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Lucas Santos

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Rafael Pinheiro

João Carlos Souza Campos

Universidade Federal do Rio Grande do Sul

Paulo César Veiga Jardim

Sandro Fernandes da Silva

UFLA - Federal University of Lavras

UFBA - Federal University of Bahia

Liliane Vidal De Oliveira Damas

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Papers by Lucas Santos

Avaliação Do Índice De Massa Corporal e Perímetro Abdominal De Agricultores De Salvador Do Sul/RS

Caxias do Sul-RS-CEP: 95020-472 Palavras-chave: Agricultores, índice de massa corporal, perímetro... more Caxias do Sul-RS-CEP: 95020-472 Palavras-chave: Agricultores, índice de massa corporal, perímetro abdominal INTRODUÇÃO: Tem-se observado dados relevantes que mostram, tanto em adultos, como crianças, de países desenvolvidos e subdesenvolvidos, uma proporção crescente de pessoas em sobrepeso e obesidade (WHO, 1988). Esses estudos demonstraram que os fatores que levam ao sobrepeso/obesidade são: idade, sexo, raça, classe socio-econômica e nível de atividade física. FUNDAMENTAÇÃO TEÓRICA: Sabe-se que no meio rural, as atividades laborais são muito intensas e estão diretamente ligadas à tarefas que envolvem o cultivo da terra. No entanto, assim como em outros grupos populacionais, estudos tem mostrado que os trabalhadores rurais, apresentam valores elevados de IMC e perímetro abdominal, fatores que estão associados diretamente com o desenvolvimento de doenças crônico-degenerativas. (MATOS; LADEIA, 2003; VENKATRAMANA; PALAKURU, 2002). Em estudo conduzido por Patterson et al. (2004), em u...

Uma reflexão sobre a pesca distante da dialética newtoniana: o cerco e a tainha

Cadernos de Campo (São Paulo, 1991)

Como uma tentativa de fazer alguns entrelaçamentos entre a biologia e a antropologia, por meio de... more Como uma tentativa de fazer alguns entrelaçamentos entre a biologia e a antropologia, por meio desse artigo pretendo descrever os processos cotransformacionais que se realizam antes e durante a captura de peixes por uma armadilha, na região sul da ilha do Cardoso (Cananeia, SP). Trazendo as coisas a vida, em um agenciamento distribuído, para que a armadilha de pesca cerco sejaeficiente, diversos caminhos são traçados e convergidos entre humanos e não humanos. Com isso, as atuações do cerco não estão limitadas apenas ao ambiente fluvioestuarino insular, mas atravessam as conexões com o mar (barras de Ararapira e Cananeia) e se estendem para outras regiões do Brasil.

Problemas de comunicação entre cetáceos e outros mamíferos

Revista do Instituto de Estudos Brasileiros

A primeira versão deste artigo, publicada em 1966 pela editora da Universidade da Califórnia no c... more A primeira versão deste artigo, publicada em 1966 pela editora da Universidade da Califórnia no capítulo 25 do livro Whales, dolphins and porpoises (editado por Kenneth S. Norris), foi republicada no célebre livro de Gregory Bateson Steps to an ecology mind, que teve sua última publicação pela Universidade de Chicago, no ano 2000. Embora haja divergência mínima entre o original e a publicação mais recente, os tradutores se baseiam na última versão para esta tradução.

Acompanhamento diário de margens: proposta de uma ferramenta informatizada para otimizar a análise custo-volume-lucro em micro e pequenas empresas multiprodutoras

O presente artigo apresenta uma ferramenta desenvolvida no MS-Excel que visa melhorar a acuracia ... more O presente artigo apresenta uma ferramenta desenvolvida no MS-Excel que visa melhorar a acuracia da analise custo-volume-lucro em micro e pequenas empresas (MPEs) multiprodutoras. Elaborada a partir das limitacoes da aplicacao pratica dos conceitos da analise custo-volume-lucro em ambiente de empresas multiprodutoras e considerando as restricoes de recursos comuns as MPEs, a ferramenta proposta e de facil utilizacao e, quando comparada com os resultados obtidos por estimativas de margens de contribuicoes medias, apresenta ganhos consideraveis na confiabilidade dos resultados apresentados. Sua aplicacao foi realizada atraves de um estudo de caso em uma empresa de recarga de cartuchos. Atraves dos resultados obtidos foi possivel identificar divergencias de aproximadamente 30% entre os valores estimados pelos gestores da empresa e os obtidos pelo acompanhamento diario de margens.

