Manuel Macia

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Ioana Mozos

University Of Medicine And Pharmacy Timisoara

Joost Smolders

Erasmus University Rotterdam

Annelise Barron

Stanford University

Andres Moreno Moreno

University of Castilla-La Mancha

Takele Gezahegn Demie

St Paul's School

Susu Zughaier

Emory University

Neelima Mondal

Jawaharlal Nehru University,New Delhi,India

Siane Rosas

Universidade Federal do Rio de Janeiro (UFRJ)

Miguel Maestro

Universidade da Coruña

Zaida Araujo

Universidad Central de Venezuela

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Papers by Manuel Macia

Secular trends on traditional ecological knowledge: An analysis of changes in different domains of knowledge among Tsimane' men

by Ana Catarina Luz, Jaime Paneque-Gálvez, and Manuel Macia

Learning and Individual Differences, 2013

and sharing with colleagues.

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Partial Substitution of Sodium Lactate for Sodium Acetate in the Bath Fluid for Hemodialysis

Artificial Organs, 2008

The role of renin-angiotensin-aldosterone system in the progression of chronic kidney disease

Treatment of Hyperlipemia in Diabetic Patients on Dialysis with a Physiological Substance

American Journal of Nephrology, 1991

Hyperlipemia is a very frequent complication of the diabetic patient on dialysis. There is diffic... more Hyperlipemia is a very frequent complication of the diabetic patient on dialysis. There is difficulty of treatment with the diet, because the dietary restriction already imposed on these patients and the secondary effects and toxicity of the available drugs in uremics aggravate the problem. We have treated 22 diabetic patients on dialysis (8 on hemodialysis and 14 on continuous ambulatory peritoneal dialysis) suffering from hyperlipemia with pantethine, a physiological substance and coenzyme A precursor in the Krebs cycle. With the administration of an oral dose of 900 mg/day we obtained a reduction of total cholesterol (275 +/- 72 vs. 231 +/- 54 mg/dl; p less than 0.001), very-low-density lipoprotein (VLDL)-cholesterol (66 +/- 36 vs. 46 +/- 18 mg/dl; p less than 0.01) and triglycerides (332 +/- 182 vs. 227 +/- 90 mg/dl; p less than 0.01) at 2 months. High-density lipoprotein (HDL)-cholesterol did not change, but the total cholesterol/HDL-cholesterol ratio decreased significantly (p less than 0.05). Total cholesterol, VLDL and triglycerides showed a progressive and significant reduction at 4 and 6 months. No changes were observed in serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, uric acid, blood glucose and glycosylated hemoglobin. Gastric discomfort in 2 patients and pruritus in another one were the secondary effects related. Pantethine was shown to be a very effective hypolipemic agent in diabetic patients on dialysis with a great tolerance.

Effect of recombinant human erythropoietin treatment on circulating reticulated platelets in uremic patients: Association with early improvement in platelet function

American Journal of Hematology, 1998

We studied the hemodynamic changes and the incidence of hypertension after correction of anemia w... more We studied the hemodynamic changes and the incidence of hypertension after correction of anemia with recombinant human erythropoietin (rhEPO) in 25 hemodialysis (HD) and in 27 continuous ambulatory peritoneal dialysis (CAPD) patients with a mean age of 44.6 years and a mean time on dialysis of 43.6 months. We analyzed basal and final hemoglobin concentrations, time elapsed to reach target hemoglobin, rhEPO dosage, and the following echocardiographic parameters: left ventricular end-systolic and end-diastolic diameters and volumes, posterior wall thickness, interventricular septum, ejection fraction, fractional fiber shortening, cardiac output index, and peripheral vascular resistance index. We did not find any significant difference between HD and CAPD patients in basal and final hemoglobin, concentrations, time elapsed to reach target hemoglobin, dose of rhEPO received for response, and incidence of hypertension. Changes were more evident in HD patients, with a decrease of 15% in cardiac output index and an equal increase of peripheral vascular resistance,. In the patients on CAPD, these variations were less important, with a decrease in cardiac output index of 10% and no significant change in peripheral vascular resistance. Despite both techniques showing the occurrence of hypertension, the left ventricular mass stabilized during the study time. We conclude that CAPD seems to modulate the changes observed in hemodynamic parameters after rhEPO treatment.

