivity, and water vapor transmission rate (WVTR). The cytotoxicity of the hydrogels was investigated in L929 cells. Skin irritation and wound healing properties were evaluated in Sprague-Dawley rats. BC/AA hydrogels had a macroporous network structure, high swelling ratio (4000-6000% at 24h), and high WVTR (2175-2280 g/m(2)/day). The hydrogels were non-toxic in the cell viability assay. In vivo experiments indicated that hydrogels promoted faster wound-healing, enhanced epithelialization, and accelerated fibroblast proliferation compared to that in the control group. These results suggest that BC/AA hydrogels are promising materials for burn dressings.
Healing wounds is an important attempt to keep the internal higher organs safe. Complications in ... more Healing wounds is an important attempt to keep the internal higher organs safe. Complications in topical wound healing may lead to the formation of scars, which can affect the patient’s quality of life. Although several approaches are ongoing in parallel in the exploration of natural compounds via advanced delivery, in this article, an attempt has been made to highlight tocotrienol. Tocotrienol is a natural form of vitamin E and has shown its potential in certain pharmacological activities better than tocopherol. Its antioxidant, anti-inflammatory, cell signal-mediating effects, angiogenic properties, management of scar, and promotion of wound environment with essential factors have shown potential in the management of topical wound healing. Therefore, this review has aimed to focus on recent advances in topical wound healing through the application of tocotrienols. Challenges in delivering tocotrienols to the topical wound due to its large molecular weight and higher logP have also...
International Journal For Multidisciplinary Research
The concept of Nutraceuticals was first introduced in the survey from the UK, Germany and France,... more The concept of Nutraceuticals was first introduced in the survey from the UK, Germany and France, where diet is rated more highly by consumers than exercise or hereditary factors for achieving good health. The word nutritional is a blend of the words nutrition and pharmaceuticals. Nutraceuticals, in broad terms, are foods or parts of foods that play a significant role in modifying and maintaining normal physiological function that maintains healthy human being. “Let food be your medicine’’ is a common misquotation attributed to Hippocrates, who is the father of western medicine, according to the health Canada. Nutraceuticals are foods or products prepared from food but sold in the forms of pills, powder, etc. (portion) or in other medicinal forms not usually associated with food. The benefits of Nutraceuticals are limitless as well as effective in everyday life, from physiological heath Nutraceuticals have the potential to treat a wide array of illness and ailments. Recent studies h...
A single ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) that causes inflam... more A single ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) that causes inflammation of the colonic mucosa at the distal colon and rectum. The mainstay therapy involves anti-inflammatory immunosuppression based on the disease location and severity. The disadvantages of using systemic corticosteroids for UC treatment is the amplified risk of malignancies and infections. Therefore, topical treatments are safer as they have fewer systemic side effects due to less systemic exposure. In this context, pH sensitive and enzymatically triggered hydrogel of pectin (PC) and polyacrylamide (PAM) has been developed to facilitate colon-targeted delivery of budesonide (BUD) for the treatment of UC. The hydrogels were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), swelling ratio, and drug release. FT-IR spectroscopy confirmed the grafting as well loading of BUD in hydrogel. XRD showed the amorphous nature of hydrogel and increment in cry...
Hidradenitis suppurativa (HS) has been considered an orphan disease with limited treatments avail... more Hidradenitis suppurativa (HS) has been considered an orphan disease with limited treatments available. The available topical treatment for this condition is clindamycin lotion; however, short retention and frequent application are the main setbacks. Thus, the present study aimed to attain an optimized antibacterial in situ spray formulation for the hidradenitis suppurativa skin condition, which gels once in contact with the skin surface at around 37 °C and possesses bioadhesion as well as sustained-release properties of the incorporated drug. Different concentrations of thermo-reversible gelling polymer, Pluronic F-127, were investigated along with the selected bioadhesive polymers, HPMC and SA. The optimized formulation F3 consisting of 18% Pluronic F-127 with 0.2% HPMC and 0.2% SA was characterized based on various physicochemical properties. The gelation temperature of F3 was found to be 29.0 ± 0.50 °C with a gelation time of 1.35 ± 0.40 min and a pH of 5.8. F3 had the viscosity ...
