Papers by Mohammed al-Mogbel
Molecules
Mycobacterium tuberculosis (Mtb), an acid-fast bacillus that causes Tuberculosis (TB), is a patho... more Mycobacterium tuberculosis (Mtb), an acid-fast bacillus that causes Tuberculosis (TB), is a pathogen that caused 1.5 million deaths in 2020. As per WHO estimates, another 4.1 million people are suffering from latent TB, either asymptomatic or not diagnosed, and the frequency of drug resistance is increasing due to intrinsically linked factors from both host and bacterium. For instance, poor access to TB diagnosis and reduced treatment in the era of the COVID-19 pandemic has resulted in more TB deaths and an 18% reduction in newly diagnosed cases of TB. Additionally, the detection of Mtb isolates exhibiting resistance to multiple drugs (MDR, XDR, and TDR) has complicated the scenario in the pathogen’s favour. Moreover, the conventional methods to detect drug resistance may miss mutations, making it challenging to decide on the treatment regimen. However, owing to collaborative initiatives, the last two decades have witnessed several advancements in both the detection methods and drug...
Antibiotics
Antimicrobial resistance (AMR) is a global problem that also includes countries of the Arabian Pe... more Antimicrobial resistance (AMR) is a global problem that also includes countries of the Arabian Peninsula. Of particular concern, is the continuing development of extended-spectrum β-lactamases (ESBLs) in the countries of this region. Additionally, antibiotic treatment options for ESBL-producing bacteria are becoming limited, primarily due to the continuing development of carbapenem resistance (CR), carbapenems being frequently used to treat such infections. An overview of recent publications (2018–2021) indicates the presence of ESBL and/or CR in patients and hospitals in most countries of the Arabian Peninsula, although the delay between microbial isolation and publication inevitably makes an accurate analysis of the current situation rather difficult. However, there appears to be greater emphasis on CR (including combined ESBL and CR) in recent publications. Furthermore, although publications from Saudi Arabia are the most prevalent, this may simply reflect the increased interest ...
Pathogens
Monkeypox is a rare disease but is increasing in incidence in different countries since the first... more Monkeypox is a rare disease but is increasing in incidence in different countries since the first case was diagnosed in the UK by the United Kingdom (UK) Health Security Agency on 6 May 2022. As of 9 August, almost 32,000 cases have been identified in 89 countries. In endemic areas, the monkeypox virus (MPXV) is commonly transmitted through zoonosis, while in non-endemic regions, it is spread through human-to-human transmission. Symptoms can include flu-like symptoms, rash, or sores on the hands, feet, genitalia, or anus. In addition, people who did not take the smallpox vaccine were more likely to be infected than others. The exact pathogenesis and mechanisms are still unclear; however, most identified cases are reported in men who have sex with other men (MSM). According to the CDC, transmission can happen with any sexual or non-sexual contact with the infected person. However, a recent pooled meta-analysis reported that sexual contact is involved in more than 91% of cases. Moreov...
Microorganisms
Vaccines are vital for prevention and control of mycoplasma diseases. The exploration of a vaccin... more Vaccines are vital for prevention and control of mycoplasma diseases. The exploration of a vaccine candidate for the development of a vaccine is imperative. The present study envisages the evaluation of immune and oxidative response against an adjuvanted, sonicated antigen of Mycoplasma capricolum subsp. capripneumonia in male Angora rabbits (1 year old, 2 Kg) divided in four groups, each having six animals. Group 1 was the healthy control and received 1 mL PBS via subcutaneous route. Group 2 was administered 1 mL of saponin-adjuvanted and -sonicated antigen, Group 3 was given 1 mL of montanide ISA 50-adjuvanted and-sonicated antigen, and Group 4 was given 1 mL of standard vaccine via subcutaneous route. Animals were evaluated for cellular and humoral immune response and oxidative parameters at 0, 7, 14, 21, and 28 days of the study. Total leukocytic, neutrophilic, and basophilic counts showed a significant (p < 0.05) increase in vaccinated groups compared to the healthy group on...
Microorganisms
Enterobacter cloacae is mainly responsible for sepsis, urethritis, and respiratory tract infectio... more Enterobacter cloacae is mainly responsible for sepsis, urethritis, and respiratory tract infections. These bacteria may affect the transcription of the host and particularly their immune system by producing changes in their epigenetics. In the present study, four proteins of Enterobacter cloacae were used to predict the epitopes for the construction of an mRNA vaccine against Enterobacter cloacae infections. In order to generate cellular and humoral responses, various immunoinformatic-based approaches were used for developing the vaccine. The molecular docking analysis was performed for predicting the interaction among the chosen epitopes and corresponding MHC alleles. The vaccine was developed by combining epitopes (thirty-three total), which include the adjuvant Toll-like receptor-4 (TLR4). The constructed vaccine was analyzed and predicted to cover 99.2% of the global population. Additionally, in silico immunological modeling of the vaccination was also carried out. When it enter...