Aparelho Ortopédico Funcional SN11

Revista de Odontologia Contemporânea

Problema De Roteirização De Delivery De Comida

Engenharia de produção: produtividade e competitividade

Baroreflex Sensitivity And Autonomic Modulation In Elders With Hypertension Undergoing Lifestyle Interventions: Secondary Outcomes Of The Hael Study

Medicine & Science in Sports & Exercise

Growth and Mineral Composition of Tropical Forage Legumes Inoculated with Rhizobia

BRAZILIAN JOURNAL OF AGRICULTURE - Revista de Agricultura

The objective of this paper was to evaluate the influence of indigenous and inoculated rhizobia a... more The objective of this paper was to evaluate the influence of indigenous and inoculated rhizobia and ammonium sulfate fertilizer on growth and mineral composition of the herbaceous legumes, Calopo (Calopogonium mucunoides), Ea Ea (Desmodium heterocarpon subsp. ovalifolium) and Kudzu (Pueraria phaseoloides), which are commonly used as forage plants and cover crops in Brazil. The treatments did not exhibit differences for total biomass of nodules. Lime application along with basic fertilization (without N) permitted nodulation and full growth and development of forages with native rhizobia.

O ‘Criador’ e os ‘barcos grandes’: imaginando políticas institucionais pesqueiras e ambientais

Boletim do Museu Paraense Emílio Goeldi. Ciências Humanas

Resumo Cardumes de tainha participam anualmente das paisagens marítimas da vila do Pontal do Lest... more Resumo Cardumes de tainha participam anualmente das paisagens marítimas da vila do Pontal do Leste, ilha do Cardoso, Cananeia, São Paulo. As práticas pesqueiras focadas nesses peixes são costumeiras na vila, mas estão fracassando pela competição com as ‘traineiras’ de diversas localidades da região Sul do Brasil. As traineiras são ‘barcos grandes’ de pesca industrial, com grande poder de pesca. Além das intensas predações dessas embarcações estarem trazendo perturbações nas atividades dos pescadores da vila, e nos processos reprodutivos e de crescimento das próprias tainhas, estão também ocasionando conflitos com os ensinamentos do ‘Criador’ (Deus, no Cristianismo). Enquanto o Criador instrui aos habitantes da vila de que existem limiares de predação para qualquer animal não humano, os barcos grandes, motivados pelo mercado e pelo capital, desrespeitam esses ensinamentos. Um dos objetivos deste artigo é descrever a complexa malha cosmopolítica, analisando algumas controvérsias que e...

Peripheral Blood as Tool to Determine Gene Expression Patterns in Patients with Psychiatric, Neurological and Other Common Disorders: A Systematic Review and Meta-Analysis Protocol

Introduction: Common diseases are influenced by a variety of factors that can enhance one person&... more Introduction: Common diseases are influenced by a variety of factors that can enhance one person's susceptibility to developing a specific condition. Complex traits have been investigated in several biological levels. One that reflects the high interconnectivity and interaction of genes, proteins and transcription factors is the transcriptome. In this study, we disclose the protocol for a systematic review and meta-analysis aiming at summarizing the available evidence regarding transcriptomic gene expression levels of peripheral blood samples comparing subjects with psychiatric, neurological and other common disorders to healthy controls. Methods and analysis: The investigation of the transcriptomic levels in the peripheral blood enables the unique opportunity to unravel the etiology of common diseases in patients ex-vivo. However, the experimental results should be minimally consistent across studies for them to be considered as the best approximation of the true effect. In ord...

Application and Analysis of the moving mesh algorithm AMI in a small scale HAWT: validation with field test’s results against the frozen rotor approach

Energy

Abstract The wind power contribution for the global energy matrix and its technological and comme... more Abstract The wind power contribution for the global energy matrix and its technological and commercial maturity becomes an important fact for the sustainable energy development. The CFD studies gain importance with the computational progress to improve the efficiency of wind turbines on the aerodynamic criteria. The RANS models show the best relation between accuracy and required computational effort. The present article investigates the application of Arbitrary Mesh Interface (AMI) in transient regime and k-ω SST turbulence model in its standard setting to obtain the Power Coefficient of a small HAWT by using OpenFOAM (pimpleDyMFoam). The numerical results were comparable with the field test results and the numerical results obtained with frozen rotor approach, in stationary regime (simpleFoam) and the same turbulence model. The findings showed good agreement between simulations and experiments. The moving mesh approach with layers addition over the blade's surface, for the adjustment of y+ values, was determinant for the results and reproduced well the three-dimensional dynamic effects of flow for this application. The frozen rotor approach resembled the condition of a stopped rotor and its weaknesses are presented and discussed. The numerical results lied between the highest and the mean experimental values and consistently within the confidence interval.