Abstract A drug is effective in their molecular form; thus solubility in the biological fluid is ... more Abstract A drug is effective in their molecular form; thus solubility in the biological fluid is important. Pharmaceutical researchers are continuously working on the improvement of solubility of poorly aqueous soluble drugs using novel drug delivery platforms. Being the majority of the new chemical entities are impacted at the development stages due to the solubility characteristics, these novel drug delivery platforms showed a potential role on the improvement of solubility, and thus, bioavailability, increased residence within the biological system, targeting to the site-specific release and decreased toxicity. In short, therapeutic outcome can be improved by this novel drug delivery platform. Among the different approaches of improving solubility, viz. chemical modification, pH adjustment, micronization, micellar solubilization, cosolvency and solid dispersion, nanotechnology-based formulation approaches have shown tremendous performance in drug delivery. Among, dendrimers of different types, different structures, terminal surface groups and hydrophobic void spaces showed potential to formulate according to the necessity. They had shown to improve the solubility of different classes of drugs. This chapter had been focused on the solubility enhancement of drug candidates with special emphasis on the dendrimer-based formulation.
The eyes are the window to the world and the key to communication, but they are vulnerable to mul... more The eyes are the window to the world and the key to communication, but they are vulnerable to multitudes of ailments. More serious than is thought, corneal infection by herpes simplex viruses (HSVs) is a prevalent yet silent cause of blindness in both the paediatric and adult population, especially if immunodeficient. Globally, there are 1.5 million new cases and forty thousand visual impairment cases reported yearly. The Herpetic Eye Disease Study recommends topical antiviral as the front-line therapy for HSV keratitis. Ironically, topical eye solutions undergo rapid nasolacrimal clearance, which necessitates oral drugs but there is a catch of systemic toxicity. The hurdle of antiviral penetration to reach an effective concentration is further complicated by drugs’ poor permeability and complex layers of ocular barriers. In this current review, novel delivery approaches for ocular herpetic infection, including nanocarriers, prodrugs, and peptides are widely investigated, with speci...
The potential role of naringenin (NAR), a natural flavonoid, in the treatment of chronic wound ha... more The potential role of naringenin (NAR), a natural flavonoid, in the treatment of chronic wound has prompted the present research to deliver the drug in nanoemulsion (NE) form, where synergistic role of chitosan was achieved through development of chitosan-coated NAR NE (CNNE). The NE consisted of Capryol 90, Tween 20 and Transcutol P, which was fabricated by low-energy emulsification method to encapsulate NAR within the oil core. The optimization of the formulated NEs was performed using Box–Behnken statistical design to obtain crucial variable parameters that influence globule size, size distribution and surface charge. Finally, the optimized formulation was coated with different concentrations of chitosan and subsequently characterized in vitro. The size of the CNNE was found to be increased when the drug-loaded formulation was coated with chitosan. Controlled release characteristics depicted 67–81% release of NAR from the CNNE, compared to 89% from the NE formulation. Cytotoxicit...
Increasing incidence of demented patients around the globe with limited FDA approved conventional... more Increasing incidence of demented patients around the globe with limited FDA approved conventional therapies requires pronounced research attention for the management of the demented conditions in the growing elderly population in the developing world. Dementia of Alzheimer’s type is a neurodegenerative disorder, where conventional therapies are available for symptomatic treatment of the disease but possess several peripheral toxicities due to lack of brain targeting. Nanotechnology based formulations via intranasal (IN) routes of administration have shown to improve therapeutic efficacy of several therapeutics via circumventing blood-brain barrier and limited peripheral exposure. Instead of numerous research on polymeric and lipid-based nanocarriers in the improvement of therapeutic chemicals and peptides in preclinical research, a step towards clinical studies still requires wide-ranging data on safety and efficacy. This review has focused on current approaches of nanocarrierbased ...
This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Journal of Traditional and Complementary Medicine, 2018
Herbal medicine, phytomedicine or botanical medicine are synonymous, utilizes plants intended for... more Herbal medicine, phytomedicine or botanical medicine are synonymous, utilizes plants intended for medicinal purposes. Medicinal use of herbal medicine in the treatment and prevention of diseases including diabetes has a long history compared to conventional medicine. Diabetes is one of the major public health concerns over the world. Diabetes or hyperglycemia is considered to be one of the common public health hazard; optimal control of which is still not possible. Persistent hyperglycemia or uncontrolled diabetes has the potential to cause serious complications such as kidney disease, vision loss, cardiovascular disease, and lower-limb amputations which contributed towards morbidity and mortality in diabetes. There are various approaches to treat and prevent diabetes as well as its secondary complications, one of it is herbal medicines. However, the selection of herbs might depends on several factors, which include the stage of progression of diabetes, types of comorbidities that the patients are having, availability, affordability as well as the safety profile of the herbs. This review focuses on the herbal and natural remedies that play the role in the treatment or prevention of this morbid disorder e diabetes, including their underlying mechanisms for the blood glucose-lowering property and the herbal products already been marketed for the remedial action of diabetes.
