We report a case of a dirofilariasis manifesting as a breast nodule in a 32-year-old Tunisian wom... more We report a case of a dirofilariasis manifesting as a breast nodule in a 32-year-old Tunisian woman. It appeared as a relatively well-circumscribed and slightly dense nodule on mammography and was hypoechogenic with enhanced through transmission on ultrasonographic examination. The patient was treated by surgical resection. Histopathologic analysis could identify viable female and male worms as Dirofilaria repens. Dirofilaria is
We present a comparative analysis of cell-mediated immunity between circulating lymphocytes and t... more We present a comparative analysis of cell-mediated immunity between circulating lymphocytes and tumor-infiltrating lymphocytes (TIL) from patients with nasopharyngeal carcinoma (NPC). Phenotypic analysis using a panel of monoclonal antibodies (MAbs) to define lymphocytic subsets has revealed a selective homing of phenotypically lytic cells such as CD8- and CD16-positive cells, but a low percentage of macrophages when compared to PBL of NPC patients. Also, PBL and TIL contain an equivalent percentage of activated T-lymphocytes expressing HLA-DR molecules and IL-2 receptors. Functionally, TIL exhibit an abolished NK-cell activity and concomitant decrease of proliferative response to phytohemagglutinin (PHA) and concanavalin A (ConA) stimulation when compared with PBL.
A large body of evidence has suggested that the Epstein-Barr virus (EBV) is strongly associated w... more A large body of evidence has suggested that the Epstein-Barr virus (EBV) is strongly associated with undifferentiated nasopharyngeal carcinoma. Immunologically, this neoplasia is characterized by the absence of anti-EBV circulating cytotoxic T lymphocytes (CTL), despite a high number of peripheral activated CD8+ cells, as previously determined in our laboratory. In order to determine whether the absence of anti-EBV CTL is related to a reduced number of circulating anti-EBV effector cells, we attempted to expand these hypothetical specific T cells by induction of proliferation with recombinant interleukin-2 (rIL-2), in the, absence of any stimulator cells. Optimal conditions for stimulation of peripheral blood lymphocytes (PBL) of nasopharyngeal patients were obtained with 100 U/ml rIL-2 during 10 days of culture. PBL treated with rIL-2 induced a selective expansion of CD8 + cells and generated a potent cytotoxicity towards autologous or HLA-compatible lymphoblastoid cell lines, used as target cells in a chromium-release thest. However, this cytolysis was non-MHC-restricted, since, the monoclonal antibodies anti-(HLA class I) and anti-(HLA class II) were inefficient in inhibiting this cytotoxicity. Interestingly, purified CD8 + cells acquired the capacity for non-MHC-restricted cytolysis.
Objectif. -Analyser les aspects cliniques, radiologiques, thérapeutiques et évolutifs de la radio... more Objectif. -Analyser les aspects cliniques, radiologiques, thérapeutiques et évolutifs de la radionécrose cérébrale après traitement pour cancer du nasopharynx.
We report an uncommon case of Hodgkin's disease confined to the nasopharynx. An isolated poly... more We report an uncommon case of Hodgkin's disease confined to the nasopharynx. An isolated polypoid mass of the nasopharynx was observed in a 41-year-old man presenting with increasing bilateral nasal obstruction. Histological study revealed a mixed cellularity type of Hodgkin's disease. Immunohistochemical analysis revealed CD30 and LMP1 expression and a lack of reactivity to CD15, CD3 and CD20. Serological tests excluded recent infection with Epstein-Barr virus. HD of nasopharynx is rare, but has to be recognized as such in view of appropriate treatment.
Purpose. -Nasopharyngeal cancer is the commonest head and neck cancer in Tunisia treated with rad... more Purpose. -Nasopharyngeal cancer is the commonest head and neck cancer in Tunisia treated with radiotherapy. A dose effect relationship is established in this tumor. The aim of this study is to describe our Low-dose-rate endocavitary brachytherapy using a personalized mold called Tunis applicator.
Reçu le 1 avril 2005 ; reçu en forme révisée le 25 mai 2005 ; accepté le 22 juin 2005 Disponible ... more Reçu le 1 avril 2005 ; reçu en forme révisée le 25 mai 2005 ; accepté le 22 juin 2005 Disponible sur internet le 19 septembre 2005
Objectif de l'étude.-Étudier les aspects thérapeutiques et évolutifs des métastases cérébrales en... more Objectif de l'étude.-Étudier les aspects thérapeutiques et évolutifs des métastases cérébrales en fonction des différents facteurs pronostiques. Patients et méthodes.-Cent trente et un patients atteints de métastases cérébrales ont été adressés dans le service de radiothérapie entre janvier 2004 et décembre 2006. La survie des malades a été étudiée en fonction des tableaux cliniques et des aspects thérapeutiques. Résultats.-Les 31 femmes et 100 hommes étaient âgés en moyenne de 57 ans. La tumeur primitive était pulmonaire dans 72 % des cas et mammaire dans 15 %.
Cancer radiothérapie : journal de la Société française de radiothérapie oncologique
Radio-induced tumor have been known for a long time to occur after treatment of cancer during chi... more Radio-induced tumor have been known for a long time to occur after treatment of cancer during childhood. This entity is exceptional following radiotherapy of the cavum. Skull and facial osteosarcoma were described after treatment of UCNT. We report two observations of radio-induced tumors arising, respectively three and seven years after treatment of UCNT. The first one is a temporoparietal glioblastoma and the second is a rhino- and pharyngeal myxoma. The two patients are alive after treatment of the second tumor. The delay of appearance of these tumors, their situation in the field's irradiated and dose received suggests their radio-induced nature. However, the cytogenetic study is necessary to confirm the implication of radiotherapy in the genesis of these cancers.