Functional myology of the thoracic limb in Pampas fox (Lycalopex gymnocercus): a descriptive and comparative analysis

Journal of anatomy, Jan 14, 2018

The characteristics of the muscles of the thoracic limb were evaluated in 22 specimens of Lycalop... more The characteristics of the muscles of the thoracic limb were evaluated in 22 specimens of Lycalopex gymnocercus. Descriptive and comparative analyses showed similarity with other canids in terms of topography and tendon insertions. Differences with the domestic dog were observed in the pectoralis profundus, triceps brachii and interflexorii muscles. Intraspecific variations were observed in the rhomboideus capitis, serratus ventralis cervicis, extensor carpi radialis, extensor digiti I and II, lumbricales, flexor digiti I brevis, abductor digiti I brevis, and flexor digiti V muscles. The analyses of muscle architecture carried out in nine specimens showed that there was no difference in muscle percentage mass in the thoracic limb of males and females, but a young specimen showed significant lower percentage mass. The triceps brachii caput longus muscle showed the greatest mass, the subscapularis muscle showed the greatest physiological cross-sectional area value, and the extrinsic m...

Individual Muscle Hypertrophy and Strength Responses to High vs. Low Resistance Training Frequencies

Journal of strength and conditioning research, Jan 4, 2018

Damas, F, Barcelos, C, Nóbrega, SR, Ugrinowitsch, C, Lixandrão, ME, Santos, LMEd, Conceição, MS, ... more Damas, F, Barcelos, C, Nóbrega, SR, Ugrinowitsch, C, Lixandrão, ME, Santos, LMEd, Conceição, MS, Vechin, FC, and Libardi, CA. Individual muscle hypertrophy and strength responses to high vs. low resistance training frequencies. J Strength Cond Res XX(X): 000-000, 2018-The aim of this short communication was to compare the individual muscle mass and strength gains with high (HF) vs. low (LF) resistance training (RT) frequencies using data from our previous study. We used a within-subject design in which 20 subjects had one leg randomly assigned to HF (5× per week) and the other to LF (2 or 3× per week). Muscle cross-sectional area and 1 repetition maximum were assessed at baseline and after 8 weeks of RT. HF showed a higher 8-week accumulated total training volume (TTV) (p < 0.0001) compared with LF. Muscle cross-sectional area and 1 repetition maximum values increased significantly and similarly for HF and LF protocols (p > 0.05). This short communication highlights that some ...

Patterns of vector species richness and species composition as drivers of Chagas disease occurrence in Brazil

International journal of environmental health research, Jan 31, 2018

Chagas disease represents one of the major health issue in Latin America. Epidemiological control... more Chagas disease represents one of the major health issue in Latin America. Epidemiological control is focused on disease vectors, so studies on the ecology of triatomine vectors constitute a central strategy. Recently, research at large spatial scale has been produced, and authors commonly rely on the assumption that geographical regions presenting good environmental conditions for most vector species are also those with high risk of infection. In the present work, we provide an explicit evaluation for this assumption. Employing species distribution models and epidemiological data for Chagas disease in Brazilian territory, our results show that species richness is a poor predictor for the observed pattern of Chagas disease occurrence. Species composition proved to be a better predictor. We stress that research on macroecology of infectious diseases should go beyond the analysis of biodiversity patterns and consider human infections as a central part of the focal ecological systems.

Ayahuasca and Its DMT- and β-carbolines - Containing Ingredients Block the Expression of Ethanol-Induced Conditioned Place Preference in Mice: Role of the Treatment Environment

Frontiers in pharmacology, 2018

Ayahuasca is a hallucinogenic beverage produced from the decoction of (Bc) and (Pv), β-carboline-... more Ayahuasca is a hallucinogenic beverage produced from the decoction of (Bc) and (Pv), β-carboline- and -dimethyltryptamine(DMT)-containing plants, respectively. Accumulating evidence suggests that ayahuasca may have therapeutic effects on ethanol abuse. It is not known, however, whether its effects are dependent on the presence of DMT or if non-DMT-containing components would have therapeutic effects. The aim of the present study was to investigate the rewarding properties of ayahuasca (30, 100, and 300 mg/kg, orally), Bc (132, 440, and 1320 mg/kg, orally) and Pv (3.75, 12.5 and 37.5 mg/kg, i.p.) extracts and their effects on ethanol (1.8 g/kg, i.p.) reward using the conditioned place preference (CPP) paradigm in male mice. Animals were conditioned with ayahuasca, Bc or Pv extracts during 8 sessions. An intermediate, but not a high, dose of ayahuasca induced CPP in mice. Bc and Pv did not induce CPP. Subsequently, the effects of those extracts were tested on the development of ethano...