Materials science & engineering. C, Materials for biological applications, 2018
Oral cavity is a gateway to the entire body and protection of this gateway is a major goal in den... more Oral cavity is a gateway to the entire body and protection of this gateway is a major goal in dentistry. Plaque biofilm is a major cause of majority of dental diseases and although various biomaterials have been applied for their cure, limitations pertaining to the material properties prevent achievement of desired outcomes. Nanoparticle applications have become useful tools for various dental applications in endodontics, periodontics, restorative dentistry, orthodontics and oral cancers. Off these, silver nanoparticles (AgNPs) have been used in medicine and dentistry due to its antimicrobial properties. AgNPs have been incorporated into biomaterials in order to prevent or reduce biofilm formation. Due to greater surface to volume ratio and small particle size, they possess excellent antimicrobial action without affecting the mechanical properties of the material. This unique property of AgNPs makes these materials as fillers of choice in different biomaterials whereby they play a v...
Drug delivery and translational research, Oct 18, 2018
Treatment of glioblastoma multiforme (GBM) is a predominant challenge in chemotherapy due to the ... more Treatment of glioblastoma multiforme (GBM) is a predominant challenge in chemotherapy due to the existence of blood-brain barrier (BBB) which restricts delivery of chemotherapeutic agents to the brain together with the problem of drug penetration through hard parenchyma of the GBM. With the structural and mechanistic elucidation of the BBB under both physiological and pathological conditions, it is now viable to target central nervous system (CNS) disorders utilizing the presence of transferrin (Tf) receptors (TfRs). However, overexpression of these TfRs on the GBM cell surface can also help to avoid restrictions of GBM cells to deliver chemotherapeutic agents within the tumor. Therefore, targeting of TfR-mediated delivery could counteract drug delivery issues in GBM and create a delivery system that could cross the BBB effectively to utilize ligand-conjugated drug complexes through receptor-mediated transcytosis. Hence, approach towards successful delivery of antitumor agents to th...
Being an emerging transdermal delivery tool, nanoemulgel, has proved to show surprising upshots f... more Being an emerging transdermal delivery tool, nanoemulgel, has proved to show surprising upshots for the lipophilic drugs over other formulations. This lipophilic nature of majority of the newer drugs developed in this modern era resulting in poor oral bioavailability, erratic absorption and pharmacokinetic variations. Therefore, this novel transdermal delivery system has been proved to be advantageous over other oral and/or topical drug delivery to avoid such disturbances. These nanoemulgels are basically oil-in-water nanoemulsions gelled with the use of some gelling agent in it. This gel phase in the formulation is non-greasy which favors user compliance and stabilize the formulation through reduction in surface as well as interfacial tension. Simultaneously, it can be targeted more specifically to the site of action and can avoid first pass metabolism and relieve the user from gastric/systemic incompatibilities. This brief review is focused on nanoemulgel as a better topical drug ...
Fast swelling highly porous superporous hydrogels (SPH) are synthesized through a method utilizin... more Fast swelling highly porous superporous hydrogels (SPH) are synthesized through a method utilizing rapid solution polymerization of acrylic acid for development of gastric retention devices. The swelling property, mechanical strength and release profile of SPH containing Metformin was investigated by changing the amount of crosslinking agents, (Bis) and AcDiSol. The results indicate that swelling ratio increases in the concentration range of 1%-2.5% w/v of Bis while beyond 2.5% w/v the swelling ratio slightly decreases but is not significant. Mechanical strength of the SPH was significantly increased by increasing the concentration of Bis from 1%-3.5% w/v. The release kinetics of SPH containing different crosslinker concentrations was measured in 0.1NHCl which was found to be consistent with the expected swelling behavior. AcDiSol was an important factor in maintaining the capillary structure required for fast swelling. Increase in AcDiSol resulted in decrease in swelling ratio of composite from 98.36±0.5% to 85.57±0.4%. As the amount of AcDiSol increases the mechanical strength increases due to increased cross linking density of the Superporous Hydrogel. This study indicates that superporous hydrogel composite possessed two properties necessary for gastric retention i.e., fast swelling and mechanical strength.