African Journal of Microbiology Research, Jan 14, 2015
Staphylococ resistant S. prevalence MRSA (HA-M were labora protocols. A guidelines. detecting m d... more Staphylococ resistant S. prevalence MRSA (HA-M were labora protocols. A guidelines. detecting m distribution students, 1 laboratory s year studen 26 MRSA iso with SCCme other group Valentine le MRSA isolat Our study re no exposur relatedness this study in role in the e Key words: molecular typ TRODUCTION thicillin-resist tential harmf 6-70, 14 Janua AJMR2014.6832 r: 7897D29501 8 015 n the copyrigh cademicjourn Research alence phyloco nce stu h agnostics and ccus aureus aureus (MR and the dist MRSA) amon atory staff. N Antibiotic sus Methicillin re mecA gene. St of CA-MRSA 00% (2/2) fro science stude nts and 40% (olates, there ec type IV; an p. Additionall eukocidin (PV tes showed a eports a high re to the ho , presence o nteresting, as pidemiology : Methicillin r ping. N ant Staphylo ful pathogen ary, 2015 2 15 ht of this article als.org/AJMR h Paper e and d occus udents hospita M Personalized Rec
Diagnostic Microbiology and Infectious Disease, 2012
R espiratory viral infections account for significant morbidity and mortality especially in young... more R espiratory viral infections account for significant morbidity and mortality especially in young children worldwide. Human metapneumovirus (hMPV) encompassing illnesses ranging from mild respiratory problems to bronchiolitis and severe pneumonia. From January to December 2007, Two hundred and twenty nasopharyngeal aspirates (NPA) were collected from children younger than or equal 13 years old hospitalized with lower respiratory tract infection to detect hMPV by RT-PCR, and to clone and sequence the hMPV positive samples. Human metapneumovirus was detected in 28 (12.7%) specimens with a median age of 7 months ranging from 1.3-24 months. Human metapneumovirus type A and type B were detected in 26(93%) and 8(28.6%) of specimens, respectively. Co-infection with hMPV type A and type B were detected in 6(21.4%) specimens positive for hMPV. The major clinical diagnosis of hMPV positive patients was bronchiolitis (75%). Human metapneumovirus and hMPV type B, were found significantly associated with bronchiolitis (p= 0.03 and 0.01 respectively). Human metapneumovirus and hMPV type A were found significantly associated with pneumonia (p= 0.004 and 0.002 respectively). The main symptoms in patients infected with hMPV were cough (92.9%), fever (82.1%), and wheezing (78.6%) with a significant association of hMPV type A with fever (p= 0.018). Human metapneumovirus was seasonally distributed; most infections with hMPV were reported in the late winter and early spring. The peak of hMPV incidence was in February (10/28; 35.7%). Sequencing of purified plasmid DNA was performed in forward and reverse direction to confirm the results of hMPV positive samples which scored 97% identities to hMPV type A genome isolate NL/17/00 and showing C-T variation that had no effect on the amino acid sequence; F(Phe)-F(Phe).
The inorganic ferric ion has been successfully removed from water by adsorption onto experiments ... more The inorganic ferric ion has been successfully removed from water by adsorption onto experiments are carried out by a batch technique. The influences of adsorption conditions, such as initial concentration of f 50, 100, 150 and 200 mg L), the dosage of CDPS (2, 6, 10., 20, 30, 40 and 100 g L (0 – 180 min.) have been taken in consideration. temperature increases; meanwhile, it decreases with increasing the initial concentration of ferric io removal achieved is 92 %. Depending on the adsorption thermodynamic model, the adsorption mechanism of aqueous ferric ion ont CDPS follows Freundlich isotherm model (R = 0.986). The capacity ( respectively. The results reveal that the adsorption mechanism of ferric ion on CDPS solid particles is chemisorptions, heter multilayer, unfavorable (RL = 1.609) and spontaneous in nature (Δ particles has achieved Lagergren pseudo-second order model ( capacities have been calculated. The new information in this study sugge removing ferric ions from water.