Pharmaceutical Services in Primary Health Care: are pharmacists and users on the same page?

Ciencia & saude coletiva, 2017

This study investigated structural and organizational characteristics of the Pharmaceutical Servi... more This study investigated structural and organizational characteristics of the Pharmaceutical Services based on Primary Health Care (PHCPS) from the viewpoints of users and pharmacists. A mixed method design was applied, combining one-to-one semi-structured interviews with four pharmacists in charge of five public dispensing facilities and 69 users, with a secondary database analysis. Data were collected from February to August 2014 in Divinópolis, a municipality in Minas Gerais State. PHCPS were similar in terms of general activities performed and staff profile and background. While users were concerned about medicines' availability and improvements related to the PHCPS' conveniences and personnel, pharmacists pointed out problems regarding infrastructure to storage. Despite most users had low information on how to use their medicines, no pharmacists declared to participate in medicines dispensing activities. There was a low match between users and pharmacists viewpoints and ...

Como os cães sonham

Ponto Urbe, 2016

Como os cães sonham Naturezas amazônicas e as políticas do engajamento transespécies How dogs dre... more

Prevalence and vertical transmission of human pegivirus among pregnant women infected with HIV

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, Jan 8, 2017

To determine the prevalence of human pegivirus (HPgV) and factors associated with vertical transm... more To determine the prevalence of human pegivirus (HPgV) and factors associated with vertical transmission among pregnant women infected with HIV. A retrospective cross-sectional study was conducted among pregnant women treated at an HIV reference service in Rio Grande, Brazil, between January 1, 2010, and January 1, 2015. The polymerase chain reaction was used to diagnose HPgV infection among the women and their neonates. Clinical, obstetric, and neonatal data were obtained from medical records. Infection with HPgV was detected among 16 (25%) of 63 women and 5 (8%) of 63 newborns, corresponding to a vertical transmission rate of 31%. Multivariate analysis demonstrated that the absence of prenatal care was the only risk factor for vertical transmission of HPgV (prevalence ratio 19.61, 95% confidence interval 1.29-297.48; P=0.032). Prenatal care could protect against vertical transmission of HPgV among women infected with HIV; however, studies among HIV-negative individuals are still re...

Glycobiology Modifications in Intratumoral Hypoxia: The Breathless Side of Glycans Interaction

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Jan 3, 2017

Post-translational and co-translational enzymatic addition of glycans (glycosylation) to proteins... more Post-translational and co-translational enzymatic addition of glycans (glycosylation) to proteins, lipids, and other carbohydrates, is a powerful regulator of the molecular machinery involved in cell cycle, adhesion, invasion, and signal transduction, and is usually seen in both in vivo and in vitro cancer models. Glycosyltransferases can alter the glycosylation pattern of normal cells, subsequently leading to the establishment and progression of several diseases, including cancer. Furthermore, a growing amount of research has shown that different oxygen tensions, mainly hypoxia, leads to a markedly altered glycosylation, resulting in altered glycan-receptor interactions. Alteration of intracellular glucose metabolism, from aerobic cellular respiration to anaerobic glycolysis, inhibition of integrin 3α1β translocation to the plasma membrane, decreased 1,2-fucosylation of cell-surface glycans, and galectin overexpression are some consequences of the hypoxic tumor microenvironment. Ad...

Towards the Classical Description of Halogen Bonds: A Quantum Based Generalized Empirical Potential for F, Cl and Br

The journal of physical chemistry. A, Jan 14, 2017

The electronic effects in supramolecular systems are a great challenge for computational chemistr... more The electronic effects in supramolecular systems are a great challenge for computational chemistry, and the understanding of ligand-protein interactions driven by Halogen Bonds can be limited by Molecular Mechanics point of view. In fact, the variations of the Halogen Bond acceptors, such as an aromatic ring and electrons lone pairs, restrict the classical approximations even more. Our work enhances the statement that Halogen Bonds are led mainly by orbital interactions via σ*C-X. Nonetheless, we have pointed a straight relationship between the maximum ESP value on the σ-hole and the LUMO energy levels of the Halogen Bond donor. In line with this scenario, the current work introduces a new promising empirical potential based on quantum parameterizations able to describe general halogen bonded systems. The new parameters allow force fields to detect variations on the molecular electronic structure of halogenated organic compounds to improve the description of fluorine, chlorine and b...