We report a case of a dirofilariasis manifesting as a breast nodule in a 32-year-old Tunisian wom... more We report a case of a dirofilariasis manifesting as a breast nodule in a 32-year-old Tunisian woman. It appeared as a relatively well-circumscribed and slightly dense nodule on mammography and was hypoechogenic with enhanced through transmission on ultrasonographic examination. The patient was treated by surgical resection. Histopathologic analysis could identify viable female and male worms as Dirofilaria repens. Dirofilaria is
We present a comparative analysis of cell-mediated immunity between circulating lymphocytes and t... more We present a comparative analysis of cell-mediated immunity between circulating lymphocytes and tumor-infiltrating lymphocytes (TIL) from patients with nasopharyngeal carcinoma (NPC). Phenotypic analysis using a panel of monoclonal antibodies (MAbs) to define lymphocytic subsets has revealed a selective homing of phenotypically lytic cells such as CD8- and CD16-positive cells, but a low percentage of macrophages when compared to PBL of NPC patients. Also, PBL and TIL contain an equivalent percentage of activated T-lymphocytes expressing HLA-DR molecules and IL-2 receptors. Functionally, TIL exhibit an abolished NK-cell activity and concomitant decrease of proliferative response to phytohemagglutinin (PHA) and concanavalin A (ConA) stimulation when compared with PBL.
A large body of evidence has suggested that the Epstein-Barr virus (EBV) is strongly associated w... more A large body of evidence has suggested that the Epstein-Barr virus (EBV) is strongly associated with undifferentiated nasopharyngeal carcinoma. Immunologically, this neoplasia is characterized by the absence of anti-EBV circulating cytotoxic T lymphocytes (CTL), despite a high number of peripheral activated CD8+ cells, as previously determined in our laboratory. In order to determine whether the absence of anti-EBV CTL is related to a reduced number of circulating anti-EBV effector cells, we attempted to expand these hypothetical specific T cells by induction of proliferation with recombinant interleukin-2 (rIL-2), in the, absence of any stimulator cells. Optimal conditions for stimulation of peripheral blood lymphocytes (PBL) of nasopharyngeal patients were obtained with 100 U/ml rIL-2 during 10 days of culture. PBL treated with rIL-2 induced a selective expansion of CD8 + cells and generated a potent cytotoxicity towards autologous or HLA-compatible lymphoblastoid cell lines, used as target cells in a chromium-release thest. However, this cytolysis was non-MHC-restricted, since, the monoclonal antibodies anti-(HLA class I) and anti-(HLA class II) were inefficient in inhibiting this cytotoxicity. Interestingly, purified CD8 + cells acquired the capacity for non-MHC-restricted cytolysis.
Objectif. -Analyser les aspects cliniques, radiologiques, thérapeutiques et évolutifs de la radio... more Objectif. -Analyser les aspects cliniques, radiologiques, thérapeutiques et évolutifs de la radionécrose cérébrale après traitement pour cancer du nasopharynx.
We report an uncommon case of Hodgkin's disease confined to the nasopharynx. An isolated poly... more We report an uncommon case of Hodgkin's disease confined to the nasopharynx. An isolated polypoid mass of the nasopharynx was observed in a 41-year-old man presenting with increasing bilateral nasal obstruction. Histological study revealed a mixed cellularity type of Hodgkin's disease. Immunohistochemical analysis revealed CD30 and LMP1 expression and a lack of reactivity to CD15, CD3 and CD20. Serological tests excluded recent infection with Epstein-Barr virus. HD of nasopharynx is rare, but has to be recognized as such in view of appropriate treatment.
Purpose. -Nasopharyngeal cancer is the commonest head and neck cancer in Tunisia treated with rad... more Purpose. -Nasopharyngeal cancer is the commonest head and neck cancer in Tunisia treated with radiotherapy. A dose effect relationship is established in this tumor. The aim of this study is to describe our Low-dose-rate endocavitary brachytherapy using a personalized mold called Tunis applicator.
Reçu le 1 avril 2005 ; reçu en forme révisée le 25 mai 2005 ; accepté le 22 juin 2005 Disponible ... more Reçu le 1 avril 2005 ; reçu en forme révisée le 25 mai 2005 ; accepté le 22 juin 2005 Disponible sur internet le 19 septembre 2005
Objectif de l'étude.-Étudier les aspects thérapeutiques et évolutifs des métastases cérébrales en... more Objectif de l'étude.-Étudier les aspects thérapeutiques et évolutifs des métastases cérébrales en fonction des différents facteurs pronostiques. Patients et méthodes.-Cent trente et un patients atteints de métastases cérébrales ont été adressés dans le service de radiothérapie entre janvier 2004 et décembre 2006. La survie des malades a été étudiée en fonction des tableaux cliniques et des aspects thérapeutiques. Résultats.-Les 31 femmes et 100 hommes étaient âgés en moyenne de 57 ans. La tumeur primitive était pulmonaire dans 72 % des cas et mammaire dans 15 %.
Cancer radiothérapie : journal de la Société française de radiothérapie oncologique
Radio-induced tumor have been known for a long time to occur after treatment of cancer during chi... more Radio-induced tumor have been known for a long time to occur after treatment of cancer during childhood. This entity is exceptional following radiotherapy of the cavum. Skull and facial osteosarcoma were described after treatment of UCNT. We report two observations of radio-induced tumors arising, respectively three and seven years after treatment of UCNT. The first one is a temporoparietal glioblastoma and the second is a rhino- and pharyngeal myxoma. The two patients are alive after treatment of the second tumor. The delay of appearance of these tumors, their situation in the field's irradiated and dose received suggests their radio-induced nature. However, the cytogenetic study is necessary to confirm the implication of radiotherapy in the genesis of these cancers.
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Papers by M. Maalej