International Journal Of Pharmaceutical Research And Allied Sciences
International Journal Of Pharmaceutical Research And Allied Sciences
Infection and Drug Resistance, 2021
Objective The aim of this study was to retrospectively characterize E. coli and K. pneumoniae iso... more Objective The aim of this study was to retrospectively characterize E. coli and K. pneumoniae isolates obtained from neonates during a suspected NICU outbreak of infection in Ha’il, Saudi Arabia during a period of one month (April 2014). Methods Antibiotic susceptibility patterns, molecular characterization for antibiotic-resistant genes (blaTEM, blaSHV, and blaCTX-M), and genotyping by PFGE and MLST were performed. Results A total of 24 E. coli and 48 K. pneumoniae isolates were cultured from neonates that had been admitted to the NICU. Among E. coli, the majority of isolates (19/24) were ESBL-positive and all of these nineteen (100%) harbored the CTX-M-15 gene. A total of 15% (3/19) were co-producers of CTX-M-15 and SHV-12, and 68.4% (13/19) were co-producers of CTX-M-15 and TEM-1. Among K. pneumoniae isolates, 87.5% (42/48) were ESBL positive with 92.85% (39/42) of these isolates containing the CTX-M-15 gene. A total of 97% (38/39) of K. pneumoniae were co-producers of CTX-M-15 a...
Medicina
Background and Objectives: The multidrug resistant (MDR) bacterial pathogenic infection is one of... more Background and Objectives: The multidrug resistant (MDR) bacterial pathogenic infection is one of the chief worldwide public health threat to humanity. The development of novel antibiotics against MDR Gram negative bacteria has reduced over the last half century. Research is in progress regarding the treatment strategies that could be engaged in combination with antibiotics to extend the duration of these life-saving antibacterial agents. The current study was therefore planned to assess the synergistic effects of bovine lactoferrin (bLF) in combination with different antibiotics that are conventionally used. This synergism would provide a newer therapeutic choice against MDR pathogens. LF is present in mucosal secretions, vastly in milk. LF is considered an important constituent in host defense. In previous reports, LF has been co-administered as a combination antibiotic therapy. Materials and Methods: This study included synergistic (LF + appropriate antibiotic) exposure against 1...
Oxford Medical Case Reports
Nocardia cyriacigeorgica (N. cyriacigeorgica) is most frequently associated with human infections... more Nocardia cyriacigeorgica (N. cyriacigeorgica) is most frequently associated with human infections, including chronic bronchitis, pulmonary disease and brain abscesses. In general, N. cyriacigeorgica causes infections in immunocompromised individuals and has been reported in clinical samples worldwide. However, the isolation and speciation of N. cyriacigeorgica in the routine diagnostic microbiology laboratory are complicated and time consuming. Recent mass spectrometry techniques such as matrix-assisted laser desorption/ionization time-of-flight-mass spectrometry (MALDI-TOF-MS) have been successfully integrated into many routine diagnostic microbiology laboratories, allowing for the rapid, accurate and simple identification and speciation of many different microorganisms, including difficult-to-identify bacterial species. Here, we present a case report of a 65-year-old female patient from the neurology ward of Prince Sultan Military Medical City in Riyadh, Saudi Arabia, who was infe...
Food Science & Nutrition
An escalation has been found in foodborne outbreaks caused by pathogens especially in developing ... more An escalation has been found in foodborne outbreaks caused by pathogens especially in developing countries. These foodborne outbreaks cause most of food contamination and poisoning cases leading to serious diseases and may be to death (Blackburn &
International archives of allergy and immunology, Jan 29, 2018
Depression and smoking contribute to the prognosis of autoimmune rheumatoid arthritis (RA). Advan... more Depression and smoking contribute to the prognosis of autoimmune rheumatoid arthritis (RA). Advanced glycation end products (AGEs) are also detected in RA patients. This study correlates RA in patients with various levels of depression and a history of smoking through the detection of antibodies against AGEs of proteins. Sixty RA subjects were selected and divided into 4 groups based on their levels of depression and smoking habits. The division was as follows: group I consisted of RA patients classified as depressed (RA-D); group II consisted of RA patients with a history of smoking (RA-S); group III consisted of RA patients suffering from depression who were also smokers (RA-DS); and group IV consisted of patients with RA alone (RA-A), i.e., not depressed and non-smokers. In vitro human serum albumin (HSA) was modified by glucose, and the modifications were studied by biochemical and biophysical techniques. Glycated (G)-HSA was used as an antigen, and autoantibodies against G-HSA ...
Reviews in Medical Microbiology
Brazilian Journal of Microbiology, 2016
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Papers by Mohammed al-Mogbel