Effects of angiotensin converting enzyme inhibition on neointimal proliferation in a porcine coronary injury model

American Heart Journal, 1993

Angiotensin-receptor blockers for renal protection in Type 2 diabetes

Aging Health, 2006

ABSTRACT

Shifting dynamics of climate-functional groups in old-growth Amazonian forests

Http Dx Doi Org 10 1080 17550874 2012 715210, 2014

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[Chronic lead poisoning and the EDTA test]

Medicina Clínica

Diabetic patients on CAPD need less aluminum hydroxide as a phosphate binder than non-diabetics

Advances in peritoneal dialysis. Conference on Peritoneal Dialysis

A retrospective study was done in 86 patients on dialysis in order to evaluate the doses of alumi... more A retrospective study was done in 86 patients on dialysis in order to evaluate the doses of aluminum hydroxide (OH3 Al) received to achieve a better serum phosphate control. Thirty-seven patients were treated with continuous ambulatory peritoneal dialysis (CAPD) divided in 22 diabetics and 15 non-diabetics. Forty-nine patients were treated with hemodialysis (HD), 12 diabetics and 37 non-diabetics. The doses of 1-25 Dihidroxycholecalciferol (1-25 DOH-D3) were similar in all patients. The serum phosphate levels were similar in CAPD and HD patients with smaller doses of OH3 AL in CAPD patients (p less than 0.001). Diabetics on either technique need less OH3 AL in CAPD (CAPD p less than 0.01; HD p less than 0.05) to achieve the same or better control of serum phosphorus than non-diabetics. The overload of glucose on CAPD and the maintained hyperglycemia on diabetes mellitus would shift phosphorus into the cell and could explain these results. Finally, the less needs of aluminum hydroxide on diabetic patients could contribute to their protection against aluminum deposition and its effects.

Hiperlipidemia en el trasplante renal. Tratamiento con pantetina

ABSTRACT

Peritoneal clearances, protein losses and ultrafiltration in diabetic patients after four years on CAPD

Advances in peritoneal dialysis. Conference on Peritoneal Dialysis

Peritoneal clearances of urea (C(urea)) and creatinine (Ccr), peritoneal protein losses (PL) and ... more Peritoneal clearances of urea (C(urea)) and creatinine (Ccr), peritoneal protein losses (PL) and ultrafiltration (UF) were retrospectively evaluated in 12 diabetic patients on continuous ambulatory peritoneal dialysis (CAPD) during a four year study. The average of three determinations each year was calculated. There were not significant differences in C(urea) (ml/24 hours), Ccr (ml/24 hours), PL (g/24 hours) and UF (ml/24 hours) between the four years and basal values or in the year to year studies. Seven patients did not modify their CAPD schedule during the four years study and we did not find any statistical differences in this group in the parameters studied. There was an average incidence of peritonitis of 4.7 episodes, higher in the 2 first years (p less than 0.05). The peritonitis incidence did not affect any of the functional parameters evaluated. The results of our study suggest that C(urea), Ccr, PL and UF in diabetic patients are not affected by long-term CAPD or by the peritonitis incidence.

Fructosamine levels in CAPD: its value as glycemic index

Advances in peritoneal dialysis. Conference on Peritoneal Dialysis

We have studied fructosamine (measured by colorimetric methods) and glycosylated hemoglobin (HbA1... more We have studied fructosamine (measured by colorimetric methods) and glycosylated hemoglobin (HbA1c) using a high pressure liquid chromatography (HPLC) in 20 uremic patients managed conservatively (8 diabetics and 12 non-diabetics) and 20 patients treated with continuous ambulatory peritoneal dialysis (CAPD) including 12 diabetics and 8 non-diabetics. Twenty healthy subjects were used as control group. We have correlated the mean blood glucose (MBG) of the preceding days to fructosamine and HbA1c measurements. No differences were detected in mean fructosamine and HbA1c levels in non-diabetics patients in the CAPD or conservatively treated groups compared to controls. In diabetic patients undergoing conservative treatment or CAPD, mean fructosamine and HbA1c values were elevated when compared with control group. Both glycemic indicators were increased in most of the diabetic patients, was higher values in those patients with higher MBG. There was a good correlation in CAPD diabetic patients between fructosamine and HbA1c with MBG of the 21 previous days (r = 0.84, p less than 0.01 and r = 0.74, p less than 0.01 respectively). There was also correlation between fructosamine and HbA1c in CAPD diabetic patients (r = 0.78, p less than 0.01). We conclude that fructosamine does not seem to be influenced by uremia or by CAPD. Fructosamine and also glycosylated hemoglobin, when c-fraction is measured and HPLC method is used, can be utilized as glycemic indexes in CAPD diabetic patients.

