Papers by M. Heinrich Seegenschmiedt
Radiation Oncology, Apr 19, 2018
Background: The aim of this prospective clinical quality assessment was to evaluate the short-ter... more Background: The aim of this prospective clinical quality assessment was to evaluate the short-term and long-term efficacy of low dose radiotherapy (RT) for calcaneodynia, achillodynia, painful gonarthrosis, painful bursitis trochanterica, and painful shoulder syndrome. Methods: Between October 2011 and October 2013, patients with calcaneodynia, achillodynia, painful gonarthrosis, painful bursitis trochanterica, and painful shoulder syndrome were recruited for this prospective clinical quality assessment. Single doses of 0.5-1.0 Gy and a total dose of 6.0 Gy per series were used. Pain was measured before and directly after RT (early response) with a visual analogue scale (VAS). Additionally, pain relief was measured with the four-scale pain score according to "von Pannewitz" (VPS) immediately at the end of RT and during follow-up. Within this context we defined a good response as complete pain relief and markedly improved. The assessment of the long-term efficacy was carried out by a telephone survey. Results: 703 evaluable patients (461 female, 242 male) with a mean age of 63.2 years (28-96) were recruited for this prospective clinical quality assessment. In 254 patients RT was performed with the linear accelerator, 449 patients received orthovoltage radiotherapy. After a median follow-up of 33 months (3-60) 437 patients could be reached for evaluation of follow up results. The mean VAS value before treatment was 6.63 (1.9-10) and immediately on completion of RT 4.51 (0-10) (p < 0,001). Concerning the VPS immediately on completion of RT, a good response could be achieved in 264/703 patients (37.6%), and with the follow up in 255/437 patients (58.4%) (p < 0.001). Only in patients with gonarthrosis we could not observe a significantly improved long-term success in comparison to the results immediately after RT (30.2% versus 29.9%). Conclusion: Low dose RT is a very effective treatment for the management of calcaneodynia, achillodynia, painful gonarthrosis, painful bursitis trochanterica, and painful shoulder syndrome. Due to the delayed onset of analgesic effects low dose RT results in a significantly improved long-term efficacy in comparison to the results immediately after RT particularly in patients with calcaneodynia, achillodynia, bursitis trochanterica, and shoulder syndrome.
Kontrastmittel-Clearance als Maß der Nierenfunktion bei Patienten mit Nierenarterienstenosen (NAST)
RöFo, Jul 1, 1991
: The quantitative estimation of the characteristic radiation from 127I following external stimul... more : The quantitative estimation of the characteristic radiation from 127I following external stimulation by 241americium photons makes it possible to estimate iodine concentration. The plasma concentration of non-ionic contrast media handled by glomerular filtration was measured in 16 patients with renal artery stenosis. This was done during diagnostic angiography or percutaneous dilatation, either at an early stage (one to two hours) or at a late stage (five to eight hours). Assuming an exponential excretory function, a clearance value could be calculated. The results were compared with the clearance values of a tubular excreted radiopharmaceutical (99m technetium-MAG3). Despite the different excretory mechanisms, there was a statistically significant correlation between the scintigraphic and contrast clearances at the later time (r = 0.85, p is less than 0.001). At the earlier stage, there was no signification correlation (r = 0.46, p is greater than 0.05). The correlation between the later values and the serum creatinin level was moderately significant (r = 0.55, p less than 0.05).
In Reply to Peñagarícano
International Journal of Radiation Oncology Biology Physics, Jul 1, 2017
Review of Radiation Therapy for Palmar and Plantar Fibromatosis (Dupuytren and Ledderhose Disease)
Palmar fibromatosis and plantar fibromatosis, called Dupuytren disease and Ledderhose disease (DD... more Palmar fibromatosis and plantar fibromatosis, called Dupuytren disease and Ledderhose disease (DD, LD), respectively, are chronic inflammatory and hyperproliferative connective tissue disorders which involve the palmar fascia of the hand and the plantar fascia of the foot, where they produce nodules, cords, and contractures; in addition, the overlaying subcutaneous fat and skin layers can be affected. These digitopalmar and digitoplantar alterations are part of a deforming and progressive, irreversible condition and part of a systemic connective tissue disorder (Enzinger and Weiss 1995), which is characterized by typical biochemical changes and additional fibrous deposits located at the dorsal PIP joint (forming knuckle pads), on the ear helix, the hand wrist, the elbow, and the penis forming a penile angulation (Peyronie disease). Although the tissue changes appear to have some pathohistological similarities, many studies and research efforts to identify a single cause of this generalized disorder have failed so far (Tomasek et al. 1999; Rudolph and Vande Berg 1991). Although numerous hypotheses exist about the disease onset and progression, the specific role of mesenchymal stem cells, fibroblasts, and myofibroblasts and the correlation with the clinical development of DD and LD are still not conclusively answered (Rodel and Seegenschmiedt 2016).
