Hepatitis C virus (HCV) is a member of Flaviviridae family and one of the major causes of liver d... more Hepatitis C virus (HCV) is a member of Flaviviridae family and one of the major causes of liver disease. There are about 175 million HCV infected patients worldwide that constitute 3% of world's population. The main route of HCV transmission is parental however 90% intravenous drug users are at highest risk. Standard interferon and ribavirin remained a gold standard of chronic HCV treatment having 38-43% sustained virological response rates. Currently the standard therapy for HCV is pegylated interferon (PEG-INF) with ribavirin. This therapy achieves 50% sustained virological response (SVR) for genotype 1 and 80% for genotype 2 & 3. As pegylated interferon is expensive, standard interferon is still the main therapy for HCV treatment in under developed countries. On the other hand, studies showed that pegylated IFN and RBV therapy has severe side effects like hematological complications. Herbal medicines (laccase, proanthocyandin, Rhodiola kirilowii) are also being in use as a natural and alternative way for treatment of HCV but there is not a single significant report documented yet. Best SVR indicators are genotype 3 and 2, < 0.2 million IU/mL pretreatment viral load, rapid virological response (RVR) rate and age <40 years. New therapeutic approaches are under study like interferon related systems, modified forms of ribavirin, internal ribosome entry site (HCV IRES) inhibitors, NS3 and NS5a inhibitors, novel immunomodulators and specifically targeted anti-viral therapy for hepatitis C compounds. More remedial therapies include caspase inhibitors, anti-fibrotic agents, antibody treatment and vaccines.
Internet and networks applications are growing very fast, so the needs to protect such applicatio... more Internet and networks applications are growing very fast, so the needs to protect such applications are increased. Encryption algorithms play a main role in information security systems. On the other side, those algorithms consume a significant amount of computing resources such as CPU time, memory, and battery power. This paper provides evaluation of six of the most common encryption algorithms namely: AES (Rijndael), DES, 3DES, RC2, Blowfish, and RC6. A comparison has been conducted for those encryption algorithms at different settings for each algorithm such as different sizes of data blocks, different data types ,battery power consumption, different key size and finally encryption/decryption speed. Simulation results are given to demonstrate the effectiveness of each algorithm. .
Hepatitis C virus (HCV) is a member of Flaviviridae family and one of the major causes of liver d... more Hepatitis C virus (HCV) is a member of Flaviviridae family and one of the major causes of liver disease. There are about 175 million HCV infected patients worldwide that constitute 3% of world's population. The main route of HCV transmission is parental however 90% intravenous drug users are at highest risk. Standard interferon and ribavirin remained a gold standard of chronic HCV treatment having 38-43% sustained virological response rates. Currently the standard therapy for HCV is pegylated interferon (PEG-INF) with ribavirin. This therapy achieves 50% sustained virological response (SVR) for genotype 1 and 80% for genotype 2 & 3. As pegylated interferon is expensive, standard interferon is still the main therapy for HCV treatment in under developed countries. On the other hand, studies showed that pegylated IFN and RBV therapy has severe side effects like hematological complications. Herbal medicines (laccase, proanthocyandin, Rhodiola kirilowii) are also being in use as a natural and alternative way for treatment of HCV but there is not a single significant report documented yet. Best SVR indicators are genotype 3 and 2, < 0.2 million IU/mL pretreatment viral load, rapid virological response (RVR) rate and age <40 years. New therapeutic approaches are under study like interferon related systems, modified forms of ribavirin, internal ribosome entry site (HCV IRES) inhibitors, NS3 and NS5a inhibitors, novel immunomodulators and specifically targeted anti-viral therapy for hepatitis C compounds. More remedial therapies include caspase inhibitors, anti-fibrotic agents, antibody treatment and vaccines.
Internet and networks applications are growing very fast, so the needs to protect such applicatio... more Internet and networks applications are growing very fast, so the needs to protect such applications are increased. Encryption algorithms play a main role in information security systems. On the other side, those algorithms consume a significant amount of computing resources such as CPU time, memory, and battery power. This paper provides evaluation of six of the most common encryption algorithms namely: AES (Rijndael), DES, 3DES, RC2, Blowfish, and RC6. A comparison has been conducted for those encryption algorithms at different settings for each algorithm such as different sizes of data blocks, different data types ,battery power consumption, different key size and finally encryption/decryption speed. Simulation results are given to demonstrate the effectiveness of each algorithm. .
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Papers by Madiha Munir