Severe pancitopenia associated with antithyroid drugs in a patient with Graves' disease and chronic renal failure

Clinical nephrology

Androgens for the treatment of anemia in peritoneal dialysis patients

Advances in peritoneal dialysis. Conference on Peritoneal Dialysis

Before the advent of recombinant human erythropoietin (EPO), androgens were used for treatment of... more Before the advent of recombinant human erythropoietin (EPO), androgens were used for treatment of anemia in dialysis patients. However, after the availability of recombinant EPO in the 1980s, the use of these substances was abondoned. We have previously reported that androgens have beneficial actions on anemia in selected hemodialysis patients. In the present study we have analyzed the effects of androgen administration on hematologic parameters in peritoneal dialysis patients. We evaluated 9 patients treated for 6 months with nandrolone decanoate (200 mg/week intramuscularly). Hemoglobin and hematocrit values experienced a significant increment with respect to basal values during the study (9.2 +/- 0.7 g/dL and 27.7% +/- 2.3% at basal vs. 11.9 +/- 0.5 g/dL and 35.3% +/- 1.6% at month 6, respectively; P &amp;amp;lt; 0.001). In addition to the effects on the hematologic parameters, androgen administration also had beneficial anabolic actions with a significant increment in the serum concentration of total proteins and albumin (basal, 6.1 +/- 0.3 g/dL and 3.1 +/- 0.4 g/dL vs. 6.7 +/- 0.4 g/dL and 3.8 +/- 0.4 g/dL at month 6, respectively, P &amp;amp;lt; 0.01). The only adverse effect was a rise in the serum concentration of triglycerides (176 +/- 54 mg/dL vs. 144 +/- 53 mg/dL, P &amp;amp;lt; 0.01). In conclusion, androgen administration has beneficial effects on erythropoiesis as well as positive anabolic actions in patients under peritoneal dialysis.

Hemodialysis urea rebound and membrane biocompatibility: accuracy of Kt/V estimations

Artificial Organs

To date, the magnitude, causes, and factors that govern urea rebound are not clearly defined. Thi... more To date, the magnitude, causes, and factors that govern urea rebound are not clearly defined. This study was undertaken to determine the possible influence of the biocompatibility of dialyzer membrane on urea rebound and to assess the participation of rebound in the calculation of Kt/V-urea by different methods. Blood urea samples were obtained before, and at 2, 30, and 60 min posthemodialysis in 8 patients undergoing dialysis with 2 different membranes, Cuprophan and polyacrylonitrile (24 sessions with each membrane). Urea rebound was documented in all patients. The degree of rebound was large,

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Severe pancytopenia associated with antithyroid drugs in a patient with Graves' disease and chronic renal failure

Clinical nephrology

Amino acid losses during hemodialysis with polyacrylonitrile membranes: effect of intradialytic amino acid supplementation on plasma amino acid concentrations and nutritional variables in nondiabetic patients

The American journal of clinical nutrition, 2000

Malnutrition is highly prevalent in hemodialysis patients. Amino acid (AA) losses during the dial... more Malnutrition is highly prevalent in hemodialysis patients. Amino acid (AA) losses during the dialysis procedure may be a contributing factor. The objectives of this study were 1) to prospectively evaluate AA losses and their effect on plasma AA concentrations during dialysis with polyacrylonitrile at baseline and after administration of AAs by intradialysis and 2) to investigate the effects of intradialytic AA supplementation on nutritional status. Seventeen stable patients without diabetes who were receiving hemodialysis were studied. In the first phase, AA losses were evaluated over 2 wk in 10 patients randomly assigned to receive AA supplementation. AA losses were analyzed during the first week without supplementation and during the second week with AA administration. In the second phase, the patients' nutritional status was investigated after 3 mo of AA supplementation and was compared with those in 7 patients not receiving AAs. Mean +/- SD) AA losses during a 4-h dialysis s...