Avaliação Do Índice De Massa Corporal e Perímetro Abdominal De Agricultores De Salvador Do Sul/RS

Caxias do Sul-RS-CEP: 95020-472 Palavras-chave: Agricultores, índice de massa corporal, perímetro... more Caxias do Sul-RS-CEP: 95020-472 Palavras-chave: Agricultores, índice de massa corporal, perímetro abdominal INTRODUÇÃO: Tem-se observado dados relevantes que mostram, tanto em adultos, como crianças, de países desenvolvidos e subdesenvolvidos, uma proporção crescente de pessoas em sobrepeso e obesidade (WHO, 1988). Esses estudos demonstraram que os fatores que levam ao sobrepeso/obesidade são: idade, sexo, raça, classe socio-econômica e nível de atividade física. FUNDAMENTAÇÃO TEÓRICA: Sabe-se que no meio rural, as atividades laborais são muito intensas e estão diretamente ligadas à tarefas que envolvem o cultivo da terra. No entanto, assim como em outros grupos populacionais, estudos tem mostrado que os trabalhadores rurais, apresentam valores elevados de IMC e perímetro abdominal, fatores que estão associados diretamente com o desenvolvimento de doenças crônico-degenerativas. (MATOS; LADEIA, 2003; VENKATRAMANA; PALAKURU, 2002). Em estudo conduzido por Patterson et al. (2004), em u...

Uma reflexão sobre a pesca distante da dialética newtoniana: o cerco e a tainha

Cadernos de Campo (São Paulo, 1991)

Como uma tentativa de fazer alguns entrelaçamentos entre a biologia e a antropologia, por meio de... more Como uma tentativa de fazer alguns entrelaçamentos entre a biologia e a antropologia, por meio desse artigo pretendo descrever os processos cotransformacionais que se realizam antes e durante a captura de peixes por uma armadilha, na região sul da ilha do Cardoso (Cananeia, SP). Trazendo as coisas a vida, em um agenciamento distribuído, para que a armadilha de pesca cerco sejaeficiente, diversos caminhos são traçados e convergidos entre humanos e não humanos. Com isso, as atuações do cerco não estão limitadas apenas ao ambiente fluvioestuarino insular, mas atravessam as conexões com o mar (barras de Ararapira e Cananeia) e se estendem para outras regiões do Brasil.

Problemas de comunicação entre cetáceos e outros mamíferos

Revista do Instituto de Estudos Brasileiros

A primeira versão deste artigo, publicada em 1966 pela editora da Universidade da Califórnia no c... more A primeira versão deste artigo, publicada em 1966 pela editora da Universidade da Califórnia no capítulo 25 do livro Whales, dolphins and porpoises (editado por Kenneth S. Norris), foi republicada no célebre livro de Gregory Bateson Steps to an ecology mind, que teve sua última publicação pela Universidade de Chicago, no ano 2000. Embora haja divergência mínima entre o original e a publicação mais recente, os tradutores se baseiam na última versão para esta tradução.

Acompanhamento diário de margens: proposta de uma ferramenta informatizada para otimizar a análise custo-volume-lucro em micro e pequenas empresas multiprodutoras

O presente artigo apresenta uma ferramenta desenvolvida no MS-Excel que visa melhorar a acuracia ... more O presente artigo apresenta uma ferramenta desenvolvida no MS-Excel que visa melhorar a acuracia da analise custo-volume-lucro em micro e pequenas empresas (MPEs) multiprodutoras. Elaborada a partir das limitacoes da aplicacao pratica dos conceitos da analise custo-volume-lucro em ambiente de empresas multiprodutoras e considerando as restricoes de recursos comuns as MPEs, a ferramenta proposta e de facil utilizacao e, quando comparada com os resultados obtidos por estimativas de margens de contribuicoes medias, apresenta ganhos consideraveis na confiabilidade dos resultados apresentados. Sua aplicacao foi realizada atraves de um estudo de caso em uma empresa de recarga de cartuchos. Atraves dos resultados obtidos foi possivel identificar divergencias de aproximadamente 30% entre os valores estimados pelos gestores da empresa e os obtidos pelo acompanhamento diario de margens.