The present study was aimed at evaluating time dependent and dose dependent antioxidant effect of... more The present study was aimed at evaluating time dependent and dose dependent antioxidant effect of extract of Sida veronicaefolia (ESV) and the reductive capabilities of extract compared to ascorbic acid (reference).
The efficacy for pain and stiffness associated with arthralgia of the knee and hip was evaluated ... more The efficacy for pain and stiffness associated with arthralgia of the knee and hip was evaluated based on locomotive syndrome risk test. Furthermore, w-3polyunsaturated fatty acids (EPA and DHA) and L-Arginine with AVJ revealed a possible dietary efficacy for Parkinson's disease (PD) patients at stage 3. Prophylactic possible efficacies of AVJ as bio-functional scaffolds are fully expected for increasing collagen synthesis in knee and/or hip joint healing and for mitigation of risk factors of PD patients with diabetes.
Chemically, acrylamide is a vinyl monomer which is crystalline, odorless, and highly water-solubl... more Chemically, acrylamide is a vinyl monomer which is crystalline, odorless, and highly water-soluble have multiple chemicals, pharmaceuticals, and industrial applications. Acrylamide (Am) is a well-documented neurotoxicant in both experimental animal and human. This neurotoxicity is mainly due to the cerebellar Purkinje cell damage and central-peripheral distal axonopathy [1,2]. Am present as a residue impurity is evident in most of the polymeric preparations containing acrylamide as reactant [3,4]. Prior to the application of these polymers as therapeutic carrier, preliminary safety assessments on chemicals used in the drug delivery formulation are necessary according to the Organization for Economic Cooperation and Development (OECD) guidelines. This study reports on the synthesis and toxicity of bacterial cellulose-poly(acrylamide-sodium acrylate) hydrogel using solubilized bacterial cellulose in NaOH/urea solution. The Am-grafted bacterial cellulose (BC) three-dimensional cross-link structure was synthesized by microwave irradiation [5]. As a new therapeutic carrier, several criteria are required to be fulfilled, and these include being noncytotoxic, biocompatible, and nonacute oral toxicity [6]. Hence, further application of polymer as oral therapeutic carrier needs in depth safety evaluation along with neurotoxicological investigation. Adult female ICR mice (25-28 g), obtained from Laboratory Animal Centre of Universiti Kebangsaan Malaysia, were used in this study. The approval for the study protocol was given by Animal Ethics Committee (FF/2013/CAIRUL/15-MAY/522-MAY-2013-DEC-2013). The mice were housed in a controlled temperature maintained between 20 and 22°C with 50-60% relative humidity and dark-light cycles of 12 h. Water and food were freely accessible to the animals. All mice were in quarantine for a week before treatment. Acute oral toxicity of Am-grafted BC was performed as per OECD guidelines for the test of chemicals 425.
Address for correspondence: Mr. Rohit K Verma, Department of Pharmaceutics, Babu Banarasi Das Nat... more Address for correspondence: Mr. Rohit K Verma, Department of Pharmaceutics, Babu Banarasi Das National Institute of Technology and Management, Lucknow, Uttar Pradesh - 227105, India. E-mail: [email protected] ... The objective of this study was to describe and ...
This investigation describes the preparation and in vitro evaluation of gastroretentive buoyant S... more This investigation describes the preparation and in vitro evaluation of gastroretentive buoyant Sodium alginate microbeads of theophylline to increase the residence time in stomach and to modulate the release behaviour of the drug. Hydrophilic polymer Methocel K100M was ...
Natural polymer-based hydrogels are of interest to health care professionals as wound dressings o... more Natural polymer-based hydrogels are of interest to health care professionals as wound dressings owing to their ability to absorb exudates and provide hydration for healing. The aims of this study were to develop and characterize bacterial cellulose/acrylic acid (BC/AA) hydrogels synthesized by electron beam irradiation and investigate its wound healing potential in an animal model. The BC/AA hydrogels were characterized by SEM, tensile strength, water absorptivity, and water vapor transmission rate (WVTR). The cytotoxicity of the hydrogels was investigated in L929 cells. Skin irritation and wound healing properties were evaluated in Sprague-Dawley rats. BC/AA hydrogels had a macroporous network structure, high swelling ratio (4000-6000% at 24h), and high WVTR (2175-2280 g/m(2)/day). The hydrogels were non-toxic in the cell viability assay. In vivo experiments indicated that hydrogels promoted faster wound-healing, enhanced epithelialization, and accelerated fibroblast proliferation compared to that in the control group. These results suggest that BC/AA hydrogels are promising materials for burn dressings.
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