[Current peritoneal dialysis compared with haemodialysis: medium-term survival analysis of incident dialysis patients in the Canary Islands in recent years]

Nefrología : publicación oficial de la Sociedad Española Nefrologia, 2011

Important differences in patient survival exist between peritoneal dialysis (PD) and haemodialysi... more Important differences in patient survival exist between peritoneal dialysis (PD) and haemodialysis (HD). Several different studies have shown that PD yields a better survival rate than HD in the first and second years of treatment, especially in younger patients and non-diabetic patients with low comorbidity, whereas HD produces better results in diabetic patients, elderly patients, and in patients with greater comorbidity. In recent years, interesting changes have occurred in PD units in the Canary Islands, such as the introduction of peritoneal dialysis solutions with bicarbonate dialysate and low content of glucose degradation products, extended use of automated dialysis, and continuity of physicians and nurses in PD units, in addition to enhancing visits for advanced chronic kidney disease (ACKD). This situation led us to perform our study with the primary objective of comparing medium-term survival among incident dialysis patients on HD versus PD in recent years in the Canary I...

[Heparin-induced thrombocytopenia in hemodialysis. Case report and review of the literature]

Nefrología : publicación oficial de la Sociedad Española Nefrologia, 2006

Thrombocytopenia is a potential complication of heparin therapy. There are two forms of heparin-i... more Thrombocytopenia is a potential complication of heparin therapy. There are two forms of heparin-induced thrombocytopenia (HIT). Type-I HIT is characterized by a mild decrease in platelet count that occurs within the first 2-4 days after heparin initiation. The platelet count often returns to normal without stop heparin treatment. The mechanism of thrombocytopenia appears to be due to a direct effect of heparin on platelet activation. The second form (type-II) is an immune-mediated disorder characterized by severe thrombocytopenia, which may include both arterial and venous thrombosis. We present a case of type-II HIT occurred in a hemodialysis patient resulting in acute pulmonary embolism and peripheral venous thrombosis, and review the literature.

Secular trends on traditional ecological knowledge: An analysis of changes in different domains of knowledge among Tsimane' men

by Ana Catarina Luz, Jaime Paneque-Gálvez, and Manuel Macia

Learning and Individual Differences, 2013

and sharing with colleagues.

Download

Partial Substitution of Sodium Lactate for Sodium Acetate in the Bath Fluid for Hemodialysis

Artificial Organs, 2008

The role of renin-angiotensin-aldosterone system in the progression of chronic kidney disease

Treatment of Hyperlipemia in Diabetic Patients on Dialysis with a Physiological Substance

American Journal of Nephrology, 1991

Effect of recombinant human erythropoietin treatment on circulating reticulated platelets in uremic patients: Association with early improvement in platelet function

American Journal of Hematology, 1998

Effects of angiotensin converting enzyme inhibition on neointimal proliferation in a porcine coronary injury model

American Heart Journal, 1993

Angiotensin-receptor blockers for renal protection in Type 2 diabetes

Aging Health, 2006

ABSTRACT

Shifting dynamics of climate-functional groups in old-growth Amazonian forests

Http Dx Doi Org 10 1080 17550874 2012 715210, 2014

Download

[Chronic lead poisoning and the EDTA test]

Medicina Clínica

Diabetic patients on CAPD need less aluminum hydroxide as a phosphate binder than non-diabetics

Advances in peritoneal dialysis. Conference on Peritoneal Dialysis

Hiperlipidemia en el trasplante renal. Tratamiento con pantetina

ABSTRACT

Peritoneal clearances, protein losses and ultrafiltration in diabetic patients after four years on CAPD

Advances in peritoneal dialysis. Conference on Peritoneal Dialysis

Fructosamine levels in CAPD: its value as glycemic index

Advances in peritoneal dialysis. Conference on Peritoneal Dialysis

Severe pancitopenia associated with antithyroid drugs in a patient with Graves' disease and chronic renal failure

Clinical nephrology

Androgens for the treatment of anemia in peritoneal dialysis patients

Advances in peritoneal dialysis. Conference on Peritoneal Dialysis

Hemodialysis urea rebound and membrane biocompatibility: accuracy of Kt/V estimations

Artificial Organs

Download

Severe pancytopenia associated with antithyroid drugs in a patient with Graves' disease and chronic renal failure

Clinical nephrology

The American journal of clinical nutrition, 2000

[Current peritoneal dialysis compared with haemodialysis: medium-term survival analysis of incident dialysis patients in the Canary Islands in recent years]

Nefrología : publicación oficial de la Sociedad Española Nefrologia, 2011

[Heparin-induced thrombocytopenia in hemodialysis. Case report and review of the literature]

Nefrología : publicación oficial de la Sociedad Española Nefrologia, 2006

Manuel Macia

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