Aparelho Ortopédico Funcional SN11

Revista de Odontologia Contemporânea

Problema De Roteirização De Delivery De Comida

Engenharia de produção: produtividade e competitividade

Baroreflex Sensitivity And Autonomic Modulation In Elders With Hypertension Undergoing Lifestyle Interventions: Secondary Outcomes Of The Hael Study

Medicine & Science in Sports & Exercise

Growth and Mineral Composition of Tropical Forage Legumes Inoculated with Rhizobia

BRAZILIAN JOURNAL OF AGRICULTURE - Revista de Agricultura

The objective of this paper was to evaluate the influence of indigenous and inoculated rhizobia a... more The objective of this paper was to evaluate the influence of indigenous and inoculated rhizobia and ammonium sulfate fertilizer on growth and mineral composition of the herbaceous legumes, Calopo (Calopogonium mucunoides), Ea Ea (Desmodium heterocarpon subsp. ovalifolium) and Kudzu (Pueraria phaseoloides), which are commonly used as forage plants and cover crops in Brazil. The treatments did not exhibit differences for total biomass of nodules. Lime application along with basic fertilization (without N) permitted nodulation and full growth and development of forages with native rhizobia.

O ‘Criador’ e os ‘barcos grandes’: imaginando políticas institucionais pesqueiras e ambientais

Boletim do Museu Paraense Emílio Goeldi. Ciências Humanas

Resumo Cardumes de tainha participam anualmente das paisagens marítimas da vila do Pontal do Lest... more Resumo Cardumes de tainha participam anualmente das paisagens marítimas da vila do Pontal do Leste, ilha do Cardoso, Cananeia, São Paulo. As práticas pesqueiras focadas nesses peixes são costumeiras na vila, mas estão fracassando pela competição com as ‘traineiras’ de diversas localidades da região Sul do Brasil. As traineiras são ‘barcos grandes’ de pesca industrial, com grande poder de pesca. Além das intensas predações dessas embarcações estarem trazendo perturbações nas atividades dos pescadores da vila, e nos processos reprodutivos e de crescimento das próprias tainhas, estão também ocasionando conflitos com os ensinamentos do ‘Criador’ (Deus, no Cristianismo). Enquanto o Criador instrui aos habitantes da vila de que existem limiares de predação para qualquer animal não humano, os barcos grandes, motivados pelo mercado e pelo capital, desrespeitam esses ensinamentos. Um dos objetivos deste artigo é descrever a complexa malha cosmopolítica, analisando algumas controvérsias que e...

Peripheral Blood as Tool to Determine Gene Expression Patterns in Patients with Psychiatric, Neurological and Other Common Disorders: A Systematic Review and Meta-Analysis Protocol

Introduction: Common diseases are influenced by a variety of factors that can enhance one person&... more Introduction: Common diseases are influenced by a variety of factors that can enhance one person's susceptibility to developing a specific condition. Complex traits have been investigated in several biological levels. One that reflects the high interconnectivity and interaction of genes, proteins and transcription factors is the transcriptome. In this study, we disclose the protocol for a systematic review and meta-analysis aiming at summarizing the available evidence regarding transcriptomic gene expression levels of peripheral blood samples comparing subjects with psychiatric, neurological and other common disorders to healthy controls. Methods and analysis: The investigation of the transcriptomic levels in the peripheral blood enables the unique opportunity to unravel the etiology of common diseases in patients ex-vivo. However, the experimental results should be minimally consistent across studies for them to be considered as the best approximation of the true effect. In ord...

Application and Analysis of the moving mesh algorithm AMI in a small scale HAWT: validation with field test’s results against the frozen rotor approach

Energy

Abstract The wind power contribution for the global energy matrix and its technological and comme... more Abstract The wind power contribution for the global energy matrix and its technological and commercial maturity becomes an important fact for the sustainable energy development. The CFD studies gain importance with the computational progress to improve the efficiency of wind turbines on the aerodynamic criteria. The RANS models show the best relation between accuracy and required computational effort. The present article investigates the application of Arbitrary Mesh Interface (AMI) in transient regime and k-ω SST turbulence model in its standard setting to obtain the Power Coefficient of a small HAWT by using OpenFOAM (pimpleDyMFoam). The numerical results were comparable with the field test results and the numerical results obtained with frozen rotor approach, in stationary regime (simpleFoam) and the same turbulence model. The findings showed good agreement between simulations and experiments. The moving mesh approach with layers addition over the blade's surface, for the adjustment of y+ values, was determinant for the results and reproduced well the three-dimensional dynamic effects of flow for this application. The frozen rotor approach resembled the condition of a stopped rotor and its weaknesses are presented and discussed. The numerical results lied between the highest and the mean experimental values and consistently within the confidence interval.