15.1 Supportive Maßnahmen in der Strahlentherapie der Haut: Modulation der Strahlenwirkung an der Haut
International Journal of Radiation Oncology Biology Physics, 1999
External Thermoradiotherapy in Superficial Tumors:Basic Considerations and Results
The Journal of JASTRO, Dec 25, 1993
Clinical Rationale for Thermoradiotherapy
Springer eBooks, 1996
Oncological research has advanced in many areas, including surgery, chemotherapy (CT), radiothera... more Oncological research has advanced in many areas, including surgery, chemotherapy (CT), radiotherapy (RT), and immunotherapy, but only in a few cancers has long-term control of locally advanced and disseminated disease been routinely attained. For most cancers, local tumor control is still the primary treatment goal, and determines long-term outcome.
Radiotherapy for Graves' Orbitopathy: Results of a National Survey
Strahlentherapie Und Onkologie, Jun 1, 2003
Graves&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; orbitopathy (GO) ... more Graves&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; orbitopathy (GO) is a widely accepted indication for radiation therapy (RT). In conjunction with the German Cooperative Group on Radiotherapy for Benign Diseases (GCG-BD), a national survey was conducted in order to assess whether or not there is a consensus on the indication for RT and various treatment factors which were studied. A questionnaire was circulated to 190 RT institutions to obtain relevant data concerning the patients&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; workload, stage-dependent indication, and diagnostic procedures, which were considered to be necessary. Further questions addressed details on radiation technique and dose-fractionation schedules, the combined use of corticoids, and salvage RT after previous treatment failure following RT. With a response rate of 152/190 (80%), the survey is nationally representative. Based on the case workload, an estimated annual number of 1,600 GO cases are treated in German radiotherapy departments. With an 88% consensus, stages II-V are the typical indications. 85% considered imaging studies necessary for indication and only 48% for laboratory tests. 76% of the institutions used total doses in the range of 15-20 Gy, and conventional fractionation was most common (57%). 82% used a face mask fixation and 67% CT-based treatment planning. Approximately 50% would prescribe salvage RT, and total doses in the range of 20-40 Gy were considered to be acceptable. The survey revealed a consensus concerning most of the factors studied. We recommend to review the patterns of care for RT of other entities of benign diseases and to implement a quality assurance program both on national and international levels.
Endokrine Orbitopathie: Vergleich der Langzeitergebnisse und Klassifikationen nach Radiotherapie
Strahlentherapie Und Onkologie, Sep 1, 1998
Zusammenfassung Hintergrund Diese Studie vergleicht vier verschiedene Klassifikationen bei Patie... more Zusammenfassung Hintergrund Diese Studie vergleicht vier verschiedene Klassifikationen bei Patienten mit fortgeschrittener, therapierefraktärer endokriner Orbitopathie und untersucht deren prognostische Wertigkeit. Patienten und Methode Von 1984 bis 1994 wurden 60 konsekutive Patienten (49 Frauen, elf Männer) wegen progredienter, therapierefraktärer endokriner Orbitopathie bestrahlt (Linac 6 MV, 10mal 2 Gy). Im Verlauf wurden die Symptome und funktionellen Einschränkungen nach vier Klassifikationen bewertet: Werner-Score, modifizierter ATA-Score,
International Journal of Radiation Oncology Biology Physics, Jul 1, 1994
,90 patients with localized tumors were treated in a Phase I/II trial-w-dose 19'Ir brachytherapy ... more ,90 patients with localized tumors were treated in a Phase I/II trial-w-dose 19'Ir brachytherapy (IRT) plus interstitial 915 MHz microwave (MW) hyperthermia (IHT) and external beam radiotherapy (ERT). Tumors were classified as locally advanced primary (class 1: 27), recurrent (class 2: 40), metastatic (class 3: 10) and persistent (class 4: 13) lesions. The treatment sites included tumors of the head and neck (62), pelvis (26), and others (2). The mean cuboidal tumor volume was 63 cm3 (range: 8-288 cm3). Most recurrent and metastatic lesions (48) had received prior treatment including ERT. METHODS AND MATERIALS: The treatment protocol prescribed two heating sessions (each 60 min) at 41-44°C before and after IRT. One hundred sixty-one IHT sessions were evaluated. Invasive thermal data were recorded at an average of 18 sites throughout the implant volume. Several thermal variables were analyzed (e.g.,
15.1 Supportive Maßnahmen in der Strahlentherapie der Haut: Literatur
15.1 Supportive Maßnahmen in der Strahlentherapie der Haut: Konzept der kutanen Funktionseinheit
[Radiotherapy for painfull heel spurs]
PubMed, Apr 17, 2008
Effects of fractionation and dose rate in PDR-brachytherapy (PDR-BT) of B14-fibroblasts
European Journal of Cancer, Sep 1, 1997
Springer eBooks, 2012
The use of general descriptive names, registered names, trademarks, etc. in this publication does... more The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specifi c statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature.
Konventionelle Therapieverfahren
Elsevier eBooks, 2006
Radiotherapy and Oncology, 2005
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Papers by M. Heinrich Seegenschmiedt