Papers by Luis Espín Gómez
![Research paper thumbnail of {"__content__"=>"B Cell Defects Observed in Knockout Mice Are a Consequence of a Mutation Frequently Found in Inbred Strains.", "i"=>[{"__content__"=>"Nod2"}, {"__content__"=>"Dock2"}]}](https://attachments.academia-assets.com/115458105/thumbnails/1.jpg)
Journal of immunology (Baltimore, Md. : 1950), Jan 16, 2018
Phenotypic differences among substrains of laboratory mice due to spontaneous mutations or pre-ex... more Phenotypic differences among substrains of laboratory mice due to spontaneous mutations or pre-existing genetic variation confound the interpretation of targeted mutagenesis experiments and contribute to challenges with reproducibility across institutions. Notably, C57BL/6 Hsd mice and gene-targeted mice that have been backcrossed to this substrain have been reported to harbor a duplication in exons 28 and 29 of In this study, we demonstrate the presence of this variant in the widely used mice. Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) is a cytosolic innate immune receptor associated with inflammatory bowel disease susceptibility. Consistent with a role of NOD2 in an immunological disorder, mice bred at our institution displayed multiple B cell defects including deficiencies in recirculating B cells, marginal zone B cells, and B1a cells in vivo, as well as defects in class switch recombination in vitro. However, we found that these effects are due to the ...
The Journal of experimental medicine, Jan 31, 2017
A variant of the autophagy gene ATG16L1 is associated with Crohn's disease, an inflammatory b... more A variant of the autophagy gene ATG16L1 is associated with Crohn's disease, an inflammatory bowel disease (IBD), and poor survival in allogeneic hematopoietic stem cell transplant recipients. We demonstrate that ATG16L1 in the intestinal epithelium is essential for preventing loss of Paneth cells and exaggerated cell death in animal models of virally triggered IBD and allogeneic hematopoietic stem cell transplantation. Intestinal organoids lacking ATG16L1 reproduced this loss in Paneth cells and displayed TNFα-mediated necroptosis, a form of programmed necrosis. This cytoprotective function of ATG16L1 was associated with the role of autophagy in promoting mitochondrial homeostasis. Finally, therapeutic blockade of necroptosis through TNFα or RIPK1 inhibition ameliorated disease in the virally triggered IBD model. These findings indicate that, in contrast to tumor cells in which autophagy promotes caspase-independent cell death, ATG16L1 maintains the intestinal barrier by inhibit...
Cell Host & Microbe, 2013
Polymorphisms in the essential autophagy gene Atg16L1 have been linked with susceptibility to Cro... more Polymorphisms in the essential autophagy gene Atg16L1 have been linked with susceptibility to Crohn's disease, a major type of inflammatory bowel disease (IBD). Although the inability to control intestinal bacteria is thought to underlie IBD, the role of Atg16L1 during extracellular intestinal bacterial infections has not been sufficiently examined and compared to the function of other IBD susceptibility genes, such as Nod2, which encodes a cytosolic bacterial sensor. We find that Atg16L1 mutant mice are resistant to intestinal disease induced by the model bacterial pathogen Citrobacter rodentium. An Atg16L1 deficiency alters the intestinal environment to mediate an enhanced immune response that is dependent on monocytic cells, but this hyperimmune phenotype and its protective effects are lost in Atg16L1/Nod2 double-mutant mice. These results reveal an immunosuppressive function of Atg16L1 and suggest that gene variants affecting the autophagy pathway may have been evolutionarily maintained to protect against certain life-threatening infections.
Thesis Chapters by Luis Espín Gómez
Research process on content management in small and medium enterprises in the Region of Murcia.
Conference Presentations by Luis Espín Gómez
Trainspotting 2 (2016, Dany Boyle) es el fiel reflejo de un lenguaje cinematográfico que habla so... more Trainspotting 2 (2016, Dany Boyle) es el fiel reflejo de un lenguaje cinematográfico que habla sobre el no-lugar como espacio discursivo para una generación abortada en el marco de la crisis de la hegemonía cultural europea y global. Desde un punto de vista antropológico, filosófico y de las ciencias sociales, a través de la teoría del texto trazaré un análisis que nos permita entender esta película y sus factores, que nos revelan un subconsciente colectivo que define la narrativa cinematográfica en un marco de tránsito hacia la narrativa transmedia.
Teaching Documents by Luis Espín Gómez
Banksy es una identidad que pone en entre dicho los sistemas de control de la información generad... more Banksy es una identidad que pone en entre dicho los sistemas de control de la información generados por los gobiernos occidentales, a través de un discurso visual apoyado por la ironía como arma dialéctica de destrucción masiva. La ocultación premeditada de los datos biográficos de Banksy ha conseguido generar un mito, o lo que es lo mismo, ha conseguido difundir una corriente de información cuya fuente es la imaginación, evitando los hechos empíricos y objetivos. Banksy consigue que su historia pertenezca a la cultura popular de la misma manera que se articulan los mitos.
Drafts by Luis Espín Gómez
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Papers by Luis Espín Gómez
Thesis Chapters by Luis Espín Gómez
Conference Presentations by Luis Espín Gómez
Teaching Documents by Luis Espín Gómez
Drafts by Luis Espín Gómez