Functional myology of the thoracic limb in Pampas fox (Lycalopex gymnocercus): a descriptive and comparative analysis

Journal of anatomy, Jan 14, 2018

The characteristics of the muscles of the thoracic limb were evaluated in 22 specimens of Lycalop... more The characteristics of the muscles of the thoracic limb were evaluated in 22 specimens of Lycalopex gymnocercus. Descriptive and comparative analyses showed similarity with other canids in terms of topography and tendon insertions. Differences with the domestic dog were observed in the pectoralis profundus, triceps brachii and interflexorii muscles. Intraspecific variations were observed in the rhomboideus capitis, serratus ventralis cervicis, extensor carpi radialis, extensor digiti I and II, lumbricales, flexor digiti I brevis, abductor digiti I brevis, and flexor digiti V muscles. The analyses of muscle architecture carried out in nine specimens showed that there was no difference in muscle percentage mass in the thoracic limb of males and females, but a young specimen showed significant lower percentage mass. The triceps brachii caput longus muscle showed the greatest mass, the subscapularis muscle showed the greatest physiological cross-sectional area value, and the extrinsic m...

Individual Muscle Hypertrophy and Strength Responses to High vs. Low Resistance Training Frequencies

Journal of strength and conditioning research, Jan 4, 2018

Damas, F, Barcelos, C, Nóbrega, SR, Ugrinowitsch, C, Lixandrão, ME, Santos, LMEd, Conceição, MS, ... more Damas, F, Barcelos, C, Nóbrega, SR, Ugrinowitsch, C, Lixandrão, ME, Santos, LMEd, Conceição, MS, Vechin, FC, and Libardi, CA. Individual muscle hypertrophy and strength responses to high vs. low resistance training frequencies. J Strength Cond Res XX(X): 000-000, 2018-The aim of this short communication was to compare the individual muscle mass and strength gains with high (HF) vs. low (LF) resistance training (RT) frequencies using data from our previous study. We used a within-subject design in which 20 subjects had one leg randomly assigned to HF (5× per week) and the other to LF (2 or 3× per week). Muscle cross-sectional area and 1 repetition maximum were assessed at baseline and after 8 weeks of RT. HF showed a higher 8-week accumulated total training volume (TTV) (p < 0.0001) compared with LF. Muscle cross-sectional area and 1 repetition maximum values increased significantly and similarly for HF and LF protocols (p > 0.05). This short communication highlights that some ...

Patterns of vector species richness and species composition as drivers of Chagas disease occurrence in Brazil

International journal of environmental health research, Jan 31, 2018

Chagas disease represents one of the major health issue in Latin America. Epidemiological control... more Chagas disease represents one of the major health issue in Latin America. Epidemiological control is focused on disease vectors, so studies on the ecology of triatomine vectors constitute a central strategy. Recently, research at large spatial scale has been produced, and authors commonly rely on the assumption that geographical regions presenting good environmental conditions for most vector species are also those with high risk of infection. In the present work, we provide an explicit evaluation for this assumption. Employing species distribution models and epidemiological data for Chagas disease in Brazilian territory, our results show that species richness is a poor predictor for the observed pattern of Chagas disease occurrence. Species composition proved to be a better predictor. We stress that research on macroecology of infectious diseases should go beyond the analysis of biodiversity patterns and consider human infections as a central part of the focal ecological systems.

Ayahuasca and Its DMT- and β-carbolines - Containing Ingredients Block the Expression of Ethanol-Induced Conditioned Place Preference in Mice: Role of the Treatment Environment

Frontiers in pharmacology, 2018

Ayahuasca is a hallucinogenic beverage produced from the decoction of (Bc) and (Pv), β-carboline-... more Ayahuasca is a hallucinogenic beverage produced from the decoction of (Bc) and (Pv), β-carboline- and -dimethyltryptamine(DMT)-containing plants, respectively. Accumulating evidence suggests that ayahuasca may have therapeutic effects on ethanol abuse. It is not known, however, whether its effects are dependent on the presence of DMT or if non-DMT-containing components would have therapeutic effects. The aim of the present study was to investigate the rewarding properties of ayahuasca (30, 100, and 300 mg/kg, orally), Bc (132, 440, and 1320 mg/kg, orally) and Pv (3.75, 12.5 and 37.5 mg/kg, i.p.) extracts and their effects on ethanol (1.8 g/kg, i.p.) reward using the conditioned place preference (CPP) paradigm in male mice. Animals were conditioned with ayahuasca, Bc or Pv extracts during 8 sessions. An intermediate, but not a high, dose of ayahuasca induced CPP in mice. Bc and Pv did not induce CPP. Subsequently, the effects of those extracts were tested on the development of ethano...

Pharmaceutical Services in Primary Health Care: are pharmacists and users on the same page?

Ciencia & saude coletiva, 2017

This study investigated structural and organizational characteristics of the Pharmaceutical Servi... more This study investigated structural and organizational characteristics of the Pharmaceutical Services based on Primary Health Care (PHCPS) from the viewpoints of users and pharmacists. A mixed method design was applied, combining one-to-one semi-structured interviews with four pharmacists in charge of five public dispensing facilities and 69 users, with a secondary database analysis. Data were collected from February to August 2014 in Divinópolis, a municipality in Minas Gerais State. PHCPS were similar in terms of general activities performed and staff profile and background. While users were concerned about medicines' availability and improvements related to the PHCPS' conveniences and personnel, pharmacists pointed out problems regarding infrastructure to storage. Despite most users had low information on how to use their medicines, no pharmacists declared to participate in medicines dispensing activities. There was a low match between users and pharmacists viewpoints and ...

Como os cães sonham

Ponto Urbe, 2016

Como os cães sonham Naturezas amazônicas e as políticas do engajamento transespécies How dogs dre... more

Prevalence and vertical transmission of human pegivirus among pregnant women infected with HIV

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, Jan 8, 2017

To determine the prevalence of human pegivirus (HPgV) and factors associated with vertical transm... more To determine the prevalence of human pegivirus (HPgV) and factors associated with vertical transmission among pregnant women infected with HIV. A retrospective cross-sectional study was conducted among pregnant women treated at an HIV reference service in Rio Grande, Brazil, between January 1, 2010, and January 1, 2015. The polymerase chain reaction was used to diagnose HPgV infection among the women and their neonates. Clinical, obstetric, and neonatal data were obtained from medical records. Infection with HPgV was detected among 16 (25%) of 63 women and 5 (8%) of 63 newborns, corresponding to a vertical transmission rate of 31%. Multivariate analysis demonstrated that the absence of prenatal care was the only risk factor for vertical transmission of HPgV (prevalence ratio 19.61, 95% confidence interval 1.29-297.48; P=0.032). Prenatal care could protect against vertical transmission of HPgV among women infected with HIV; however, studies among HIV-negative individuals are still re...

Glycobiology Modifications in Intratumoral Hypoxia: The Breathless Side of Glycans Interaction

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Jan 3, 2017

Post-translational and co-translational enzymatic addition of glycans (glycosylation) to proteins... more Post-translational and co-translational enzymatic addition of glycans (glycosylation) to proteins, lipids, and other carbohydrates, is a powerful regulator of the molecular machinery involved in cell cycle, adhesion, invasion, and signal transduction, and is usually seen in both in vivo and in vitro cancer models. Glycosyltransferases can alter the glycosylation pattern of normal cells, subsequently leading to the establishment and progression of several diseases, including cancer. Furthermore, a growing amount of research has shown that different oxygen tensions, mainly hypoxia, leads to a markedly altered glycosylation, resulting in altered glycan-receptor interactions. Alteration of intracellular glucose metabolism, from aerobic cellular respiration to anaerobic glycolysis, inhibition of integrin 3α1β translocation to the plasma membrane, decreased 1,2-fucosylation of cell-surface glycans, and galectin overexpression are some consequences of the hypoxic tumor microenvironment. Ad...

Towards the Classical Description of Halogen Bonds: A Quantum Based Generalized Empirical Potential for F, Cl and Br

The journal of physical chemistry. A, Jan 14, 2017

The electronic effects in supramolecular systems are a great challenge for computational chemistr... more The electronic effects in supramolecular systems are a great challenge for computational chemistry, and the understanding of ligand-protein interactions driven by Halogen Bonds can be limited by Molecular Mechanics point of view. In fact, the variations of the Halogen Bond acceptors, such as an aromatic ring and electrons lone pairs, restrict the classical approximations even more. Our work enhances the statement that Halogen Bonds are led mainly by orbital interactions via σ*C-X. Nonetheless, we have pointed a straight relationship between the maximum ESP value on the σ-hole and the LUMO energy levels of the Halogen Bond donor. In line with this scenario, the current work introduces a new promising empirical potential based on quantum parameterizations able to describe general halogen bonded systems. The new parameters allow force fields to detect variations on the molecular electronic structure of halogenated organic compounds to improve the description of fluorine, chlorine and b...